Longevity Science

There’s a moment in advanced Parkinson’s disease that doctors call “OFF” time. It’s when the pills stop working mid-cycle, and a person who was walking and talking normally an hour ago suddenly can’t get out of a chair. It happens unpredictably, sometimes several times a day, and it’s one of the cruelest parts of a disease that already takes ...

By Bernard Siegel The next era of healthspan will not be built by science alone. It will require collaboration among researchers, clinicians, innovators, investors, advocates, caregivers, policymakers, and the communities they serve. That is the purpose of the Translational Longevity Summit, October 7–11, during Boston Longevity Week. Hosted at On...

Researchers here provide a proof of concept for the use of Raman spectroscopy to non-invasively measure the burden of senescent cells in an imaged tissue. This works because Raman imaging can provide distinct signatures of different molecules via scattering of photons. Provided the field of imaging is sufficiently constrained, it is possible to p...

One of the more interesting new concepts in aging research is that repeated activation of the DNA damage response may cause epigenetic changes in the management of nuclear DNA structure that are characteristic of aging. It neatly explains how stochastic DNA damage to unused DNA sequences can possible contribute to aging. It also frames partial ep...

Regenxbio presented three-year durability data for Surabgene (lomparvovec) in non-proliferative diabetic retinopathy at the Retina Society 59th Annual Scientific Meeting in Los Angeles. In long-term follow-up from the Phase II ALTITUDE study (data as of 17 August 2026), a single in-office suprachoroidal administration at dose level 3 (1.0×10^12 G...

Immorta Bio Inc. was named to the 2026–27 Life Sciences cohort of Endless Frontier Labs at New York University Stern School of Business after a multi-stage evaluation of the company’s science, development strategy and commercial potential. Immorta Bio is developing two complementary therapeutic platforms: SenoMune, a senolytic immunotherapy platf...

Variant Bio has expanded its multi-year research collaboration and license agreement with Boehringer Ingelheim to include cardiovascular disease, building on prior work in kidney disease. The expanded collaboration will apply Variant Bio’s Inference platform to discover and validate novel cardiovascular targets. According to the company, the AI-...

The longevity industry has become very good at asking what we should take. Less attention is paid to a more basic question: where does it actually go? That’s the core theme of the latest episode of Longevity.Technology UNLOCKED, where host Phil Newman speaks with Dr Christopher Shade, founder and CEO of Quicksilver Scientific. Shade’s rou...

Pathways Bioscience announced that a randomized, double-blind, placebo-controlled study published in Free Radical Biology and Medicine evaluated PB125 in 20 younger adults and 24 older adults. The company claims two weeks of PB125 supplementation substantially improved vascular endothelial function in older adults, with brachial artery flow-media...

By Bernard Siegel The next era of healthspan will not be built by science alone. It will require collaboration among researchers, clinicians, innovators, investors, advocates, caregivers, policymakers, and the communities they serve. That is the purpose of the Translational Longevity Summit, October 7–11, during Boston Longevity Week. Hosted at ...

“The way this works is… at a very high level, making a new drug that's used by many people takes longer, is more expensive, and takes as many people as building the biggest skyscraper in the world. Think the Burj Khalifa.”‒ Lloyd Klickstein The post #409 ‒ Inside modern drug development: the science, economics, and regulatory hurdles behind brin...

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To...

Separating high-impact interventions from those that matter only at the margins The post Prioritizing health interventions appeared first on Peter Attia MD. ...

Type 1 conventional dendritic cells are a subclass of dendritic cell known to be an important component of the immune response to pathogens and cancerous cells, particularly focused on stimulating the activity of cytotoxic T cells. The cancer research community, as is often the case when it comes to specific components of the immune system, has l...

According to a new study, creatine supplementation might help maintain and increase lean mass even without diet or exercise. It also enhanced the effects of a combined diet and exercise intervention [1]. As people age, they often accumulate fat while losing muscle. When these changes occur together, in what is called sarcopenic obesity, they can...

Two pieces of news came out of Coya Therapeutics in a span of a week, and taken together they tell a more complete story than either one does alone. One came from a mouse study, newly published research showing an experimental drug combination calming brain inflammation [1]. The other came from an actual clinical trial: patient number 100, en...

With thanks to MuseCell Innovations, sponsor of the Longevity Biotech Report. Every number in the Longevity Biotech Report asks something different of the future. The $617 billion figure asks regulators to recognize aging as a treatable indication. The 100x figure asks society to notice value it currently leaves uncollected. The $230 ...

Telomir Pharmaceuticals is a cancer-focused company. Its clinical work is aimed at breast cancer, so a paper about failing eyesight in fish is a slightly odd thing to see under its name. The Nasdaq-listed biotech (ticker TELO) has just announced one anyway. The results are interesting enough to look at closely, though they need a fair amount ...

Fifteen minutes is all Xavier Jacq gets. On Wednesday, 30 September, in Milan, the chief scientific officer of MitoRx Therapeutics will stand up at the 62nd Annual Meeting of the European Association for the Study of Diabetes (EASD) and talk about a study in mice. It is a short slot for a drug that the company says works differently from the ...

Here’s a number worth sitting with: an estimated 99% of the chemical diversity found in nature has never been properly studied, because isolating and testing individual compounds from plants, microbes, and the human body has historically been too slow and expensive to bother. Enveda, a Colorado-based biotech, has built its entire platform aro...

