While much of the focus on cellular senescence in aging remains to find ways to selectively destroy these problem cells, there are also efforts to instead change their behavior. The reason why a growing burden of senescent cells in aged tissues is harmful, even when these cells make up only a tiny fraction of the overall cell population, is that ...

By Alejandra Borunda – NPR – Phoenix heat is notorious for the harm it causes in the short-term, like heat stroke and heart problems. Just last year, temperatures there topped 90 degrees Fahrenheit for a record-breaking 188 days. More than 140 of those days surpassed 100 degrees. A new study published in Science Advances shows […] The post Heat c...

Working with flies, mice, and human cells, scientists have demonstrated that a highly conserved protein can modulate cellular senescence, potentially opening a new avenue for future therapies [1]. Imagine what would happen if the computer code in the software we use daily began accumulating errors with time. A somewhat similar process is going ...

Drainage of cerebrospinal fluid from the brain into the body is reduced with age. The known pathways become impaired. Firstly, drainage holes in the cribriform plate behind the nose ossify and close up. Secondly the glymphatic system that carries away fluid from the brain loses lymphatic vessel density and vessel function. The outcome of reduced ...

A newly developed blood test may soon transform the clinical assessment of Alzheimer’s disease, offering not only a means to detect the condition but also a way to measure how far it has progressed. The test identifies a specific tau protein fragment in the blood – plasma MTBR-tau243 – that reflects the accumulation of insoluble tau tangles i...

Genetic medicine developer AIRNA has secured a $155 million Series B financing to advance its portfolio of RNA editing therapeutics. The funding will primarily support the development of its lead candidate, which targets a genetic mutation linked to liver and lung disease, while also expanding its focus on cardiometabolic diseases and other c...

It’s April Fool’s Day, but until we prevent our bodies from gradually deteriorating, the joke will always be on us. Here’s a no-fooling list of what’s been done to fight aging last month. Joshua “Scotch” McClure: “Infectious Disease Drives Aging”: According to McClure, his company’s synthetic version of the ubiquitous but naturally unstable ant...