Longevity Science

Many classes of therapy can be robustly manufactured with little risk of issues and do not need the full cost in time, effort, and funds of Good Manufacturing Practice (GMP) specified by the FDA in order for any given batch of the drug to be demonstrated to be safe. The most frequently used AAV vector serotypes, for example, are relatively safe i…

Decentralized science company Bio Protocol has raised $6.9 million to expand its AI-native DeSci platform designed to accelerate biotech funding and drug discovery. The round, coincides with the launch of Bio V2, an upgraded version of its decentralized research infrastructure. The Switzerland-based entity is billed as a full-stack platfo…

September is World Alzheimer’s Month, which is a good reminder of how important it is to protect our brain health long before problems arise. While many associate mental wellness with memory exercises or diet, new research reveals a surprising factor in maintaining cognitive sharpness: our hearing. In fact, a recent JAMA study suggests that p…

In Aging Cell, researchers have outlined the relationship between Alzheimer’s, increased pain sensitivity, and the enzyme LPCAT2. The key characteristics of Alzheimer’s disease, such as cognitive decline and brain deterioration, are very well-known [1]. However, other symptoms, such as pain sensitivity, may precede these key manifestations, prov…

Protein bars have become pantry staples for health-conscious consumers, from gym-goers to busy professionals grabbing meals on the go. But can your protein bar serve as a longevity bar and actually help you age better? In reality, most “healthy” protein bars promise high protein and great taste, but few deliver meaningful benefits for long-te…

Optigenex Inc. says a human trial involving healthy adults found statistically significant improvements in attention, memory, executive function and social cognition after daily intake of ac-11®. According to the company these results emerge from a randomized, double-blind, placebo-controlled, cross-over study conducted by the University of Northe…

Ferroptosis is a form of programmed cell death driven by iron accumulation and involving extensive lipid peroxidation as the kill mechanism. Senescent cells accumulate with age to cause tissue dysfunction and are resistant to programmed cell death. Most present approaches to the selective destruction of senescent cells as a form of therapy involv…

Character Biosciences, a precision medicine company focused on polygenic diseases, has appointed four senior executives to its leadership team. Those additions are Robert Kim, M.D., MBA as Chief Medical Officer; Daniel Elgort, Ph.D. as Chief Data & Analytics Officer; Josh Buddle as Head of Clinical Network and Longitudinal Research; and Jessam…

Humacyte, Inc. announced the publication of preclinical results assessing its coronary tissue engineered vessel (CTEV) as a graft in coronary artery bypass surgery (CABG) in a non-human primate model. According to the company, the CTEV remained open (patent) for six months, recellularized with host cells, and remodeled to reduce size mismatch with…

A new study conducted by Aviv Clinics in collaboration with the Sagol Center at Shamir Medical Center and Weizmann Institute examines hyperbaric oxygen therapy (HBOT) as a biologically based treatment for long-term post-traumatic stress disorder (PTSD). The research focused on 56 male veterans with chronic PTSD who had not responded adequately to …

The aging of the immune system leads to chronic inflammatory signaling, a consequence of the accumulation of forms of molecular damage and the maladative changes in cell behavior that occur in response to that damage. It is easy enough to point to the inflammation of aging and link it to accelerated onset and progression of all of the common age-…

by Eleanor Garth – Longevity.Technology – As the Global Longevity Summit in Geneva draws closer (28–30 October 2025), excitement is building around its line-up of heavyweight speakers. With a theme of Mastering the Aging Clock: The Science of Longevity, the Summit will bring together leading researchers and clinicians to explore how translational …

Many proteins can form transient aggregates, in which misfolding or chemical decoration allows solid clumps of protein to precipitate from solution and disrupt cellular biochemistry. A much smaller number of proteins can form persistent aggregates, however, and this unfortunate mechanism is an important contributing cause of a variety of age-rela…

The Global Longevity Summit, entitled Mastering the Aging Clock: The Science of Longevity, will convene in Geneva this October, bringing together international leaders in science, medicine and innovation under the banner Transform Your Practice and Patient Care. With education and clinical adoption at its core, the event reflects a broader sh…

For those of us in the Northern Hemisphere, autumn is underway. The fall is a time when the leaves that are green turn to brown, so let us see what the Lifespan team has been working on to help our field keep our own metaphorical leaves green and healthy. As always, we have been bringing you the best longevity and aging research news this summer…

