Longevity Science

From hibernating ground squirrels to aging dogs, a new episode of Longevity Technology Unlocked makes a bold case: some of the most important clues for human longevity may be hiding in plain sight – in the animal kingdom. Longevity science often talks like the future will be built in a clean room. Sequencing more human genomes, collecting…

The pro-Alzheimer’s allele APOE4 makes hippocampal neurons in mice smaller and hyperexcitable. This effect, which resembles epilepsy and accelerated aging, can be mitigated by manipulating a neuronal protein [1]. Alzheimer’s disease begins long before symptoms appear, building silently for decades. The single strongest genetic risk factor for th…

When skin looks healthier, firmer, and more youthful, that usually reflects something deeper than surface appearance alone. Skin aging is driven not just by time, but by biology: oxidative stress, cellular wear, and the body’s ability to respond to damage over time. That is what makes a published 2024 study in Nutrients so notable. In a sophi…

Cymbiotika announced that it has entered a strategic partnership with human biologist Gary Brecka, founder of The Ultimate Human, to align Brecka’s protocol-driven performance approach with Cymbiotika’s liposomal nutrient delivery technology. The San Diego-based brand said the partnership will make select Cymbiotika formulations a featured supple…

Beacon Biosignals has upsized its Series B financing to $97 million, bringing cumulative funding to over $132 million, according to the company. The extension adds new investors JSL Health, Palo Santo VC, Kicker Ventures and Samsung Next to a syndicate that previously led an $86 million Series B, including Innoviva, GV, S32, Catalio Capital Manage…

Cellular senescence has been increasingly implicated in the development of pulmonary fibrosis, a largely irreversible condition with a poor prognosis under the current standard of care. An early clinical trial of first generation senolytic drugs to clear senescent cells showed promising results, but the condition remains a low priority among comp…

uPAR is expressed as a surface marker on senescent cells, and researchers have published the results of targeting chimeric antigen receptor (CAR) T cell therapies to uPAR in the context of clearing senescent cells from aged tissues. Absent an enormous reduction in cost, it is unlikely that CAR T therapies will see much use in this context, but th…

by Anne Trafton | MIT News – The cells can survive in the body for at least three months, producing enough insulin to control blood sugar levels, research shows. Most diabetes patients must carefully monitor their blood sugar levels and inject insulin multiple times per day, to help keep their blood sugar from getting too high. As a possible a…

By Kyle Umipig – Longevity.Technology – Roatán-based longevity clinic adds Klotho to its non-permanent gene therapy lineup, widening its bet on high-end healthspan medicine. In longevity, some therapies quietly build a cult following among physicians, biohackers and investors before the wider world catches on. Klotho belongs in this category, and …

In drug discovery, finding something truly new is getting harder. Not because scientists have stopped looking, but because much of the industry keeps searching through the same old drawers. The tools may be more sophisticated now – AI, automation, predictive models – but if everyone is working from similar chemical libraries, they often end u…

Some diseases move fast in the lab, but osteosarcoma. For nearly 40 years, the standard playbook for this aggressive bone disease – most often diagnosed in children, teenagers and young adults – has remained stubbornly familiar: chemotherapy, surgery, then hope that the disease does not come back or spread. In an era when oncology has produce…

There is an irony at the center of the GLP-1 boom. Drugs designed to help people lose weight and improve metabolic health are being hailed as some of the most important medical advances of the decade. But as more patients slim down, a different kind of concern is showing up in doctors’ offices: what happens when feeling healthier also changes…

Rapamycin is increasingly prescribed off-label by anti-aging physicians based on animal studies and very limited human data (even including the relatively recent crowdfunded PEARL trial) for it to improve late-life metabolism. Rapamycin and other mTOR inhibitors are calorie restriction mimetics, provoking a greater level of autophagy to improve c…

Researchers have discovered a potential treatment for post-operative delirium, which accelerates cognitive decline in older people. Roughly a quarter of older people suffer from delirium after surgery [1], which rises to around half if the surgery is particularly invasive or high-risk [2]. This increases the length of hospital stays and roughly …

