Longevity Science

Washington DC has always been a city of change – a place where rules are rewritten and intellectuals debate the future of the nation. But from June 29 to July 1, 2026, the energy felt entirely unique. While the capital bustled with visitors celebrating America 250 and reflecting on our first two centuries, the longevity industry gathered to m...

What happens when a government finally admits that people living longer isn’t a future problem – it’s today’s reality? Most US states have published reports, convened commissions or launched task forces to prepare for aging populations. The challenge is that many of those efforts are tied to election cycles. A new administration arrives, ...

What if one drug could help someone rushed into the emergency room after a stroke and also slow the steady progression of Parkinson’s disease? At first glance, the idea sounds almost contradictory. Stroke is sudden, measured in minutes and hours. Parkinson’s unfolds quietly over years, sometimes decades. One is an acute medical emergency;...

Kenai Therapeutics has completed enrollment in the REPLACE Phase 1b/2a clinical trial of RNDP-001 for moderate to moderate-severe idiopathic Parkinson’s disease, the company announced on 7 July 2026, in San Diego. RNDP-001 is an off-the-shelf, allogeneic neuron replacement cell therapy designed to restore dopaminergic neurons lost in Parkinson’s ...

FibroBiologics completed manufacturing of a third batch of its CYWC628 drug product for the ongoing Phase 1/2 clinical trial in patients with diabetic foot ulcers. The batch was produced under cGMP standards and is undergoing required safety and quality testing ahead of release for clinical use. Upon release of the third batch, the company expect...

Elysium reported results from an open-label pilot study of 40 healthy women over 35, 32 of whom self-reported symptoms associated with the menopause transition and eight who reported minimal or no symptoms. Participants received Basis for seven days. After seven days, participants in the symptom group self-reported reductions of 50 percent or mor...

By Darren Incorvaia – Fierce Biotech – CAR-T cell therapy has flourished since its first use in 2010, leading to seven approved medicines for various blood cancers. But adapting the powerful technique, which involves engineering a patient’s own T cells to fight cancer, to solid tumors has proven a vexing challenge. Last week, a biotech finally ...

Insilico Medicine, a generative AI-driven clinical-stage biotech listed on the Hong Kong Stock Exchange (03696.HK), issued a positive profit alert for the six months ended 30 June 2026. The company expects revenue of approximately USD102.5 million to USD106.5 million, a year-on-year increase of about 272.7% to 287.3%. Net profit is projected at a...

Amprion, headquartered in San Diego, announced on 8 July 2026 that it reached an agreement with Decathlon Capital Partners for a multi-million-dollar growth-funding investment to expand diagnostic testing capacity for neurodegenerative diseases, including Parkinson’s disease, Lewy body dementia and Alzheimer’s disease. According to the company, t...

Vaccinations can produce a lasting effect known as trained immunity, altering the behavior of the innate immune system and resulting in both a reduction in the chronic inflammation of aging and a more effective immune response to unrelated infectious agents. Arguably the largest body of research into trained immunity involves the BCG vaccine for ...

Senescent cells are involved in tissue regeneration. Cells enter a senescent state following injury, and in the usual course of events assist in the intricate coordination between immune cells, stem cells, and other cell types that is required to regrow tissue. These senescent cells are then cleared by the immune system. With age, in poorly regen...

By University of Colorado at Boulder – Science Daily – A Colorado research team has created experimental osteoarthritis treatments that appear to regenerate damaged joints rather than just relieve pain. In animal studies, a single injection restored arthritic joints to a healthy state within weeks, while a second therapy repaired cartilage and bon...

A perspective published in Aging and Disease has recommended the use of underground laboratory space in order to remove the effects of surface radiation on biological clocks. The cascading failure of bodily systems, leading to the loss of organ function, sits downstream of fundamental damage to genomics and epigenomics. However, how much of this...

There is a large body of evidence in animal studies to show that treatment with dasatinib and quercetin clears a fraction of the lingering senescent cells present in tissues throughout the body to restore more youthful function to many different organs and systems. Today's open access paper, focused on kidney rejuvenation via removal of senescent...

The longevity landscape shifted in May at a landmark public meeting convened by the Reagan-Udall Foundation for the FDA. Co-sponsored by ARPA-H’s PROSPR program and the XPRIZE Foundation, the summit tackled the commercial ecosystem’s most stubborn bottleneck: translating structural geroscience breakthroughs into concrete, regulatorily approve...

Most collaborations between universities and pharma companies are built around a single goal to answer one research question, develop one technology or test one drug candidate. Once the project ends (or the funding dries up), the partnership often ends with it. Even when the science is promising, disagreements over intellectual property, shif...

