Longevity Science

Healthy Longevity Medicine Society (HLMS) and Longevity Clinics World (LCW) have signed a Memorandum of Understanding (MOU) setting out a framework for collaboration in evidence-based Healthy Longevity Medicine worldwide. The agreement pairs HLMS’s scientific and clinical expertise with LCW’s global clinic network and media platforms; the sha...

For years, the hunt for longevity’s ‘holy grail’ has often centered on finding the one biological marker that reveals how fast we are really aging. A blood test, a protein, a molecule – something simple that could tell us where we stand. But what if that is the wrong question? A newly published Journal of Translational Medicine Perspe...

Picture the pitch: a clinic visit where a nurse swaps out your plasma, the way a mechanic swaps out old oil, and sends home biomarkers to prove your biological age dropped afterward. It sounds more like a luxury longevity clinic fantasy than a mainstream medical procedure, but therapeutic plasma exchange (TPE) has been a hospital staple for m...

Innovent Biologics and Daiichi Sankyo have entered an exclusive agreement under which Daiichi Sankyo will handle development, manufacturing and supply of Vanflyta while Innovent holds sole commercialization rights and will lead market promotion in China. The company claims Vanflyta was approved in China in June 2026 for use in combination with st...

Sana Biotechnology reported second quarter 2026 financial results and business highlights, ending June 30 with $160.5 million in cash, cash equivalents and marketable securities and an expected cash runway into mid-2027. The company raised aggregate net proceeds of $93.3 million in Q2 from at-the-market sales and an equity financing, and Mayo Cli...

Coya Therapeutics provided second quarter 2026 financial results and a corporate update, according to the company. Enrollment in the ALSTARS Phase 2 trial advanced with the first cohort progressing into the 24-week blinded active treatment extension, and the company received FDA Fast Track designation for COYA 302 for the treatment of ALS. The co...

Neuro Force One appeared at the 2026 Texas High School Coaches Association Coaching School & Convention in Houston, introducing its NF1 Coaches & Teams Platform, NF1 mobile app and NF1 RESET, a three-part gut-health and nutritional-support system. The company offered participating schools complimentary one-year access to the NF1 Coaches &...

Iron metabolism is strongly connected to oxidative stress, the excessive production of reactive oxygen species and other oxidative molecules that outpaces the ability of cells to avoid, resist, or repair the consequent damage. It can lead to a form of programmed cell death called ferroptosis. Here, researchers describe how iron metabolism and fer...

That we cannot accurately and robustly measure biological age is a major impediment to the development of rejuvenation therapies. Without the ability to quickly focus on approaches with the largest effects on biological age, the field spends far too much time on marginal classes of therapy, and optimization of any given approach is challenging, h...

By Jolanda van Hal – Nutrition Insight – The nutricosmetics industry is transitioning beyond traditional skin care and anti-aging claims as consumers increasingly connect appearance with longevity and overall health. Industry experts highlight opportunities in multifunctional, clinically backed solutions targeting the gut-skin axis, metabolic beau...

Your heart beats roughly 100,000 times a day. Shave five beats per minute off that, and you’ve asked it to do about 7,000 fewer contractions before tomorrow morning. That basic math is why researchers have tracked this number for decades. Across large populations, people with lower resting heart rates tend to live longer. Resting ...

Alzheimer's disease, and the other common age-related neurodegenerative conditions, are characterized by chronic inflammation in brain tissue. Aging in general is characterized by an increased level of constant inflammatory signaling. Numerous different mechanisms contribute to this constant inflammation, such as maladaptive reactions to mitochon...

First across the line, not necessarily first to reach patients. On 10 August, the Medicines and Healthcare products Regulatory Agency (MHRA) authorized orforglipron, sold as Foundayo, making the UK the first country in Europe, and the first regulator anywhere, to approve an oral GLP-1 receptor agonist for both weight management and type 2 dia...

A new study proposes a theoretical framework that explains why the more complex an animal is, the harder it is to move the needle on its rate of aging [1]. A familiar puzzle in geroscience is that while many of the same longevity-related pathways are highly evolutionarily conserved, manipulating them can produce enormous lifespan gains in simple...

Twenty teams have reached the final stage of XPRIZE Healthspan, the seven-year, $101 million competition seeking therapeutics capable of restoring muscle, cognitive and immune function lost through age-related decline. Ten have also secured $1 million Milestone 2 awards; from 2026 to 2029, the finalists will move into clinical trials lasting ...

XPRIZE Healthspan has selected 20 finalists to advance to the clinical phase of its seven-year, $101 million competition, with ten teams receiving $1 million Milestone 2 awards to support further development and testing of interventions targeting age-related functional decline. The finalists span a deliberately heterogeneous field of ther...

