Updated 12:31pm | May 22, 2025
29 minutes
In Aging Cell, researchers have found that exposing ordinary Black 6 mice to a more natural environment accelerates rather than slows the aging of their livers. It is a well-known fact that laboratory animals live in controlled conditions beyond that of wild animals or even most pets. Temperature and food are regulated, and social interactions …
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The recent launch of Stately Bio has highlighted a key bottleneck in regenerative medicine: the inability to monitor living cells in real time without destroying them. After three years in stealth mode, the Palo Alto-based startup emerged this month with $12 million in seed funding and a platform that combines machine learning and advanced im…
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The field of longevity science continues to edge into public discourse and policy relevance with the steady cadence of private initiative. The latest signal comes from Southern California, where R Rex Parris, Mayor of Lancaster and co-founder of regenerative medicine company ReParris, has committed $10 million to the University of Southern Ca…
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The Longevity Science Foundation (LSF), a nonprofit organization dedicated to funding research aimed at extending the healthy human lifespan, is proud to announce a grant award to the University of Copenhagen’s Center for Healthy Aging within the Department of Cellular and Molecular Medicine, for the study “Rejuvenating the Aging Brain.” The resea…
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The balance of microbial populations making up the gut microbiome shifts with age. Inflammatory species and those generating harmful metabolites increase in number at the expense of species that generate beneficial metabolites. This is why approaches that rejuvenate the gut microbiome, forcing it back into a more youthful balance of populations, …
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Researchers here outline an interesting approach to trapping misfolded amyloid-β before it can aggregate and disrupt the biochemistry of the brain. Without the ability to aggregate into solid structures, the misfolded amyloid-β will break down or be cleared without causing harm. It remains to be seen as to how well this does in practice, but it i…
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It has been announced that the inaugural Enhanced Games will take place in Las Vegas over Memorial Day Weekend in 2026. The controversial event permits athletes – and indeed encourages them – to use performance-enhancing drugs and technologies under medical supervision. The 2026 Enhanced Games will take place in a purpose-built facility i…
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By Alexa Mikhail – Fortune – The contestants in a race to extend life are on their second lap. In a seven-year global competition, teams are rushing to discover novel therapeutics and interventions that can extend human life by a decade and help people age well. In 2023, Peter Diamandis, an entrepreneur, self-proclaimed futurist, and […] The post…
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European cryonics lab Tomorrow.Bio today secured the first close of a €5 million seed funding round to support its international expansion and R&D efforts. The Berlin-based startup says it plans to extend its operations into the United States, beginning with initial bases in New York, California and Florida, while also increasing its inve…
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One of the challenges inherent in developing an industry of medical development aimed at the treatment of aging is that present regulatory structure and investment culture actively discourage any attempt to quantify effects on life span. While aging clocks are interesting, they cannot yet be relied upon, and no-one is willing to fund the lengthy …
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In a recent study, researchers investigated how restricting dietary methionine and inhibiting the tyrosine degradation pathway affects healthspan in aged mice. While affecting tyrosine didn’t show any benefits, methionine restriction improved many, but not all, measures of healthspan, including frailty, pathological disease burden, and neuromuscul…
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As interest in the cellular roots of aging intensifies, a new study published in Nature places clonal hematopoiesis – often viewed through the lens of oncogenic risk – into a broader biological narrative. Researchers from the Centre for Genomic Regulation and IRB Barcelona have developed EPI-clone, a transgene-free method for clonal lineage t…
By Neuroscience News – New research suggests that while general curiosity tends to decline with age, specific curiosity, or “state curiosity”, actually increases later in life, potentially protecting against cognitive decline. Older adults showed heightened interest in learning new information, especially topics related to personal interests, whic…
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Longevity biotech Juvenescence today announced the first close of its Series B-1 financing round, securing $76 million to support the continued development of its AI-driven clinical pipeline focused on age-related diseases. The round was led by M42, a tech-enabled healthcare company headquartered in Abu Dhabi, with additional participation fr…
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Regeneron, already a leader in leveraging genetic data for drug development, will now control 23andMe’s biobank – one of the world’s largest, with genetic and phenotypic data from over 15 million individuals. This dwarfs Regeneron’s existing 3 million exome database and even surpasses the UK Biobank, which holds data on approximately 500,000 …