The first wave of GLP-1 drugs changed the conversation around obesity. They helped people eat less and lose weight, but they also raised a bigger question: what comes next? For many researchers, the future isn’t simply about helping people shed pounds. It’s about treating the web of metabolic problems that quietly drive chronic disease, f...

Haut.AI launched Body Analysis, an AI-powered full-body skin analysis platform designed to help beauty and wellness brands deliver personalized, data-driven bodycare at scale. The module expands the firm’s skin-analysis suite beyond the face and provides objective, quantitative skin measurement across the full body through a single unified pipeli...

Alterity Therapeutics received official End-of-Phase 2 meeting minutes from the U.S. Food and Drug Administration confirming a registrational pathway for ATH434 in multiple system atrophy. The minutes confirm key elements of the Phase 3 program announced 9 June 2026, and indicate the FDA agreed that a single pivotal Phase 3 trial, supported by co...

Catalent and Nanoscope Therapeutics expanded their collaboration to support late-phase clinical and commercial supply of MCO-010, Nanoscope’s lead optogenetic gene therapy. Under the agreement, Catalent will provide commercial-compliant packaging and distribution and has secured the commercial packaging validation program to support Nanoscope’s B...

RoslinCT and BlueRock Therapeutics have entered a strategic partnership to broaden access to BlueRock’s clinical-grade induced pluripotent stem cell lines for cell therapy developers. RoslinCT will add access to BlueRock’s clinical-grade lines alongside its own and will offer matched research-grade samples to prospective customers, while BlueRock...

Aptorum Group Limited and DiamiR Biosciences announced that DiamiR will present three posters at the Alzheimer’s Association International Conference (AAIC) in London 11-15 July 2026, showcasing biomarker work from DiamiR’s CLIA-certified, CAP-accredited laboratory. Alidad Mireskandari, Ph.D., DiamiR’s chief executive officer, is listed as presen...

Animal studies suggest that the composition of the gut microbiome is at least as important as diet and exercise when it comes to influencing the pace and progression of aging. Both diet and exercise influence the gut microbiome as well - nothing in the body acts in isolation. The composition of the gut microbiome changes with age, and in animal s...

Researchers here describe an approach to encouraging regrowth of small vessels in heart tissue, involving transplantation of organoids composed of the various cell types needed to form new vessels. Like other cell therapy strategies for an injured or aged heart, delivery involves making a patch of pseudo-tissue that is layered onto the surface of...

By Michelle Starr – Science Alert – The kids are growing up so fast these days, but maybe not in the way you think. A new study of adults suggests that more recent generations are biologically older than earlier generations were at the same age – based on a range of blood markers. That doesn’t […] The post Younger Adults May Be Aging Faster Than ...

The point of studying the biochemistry of very long-lived humans is to try to better understand which of the many underlying mechanisms of damage and dysfunction that drive degenerative aging are the most important and thus should be prioritized for the development of therapies. One can look at the differences in the sequences of proteins, expres...

In a recently published perspective paper, the author argues that the UK’s official health guidelines on physical activity and protein intake should be revised to recommend levels necessary to achieve optimal health, rather than the bare minimum currently recommended [1]. Current government guidelines on nutrition and physical activity are desig...

The Longevity Investors Conference (LIC) returns to Le Grand Bellevue in Gstaad, Switzerland, from 14 to 17 September, bringing together investors, founders, scientists and clinicians for four days of discussion centred on one of the sector’s defining questions – not simply what will extend healthy lifespan, but what will attract the capital ...

To understand whether a treatment is working, researchers need data. Lots of it. But collecting that data usually means asking people – many of them older adults living with cognitive decline – to travel repeatedly to specialist clinics, complete lengthy assessments and return months later to do it all again. The result is expensive studies b...

What if the biggest breakthrough in treating type 1 diabetes isn’t replacing the cells that make insulin but convincing the body to simply leave them alone? For many people living with type 1 diabetes (T1D), replacing lost insulin-producing cells has always sounded like the obvious answer. The problem is that the immune system often sees ...

The more severe later stages of Alzheimer's disease are characterized by altered forms of tau protein aggregating inside neurons to cause dysfunction, inflammation, and cell death. Researchers here show that tau can spread between neurons via extracellular vesicles, and identify the protein arc as necessary to this process. Once a mechanism invol...

By Inside Precision Medicine – REGEN4HD, a Phase Ib/IIa from UCI Health, aims to slow disease progression, protect brain cells, and possibly repair neural circuit Huntington’s disease therapeutics have reached a historic milestone—the first patient has successfully received an experimental neural stem cell therapy at UCI Health. This groundbreak...