Generative AI startup Biostate AI has entered the race to accelerate biomedical discovery with the launch of K-Dense Beta, a multi-agent AI system designed to compress research timelines from years to days. The company’s technology has already demonstrated its potential in aging and longevity research in a collaboration with renowned aging re…

Rona Therapeutics has filed an Investigational New Drug (IND) application with the Australian Human Research Ethics Committee for RN3161, a GalNAc-conjugated small interfering RNA (siRNA) designed to target the gene INHBE as a therapy for adults with overweight and obesity. According to the company, INHBE produces Activin E in the liver, which reg…

The composition of the gut microbiome changes with age, and researchers have demonstrated that many of these changes correlate with worse outcomes in aging. In animal studies, altering the composition of the gut microbiome to be more youthful produces health benefits, indicating that changes in the gut microbiome contribute to aging, but similar …

The innate immune cells known as macrophages adopt different packages of behaviors (known as polarizations) depending on circumstances. Most research is focused on the difference between the pro-inflammatory M1 polarization and the anti-inflammatory M2 polarization. M2 is considered to be more regenerative, and many issues in aging are thought to…

By Gina Park – The Philadelphia Tribune – Too busy to go to the gym? Don’t worry — you can stay healthy by incorporating at least 15 minutes of fast walking into your everyday routine,new research suggests. In general, it’s recommended that people commit to 150 minutes of moderate activity per week to see sufficient […] The post Fast walking is a…

Deepcell, a company specialising in AI-powered, label-free single cell morphology profiling and sorting, will provide its REM-I platform to integrate into InGel Therapeutics’ therapeutic development pipeline. The companies said the REM-I platform enables high-dimensional morphological insights that accelerate discovery and optimisation of cell the…

Rubedo Life Sciences has announced that the U.S. Food and Drug Administration (FDA) has cleared its Investigational New Drug (IND) application for RLS-1496 to begin a Phase 1b/2a clinical trial in patients with actinic keratosis, according to the company. RLS-1496 is a first-in-class, selective glutathione peroxidase 4 (GPX4) modulator being deve…

Cyclo Therapeutics, through a collaboration with Rafael Holdings, reported preliminary findings from a Phase 3 sub-study of its investigational therapy Trappsol® Cyclo (hydroxypropyl-beta-cyclodextrin) for Niemann-Pick Disease Type C1 (NPC1). The open-label, single-arm trial assessed patients younger than three years old over 48 weeks. According …

In a recent study, researchers investigated aging- and disease-associated changes in gene expression related to epithelial-mesenchymal transition. Inducing the Yamanaka factors in mice allowed them to rejuvenate cells and tissues and reverse some of these aging-associated changes [1]. Aging-related epigenetic changes result in decreased capacity…

The peripheral nervous system is capable of regeneration, albeit not as much as desired. Lasting loss of function following injury is certainly possible, particularly following injury to larger nerves. The research community has long been interested in finding ways to improve this situation, some of which might be applicable to the much less rege…

[Mountain View, September 17, 2025] — Lifespan Research Institute (LRI) today announced the launch of the Public Longevity Group (PLG), a new initiative focused on bridging the cultural gap between scientific breakthroughs in aging and their public acceptance. To kickstart its work, PLG has opened a crowdfunding campaign to develop tools that meas…

Imagine being able to map a person’s likely health trajectory twenty years into the future, not with certainty, but with probabilities calibrated across hundreds of possible conditions. That is the claim of a new generative AI model developed by EMBL, the German Cancer Research Centre (DKFZ) and the University of Copenhagen, which uses anonym…

The most interesting comparative biology programs aim to use the cellular biochemistry of unusually regenerative, long-lived, and cancer resistant species as a tool to better understand our vulnerabilities to aging and injury. In principle, understanding why a species is unusually long-lived could point to a basis for therapies to slow aging in h…

Some potentially damaging molecules are produced during the normal operation of metabolism. Cells have evolved numerous mechanisms to clean up that damage, but have also evolved to treat the presence of these damaging molecules as a part of the complex systems of signaling that regulate metabolism and cell maintenance. Thus when mitochondria are …