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The authors of this open access paper provide an overview of two viewpoints on the onset and progression of neurodegenerative conditions. The biochemistry of the brain is exceptionally complex, and its dysfunction is also complex. It is clear that the aggregation of a few forms of altered protein is important in neurodegeneration, but exactly how…
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One of the tasks in which machine learning and related techniques excel is finding patterns in very large data sets and extrapolating those patterns to predict as yet undiscovered members. The outcome of combinations of known small molecule drugs and drug candidates is one such data set. There is very little known in certainty about polypharmacol…
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SQSTM1 is also known as P62. The protein expressed by this gene assists in the selection and transport of materials to be recycled via autophagy, an important stress response mechanism. Once a protein or structure has been decorated with a ubiquitin molecule, SQSTM1 binds to that protein or structure as a part of the complicated process of shuttl…
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Scientists have created engineered nanostructures that bind monomers and oligomers of harmful amyloid beta (Aβ) protein, preventing them from entering neurons and drastically increasing the cells’ survival in vitro [1]. Misfolded proteins are thought to be behind diseases like Alzheimer’s and amyotrophic lateral sclerosis (ALS). The most recogn…
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As the global geroscience community wrestles with the dual pressures of translational inertia and growing demographic urgency, an interesting initiative is taking shape in San Francisco. In a city with office vacancy rates approaching 30%, a 16-story building in the Mid-Market district – once just another casualty of post-pandemic urban drift…
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The war on sarcopenia escalated this week, with two companies announcing clinical trials targeting the age-related progressive loss of muscle mass and strength. Yesterday, we brought you news of the first human trial of Juvena Therapeutics’ muscle regeneration therapy, while today we reveal that Rejuvenate Biomed has initiated dosing in a Pha…
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Press Release by Atrium Health Wake Forest Baptist – May 15, 2025 – Dr. Minni Saluja enrolled in the Translational Biotechnology Master of Science program at the Wake Forest Institute for Regenerative Medicine because she was interested in the role regenerative medicine could play in her cosmetic dermatology practice. Two years later, Saluja says …
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A sizable portion of the health benefits (and life extension in short-lived species) resulting from the practice of calorie restriction is triggered by sensing of levels of specific amino acids. Methionine is one of the more important such amino acids, and researchers have demonstrated that low-methionine diets can produce some fraction of the be…
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Chronic inflammation is a major component of aging, disruptive to tissue structure and function. Researchers here review some of what is known of the immune system dysfunction associated with cerebral small vessel disease, noting various measures reflective of inflammation. A number of lines of evidence point to inflammation of the vascular endot…
This Balsamic Chicken and Apple Harvest Salad is part of a series of recipes exclusively developed for NOVOS, following the principles of the NOVOS Longevity Diet. While many recipes focus on specific dietary trends—like paleo, keto, or low-carb—the NOVOS Longevity Diet is designed to promote long-term health and well-being. This salad combines le…
This Better-For-You Banana Chocolate Bread is part of a series of recipes exclusively developed for NOVOS, aligning with the NOVOS Longevity Diet principles. Unlike conventional banana breads that are loaded with refined sugar, this version uses nutrient-dense ingredients like almond flour and coconut oil to provide a nutrient boost. Sweetened nat…
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The testes manufacture testosterone, generally important to long-term health. Further, germ cells resident in the testes manufacture sperm. This process of spermatogenesis is necessary for reproduction. Both of these functions decline with age. As is the case for near all outcomes of degenerative aging, the research community has yet to construct…
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What if, rather than striving to unravel aging’s every molecular cause, we simply replaced its effects? That is the question at the heart of a new Perspective published in Nature Aging by Sierra Lore, Jesse Poganik, Anthony Atala, George Church, Vadim Gladyshev, Morten Scheibye-Knudsen and Eric Verdin. In the paper, the authors propose a unif…
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The results of a Phase 1 trial of the well-known senolytic combination of dasatinib and quercetin (D+Q) in patients with Alzheimer’s disease have been published in Neurotherapeutics. What Are Senolytics? Senotherapeutics for Senescent Cells Senolytics work by targeting one of several pro-survival pathways that senescent cells use to evade apopt…
