Longevity Science

The Cat Health Company (TCHC) has announced it has raised $1.2 million in a SAFE round led by Portfolia’s Active Aging & Longevity Fund II, joined by 100 Plus Capital, Alex Zhavoronkov, Early Game Ventures (follow-on), and a syndicated angel SPV. The company says the financing will accelerate its clinical research, expand its team and adv…

A team of scientists has reviewed the clinical data regarding low-dose rapamycin therapy in healthy adults. They concluded that, while there is plenty of preclinical data regarding the impact of rapamycin, there is no sufficient evidence that low-dose rapamycin use can extend healthspan and lifespan in healthy humans [1]. Rapamycin is a well-kno…

Lithium is a mineral present in igneous rocks. From these rocks, lithium seeps into water springs and rivers, and into drinking water and foods, such as potatoes, tomatoes, cabbage, nuts, fish and cereals. People consume lithium on a daily basis via mineral water and healthy, natural foods.  NOVOS Core is a novel supplement a…

by Arundhathi Jathin and Vynavin Vinod – Healthspan Action Coalition – Longevity Science is gaining momentum worldwide as aging populations place increasing pressure on healthcare systems. Many new and upcoming breakthroughs in aging biology, regenerative medicine, and preventive care show potential to greatly improve quality of life in later year…

Allegro NV, a biomedical company developing nanotechnology-based treatments for degenerative joint disease, has reported that its Hydrocelin injectable hydrogel demonstrates superior shock-absorbing capacity compared with four market-leading hydrogels, according to the company. The results were presented at the CellMech conference in Louvain, Belg…

Telomir Pharmaceuticals has announced new preclinical data demonstrating that its investigational therapy, Telomir-1, reactivates two critical tumor suppressor genes—MASPIN and RASSF1A—in aggressive prostate cancer models. These genes are often silenced through DNA hypermethylation, a common mechanism in cancer progression. In the studies, Telomi…

There is a sizable literature of animal studies in which researchers increase or decrease intake of one specific dietary amino acid and observe the outcomes. Despite this, there are a lot of gaps and contradictory results in the understanding of the long term effects of increased intake of specific single amino acids, even for the smaller number …

Form Bio and Cure Rare Disease have entered a strategic partnership aimed at speeding development of genetic therapies for rare neuromuscular diseases, beginning with Duchenne muscular dystrophy (DMD). Under the collaboration, Form Bio will leverage its proprietary in silico and AI/ML platform to assist Cure Rare Disease in optimizing adeno-assoc…

NeuroSense Therapeutics Ltd. has reported that its experimental Alzheimer’s therapy PrimeC produced statistically significant reductions in multiple microRNAs associated with Alzheimer’s disease, according to the company. In plasma samples from its Phase 2b PARADIGM trial, PrimeC significantly reduced levels of miR-146a-5p (p = 0.007), miR-21-5p …

Serina Therapeutics, a clinical-stage biotechnology company, has drawn the first $5 million tranche of a potential $20 million financing agreement to advance its registrational trial of SER-252 for advanced Parkinson’s disease, according to the company. Subsequent funding tranches are linked to specific development milestones, including patient en…

The H. pylori bacterium is famously associated with stomach ulcers; a researcher gave himself stomach ulcers by drinking a mix containing H. pylori to prove the point, in one of the more widely publicized self-experiments of recent history. Here, researchers review the evidence for H. pylori infection to correlate with the risk of suffering an an…

BlueRock Therapeutics says that its Phase I trial of bemdaneprocel (BRT-DA01), a cell therapy for Parkinson’s disease, produced positive results at 36 months. The company claims the therapy remains safe, with evidence of implanted cell survival and clinical trends consistent with earlier observations. The trial enrolled 12 participants in an open…

Fractyl Health has revealed preclinical results for its gene therapy candidate RJVA-002, designed to encode both GIP and GLP-1 under a human insulin promoter to promote nutrient-responsive, pancreatic expression. According to the company, a single administration in a diet-induced obesity mouse model with a humanized GIP receptor produced approxima…

Methods of both modestly impairing and modestly improving mitochondrial function have been shown to slow aging in short-lived species such as flies and nematodes, albeit for different reasons. Every cell contains hundreds of mitochondria that undertake the energetic process of producing adenosine triphosphate (ATP), a chemical energy store molecu…

There was a palpable sense of optimism in Hong Kong as experts from around the world gathered for the region’s first Longevity Medicine International Summit – a moment that signalled how far the field has come, and how much potential still lies ahead. The first-ever Asia-Pacific Longevity Medicine International Summit (APAC-LMIS) in Hong …

