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Updated 10:32am | March, 19, 2026
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Longevity biotech Fauna Bio has reached a milestone in its obesity research partnership with Eli Lilly, having designated a metabolic disease drug target identified through its AI discovery platform. The California-based company said the achievement triggers an undisclosed milestone payment as part of a multi-year agreement signed with Lilly …
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An increasing number of cells in aged tissues enter a senescent state, ceasing replication and generating pro-inflammatory signals that are disruptive to tissue structure and function. In the case of innate immune cells, however, there is some question as to whether they are in fact senescent or just adopting features of senescence, and that lead…
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The standard view of the evolution of aging is that aging exists because natural selection operates more strongly on features of young animals than on features of old animals. A faster time to reproductive success will be selected over a slower time to reproductive success. This leads to the evolution of biological systems that are front-loaded f…
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By Stanford Medicine News – Stanford Medicine scientists are launching a clinical trial of prenatal transplants, using stem cells from the mother, to treat a rare genetic disease called Fanconi anemia before a baby is born. Stanford Medicine pediatric hematologist Agnieszka Czechowicz, MD, PhD, has devoted her research career to improving treat…
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Most programs aiming to produce therapies that treat aging involve some form of manipulation of cellular metabolism, usually via small molecules initially derived from screens that showed effects on function or survival in lower animals. Effect sizes are usually modest, and decrease relative to species life span as species life span increases; la…
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Imagine a world where the plastic bottle you toss into recycling could one day help heal your brain. Scientists at the University of Edinburgh are bringing that vision to life. Their groundbreaking research shows that discarded PET bottles, the kind we see in drinks and food packaging, can be transformed into L-DOPA, a frontline medication fo…
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Longevity.Technology’s DLT (decoding longevity trends) platform is an AI-native intelligence service that turns the fragmented longevity biotech landscape into a living, queryable dataset so pharma BD teams, investors and operators can find their next deal in minutes, not weeks and months. When you access DLT, you can use …
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For years we have been mapping the longevity landscape, tracking companies, capital flows and clinical progress across the ecosystem. That work has now crystallized into a different kind of business: an AI-native data infrastructure built specifically for aging and age-related disease. In a world where AI is infusing every workflow, t…
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Most of the longevity world is obsessed with “maintenance” – slowing down the clock or patching up the leaks. But in London this month, a different breed of researchers is asking a more radical question: what if we just stop trying to fix the old biological substrate and replace it instead? Welcome to Longevity Levels 9 and 10. This w…
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Longevity science has, time and time again, been rich in possibilities and poor in proof. Researchers have shown that aging can be nudged in animals. Mice live longer. Lab systems respond. Biological pathways look promising. But translating that into something that actually matters for people – more years of good health, fewer years of declin…
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A new study reported an association between having more problematic people in close networks and increased biological aging [1]. Social connection has been discussed as a factor essential for well-being, reduced epigenetic aging, and inflammatory signaling [2, 3]. However, the dark side of social connections, relationships that are toxic and str…
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The longevity field was rocked yesterday by the news that the Aging Research & Drug Discovery (ARDD) 2026 conference will not take place in Copenhagen this year. For many years, the world’s largest event dedicated to longevity science and drug development, has drawn leading minds from academia, biotech and the pharmaceutical industry to t…
What to Expect at the Smart Ageing Summit 2026: Connection, Community, and Conversations That Matter
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The Smart Ageing Summit 2026 is more than a one day event. It is a gathering of people who care deeply about living well, ageing with vitality, and supporting long term health. Taking place on May 9 at Rhodes House in Oxford, and organised by Oxford Longevity Project, a Community Interest Company, the summit brings together credible science…
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Alchemab Therapeutics has appointed Ulrich Wendt, PhD MBA, as its new Chief Business Officer to lead business development and expand partnerships with biopharma and adjacent sectors, according to the company. The move builds on Alchemab’s recent series of pharma licensing agreements, extension of Series A funding and advancement of its first thera…