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Longevity biotech Juvena Therapeutics has initiated its first human clinical trial for its lead biologic therapy designed to regenerate muscle tissue. Described as “insulin for muscle”, JUV-161 is a muscle regenerating endocrine therapy that has demonstrated efficacy in preclinical models by promoting muscle fiber formation, reversing muscle …
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Developing technologies to defeat age-related diseases by keeping people biologically younger is the goal of the rejuvenation biotechnology field. LRI created the Longevity Investor Network (LIN) to connect promising longevity tech companies with investors to get this technology to the clinic. The Longevity Investor Network (LIN) has experience…
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The tumor suppressor protein p53, encoded by the gene TP53, is thought to be a component of the trade-off between tissue maintenance and cancer risk that contributes to species life span. Too much p53 activity and cancer risk declines but life span shortens as tissue maintenance is also suppressed. To little p53 activity and life span increases, …
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It is well established that hearing loss and cognitive decline correlate with one another. There is some debate over causation, the degree to which hearing loss might contribute to cognitive decline versus both outcomes arising from the same underlying mechanisms of cell and tissue damage that drive aging. Recent studies strongly suggest that los…
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By Joanna Groom & Benjamin Broomfield – WEHI Australia – WEHI scientists have uncovered a promising new way to enhance the effectiveness of vaccines by tapping into the potential of a specific type of immune cell, opening the door to long-lasting vaccines for viruses and enhanced cancer therapies. The WEHI-led study used a novel approach […] The …
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“The more you move, the more you’re alive. The less you move, the less you’re alive.” —Peter Attia The post #349 – AMA #71: Building strength and muscle mass: how to optimize training, nutrition, and more for longevity appeared first on Peter Attia. …
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Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.or…
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Despite a reported correlation between cognitive impairment and REM sleep latency, this sleep metric is no biomarker for neurodegenerative disease The post Increased REM sleep latency and Alzheimer’s disease: important risk factor or red herring? appeared first on Peter Attia. …
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The blood-brain barrier consists of specialized cells that line blood vessels passing through the brain. These cells collectively permit only certain molecules to pass to and from the brain, maintaining the distinct biochemistry and cell populations of the central nervous system versus the rest of the body. Where the blood-brain barrier leaks, th…
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Boston-based startup Somite AI emerged this week, securing over $47 million in a Series A funding round led by Khosla Ventures for its mission to accelerate the development of human cell therapies using AI. The company is building a proprietary AI platform and foundation model called “DeltaStem”, which is designed to change the way cell thera…
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What is aging? Sadly, we don’t know. If we ask the experts in the field, they will give us different answers [1]. Consensus has not been reached on even the trivial definition of aging, let alone its primary mechanisms. But, can we cure aging without understanding it? I think not. Knowledge is essential to target the fundamental causes of a diseas…
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As the longevity sector evolves from promising prospect to a discernible market category, its investment landscape is becoming notably more curated – and the Longevity Investors Conference (LIC), returning to Gstaad this September, appears intent on reflecting that shift. Billed as a closed-door gathering of qualified investors and leading sc…
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London, UK – May 13, 2025 – Industry analysts at Longevity.Technology today published the 2024 Annual Longevity Investment Report – a full-year report on the state of investment in the longevity sector – with total financing reaching USD $8.49 billion across 331 deals. The report analyses the companies and investors behind technologies designed …
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By Danny Sullivan – Longevity.Technology – Longevity field hails ‘landmark step’ as US state establishes framework for healthcare facilities to become experimental treatment centers. The US state of Montana this week enacted a groundbreaking law that opens the door for clinics and physicians to provide experimental drugs and therapies that have no…
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The composition of the gut microbiome has been shown to change with age, undergoing a loss of beneficial microbes in favor of inflammatory microbes that contribute to the chronic inflammation of aging and onset and progression of age-related conditions. Researchers have comprehensively demonstrated in animal models that introducing a young microb…
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The consensus on air pollution is that it increases late life mortality, largely via an increase in chronic inflammation in exposed tissues in the lung. Researchers here propose that uptake of iron from inhaled particulate matter can contribute to the age-related increase of iron that takes place in the brain, and thus cause pathology. The resear…