To challenge cultural stereotypes and misconceptions about longevity, a new organization aims to engage people who create culture. Its list of “cultural ambassadors” includes Oscar- and Grammy-winning artists. Even as geroscience is becoming a respected field, producing breakthroughs and spawning dozens of startups, the public’s attitudes toward…

Swedish biotech Alzinova has received Fast Track designation from the US FDA for its vaccine targeting Alzheimer’s disease. The news comes hot on the heels of the company securing FDA approval of its Investigational New Drug (IND) application, allowing it to proceed with a Phase 2 clinical trial in the United States. The vaccine, called A…

The search for genetic determinants of longevity in humans has, on the whole, not gone well. Only a very small number of widespread gene variants (such as those in the APOE gene) manage to show effects on life span in multiple study populations, and their effect sizes are largely much smaller than those attributed to exercise. The modern existenc…

Researchers can now accurately measure the composition of the gut microbiome, and how the distribution of different microbial species changes for the worse in association with age and disease. Studies have been conducted to map specific changes in the gut microbiome to specific diseases and outcomes. Another ongoing project is to link these relat…

By Dana G. Smith – The New York Times – We asked experts in health and aging about what women really need to do to live longer. The loudest voices in the longevity movement tend to be male. But a new subset of expert-influencers — the “menoposse”— has cropped up, with hyper-specific recommendations for what […] The post Are the Longevity Rules Di…

Harness Therapeutics has unveiled its second-generation MISBA® platform, dubbed MISBA Duo, and announced a research collaboration with Ono Venture Investment, the venture arm of Ono Pharmaceutical. According to the company, MISBA Duo enables bimodal modulation — simultaneous upregulation of one target and downregulation of another. The collaborat…

Type 2 diabetes is near entirely a condition caused by the presence of excess visceral fat tissue, by being overweight or obese. Even in relatively late stages, type 2 diabetes can be reversed by low calorie diets and the consequent loss of that excess visceral fat. Visceral fat is metabolically active, and directly provokes chronic inflammation …

In Advanced Science, a team of researchers has explained how partial cellular reprogramming through the OSKM factors restores nerve repair ability to older animals. This paper focuses on Schwann cells, glial cells that are often responsible for maintaining the protective sheaths of myelin around neuronal axons and help peripheral nerves to regen…

In the week that the Nobel Prize winners for 2025 are being announced, it seems fitting that we kick things off with news from a spin-out from the lab of Nobel laureate and gene editing pioneer Jennifer Doudna. Algen Biotechnologies today announced it has entered a multi-target research partnership with AstraZeneca aimed at accelerating drug …

The DripBar, an intravenous vitamin therapy franchise, will launch a new location in Georgetown, D.C., on October 11, 2025. According to the company, this will become its latest facility in a network that already operates over 80 locations nationwide, with more than 600 in development. The Georgetown site will provide a full menu of IV drips and …

Hundreds of mitochondria are present in every cell, responsible for generating chemical energy store molecules to power cell processes. Mitochondria are the descendants of ancient symbiotic bacteria, still replicate like bacteria, and retain a remnant genome. With age mitochondria become dysfunctional for reasons relating to damage to mitochondri…

The most important lines of cancer research are those that might lead to therapies that can be applied to many (or even all) types of cancer with little adjustment of delivery or payload. This requires a mechanism that is present in most or all cancers, and which is essential to the cancer, such that cancer cells cannot just evolve away from usin…

by Dawn M. Carpenter – Milken Institute – As leaders gather in New York for the United Nations (UN) General Assembly this September, the world is also marking the midpoint of the UN’s Decade of Healthy Ageing (2021–2030). The initiative calls on nations to work together to support healthier aging for all by confronting ageism, […] The post A Midp…

The DripBar, an intravenous vitamin therapy franchise, will launch a new location in Georgetown, D.C., on October 11, 2025. According to the company, this will become its latest facility in a network that already operates over 80 locations nationwide, with more than 600 in development. The Georgetown site will provide a full menu of IV drips and …

“Science is not about being right or wrong in an absolute sense. It’s really about constantly updating our priors, understanding the probability of something as new evidence becomes emergent.” —Peter Attia The post #367 – Tylenol, pregnancy, and autism: What recent studies show and how to interpret the data appeared first on Peter Attia. …

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To…

Coronary artery calcium scoring has revolutionized cardiovascular prevention. But in women, it sometimes underestimates the risk. The post When zero doesn’t mean zero: the limits of coronary calcium in women appeared first on Peter Attia. …