Infinimmune has closed a $75 million Series A financing round to advance a pipeline of human-derived monoclonal antibodies toward clinical trials. Co-led by Regeneron Ventures and Playground Global, the syndicate brings together prominent institutional capital including RA Capital Management, Goldcrest Capital, Forge Life Science Partners, Go...

Epicrispr Biotechnologies has closed a $90 million Series C financing round, and the syndicate behind it reads like a checklist of biotech credibility: Octagon Capital and Janus Henderson Investors co-led, joined by Fidelity Management & Research Company, Cormorant Asset Management, Duquesne Family Office, Sanofi Ventures, funds managed b...

AstronauTx has exercised its option under the companies’ 2023 research collaboration and option agreement with Saniona to secure exclusive worldwide rights to research, develop, manufacture and commercialize therapeutic candidates arising from the collaboration. The multi-year collaboration has yielded development candidate ATX0926, which, accor...

Remedium Bio has completed the initial close of a planned $10 million Series A financing led by Lifespan Vision Ventures with participation from Eli Lilly and Company and HKX Capital. Harry Robb of Lifespan Vision Ventures has joined Remedium’s board in connection with the financing. Remedium’s proprietary platforms are designed to enable dura...

Atropos Health has partnered with Health Universe to embed Atropos’ real-world evidence and clinical decision-support tools into Health Universe’s AI clinical workflow platform, enabling healthcare organisations using Health Universe to access patient-specific clinical insights within existing workflows. According to the company, Atropos uses ar...

Denali Therapeutics reported second-quarter 2026 results as it transitions to a commercial-stage biotechnology company. AVLAYAH, the company’s treatment for Hunter syndrome, generated $3.6 million in net product revenue in its first full commercial quarter, and the company projects $10 million to $12 million in third-quarter revenue, according t...

Recursion Pharmaceuticals faces persistent financial and pipeline challenges despite collaborations with major drugmakers. The company reports partnerships with Genentech/Roche and Sanofi that have generated more than $500 million in milestone payments, according to the company. Its internal program REC-4881 for familial adenomatous polyposis req...

Telomir Pharmaceuticals announced the peer-reviewed publication of preclinical data showing Telomir-Zn suppressed tumor growth in prostate and triple-negative breast cancer models. The manuscript, published in the Journal of Oncology Research and Therapy (Volume 11, Issue 3), reports that Telomir-Zn modulates intracellular iron and copper to inhi...

Mitochondrial transplantation is a promising approach to treating age-related mitochondrial dysfunction. Cells readily take up mitochondria from their surroundings. The major challenge in the development of practical mitochondrial transplantation therapies is the robust production of the large numbers of mitochondria needed for a human therapy. W...

The bacterial species P. gingivalis is a cause of periodontitis, a common form of inflammatory gum disease that in addition to damaging gums, teeth, and bone in the mouth, also contributes to the development of inflammatory age-related conditions elsewhere in the body. Here researchers report on a novel approach to selectively removing P. gingiva...

By Longevity.Technology – Nicola Marino looks at a new paper proposing an evidence-based roadmap to make healthy longevity a measurable objective of public healthcare. Italy could become one of the first countries to formally explore how healthspan can be incorporated into a universal national health service. A research perspective published in Ag...

by Alan Booth – Labmate – Researchers have described a preclinical strategy that uses targeted antibodies and epitope-edited stem cells to make blood stem cell transplantation safer and more precise for sickle cell disease, beta-thalassaemia, immune deficiencies and some blood cancers A research group at the of the Dana-Farber/Boston Children’s ...

By Antonio Pequeño IV, Forbes – A review of more than 350 scientific studies published Friday found booming protein food options at grocery stores may be harming many Americans who lead sedentary lifestyles and do not need the extra intake. READ MORE The post Eating Too Much Protein? It Could Age You Faster If You’re Sedentary first appeared on H...

Researchers have discovered why the protein AGGF1 has significant effects on blood pressure and published their findings in Aging Cell. The authors begin their paper by discussing high blood pressure (hypertension), one of the most commonly known medical issues and a significant contributor to both disability and mortality in older people [1]. B...

Telomeres are repeated DNA sequences found at the ends of chromosomes. A little telomere length is lost with each cell division, and short telomeres trigger cell senescence or programmed cell death. It is a part of the system ensuring the Hayflick limit on the replication of somatic cells. The stem cells that create replacement somatic cells can ...