By BlueOakNx – LIVE EVENT: First Annual Symposium – Mitochondrial Health, Healthspan, & Aging. (presented by BlueOakNx, Inc.) Sept. 25, 2025, UCSF, San Francisco, CA. Click to learn more: Join us at the University of California at San Francisco Medical Center for a symposium featuring leading scientists presenting fundamental concepts on mitochond…

Barcelona-based INBRAIN Neuroelectronics, a company developing graphene-based brain-computer interface therapeutics (BCI-Tx), has entered into a know-how collaboration agreement with Mayo Clinic to accelerate development and commercialization of its precision BCI-Tx platform for neurological disorders, the company said. Under the agreement, INBRA…

Annovis Bio, Inc. has published results in Biomolecules showing that its newly developed dihydrate crystal form of buntanetap, which contains two moles of water, retains essentially the same pharmacokinetic (absorption, clearance, metabolism) profile as its original anhydrous form in studies involving mice, dogs, and humans. The company said that…

HCW Biologics, a clinical-stage biopharmaceutical company, has designated one of its proprietary TRBC-pembrolizumab-based immune checkpoint inhibitors as its franchise immunotherapeutic to be advanced into internal clinical development for treating solid tumours. The company said that this lead candidate, HCW11-040, is a multifunctional fusion pro…

This issue covers a newsflash about an expected update to the ISSCR’s ethical guidance on synthetic embryo models that are challenging current guidelines, and why. Then explore a fascinating conversation with Yuta Lee, CEO of HSAC member Accelerated Biosciences, which has developed a “Nvidia chip” for multiple pluripotent cell lines through a uniq…

Researchers studying neurodegenerative conditions have increasingly focused on the role of microglia in recent years. Microglia are innate immune cells analogous to the macrophages found in the rest of the body. They undertake a broad range of tasks including defense against pathogens, destruction of malfunctioning cells, coordination of tissue m…

Scientists have demonstrated that even two days on a Western-like high-fat diet reduce hippocampal glucose availability, which activates a subset of inhibitory neurons and causes memory problems in mice [1]. Metabolic disease and obesity are known to harm cognitive function and have been linked to neurodegenerative diseases such as Alzheimer’s […

Genflow Biosciences has entered into two Confidential Disclosure Agreements (CDAs) with leading animal health companies, the company said. These agreements are intended to facilitate data exchange and initiate discussions on potential collaborations. The CDAs align with Genflow’s strategy to apply its proprietary SIRT6-centenarian gene therapy pl…

BioAge Labs, in partnership with HitGen, has initiated a Phase 1 clinical trial of BGE-102, a novel, orally available small-molecule inhibitor of NLRP3 that penetrates the brain, according to the company. The study will evaluate single and multiple ascending doses (SAD/MAD), with initial SAD data expected by year-end. The inhibitor was developed …

High levels of the circulating amino acid homocysteine are regarded as a risk factor for the development of atherosclerosis. It can occur due to dietary deficiency, particularly in B vitamins, but since elevated levels are fairly common in later life there are clearly other contributing factors. Well established approaches based on diet and suppl…

International Scientific Symposium 2025 | Toronto, Canada SEPTEMBER 17-21, 2025 In-person in Toronto, Canada, with virtual attendance options –  at the Hilton Toronto, 145 Richmond St W, Toronto, ON M5H 2L2, Canada Join us for the 2025 International Scientific Symposium, taking place from September 17-21, 2025 in Toronto, Canada—a hybrid event des…

Alterity Therapeutics has disclosed results from its Phase 2 ATH434-201 clinical trial in patients with Multiple System Atrophy (MSA), according to the company. The randomized, double-blind, placebo-controlled study evaluated two doses of ATH434 (50 mg and 75 mg twice daily) over 12 months in 77 adults. The data presented at the American Neurolog…

Mesoblast has reported that the commercial launch of Ryoncil (remestemcel-L-rknd), its FDA-approved mesenchymal stromal cell (MSC) product, was a focal point at recent global healthcare conferences in New York. According to the company, the product is the first FDA-approved MSC therapy, approved for treating steroid-refractory acute graft versus h…

Parkinson’s disease and Lewy body dementia are synucleinopathies, forms of neurodegeneration characterized by the misfolding and aggregation of α-synuclein. Given an initial misfolding event, this pathology can spread from cell to cell through the nervous system and brain, one misfolded molecule encouraging others to also misfold in the same way….