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By Leila Gray – University of Washington – A novel health-assessment tool that uses eight metrics derived from a person’s physical exam and routine lab tests could be used to characterize biological age and predict the person’s risk of disability and death better than current health predictors. University of Washington School of Medicine researche…
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Stem cell therapies have expanded in use over the last 30 years, and are now widespread. Substituting extracellular vesicles for the stem cells is a more recent innovation, but also now widely used in the medical tourism industry. These treatments have shown effects on aging and longevity in animal studies, but we have no idea whether this is the…
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The Hallmarks of Aging team has returned to Cell, publishing a detailed review discussing how future methods of dealing with aging might be highly personalized. In the original and very heavily cited 2013 paper [1], Dr. López-Otín and colleagues outlined nine hallmarks of aging. In their 2023 update [2], three more were added, reflecting the en…
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The US state of Montana this week enacted a groundbreaking law that opens the door for clinics and physicians to provide experimental drugs and therapies that have not received approval from the US FDA. The new legislation, known as Senate Bill 535, was signed this week by Governor Greg Gianforte and builds upon the state’s recent expansion o…
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Neurodegeneration-focused biotech Therini Bio has secured an additional $39 million in Series A extension financing, bringing the company’s total Series A funding to $75 million. The financing will primarily be used to advance the company’s lead candidate into clinical trials for Alzheimer’s disease and diabetic macular edema (DME). Theri…
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Nucleoside reverse transcriptase inhibitors (NTRIs) were developed to treat HIV infection, interfering in the ability of the virus to replicate. Researchers here present epidemiological evidence for this class of drug to slow the onset of Alzheimer’s disease. The researchers focus on reduced inflammation as a driving mechanism, but it seems plaus…
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It seems likely that the next century will see the engineering of new humans to have genetic alterations that have been identified as wholly beneficial. It is a lot easier to edit the genomes in an embryo than it is to adjust all of the cells in an adult in the same way, due to the issues of delivery of suitable genetic medicine to all cells in a…
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By Tina Reed – Axios – Silicon Valley billionaires like Sam Altman, Peter Thiel and Jeff Bezos are pouring billions into ventures trying to slow or reverse the aging process, wagering that reprogrammable cells and AI-driven drug design can deliver a fountain of youth — or at least ward off death. Physician-researcher Eric Topol offers […] The pos…
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Aix-en-Provence, France – August 30–31, 2025 – The South of France will host the first edition of the “2060 Longevity Forum” (https://forum.2060.life), a groundbreaking event designed to position longevity as the greatest investment opportunity of our time. Taking place in one of the most beautiful, culturally rich, and longevity-friendly regions …
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It is an ugly market for biotech companies seeking funding, and this has been the case for going on two years now. In this environment companies can only survive for so long. Smaller biotech companies have been fading into oblivion left and right in this past year as investors remained very risk averse. UNITY Biotechnology, developing senolytic t…
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This week, Danish pharma giant Novo Nordisk announced new data highlighting the early cardiovascular benefits of Wegovy at the European Congress of Obesity. The company presented a secondary analysis from the Phase 3 SELECT trial, which revealed that Wegovy reduced the risk of major adverse cardiovascular events – including cardiovascular dea…
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Screening of a natural compounds library has revealed the senomorphic properties of apigenin. This natural flavonoid also demonstrated rejuvenating effects on many aging-associated molecular features as well as physical and cognitive performance, and it has a beneficial impact on cancer treatment in mice and cells [1]. Senotherapeutics are ther…
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By Kevin McMahon – Healthspan Action Coalition – Join our hosts, Junaid Mian of 1435 Capital Management and Melissa King from the Healthspan Action Coalition for this edition of Healthspan Compass. In this episode, our hosts aim to establish a foundational understanding of the biological processes of aging and clarify essential terminology in acce…
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Earlier this week, the XPRIZE Foundation announced the 40 semi-finalist teams in its $101 million Healthspan competition – a global initiative designed to catalyze scalable interventions that restore muscle, cognitive and immune function by at least a decade in adults aged 50 to 80. The competition, launched in 2023, aims to close the gap bet…
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Proteins can undergo a large range of post-translational modifications, usually the addition of one or more molecules. This changes the interactions of the protein and its role in cellular biochemistry, and thus post-translational modification is an important aspect of the way in which protein machinery functions in the cell. Acetylation is one s…