WELL Health has partnered with AliveCor to integrate Canadian-registered cardiologists from WELL’s network into AliveCor’s Kardia platform, offering paid clinician ECG reviews to Canadian users. Through the Kardia app, users can request a Clinician Review after recording an ECG; reviews are completed within 24 hours by Canadian-registered cardiol…

Muscle tissue is metabolically active to a degree perhaps not fully appreciated in past years. An only partially explored class of signals known as exerkines are generated by muscle tissue in response to physical activity and produce beneficial outcomes to cell behavior and tissue function throughout the body. Much of the signaling that passes be…

by Alisha Willett, Purdue University – PHYS.ORG – In back-to-back studies published in Nature, researchers from Purdue University and Columbia University report a naturally evolved gene-editing system that can activate genes, offering an advantage over existing CRISPR gene-editing systems that merely find and cut DNA. The research includes two co…

Epidemiological studies consistently show a sizable difference in mortality rates between those who exercise regularly and those who do not. Clearly at some point aging forces a reduction in activity, and those more impacted by aging will tend to have a greater mortality risk. But animal studies show that exercise does in fact slow aging; it does…

by FANews – We are living longer than any generation before us. That is an undeniable success story of modern medicine. Yet a more important question is emerging – one that has significant implications for individuals, employers and the healthcare system alike: are we living those extra years in good health? The distinction between lifespan […] T…

Men’s longevity has become a crowded business, but not always a coherent one. You can order a blood test online, book a telehealth consult, subscribe to a hormone program, maybe even visit a specialist if you have the time and patience. The problem is that these pieces often do not talk to each other. You end up with fragments of your health …

If you have ever had a health check-up that felt reassuring in the moment but strangely disconnected from your actual life a week later, you already understand the problem Nashville-based healthcare platform Agentis Longevity and health-tech company Ultrahuman are trying to solve. A doctor gives you lab results. Maybe you get a plan. Mayb…

Leading behavior-change company Noom is known as the app that helps people rethink their relationship with food, habits and weight. But this week, the company made it clear it wants to be seen as something bigger, as it has finalized its acquisition of Tailor Made Compounding (TMC), a licensed 503A pharmacy operating in 46 states, including C…

“The biomarkers that capture aspects of the aging process could help us prioritize which ideas are worth testing more rigorously and putting more resources into.” —Peter Attia The post #386 – Aging clocks—what they measure, how they work, and their clinical and real-world relevance appeared first on Peter Attia. …

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To…

Cells in aged tissues suffer a range of biochemical dysfunctions; broken proteins, altered structures, leakage of materials from one compartment to another. Many of these issues provoke the cell into inflammatory reactions. A range of sensors operate in every cell, triggered by different forms of damage and stress characteristic of aging, and con…

Building on two previous deals between the companies, this new agreement is potentially worth up to $2.75 billion and involves Lilly licensing assets from Insilico’s pipeline. Earlier this week, the AI-driven drug discovery company Insilico Medicine announced a large-scale collaboration with the pharmaceutical giant Eli Lilly. The deal is worth …

Curve Biosciences, the “whole-body intelligence” company aiming to detect organ dysfunction before symptoms arise, is continuing its shift from platform promise to clinical execution with the appointment of Dr Amit Singal as Chief Medical Officer. Following on from Curve’s $40 million raise last year, the move signals a clear intent to embed …

The boundary between workplace wellbeing and longevity science is beginning to blur. What was once the domain of compliance and risk mitigation is shifting, gradually but decisively, toward prevention – and, with it, a more ambitious question: can employers meaningfully influence how their workforce ages? A new blog from The Longevity Sho…

Recommendations still may not be aggressive enough, but the needle is moving The post Updated cardiovascular guidelines—statin use in patients as young as 30 appeared first on Peter Attia. …

Biological age clocks promise to measure how fast we age and accelerate the search for longevity therapies. But before they can guide medicine or clinical trials, the field must confront a fundamental question: are these clocks reliable and stable? For most of human history, aging has been measured in exactly one way: time. Each year adds…

Researchers here present an interesting view of heart failure and atrial fibrillation, providing evidence for both to be manifestations of reduced TBX5 expression. TBX5 is a transcription factor, and thus influences expression of a very large number of genes; transcription factors are thus often central points of regulation for cell and tissue be…