By Boston Consulting Group (BCG) – As the global population ages, many economies are bracing for a one-two punch: a shrinking workforce colliding with rising health and social care costs—the so-called “gray wave.” Healthy aging holds the potential not just to offset these impacts, but to add trillions in economic value by keeping people active, [……

The pharmaceutical industry suffers from all of the issues that plaque heavily regulated industries that have been heavily regulated for a long time. Costs increase, restrictions increase, the ability to create new medicines declines. Everyone sees at least part of the problem, but no one person and no one group is in a position to change enough …

In Nature Aging, researchers have identified and categorized several macrophage subtypes, including a subtype that appears with aging and another that manages nerve function. Why We Age: Chronic Inflammation Chronic inflammation refers to a persistent, low-grade buzz of immune activity that settles into the body without the drama of an infection…

Exposure to particulate matter and other air pollution is generally agreed upon to be bad for long-term health. The worse the exposure, the worse the outcome. The epidemiological data is quite convincing, particularly studies in those parts of the world where, by happenstance, very similar populations are exposed to very different degrees of air …

While the first blood-based assays are entering use for the early detection and diagnosis of Alzheimer’s disease, they remain expensive and are so far employed for only a limited number of patients. More work is needed to identify associations between circulating factors and disease progression, in order to produce better combinations of biomarke…

By Lizelda Lopez – UC San Diego Today – Findings reveal space-induced genetic, mitochondrial and inflammatory stress in blood-forming stem cells, offering insight into aging and risk of disease during long-duration space travel. Researchers from University of California San Diego Sanford Stem Cell Institute have discovered that spaceflight acceler…

“The best diet is the one that simultaneously meets the core physiologic needs, the five legs of the table, and also addresses your own individual goals and preferences.” —Peter Attia The post #364 – AMA #75: Diets: how to evaluate and implement any diet including keto, carnivore, vegan, Mediterranean, and more appeared first on Peter Attia. …

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To…

A recent study shows that moderate-intensity exercise can offset the drop in vitamin D that many experience during winter months The post Preventing seasonal declines in vitamin D with exercise appeared first on Peter Attia. …

Senescent cells accumulate with age in tissues throughout the body, primarily when a cell reaches the Hayflick limit on replication, but also because of damage or stress. When a cell becomes senescent it ceases to replicate and undergoes profound metabolic changes that cause it to secrete a pro-inflammatory, pro-growth set of signals known as the…

Scientists have demonstrated that short-term exposure to microplastics causes Alzheimer’s-like effects in mice expressing human APOE4 versus APOE3. These effects were sex-dependent, mirroring the disease in humans [1]. Exposure to tiny particles that plastic products shed (microplastics) has been linked to increased mortality and diseases [2]. M…

On September 18, 2025, Longevity Xplorer (LongX) will be hosting the first-ever “Youth in Longevity Biotech Showcase”, a virtual event featuring lightning talks from young professionals in longevity fellowships around the world. The event will cover fellow contributions and highlight the importance in supporting the next generation of leaders in a…

The category of glial cells covers all of the supporting cells of the brain, everything not a neuron, a big tent that includes immune cells such as microglia, the oligodendrocytes that manufacture myelin sheathing for axons, and the sizable astrocyte population, among others. These are very different cell populations with very different functions…

Mouse data has consistently shown fisetin to be senolytic, capable of selectively destroying the senescent cells that accumulate in tissues with age. Doses most often used are equivalent to around 20 mg/kg in humans, but dosing strategies range from a one-time course of treatment of a few days to intermittent doses provided over months. Unfortuna…

By Matt Sendesky – The Seattle Times – NABALANGA, Uganda (AP) — His father died when he was a little boy, his mother when he was a young man. His grandparents, save but one, never made it to old age either. His wife is gone now, too, in the ground with four of their children, […] The post A wave of longevity is sweeping across Africa. It isn’t re…

We are often asked why we didn’t include specific “anti-aging” ingredients in NOVOS’ longevity formulations. For example, why didn’t we include quercetin, nicotinamide riboside (NR), astragalus, or EGCG in NOVOS Core, Vital or Bars? There are various reasons why we don’t include certain ingredients in our formulations. First, there a…

It is difficult to overstate the importance of immune system dysfunction as a component of degenerative aging. All of the common fatal age-related diseases are strongly connected to immune dysfunctions, particularly the chronic inflammation that occurs with age. At the high level, researchers tend to divide immune aging into two components: immun…