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Cellino has appointed Ed Tekeian as Chief Operating Officer, adding seasoned operational leadership as the company builds out its infrastructure for personalized cell‑based therapies, the company announced. In the newly created role at the Cambridge, Massachusetts‑based biotech, Tekeian will oversee operations across engineering, platform developm…
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Cognition Therapeutics presented an analysis from the Phase 2 COG1201 SHIMMER study of Zervimesine (CT1812) in dementia with Lewy bodies at the AD/PD 2026 conference in Copenhagen, held March 17-21, 2026. According to the company, the analysis focused on behavioral and psychiatric symptoms most commonly associated with DLB and found Zervimesine tr…
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Anavex Life Sciences presented new preclinical data at the AD/PD 2026 Conference showing that blarcamesine produced significant treatment effects in an advanced alpha‑synuclein model of Parkinson’s disease, the company announced. According to the company, subjects treated with blarcamesine showed statistically significant improvements in motor fun…
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Autophagy is the name given to a collection of cellular processes responsible for recycling damaged or otherwise unwanted proteins and structures. The materials to be recycled are conveyed to a lysosome where they are broken down into raw materials that can be reused for further protein synthesis. Many of the most well studied approaches to slowi…
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As researchers continue to map the changing composition of the gut microbiome in aging and disease, in ever more detail, they increasingly uncover the problematic activities of specific microbial species and specific mechanisms by which the aging of the gut microbiome can contribute to age-related loss of function throughout the body. This opens …
By Tokyo University of Science – Science Daily – A molecule tied to longevity may have a hidden double life—boosting healthy cells on one hand and turbocharging cancer on the other. Polyamines—natural molecules found in every living cell—have become stars in the longevity world for their ability to boost cellular cleanup and support healthy aging….
By Darren Orf – Popular Mechanics – Scientists trained a brain organoid to solve a well-known engineering task, and its success demonstrates the increasing complexity of lab-grown brains. While creating organs sounds like sci-fi fodder, scientists have actually experimented with the idea for more than a century. For example, in 1907, American bi…
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Parallel Health has introduced a new technology designed to map the metabolic activity of the skin microbiome, aiming to advance precision approaches to skin aging, according to the company. The platform, called Metabolic Microbiome Profiling, identifies the bioactive compounds that skin microbes are actively producing or failing to produce, addre…
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Cognito Therapeutics presented new data on its investigational Spectris therapy for Alzheimer’s disease at the ADPD 2026 conference, according to the company. The results add to a growing body of clinical and biomarker evidence supporting the non-invasive neurostimulation platform, which is designed to modulate brain activity through synchronized …
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Atria Health is playing a central role in a newly announced partnership with Stern Cardiovascular to expand access to advanced cardiac care across the Mid-South, according to the company. The collaboration combines Stern’s clinical expertise with Atria Health’s operational and strategic capabilities to support service expansion, new site developme…
If you’ve noticed it’s harder to build muscle than it used to be — or that strength seems to diminish faster after a break from exercise — you’re not imagining it. After age 30, adults lose an average of 3% to 8% of muscle mass per decade. This gradual loss can advance to sarcopenia, a progressive condition involving declines in muscle strength, …
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London-based Ternary Therapeutics has raised $4.4 million (€4.1 million) in a seed round led by Paris-based VC daphni, alongside Pace Ventures, i&i Biotech Fund and Future Planet Capital. On paper, a $4.4 million seed may seem modest, but in today’s biotech climate, it is more like a mark of selective confidence. Investors are willing to …
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Swiss biotech Roche has secured CE mark approval for what it says is the first in-vitro diagnostic immunoassay blood test designed to identify whether a person carries ApoE4, a genetic variant tied to a higher risk of late-onset Alzheimer’s disease and found in roughly 40% to 60% of people diagnosed with the condition [1]. On paper, that …
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The longevity industry has never had a shortage of ambition. What it has often lacked is paperwork. That may sound unglamorous in a sector built on bold promises – better energy, sharper metabolism, healthier aging, longer healthspan – but it is increasingly where the real story is. As peptides, GLP-1 therapies and NAD+ protocols move fro…