As for the gut microbiome, the composition of the oral microbiome appears to change with age. The oral microbiome receives less attention than the gut microbiome, but the same scientific tools can be used to correlate specific changes with specific age-related conditions. Here, researchers correlate abundance of specific microbial species with th…

By Tiare Dunlap – UCLA Health – A team of researchers led by UCLA’s Dr. Daniel Geschwind has received a $13.9 million grant from the California Institute for Regenerative Medicine to use human stem cell-based models to uncover the molecular and cellular mechanisms underlying autism and schizophrenia and to identify drug targets for both condition…

By Ana Levinson – INC. – A recent study that followed more than 5,000 participants found that this measure lowers the risk of death. Researchers at the University at Buffalo, New York, tracked over 5,000 women from the ages of 63 to 99 over an eight year period. They discovered that stronger muscles contributed to […] The post This Fitness Metric…

Prediabetes has long been treated as a broad warning label: not diabetes yet, but close enough to warrant better habits and a closer eye on blood sugar. It is sensible advice, but new preliminary research suggests it may also be too generic. Presented at the American Heart Association’s EPI|Lifestyle Scientific Sessions 2026, the study ma…

Superpower announced a strategic partnership with Grail to give its members access to the Galleri multi-cancer early detection test. Timed with National Cancer Prevention and Early Detection Month, the Galleri test will be available as an add-on within Superpower’s preventative health platform and integrated with the platform’s 100+ biomarker pane…

Well Health has partnered with AliveCor to offer cardiologist-reviewed ECG services to Canadian users of AliveCor’s Kardia platform, integrating Canadian-registered cardiologists into Kardia’s AI-powered workflow. Through the Kardia app, users can request a Clinician Review after recording an ECG, and the company says reviews are evaluated by a C…

Designs for Health has launched NeuroCalm Peptide, a once-daily capsule the company says is formulated to support balance along the gut-brain axis and to promote calm, emotional well-being and stress resilience. The company describes the product as combining clinically studied peptides and a postbiotic to address everyday stressors and high-pressu…

Annovis secured U.S. Patent No. 12,582,632 B2 covering the prevention and treatment of neurological injuries arising from brain infections through the administration of buntanetap or related compounds. The patent, the company says, includes claims for preventive use in healthy individuals at risk of exposure and for reversal of neurological damage…

Low density lipoprotein (LDL) particles are a class of cholesterol transporter, carrying cholesterol out from the liver where it is manufactured to the rest of the body via the bloodstream. LDL and its cargo can become oxidized as a result of interactions with the variety of oxidizing molecules produced in the normal operation of metabolism. This…

In Aging Cell, researchers have described how the enzyme Pck1, a core part of metabolic activity, is required for staving off senescence in fat (adipose) cells. With the decrease in metabolic activity that frequently occurs with aging, human beings often accumulate fat. This fat, itself, also ages; this paper describes it as “one of the most vul…

  By Longevity.Technology – What if aging is not inevitable… but something we can actively manage? Phil Newman and Dr. Nina Patrick sit down with Aubrey de Grey, Chief Science Officer at the LEV Foundation, to explore how preventative medicine, intrinsic capacity, and early longevity therapeutics are reshaping the way we think about healthspan and…

In a landmark moment for biotech, the FDA last year granted accelerated approval to elamipretide, now marketed as Forzinity, to improve muscle strength in patients with a rare disease called Barth syndrome. The drug, developed by Stealth BioTherapeutics, became the first approved mitochondria-targeted therapeutic, marking a major milestone fo…

If longevity has a central tension, it is that most of us do not realize something is wrong until our bodies speak loudly enough that we can no longer ignore it. By then, the damage may not be irreversible, but the opportunity to intervene early is already smaller. That is the logic behind Baseline Nexus, a newly announced test bundle fro…

Cartilage is one of the least regenerative tissues in the body, and thus damage and aging leads to osteoarthritis, disability, and joint pain. There is considerable interest in finding ways to effectively repair or replace cartilage, provoke existing tissue into greater regenerative capacity, or adjust cellular biochemistry to make cartilage more…