HackAging.ai is the global online hackathon at the intersection of Agentic AI and longevity science, bringing together researchers, founders, and engineers to accelerate solutions that extend healthy human lifespan. Turn two weeks into a job, a useful tool, a collaboration, or a company. The event is sponsored by Retro.bio, Gero, Bio Protocol, Vi…

There is at present a tremendous appetite for the development of novel pharmacological approaches to weight loss. This is in large part a response to the rising prevalence of obesity. No robustly proven answer exists as to the question of why exactly people are now becoming obese in such large numbers. There is no shortage of hypotheses, from exc…

As our bodies age, so do our brains – but the pace and pattern are far from predetermined. At this year’s Global Longevity Summit (28–30 October 2025, Geneva), leading experts will gather under the banner Mastering the Aging Clock: The Science of Longevity to explore how breakthroughs in biology, technology and policy are reshaping healthspan…

Ophthalmology focused biotech Cirrus Therapeutics has raised $11 million in seed financing to advance a gene therapy program that targets the underlying biology of dry age-related macular degeneration (AMD), one of the leading causes of blindness in people over 50. The Cambridge, Massachusetts–based company is pursuing an approach that aims t…

Among the hallmarks of aging, DNA damage is both one of the most important and one of the hardest to crack. A couple of years ago, when I first learned about Matter Bioworks at a prominent longevity conference, I was amazed at the audacity of the small startup’s vision: actually fixing our DNA, including the mutation burden that accumulates with a…

Cryonics is important. Low-temperature storage of the brain is presently the only near-term approach that can provide those who die from old age with some greater than zero chance at a renewed life in the future. The cryonics industry has remained small since its inception decades ago, and only a few hundred people have been cryopreserved. The be…

Considerations of the role of dysfunction of oligodendrocytes and their precursor cell population in aging usually focus on myelination. Oligodendrocytes are responsible for maintaining the insulating myelin structure that wraps the axons that connect neurons, and which is required for effective propagation of nerve impulses. Researchers have sho…

By Technology Networks – Faster DNA aging predicts midlife IQ decline, with effects worsened by childhood poverty, twin study shows. The pace of your DNA aging may help predict whether your brain stays sharp or declines by the time you reach your 50s, and childhood socioeconomic background can make that decline more pronounced, according to […] T…

Klotho Neurosciences today announced it has signed a nonbinding Letter of Intent to acquire select assets from Turn Biotechnologies, in a transaction anchored by a $300 million global pharma deal, according to the company. Under the proposed deal, Klotho would obtain Turn’s ERA (Epigenetic Reprogramming of Age) platform and the eTurna RNA deliver…

LifeVantage Corporation said it has closed its previously announced acquisition of LoveBiome, a direct sales firm focused on microbiome and gut-health solutions. According to the company, the transaction includes the transfer of key operating assets and retention of critical LoveBiome personnel. LifeVantage claims the move will broaden its produc…

Gene therapies for neurodegenerative diseases that involve direct injection into portions of the brain have become acceptable enough to regulators that there is now progress towards the clinic on this front. This is despite the invasive nature of the delivery, and despite the high bar for safety that that tends to be applied to treatments that pr…

Retro Biosciences, one of the hottest startups in the longevity field, was founded about five years ago by the tech entrepreneur Joe Betts-Lacroix with a $180 million investment from his friend Sam Altman, the CEO of OpenAI. Despite its hefty war chest, the company initially pursued an image of an agile, scrappy company headquartered in refurbishe…

Longevity-focused biotech Klotho Neurosciences revealed it has issued a Letter of Intent to acquire “select assets” from Turn Biotechnologies, a biotech specializing in cellular reprogramming and mRNA-based therapies. While the announcement disclosed that Klotho would gain access to Turn’s epigenetic reprogramming platform and RNA delivery te…

When examining human epidemiological data, a web of correlations link health, life span, education, wealth, intelligence, and socioeconomic status. One can hypothesize about why these correlations exist, and to what degree different mechanisms contribute to the overall effect, but it remains challenging to draw firm conclusions from the data. For…

The liver is perhaps the most regenerative organ in the body, but like all other organs it is negatively affected by the accumulation of cell and tissue damage characteristic of aging. Liver function is reduced, while prevalent liver diseases such as metabolic dysfunction-associated steatoheptatitis occur more readily in older people than in youn…

By Joseph Arangio – Men’s Fitness – At 71, Dr. Eric Topol is living proof that aging well isn’t just about luck. The founder of the Scripps Research Translational Institute says his Oura Ring shows a heart age of 58, which is 13 years younger than his chronological age. “It felt pretty good to see […] The post This 71-Year-Old Cardiologist Says A…