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Walk into a gym today, and you’ll likely see the familiar rhythm. Treadmills humming, weights clanging, trainers guiding clients through another set. For decades, the formula for getting healthier has looked roughly the same. Move more, sweat harder, repeat. But the fitness industry is beginning to ask a different question: what if exerci…
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The future of medicine and longevity is arriving in pieces. A wearable patch here, a whole-body scan there, a blood test promising early answers, a supplement ad insisting you are already behind. For patients, it can feel less like progress and more like static. That tension is at the center of a recent event by Vail Health, a Colorado-ba…
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The gut microbiome changes with age in ways that negatively affect tissue function and health. This is known because we live in an age in which it costs little to accurately measure the composition of the gut microbiome from a stool sample: which microbial species, and the relative abundance of each species. Bacterial species can be distinguished…
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Scientists have found a positive correlation between the abundance of the bacterium Roseburia inulinivorans in the gut and muscle strength in mice and humans, although the mechanism behind it is still unclear [1]. As we age, we lose muscle mass and strength. This decline is a major driver of frailty, disability, and poor health outcomes in older…
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By Kwak Ah-ram – The CHOSUN Daily – Author argues robot relationships risk emotional complacency, lack mutual growth potential despite offering unconditional acceptance. is even more so Robots, and the People Who Love Them By Eve Herold, Translated by Kim Chang-gyu, Published by Hyunamsa, 292 pages, 20,000 Korean won Is this love, or is it […] Th…
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The aging of the brain is characterized by the formation of solid aggregates of misfolded amyloid-β peptides. This is a foundation for later loss of cognitive function and the development of the more severe, inflammatory dysfunction of late stage Alzheimer’s disease. Researchers here provide data from cell studies to suggest that the innate immun…
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by Julia Evangelou Strait – WashU Medicine – NIH funding continues study of extreme longevity in families, seeking genetic clues to healthy aging Researchers at Washington University School of Medicine in St. Louis have received an $80 million grant to continue research into the mysteries of exceptional longevity. The grant renews support for the …
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One of the avenues by which regular exercise produces health benefits is through adjustment of the composition of the gut microbiome, favoring the production of metabolites that improve health. A range of metabolites produce by gut-resident microbial species influence important cell types in the body and brain, and are to some degree necessary fo…
by James Felton – IFLScience – Swiss pharmaceutical company Novartis has settled a lawsuit by the estate of Henrietta Lacks, which alleged that the company unfairly profited from her “immortal” cell line, taken without her knowledge or consent in 1951 and still widely used in laboratories worldwide today. Born Loretta Pleasant on 1 August 1920, …
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Annovis Bio reported fiscal year 2025 financial results and corporate updates highlighting progress in the clinical development of its investigational therapy buntanetap for neurodegenerative diseases, according to the company. The Phase 3 clinical-stage biotechnology firm said the year marked a milestone with the launch of a pivotal Phase 3 trial…
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(Photo by Glenn J. Asakawa/University of Colorado) Last month saw the passing of Thomas “Tom” E. Johnson, a giant in establishing the study of aging as a legitimate field in which one could manipulate lifespan itself, long thought of as impossible. In studying the history of technology and science, it’s difficult to imagine the world without ke…
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On the matter of cellular senescence as a contributing cause of degenerative aging, there is a school of thought whose members argue that at least some senescent cells are doing something useful by existing, despite their problematic behavior. Therefore therapeutic approaches should focus on prevention of senescence (senostatics) or reducing the …
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Researchers publishing in Aging Cell have discovered that the nuclei of the cells that line injured arteries quickly become misshapen and that this leads to accelerated cellular senescence. Delivering zinc to these cells partially alleviates this dysmorphism. This paper begins with a discussion of two different concepts that, on the surface, app…
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Researchers publishing in Aging Cell have discovered that the nuclei of the cells that line injured arteries quickly become misshapen and that this leads to accelerated cellular senescence. Delivering zinc to these cells partially alleviates this dysmorphism. This paper begins with a discussion of two different concepts that, on the surface, app…
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Researchers here provide data on the correlations between (a) secreted proteins circulating in blood that are distinct to senescent cells of various types, and (b) a number of different age-related conditions. Some cell types are better than others when it comes to the strength of correlation between the burden of senescence as assessed by circul…