In Aging Cell, researchers have published their surprising findings that epigenetic clocks are not significantly related to most measurements of metabolic health after weight loss interventions. Epigenetic Clocks – What are they? An epigenetic clock is a biochemical test that uses DNA methylation levels and accumulation of methyl groups on DNA t…

Dear Colleagues, Thank you for your continued commitment to the Healthspan Action Coalition as we advance our mission in policy advocacy and public education. Current Priorities: Recognizing Healthspan as a Human Right HSAC along with other stakeholders are developing a comprehensive program to recognize healthspan as a fundamental human right, th…

By Tarun Sai Lomte – News Medical Life Sciences – In a recent study published in the journal Communications Medicine, researchers Armin Garmany and Andre Terzic at the Mayo Clinic in the USA mapped the healthspan-lifespan gap across world regions and identified gap-associated indicators. Human life expectancy continues to increase, surpassing prev…

Protein and snack bars have become mainstays of wellness culture. From gym bags to desk drawers, they’re always within reach — offering convenient, portable nutrition on the go.  But as the conversation around longevity grows louder, new questions are emerging: Can your daily bar do more than just curb hunger, supporting long-term health and …

A glass of wine with dinner. A celebratory cocktail after a big promotion. Alcohol is so woven into our daily lives and social routines that we rarely stop to question it — especially when headlines have long claimed it might even be good for us. But over the past few years, a wave of new research has challenged this belief. Contrary to the o…

An analysis of UK Biobank data showed an association between regular glucosamine use and significantly lower risks of seven non-communicable chronic diseases [1]. Glucosamine, a sugar molecule with an amine group (amino sugar), is a supplement used by almost 20% of middle-aged adults in the U.S., U.K., and Australia [2]. It is recommended for os…

Longevity Science is gaining momentum worldwide as aging populations place increasing pressure on healthcare systems. Many new and upcoming breakthroughs in aging biology, regenerative medicine, and preventive care show potential to greatly improve quality of life in later years. Unlike traditional biomedical research, which focuses on diagnosing …

by Lifespan Research Institute – Finding out what’s helpful and what’s harmful is always the challenge. Over the last month, researchers have discovered how well-known substances can confer physical benefits, delivered compounds into the bloodstream in new ways, and continued to develop new forms of medicine. Here’s what’s happened in August. read…

A new preprint study from Calico has found that the local brain environment is the primary driver of microglial aging. After being transplanted into old brains, young cells adopted aged characteristics, but their susceptibility to these signals could be turned off [1]. Brain aging holds a special place in the longevity field as a strong limiting…

Catching a glimpse of a new silver strand in the mirror can be a bit jarring, particularly if you’re on the younger side. While gray often comes with age, premature grays that appear in your 20s, 30s, or early 40s might have more to do with your body’s internal chemistry than you realize. Although you can’t stop the clock, you can support you…

by Danny Sullivan – Longevity.Technology – Milken Institute calls for greater investment in dementia research and development to help boost global healthspan and longevity. This month, the Milken Institute, a think tank focused on health, finance and philanthropy, released its Mind the Gap report, highlighting a pressing global challenge: dementia…

Healthspan Action Coalition (HSAC): In a nutshell, what’s your vision for Accelerated Biosciences? Yuta Lee (YL): We have a stem cell platform which consists of the earliest cells you can get without ethical issues. Our first priority is to cure diseases and then, in the future, to democratize stem cell therapies for prevention and longevity. […] …

Scientists have found a way to directly stimulate the assembly of Complex I in mitochondria, rescuing memory deficits in mouse models of Alzheimer’s and frontotemporal dementia [1]. Why We Age: Mitochondrial Dysfunction As they age, the mitochondria in our cells lose their ability to provide cellular energy and release reactive oxygen species th…

By Sutter Health – SciTechDaily – Scientists are rethinking aging as a treatable process, with new therapies showing potential to extend healthy years and combat multiple diseases at once. A landmark review published in the Journal of the American Medical Association explores new strategies to slow the biological processes of aging. This emerging …

“It’s a super exciting time because every time we unlock essentially a function of a certain part of the brain, there’s a very high probability that there’s going to be a therapy either through a brain-computer interface or through a new biological approach.” —Edward Chang The post #363 ‒ A new frontier in neurosurgery: restoring brain function w…