The gut microbiome generates a vast range of metabolites, some beneficial or even necessary to health, and some actively harmful, provoking chronic inflammation or other dysfunction. With age the balance of microbial populations making up the gut microbiome changes for the worse. Researchers have observed declines in the generation of some benefi...

by Kyoto University – Nanotechnology – A team of researchers led by Professor Akitsu Hotta (Department of Clinical Application) developed a comprehensive framework that combines computational prediction, experimental validation and whole-genome analysis to evaluate intended and unintended mutations arising from CRISPR-Cas9 delivered by lipid nano...

by Julia Evangelou Strait – WashU Medicine- Immune system aging linked to earlier lung cancer; fat tissue aging linked to earlier colorectal cancer Cancer is often considered a disease of aging. Older adults are at higher risk because they have had more time to accumulate cellular damage that can trigger tumor formation. But as cancer […] The pos...

Theriva Biologics announced that the Spanish Agency of Medicines and Medical Devices (AEMPS) has authorized initiation of VIRAGE2, a Phase 2a, single-arm, single-center, open-label proof-of-concept trial to test increased-frequency dosing of VCN-01 (zabilugene almadenorepvec) combined with gemcitabine/nab-paclitaxel in newly diagnosed metastatic p...

by Ingrid Fadelli – Medical Xpress – The human brain is known to naturally change with age, shrinking in size and volume after people reach their 30s or 40s. In some cases, however, it can age faster than expected, which can increase the risk of early memory loss, cognitive decline and some brain-related disorders. Faster […] The post Higher bloo...

The retina is considered a part of the central nervous system. As is the case for the brain, a barrier of specialized cells surrounding the blood vessels supplying retinal tissue controls the passage of molecules between blood and tissues. This barrier becomes dysfunctional with age and age-related conditions, and leaks inappropriate molecules in...

Scientists have linked disrupted Ca²⁺ homeostasis to aging in both progeroid and naturally aging mice. Rescuing it with a well-known antidepressant significantly increased the animals’ median and maximum lifespan [1]. Cells use calcium ions (Ca²⁺) for signaling, and a rise or fall in cytoplasmic Ca²⁺ switches many pathways on or off. Ca²⁺ homeos...

The best spermidine supplement is one that pairs a clean, whole-food source with transparent testing and a formulation your body recognizes. On those measures, Primeadine by Oxford Healthspan ranks first: a whole-food spermidine sourced from Japanese ingredients, a gluten-free alternative, and grounded in Oxford science. Choosing a spermid...

The growth in number of senescent cells with age is an important mechanism of degenerative aging. Many studies in mice have demonstrated rapid rejuvenation and reversal of many different aspects of aging and age-related conditions via selective destruction of senescent cells in aged tissues. Here, researchers review what is known of the way in wh...

Accelerated aging conditions are not really accelerated aging conditions; each is a dysfunction in which one specific mechanism runs amok, generating damage and dysfunction that superficially resembles the damage and dysfunction of aging. Most of the known accelerated aging conditions are strongly connected to malfunctions in DNA repair, and dysf...

by Renée Onque – CNBC – There is steady interest — from everyday people to researchers alike — in what it takes to live a long, healthy life. From cookbooks to research papers to the hundreds of articles you can access with a quick Google search, the amount of information to digest and advice to […] The post 5 lifestyle habits that can help you l...

Researchers have elucidated some of the links between the age-related loss of muscle (sarcopenia) and the age-related loss of bone (osteoporosis). Substantial previous research has described the relationship between muscle and bone health. While misloading can be dangerous, ordinary mechanical loading, which necessarily involves muscle use, main...

In recent years, researchers have noted that one variant of the BPIFB4 gene is associated with human longevity. This was discovered in the usual way, by noting that older populations tend to have a higher proportion of individuals carrying the variant than is the case for younger populations. In other words, individuals without the protective var...

The nature of medical regulation makes it extremely expensive to develop a new drug, and considerably less expensive to find a new use for an existing approved drug. Thus repurposing drugs receives more attention than it perhaps should, and the typical outcome is a new marginal use rather than something impressive. This will happen for treatments...

by Stephanie Edwards – Discover – Learn more about how younger generations are now aging faster than their parents and grandparents, and how this aging gap could explain the rise in early-onset cancers. For most people, a cancer diagnosis is something we don’t expect until after we hit retirement age. However, across the globe, doctors […] The po...

Aging clocks cannot be trusted to produce useful data for any novel intervention in aging. They are produced via machine learning approaches applied to biological data from a large study population, and there is very little understanding of how underlying mechanisms of aging connect to the data used to build the clock. Thus effects on aging produ...

By Texas A&M University – Science Daily – Scientists have taken a surprising step toward unlocking regeneration in mammals, showing that the ability to rebuild complex body parts may not be lost after all—it may simply be switched off. Using a two-stage treatment, researchers redirected the body’s normal healing response away from scar format...

“The more you move, the more you’re alive. The less you move, the less you’re alive.” —Peter Attia The post Building strength and muscle mass: how to optimize training, nutrition, and more for longevity (AMA #71 rebroadcast) appeared first on Peter Attia MD. ...