The longevity industry has searched for the biggest lever to extend healthy lives for years. Much of that conversation has revolved around cells, genes and the molecular mechanics of aging. However, a different question is beginning to surface, and it starts much later in life. What if one of the greatest opportunities to improve women’s ...

Technically, even very small effects can be classed as rejuvenation if they move the right markers, if they in some way reduce the burden of damage and dysfunction of aging. Exercise probably rejuvenates to some degree, by any reasonable definition. Yet we know the bounds of the possible when it comes to exercise and other widely used interventio...

Researchers here discuss a bidirectional relationship between age-related alterations in bile acid metabolism, centered in the liver, and changes in the composition of the gut microbiome. These changes take place in the context of increasing dsyfunction of the intestinal barrier with age, allowing unwanted bacteria and bacterial metabolites into ...

“Peptides as a class can be genuinely powerful, which is a reason to be more careful with them, not less. We can't normalize treating real drugs carelessly.” —Peter Attia The post #403 ‒ Peptides: separating scientific promise from marketing hype appeared first on Peter Attia MD. ...

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To...

The case for limiting protein to protect the kidneys was built in a different era of nephrology. The post Does protein restriction still make sense in modern kidney care? appeared first on Peter Attia MD. ...

Magnesium is one of the most essential minerals for human health, involved in over 300 enzymatic reactions in the body, from energy metabolism and DNA repair to nerve signaling and muscle function. Yet despite its importance, a significant portion of adults do not meet their daily magnesium requirements through diet alone.  Supplementation ca...

Reduced protein intake is robustly demonstrated to improve long-term health and slow aging in animal studies, and the human evidence is supportive. Many of the sensors and triggers of the beneficial metabolic response to fasting and other forms of calorie restriction react to protein availability specifically, increasing cellular maintenance acti...

Human Longevity Inc., a company founded in 2013 by a trio of visionaries – Craig Venter, Peter Diamandis, and Robert Hariri – initially inspired high hopes. Several years and several hundred million dollars later, however, the company entered what many people saw as a period of turmoil. Dr. Wei-Wu He, an early investor in HLI, took the helm in 201...

Calorie restriction mimetic drugs reproduce some (usually small) fraction of the beneficial metabolic changes that take place with a reduced calorie intake. An increase in the efficiency of the cellular maintenance processes of autophagy appears to be the crucial point. Researchers here report on their assessment of the alterations produced by th...

The major hormones produced by the thyroid gland are broadly influential on metabolism and the function of many organs, and thyroid dysfunction is common enough in later life for this aspect of human biochemistry to be very well studied. A range of different unpleasant outcomes and named diseases arise from various imbalances in the production of...

A team of researchers has developed Pasta, a transcriptomic clock that accurately predicts the age-related effects of various compounds and gene expressions. What Are Epigenetic Clocks An epigenetic clock is a biochemical test that uses DNA methylation levels and accumulation of methyl groups on DNA to determine biological age. There are many di...

Anti-aging medicine has long been a small specialty field of practice culturally adjacent to sports medicine, but considerably less rigorous and more derided by the mainstream. The present development of a longevity industry, based on means to slow and reverse aspects of aging conclusively demonstrated in laboratory animals and now slowly making ...

By CompareTheCloud.net – The Drug Discovery and Development Benchmark as a Service (DDD BaaS) launched on 30 July covers two evaluation suites. Drug Discovery Foundations comprises more than 300 tasks spanning disease biology, molecular property prediction, retrosynthesis, structure-based drug design, and clinical development. Drug Candidate Essen...

Questions regarding the relative importance of different mechanisms and dysfunctions to the progression of aging and eventual mortality are hard to answer definitively. Even given a straightforward class of therapies to target one specific mechanism of aging in isolation of all others, such as senolytics to clear lingering senescent cells, one st...

The heart regenerates poorly in comparison to other tissues, and the maladaptive inflammation that occurs following a heart attack does not help the situation. Fibrosis and scarring occurs in inflamed heart tissue, causing loss of function and heart failure. Stem cell therapies and the use of exosomes derived from stem cells are well demonstrated...

by Klaudia Balogh – Muscle & Fitness – Dr. David Karli explains what you need to know before spending thousands on your own. There is a level of transparency every patient should expect when considering a form of regenerative therapy, where a physician not only understands the power of what regenerative medicine is capable of […] The post The Mus...

By Jessica Hamzelou – MIT Technology Review – For the last couple of years, I’ve been following the progress of a group of individuals who believe death is humanity’s “core problem.” Put simply, they say death is wrong—for everyone. They’ve even said it’s morally wrong. They established what they consider a new philosophy, and they called […] The...