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By Dana G. Smith – The New York Times – Why health influencers are obsessed with mitochondria. Last summer, Health Secretary Robert F. Kennedy Jr. said he could tell that someone was having “mitochondrial challenges” just by looking at them. The nominee for surgeon general, Dr. Casey Means, features mitochondria prominently in her book on […] The…
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Senescent cells accumulate in tissues with age to promote degenerative aging. Senescent cells cause harm via the signals that they send to other cells, the senescence-associated secretory phenotype (SASP). The SASP is by no means fully understood, and while it clearly contains many pro-inflammatory and pro-growth signals, it probably has many oth…
By Elizabeth Dougherty – Dana-Farber Cancer Institute – In the early 1970s, the field of genetics was confined to the study of bacteria and viruses. Conventional wisdom at the time was that the tools of molecular biology couldn’t be used to study human diseases. Human cells were just too hard to access, and too slow to reproduce, but also, the te…
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“It’s hard for me to mask my personal optimism around this. I love the biological plausibility of this, and I think that obicetrapib has done something that it’s four predecessors has failed to do.” —Peter Attia The post #384 – Special episode — Obicetrapib: The CETP inhibitor with cardiovascular benefits and potential Alzheimer’s prevention appe…
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Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To…
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A 75-year-old man free of dementia despite a dominant Alzheimer’s mutation — and a possible hint for the rest of us The post An intriguing case of “exceptional resilience” against dementia appeared first on Peter Attia. …
Living longer isn’t simply about adding years to your life — it’s about adding life to your years. That’s the intention behind the NOVOS line of longevity supplements, including NOVOS Core, which targets the root biological causes of aging. However, your daily food choices are equally fundamental to living and aging well. The right foods for…
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Startup biotech companies have started to use the publication of preprint scientific papers as a way to enhance their standing with investors; putting out a preprint is considerably faster than formal publication, and requires no review process. Many startups undertake programs of research and development that are novel enough to have little in t…
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A new study suggests that microbiome remodeling is a mechanism behind age-related cognitive decline, with one particular bacterial species identified as the likely culprit. In mice, antibiotics seem to reverse this effect [1]. Memory decline is a common and debilitating feature of aging, but its mechanisms remain poorly understood. The hippocamp…
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The chemistry of structural proteins in the lens of the eye changes with age in ways that render the lens less flexible, contributing to vision issues such as presbyopia, and eventually degrade its transparency. Age-related cataracts are the outcome of chemical alterations that cloud the lens and eventually lead to blindness. Better understanding…
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Take an aging population and a measure of function, and on average that measure will decline over time. That is degenerative aging in a nutshell, a loss of function, eventually including the very important function of staying alive. Within the environment of an average decline, however, it is possible to find individuals who manage to improve fun…
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By Sebastian Ocklenburg, Ph.D. – Psychology Today – A new study shows how unpleasant people lead to accelerated biological aging. Toxic people can cause a lot of stress with their behavior Studies have shown that stress can accelerate biological aging A new study investigated the effect of toxic people on biological aging Having a toxic […] The p…
By Erin Baily – UC Davis Health – For Hai Trinh, his disease started gradually. Fatigue. Bruising easily. He thought little of it. As a mechanic, husband and father of two girls, he just kept pushing forward, attributing the persistent health challenges to his long working hours and physically demanding job. When Hai finally went to his docto…
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For the third summer in a row, Longevity Xplorer (LongX) is opening applications for the Xplore Program, a fully remote summer fellowship designed to help students and early-career professionals translate interest in longevity into practical experience. The program is structured to do two things well: (1) build a shared foundation in aging biology…
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BERKELEY, CA — The Vitalism Foundation announces Vitalist Bay 2026, the world’s largest longevity festival, returning to the Lighthaven Campus in Berkeley, California from May 14–17, 2026. Now in its second year, Vitalist Bay condenses the scope into four high-intensity days and six themes — Biotech, Investors, Replacement, Longevity Science, AI x…