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To...

Metformin failed in prostate cancer and many others—but exceptions remind us to think with precision about interventions The post Metformin and cancer: active surveillance needed appeared first on Peter Attia MD. ...

By Deidre McPhillips – CNN – New mortality data from the federal government suggests that life expectancy probably hit another record high in 2025, as death rates have continued to fall since the height of the Covid-19 pandemic. There were about 689 deaths for every 100,000 people in the US in 2025, according to a […] The post US life expectancy ...

Ethicists seem a little stuck on the idea that treatments to slow and potentially reverse aspects of aging are only available to the wealthy, or will only be available to the wealthy. Today's open access complaint about making the world a better place at least manages to also touch on what I think is the more pertinent issue, which is knowledge. ...

Many people start their morning with a multivitamin, trusting that a single daily capsule covers their nutritional bases. It’s a reasonable instinct — but if your goal is to live longer and healthier, it’s worth asking: Do multivitamins actually support longevity, or are they simply filling gaps that most people don’t have?  As interest in lo...

Restricting food access to an 8-hour window increased median lifespan in male mice by 12%. However, that might be due to voluntary caloric restriction induced by the regimen [1]. Time-restricted eating (TRE), also known as intermittent fasting, has become a popular health practice due to a slew of animal studies showing its benefits for healthsp...

Pulmonary fibrosis is an age-related condition. Good evidence connects it to the burden of senescent cells in the aging lung, but its causes are otherwise relatively poorly understood. Therapeutic options remain poor, and the prognosis for patients is quite ugly. Fibrosis is nanoscale scarring, an inappropriate buildup of excess extracellular mat...

If used sensibly, models of aging can offer some insight into the bounds of the possible with regard to which classes of biological mechanism are more or less important in determining pace of aging, onset of disease, and life span. Researchers here use a specific type of model, the saturating removal model of damage accumulation, and tinker with ...

by Andrea Corona – Drug Discovery and Development – The field’s foundational biology is no longer the limiting factor. What comes next depends on whether the industry can build the manufacturing, commercial, and clinical infrastructure to match what the science already knows how to do. Cell and gene therapy (CGT) has arrived. The question a pan...

By Aline Massuca and Victoria Pacheco – Reuters News – What is the secret to a long life? Three Brazilian sisters with a combined age of 316, who were named by Guinness this month ​as the oldest living trio of siblings in the world, may help researchers find ‌out. The DNA Longevo Project, a study […] The post Scientists seek clues to longevity fr...

Intermittent mild hypoxia has been shown to slow aging and improve health in animal studies, and is used in medicine in some contexts. It is a form of stress and encourages a hormetic response from cells that on balance improves health. Long term hypoxia or severe hypoxia tips over into outright harm, overwhelming any beneficial mechanisms that a...

If you've been researching spermidine for more than ten minutes, you've probably hit a wall of contradictory numbers. One brand claims 10mg per serving. Another leads with 800mg. A third talks about "optimal cellular doses" without specifying what that actually means in practice. And somewhere underneath all of it, you're trying to answer ...

Immune cells have their own rhythm of renewal, a rhythm that can slow with age. When it does, cells can settle into a state called senescence, one of the hallmarks of aging, where they linger in an inactive state in the body without renewing or responding the way they once did.  For the first time, researchers have new human data on someth...

Sadly, we live in an age in which the media likes to generate conflict, and in which the role of personal responsibility in most aspects of life (and certainly in the matter of medicine) is denigrated. It is a culture that rejects risks, costs, and benefits that cannot be quantified easily, and demands a centralized, legalistic approach as to who...

By Jack McNamara – Science Alert – Strength training has long been seen as something you mainly do to build muscle or look good. But a new study adds to a growing body of evidence that shows lifting weights does far more than change how we look. It may help us live longer – even […] The post Strength Training Is Linked to Longevity, 30-Year Study...

Doing something about aging seems to require action at the most basic genomic level. Here’s what’s been done there and in other areas in June. The Thalion Initiative: A New Non-Profit With Big Ambitions: The longevity field remains small and starved for resources, especially the subfield devoted to the fundamental biology of aging, despite near-...

Nature – Scientific Reports – Abstract An aging population, along with rising chronic diseases and disabilities, is increasing the demand for healthcare services; this places significant pressure on healthcare costs and public finances, particularly in countries with high public health expenditures. Asia-Pacific countries are at the forefront of g...

by Cheryl Scott- Bioprocess international Consultants from ProPharma express optimism about the trajectory of cell and gene therapy despite technical and logistical difficulties remaining in the field. A combination of automation, advanced modeling, decentralized manufacturing, and increasingly supportive regulatory frameworks is creating new pos...