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By Sanford Brnham Prebys – This month, researchers participating in the Cilento Initiative on Aging Outcomes or CIAO study will gather in Acciaroli (Pollica-Cilento) Salerno, Italy to review a decade of work and plan their next steps. Launched in 2016, the CIAO study seeks to identify key factors (biological, psychological and social) that promote…
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Scientists from the Lifespan Research Institute have discovered that a subset of T cells effectively targets senescent cells and improves outcomes in a mouse model of idiopathic pulmonary fibrosis [1]. Cellular senescence, which occurs when cells subjected to stress stop dividing and start emitting pro-inflammatory signals, is a double-edged s…
At 35, Surface Warfare Officer John T. has redefined what health means. Discover how his journey with NOVOS helped him build a sustainable, science-backed routine focused on energy, longevity, and showing up fully for his growing family. In This Article: That’s the question John T., a 35-year-old active-duty Surface Warfare Officer, began asking i…
When you think about aging well, you might consider factors like diet, exercise, and sleep. However, there’s one small nutrient you might be overlooking in the quest for longevity: vitamin D. Known as the “sunshine vitamin,” vitamin D supports not only your bones but also immune function, inflammation control, and cellular health — all of which af…
Long before fitness influencers made it trendy, walking was a popular sport and a public spectacle. In 19th century America and Europe, the professional sport of “pedestrianism” drew large crowds eager to watch athletes put one foot in front of another. As one of the world’s first spectator sports, walking became at once a form of exercise and a c…
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After a year of fiscal contraction and economic caution, the longevity sector has staged a return to form – albeit not in the manner some might have expected. Rather than chasing exuberant deal volumes or early-stage gambles, investors in 2024 favored focus over fervor; capital flowed into companies positioned to advance beyond proof-of-conce…
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By Michael Searles – The Telegraph – Selfies could predict a person’s chance of surviving cancer, a study has suggested. Doctors believe a new artificial intelligence tool that measures the “biological age” of a patient based on a photo of their face, could inform the type of cancer treatment they receive. Knowing someone’s biological age, […] Th…
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Precision medicine biotech HAYA Therapeutics has secured $65 million in Series A funding to accelerate the development of RNA-guided medicines that target chronic and age-related diseases by modulating the regulatory genome. The investment will enable the company to advance its lead therapeutic candidate into clinical trials for heart failure…
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Researchers publishing in Aging Cell have found a biochemical pathway that leads skin cells to become senescent along with a potential target for future therapies. Dermal fibroblasts are common subjects in aging research, particularly in the context of senescence. These cells have a critical purpose: they are responsible for maintaining the int…
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The race to improve how long we live well has entered a new phase. XPRIZE Healthspan, the seven-year, $101 million global competition announced in late 2023, has unveiled its first cohort of semifinalists – 100 teams from 58 countries tasked with developing therapies to extend the years we spend in good health. With the selection comes not ju…
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By Eleanor Garth – Longevity.Technology – New research reveals senescence is not a single process but a spectrum of cellular states with implications for precision longevity therapies. The accumulation of senescent cells is increasingly seen as a major contributor to aging and age-related diseases. These senescent cells – often referred to as “zom…
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“When you give women information about how their bodies work, they make great decisions for themselves.” —Rachel Rubin The post #348 ‒ Women’s sexual health, menopause, and hormone replacement therapy (HRT) | Rachel Rubin, M.D. appeared first on Peter Attia. …
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New evidence suggests they might, although we still have much to learn about the practical implications The post Do fat cells “remember” obesity even after weight loss? appeared first on Peter Attia. …
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By City of Hope – SciTechDaily – City of Hope researchers have identified a new type of stem cell, called CP-As, that emerges in middle age and drives the production of belly fat by converting into fat cells, explaining age-related abdominal weight gain. Their findings reveal that the LIFR signaling pathway activates these cells, offering […] The…
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Blog Author: Sierra Lore, PhD candidate, Verdin Lab Sierra Lore In our Nature Aging perspective, Replacement as an Aging Intervention, we introduce the term ‘replacement interventions’ as a class of therapies aimed at restoring or substituting aged cells, organs, or brain systems. In this paper, we present the first unified framework of repl…