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Species capable of exceptional regeneration also tend to have longer life spans and slowed aging relative to similar species with less proficient regenerative capabilities. Various closely related species of spiny mouse have been studied in the context of mammalian regeneration because of their ability to shed a large amount of skin and supportin…
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A group of researchers, including Matthew O’Connor of Cyclarity Therapeutics, has published a review detailing what effects 7-ketocholesterol (7KC) has in the human body. 7KC, an oxidized cholesterol (oxysterol) gets its name from being oxidized at the C7 position within the cholesterol molecule [1]. This compound is formed by non-enzymatic proc…
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Some of the organs in the body do not have to be in their current location, nor structured in a single mass of tissue, in order to carry out all of their functions. The liver is one of these organs. Many (not all, but many) of the functions of the liver could be carried out by small amounts of liver tissue distributed throughout the body. Thus th…
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Researchers here mount an argument for aging to have evolved due to the interaction between (a) limited nutrient availability in the environment and (b) the options a cell has for generating the vital chemical energy store molecule adenosine triphosphate (ATP). Broadly, ATP can be generated via glycolysis in the cytoplasm or oxidative reactions i…
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By Jessica Hamzelou – MIT Technology Review – A survey of 82 clinics around the world reveals the messy state of longevity medicine. The quest for long, healthy life—and even immortality—is probably almost as old as humans are, but it’s never been hotter than it is right now. Today my newsfeed is full of claims […] The post Longevity clinics arou…
By Jamie Bartosch – UChicago Medicine – “I was so sick and tired; I knew I couldn’t keep doing chemo,” said Cordle, 51, who lives in Mapleton, Illinois, just outside Peoria. The next step would be stem cell transplantation, also known as bone marrow transplantation. The transplant would replace Cordle’s cancerous bone marrow with new stem cell…
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Vineeta Tanwar’s scientific path has taken her from New Delhi to Nashville to Columbus, and now to Novato. After earning her PhD from AIIMS, New Delhi, she landed at Vanderbilt University, where she worked on turning stem cells into beating heart cells (which, admittedly, never gets old). She later moved to The Ohio State University to explor…
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Mitochondria are the power plants of the cell, vital to cell and tissue function. Mitochondria become damaged and dysfunctional with age, unfortunately, and this is thought to be a major contribution to age-related degeneration. That cells will take up mitochondria from the surrounding environment and put them to use has been established for some…
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A recent study published in Geriatrics debunks the assumption that an older chronological age results in an inevitable and universal decline in health. The researchers reported that a significant number of older adults who participated in the study experienced an improvement in cognitive and/or physical functioning [1]. Older age is known as a t…
As we age, maintaining mental clarity, memory, and focus becomes increasingly important — not only for productivity but also for overall quality of life. While cognitive decline is common with age, it’s not inevitable. Lifestyle changes, nutrition, and targeted supplementation with longevity supplements like NOVOS Core can help preserve and even …
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A number of existing classes of drug are suspected to be geroprotective to some degree, altering metabolism in ways that either reduce ongoing cell and tissue damage or help to resist some of the consequences of that damage. We should expect effects on life span at established doses to be modest at best, but there is always the question of how la…
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By National Institutes of Health – Altering levels of certain molecules called transcription factors reversed some of the effects of aging in mice. The findings show the potential of targeting transcription factors to counter age-related illnesses. The activity levels of many genes change as we age. Some of these changes contribute to age-related …
By Melissa Rohman – NorthWwestern Medicine – CAR T-cell immunotherapy improved progression-free and overall survival in patients with relapsed or refractory marginal zone lymphoma, according to a recent clinical trial published in The Lancet. Marginal zone lymphoma (MZL) is a group of rare and slow-growing non-Hodgkin lymphomas that develop from…
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By Sanaragen – Sanaregen Vision Therapeutics, a clinical-stage regenerative medicine company, today announced clearance by the U.S. Food and Drug Administration to conduct a Phase I/II clinical trial for SVT-001, its investigational cell therapy. The trial will assess safety and effectiveness of SVT-001 to improve retinal function and restore visi…
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In a new study, researchers have vitrified mouse brain slices and then a complete brain with encouraging results: upon rewarming, much of the neuronal function was preserved [1]. Successful cryopreservation is a coveted prize in medicine, as cryopreserving organs and tissues can make transplantation more accessible. It is also a hot (or rather v…