A range of evidence suggests that severe infection causes lasting damage that accelerates degenerative aging. That damage includes an increased burden of senescent cells and their inflammatory signaling, and changes to the immune system that reduce capacity and increase chronic inflammation. Here, researchers process epidemiological data to show …

by Roswell Park Comprehensive Cancer Center – MedicalXPress – Results of a Phase I clinical trial show that patients who undergo a blood stem cell transplant involving a donor have a lower risk of relapse and lower rates of graft-versus-host disease when they receive the targeted therapy VIC-1911 along with the standard-of-care regimen that inc…

A recent study suggests that the transition of king penguins from the wild to a zoo environment, which resembles a sedentary, well-fed Western lifestyle, results in accelerated aging and changes in metabolic pathways [1]. A sedentary lifestyle and obesity are linked to accelerated aging in humans and, at the molecular level, negatively impact th…

Animal studies show that ascending doses of nanoplastic particle infiltration into tissues eventually rise to the level of inducing dysfunction. Evidently harmful nanoplastic exposure doses are considerably higher than what are thought to be environmental exposure doses in the wild at the present time, but equally it is challenging, costly, and t…

For many hundreds of years, Easter has been associated with rebirth and rejuvenation. Let’s see what’s been done last month to rejuvenate animals and people. Support the Human Ageing Genomic Resources: João Pedro de Magalhães has launched a fundraiser to help maintain this database, which has supported thousands of scientists worldwide in aging …

Partial reprogramming involves exposure of cells to one or more of the Yamanaka factors, (OCT4, SOX2, KLF4, and MYC, collectively OSKM) in order to induce a shift in epigenetic management of nuclear DNA structure to a more youthful state, while avoiding any dedifferentiation of target cell populations into induced pluripotent stem cells. This str…

The composition of the gut microbiome changes with age to favor inflammatory microbial species at the expense of those producing useful metabolites. Fecal microbiota transplantation is a way to permanently alter the composition of the gut microbiome, moving that of the recipient much closer to that of the donor. A number of studies in mice and ot…

By Blake Brittain – Reuters News – March 27 (Reuters) – A U.S. Patent Office tribunal has ruled against Nobel Prize-winning scientists Jennifer Doudna and Emmanuelle Charpentier for a second time in their dispute with ​the Broad Institute, a joint venture of Harvard University and the Massachusetts Institute of ‌Technology, over patent rights to …

by Kriti Shukla – Harperr’s Bazaar – Merely 12 months ago, when I wrote about the surge in growth factor serums, longevity was still a niche concept in beauty circles. Now, it’s steadily becoming part of everyday skincare routines. In this evolving paradigm, a “good serum” isn’t judged solely by its 12 am dewiness, but […] The post Beyond the sur…

Astrocytes make up a sizable population of supporting and structural cells in the brain, with a broad portfolio of activities that are collectively necessary for the normal operation of brain metabolism and neural activity. Like all cell populations, astrocytes are negatively impacted by the accumulating damage and dysfunction of aging, both inte…

Arming NK and T cells with metabolite-sensing receptors enhances their ability to infiltrate tumors and improves cancer outcomes in mice in a new study [1]. One of the central challenges in cancer immunotherapy is getting the right immune cells to the right place. Natural killer (NK) cells and cytotoxic T cells can recognize and destroy cancer c…

By Tanya Akim – Forbes – High performers track every metric that moves the needle—revenue, growth, operations—yet often overlook the biological systems underpinning their decisions. Gary Brecka, renowned human biologist, biohacker, longevity expert, and founder of The Ultimate Human, is changing that narrative. Known as a “longevity guru”, he’s po…

By Eric Verdin, MD, President & CEO, Buck Institute People are always asking me what they can do to change their health trajectory. They typically do this with some trepidation, holding their breath as they await a list of the arduous do’s and don’ts they expect to hear. The good news? Not all potentially life-altering changes need to be mass…

Scientists used red blood cells as membrane donors to encapsulate healthy mitochondria and send them into diseased cells, achieving improvements across multiple models and conditions [1]. Mitochondrial diseases are a diverse group of disorders that arise when mitochondria malfunction. They are often caused by mutations in mitochondrial DNA (mtDN…