A recent study reported that the effectiveness of the senotherapeutic drug ABT-263 depends on the cell’s DNA content, which is based on the cell cycle phase at which the senescent cell was arrested [1]. Why We Age: Cellular Senescence As your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of …

Tissues in the body are supported by distinct stem cell populations that reside within structures of supporting helper cells known as stem cell niches. The primary purpose of stem cells is to deliver a supply of daughter somatic cells to replace lost cells, though they also provide signaling that affects cell behavior. All tissues undergo a slow …

Last month was full of news on both rejuvenation advocacy and rejuvenation advancements, including our new Public Longevity Group initiative along with our paper on Urolithin A being accepted into Aging Cell. Here’s what’s happened in September. Lifespan Research Institute Launches Public Longevity Group: On September 17, we announced the launch…

Researchers here offer opinions reflective of the present research mainstream on which mechanisms are important in the aging of the heart and its consequent dysfunctions. This sort of article is an interesting measure of the degree to which the “aging is accumulated damage” viewpoint exemplified by the Strategies for Engineered Negligible Senesce…

Older epidemiological study data sometimes offers the potential for reanalysis with modern aging clock algorithms to assess biological age. If the study continued since the data was obtained, then there is the possibility to demonstrate that measures of biological age do correlate well with specific long-term outcomes. The downside is that resear…

By Michael Phillips on LinkedIn– For decades, Aubrey de Grey has worked as a biomedical gerontologist and has been at the absolute forefront of the scientific fight against aging and his contributions to the field are unquestionably unmatched. In fact, he’s the first individual to start and actively maintain the discussion about the plausibility o…

By Katie Hunt – CNN – Scientists have used human skin cells to create fertilizable eggs capable of producing early embryos, an advance that could expand possibilities for fertility treatment, according to new research. The proof-of-concept study, published Tuesday in the journal Nature Communications, involved taking the nucleus, the part of the c…

PAI-1 expression increases with age, and is implicated in cellular senescence, inflammation, and detrimental remodeling of tissue, such as the generation of fibrosis. These line items are all connected, as a burden of lingering senescent cells tissues has been shown to be sufficient to cause the other two, but nothing is biochemistry is ever as s…

Scientists have discovered a possible mechanism behind age-related inflammation. It involves wrong building blocks being incorporated into mitochondrial DNA during replication and can be countered by adding the correct ones [1]. Mitochondria, the cells’ energy-producing organelles, are considered to have developed from bacteria that once entered…

Age-related macular degeneration is a prevalent cause of progressive blindness caused by cell death and structural dysfunction in the retina and nearby tissue. The usual underlying mechanisms of aging and their consequences feature prominently in present thought on causes: aggregated metabolic waste, inflammation, vascular dysfunction, and so for…

by USC Dornsife College – Technology Networks – The pace of your DNA aging may help predict whether your brain stays sharp or declines by the time you reach your 50s, and childhood socioeconomic background can make that decline more pronounced, according to researchers at the USC Dornsife College of Letters, Arts and Sciences and […] The post DNA…

YouthBio Therapeutics, a biotechnology company pioneering partial cellular reprogramming to treat diseases of aging, today announced a successful INTERACT meeting with the FDA for its lead Alzheimer’s candidate, YB002. In its formal response, the FDA agreed that existing preclinical data support the bioactivity of YB002 and YouthBio’s proposed fir…

The Conboy lab in Berkeley has discovered a treatment combination that greatly extends lifespan in old male mice and published its findings in Aging. The researchers begin this paper with a discussion of well-known interventions and their drawbacks. For example, they note that while rapamycin is effective in extending the lifespans of mice [1], …

by Rhianna-lily Smith – Technology Networks – Aging is a complex process; however, recent research suggests it might not be entirely inevitable. Scientists are studying proteins that influence how our cells age, repair themselves and maintain function over time. From enzymes that boost cellular energy to growth factors that support tissue repair, …

“When you use these learning science-based AI tutors and the apps that we have, kids can learn 10 times faster.” —Joe Liemandt The post #366 ‒ Transforming education with AI and an individualized, mastery-based education model | Joe Liemandt appeared first on Peter Attia. …

We’re preparing a detailed discussion of the claims and evidence regarding potential links between prenatal acetaminophen exposure and autism risk The post Announcing a special episode on autism and acetaminophen appeared first on Peter Attia. …

Scientists have reported a breakthrough in treating solid tumor cancers using a Velcro-like tool that targets glycans, surface sugars especially abundant in cancer cells. This potentially off-the-shelf therapy does not need adjustment to individual cancer types or patients. Antibody-based cancer immunotherapies, such as chimeric antigen receptor…