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By USC Health Sciences – Science News – A groundbreaking clinical trial is testing whether specially engineered stem cells can help the brain restore its own dopamine production in people with Parkinson’s disease. Because the condition is driven by the gradual loss of dopamine-producing cells—leading to tremors, stiffness, and slowed movement—rese…
By Oregon State University – Science Daily – Scientists at Oregon State University have engineered a powerful new nanomaterial that zeroes in on cancer cells and destroys them from the inside out. Designed to exploit cancer’s unique chemistry—its acidity and high hydrogen peroxide levels—the tiny iron-based structure sparks not one but two intens…
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The European Heart Journal has published a review of what happens to the human heart as it ages, noting the cellular effects of mitochondrial dysfunction and cellular senescence along with more visible changes such as hypertrophy and fibrosis. The reviewers begin this paper by noting the constant work of the heart, as it must unceasingly pump bl…
In 2026, consumers don’t just want food that tastes good; they want food they can trust. From biohackers to busy professionals, more people are choosing functional foods with ingredients that support their healthspan and longevity. Those choices often begin with nutrition labels, which list nutrition facts of packaged goods, including servin…
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By Cleveland Clinic – As interest in longevity and healthy aging continues to grow, a new national survey from Cleveland Clinic reveals a gap between confidence and awareness when it comes to heart health. According to the 2026 report, nearly 1 in 4 Americans (24%) aren’t sure whether they are at increased risk for heart […] The post Cleveland Cl…
By Columbia University Irving Medical Center – CAR-T cell therapy has revolutionized the treatment of many blood cancers, but has shown little success against solid tumors, which account for over 85% of all cancers. Columbia researchers have now found that a new type of cell therapy—HIT cells, a cousin to CAR-T with enhanced sensitivity—overcome…
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“If there was anything wrong with seed oils in modest quantities (again beyond the caloric effects of any oil), I’m still waiting for someone to present a convincing case for that.” —Peter Attia The post #383 ‒ AMA #81: Biological aging tests, longevity training, emerging therapies, GLP-1 RAs, sun exposure, and more appeared first on Peter Attia….
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GRAIL’s landmark cancer screening trial missed its composite endpoint, but a closer look at what was reported—and what wasn’t—suggests the verdict is far from settled. The post A failed endpoint is not a failed technology appeared first on Peter Attia. …
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Scientists have found that the ratio between poly- and monounsaturated fatty acids affects the viability of T cells as well as both humoral and anti-tumor immunity [1]. Some fats are broadly recognized as healthy while others are considered unhealthy, but the reality might be more complicated than that. Poly- and monounsaturated fats (PUFAs and …
By Elise Takahama – Seattle Times – A King County jury has awarded $24 million to the family of a man who died a day after treatment at a Seattle stem cell center. Mike Trujillo was 62, a longtime electrician who ran an electrical company in Colorado. After being diagnosed with ALS in 2017, he continued to work full time, and hike and exercise…
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By David Nield – Science Alert – Not only can the drug metformin help to effectively manage type 2 diabetes, but it may also give older women a better chance of living to the grand old age of 90, according to research published in 2025 – thanks, it seems, to a variety of anti-aging effects. […] The post Common Diabetes Drug Linked With ‘Exception…
By Will Maddox – Fierce Biotech – After dumping its sole remaining gene therapy asset last year, Pfizer has decided to exercise its option for global rights to Beam Therapeutics’ liver-targeted gene editing candidate. The agreement, announced in Beam’s end-of-year filing, follows Pfizer’s exit from the gene therapy field last February when it di…
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Researchers publishing in Aging Cell have discovered how older organisms’ susceptibility to pneumonia is related to inflammatory factors. Polymorphonuclear leukocytes, more commonly known as neutrophils, are part of the first line of defense against lung infections. Illnesses cause these immune cells to be recruited from the bone marrow in a pro…
Urolithin A has caught the attention of longevity researchers and individuals interested in living healthier for longer. Derived from foods rich in ellagic acid, urolithin A has been shown to extend healthspan and lifespan in animal models. It also shows promise in humans for decreasing inflammation, increasing mitophagy, and enhancing muscle end…
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By Elise Takahama – Seattle Times – A King County jury has awarded $24 million to the family of a man who died a day after treatment at a Seattle stem cell center. Mike Trujillo was 62, a longtime electrician who ran an electrical company in Colorado. After being diagnosed with ALS in 2017, he […] The post Seattle jury awards $24M in lawsuit agai…