Suppression of cancer is a necessary component of species longevity, and finding out how exactly cancer incidence is in some cases dramatically reduced is one of the primary goals for the field of comparative biology. Here, researchers survey known cancer-associated sequences across the genomes of long-lived and short-lived species, and see that ...

Here find a small slice of programmed aging consideration focused on some of the changes in cognitive function that take place in later life. The researchers argue that a shift in focus to integration of information, characterized by a loss of precision in episodic memory, is adaptive and selected for in older individuals. It is an interesting po...

BioCardia provided a regulatory update outlining near-term milestones for its CardiAMP and Helix programs. BioCardia is working toward a Shonin pre-market submission to Japan’s Pharmaceutical and Medical Device Agency in Q4 2026 and has supplied detailed responses to PMDA consultation questions while preparing the Shonin application, the Quality ...

Nanoscope Therapeutics will present data from its geographic atrophy and retinitis pigmentosa programs at the 26th Euretina Congress (1-4 October 2026) and at the Retina Forum in the Ophthalmology Futures Forums on 30 September 2026, in Vienna. Jordi Mones, MD, PhD, is scheduled to present the first direct-to-phase 2 randomized, controlled trial ...

Xella Health announced an integration with Oura to create a connected precision health experience designed specifically for women’s biology. The company says the collaboration combines continuous physiologic monitoring from Oura with Xella’s AI-powered multi-omic diagnostics, physician-guided care, and longitudinal treatment tracking to link biom...

UMethod Health published a peer-reviewed, real-world study in Current Aging Science that, according to the company, documented favorable cognitive outcomes associated with its AI-supported RestoreU care plans. The retrospective, nonrandomized implementation-and-outcomes analysis reviewed 345 paired cognitive tests over a mean follow-up of 14.1 mo...

Biophysical Therapeutics has launched IF1, a consumer longevity skincare brand, and opened pre-orders for an anti-aging moisturizer. The initial production run is limited to 500 units, priced at $120 each, and profits from sales will be reinvested to fund the company’s drug programs targeting cancer, age-related diseases including Alzheimer’s dis...

Apigenin is a plant flavonoid primarily found in chamomile, parsley, and celery. As an antioxidant and anti-inflammatory compound, apigenin has drawn the interest of longevity consumers and researchers alike. This article covers what apigenin is, where you get it, how it acts on sleep and NAD+, and what the human evidence says. Apigenin i...

Researchers have discovered that BNIP3, which regulates mitochondrial maintenance, is increased with aging, harming the heart’s ability to process energy. Mitochondrial transplantation was found to be effective against this increase in a mouse model. Mitochondrial Dysfunction As they age, the mitochondria in our cells lose their ability to provi...

It is well understood in the aging research community that the lack of a useful, consensus measure of biological age or pace of biological aging is a considerable hindrance to progress. If researchers could quickly measure the pace of aging or the state of aging in a robust way, then discovery and optimization of interventions would proceed a gre...

A particular kind of frustration is getting a stack of lab results back and not really knowing what to do with them. The numbers are there, the ranges are there, but turning that into an actual plan usually means either a follow-up appointment or a lot of solo googling. Function Health, the Austin-based company built around large-scale biomar...

The average doctor’s appointment in the US lasts 15 minutes, according to Ultrahuman. That’s barely long enough to explain what’s bothering you, let alone a medical history scattered across a handful of clinics, hospitals and labs that may never have swapped notes. Ultrahuman would like to help with that. The wearables company has launche...

Thirty people with bad knees got one injection. Six months later, most of them were still doing better. That’s the headline finding out of Liège, Belgium, where biomedical company Allegro just released the latest results from its ongoing Hydrocelin trial, and it’s the kind of number that tends to get buried under clinical language, so it’s wo...

Researchers have started on the long process of transferring promising genes from long-lived species into short-lived species, one by one, with each such transfer as a test of how important that specific difference is to the progression of aging and species longevity. Differences in the presence of hyaluronan in the extracellular matrix are thoug...

Many approaches to modestly slow aging in short-lived species involve a mild mitochondrial dysfunction that that somewhat increases the level of reactive oxygen species generated in the course of producing adenosine triphosphate (ATP) to power the cell. Reactive oxygen species react with and damage molecular machinery throughout the cell, damage ...

The cGAS protein is a sensor for mislocalized DNA in the cell cytoplasm, and responds by triggering STING, a regulator of the inflammatory response to damage and dysfunction. The cGAS-STING interaction produces some fraction of the maladaptive chronic inflammation characteristic of aging, as, among other reasons, mitochondrial dysfunction tends t...

Results from a recent study suggest a delay in ovarian aging in mice following treadmill training; this effect was mediated by adiponectin. Pharmacologically activating adiponectin receptors extended reproductive span in mice. [1] The female reproductive system strongly influences the female aging trajectory, and its impact goes well beyond the ...

Researchers here take a very broad tour of the established literature on the comparative biology of aging in long lived species of all sorts, picking from those that can live more than 250 years, whether plant or animal, and comparing reported differences in biochemistry both between species and between individuals of the same species. It seems j...

Rationing of sugar in the United Kingdom in the years immediately following the Second World War forms a natural experiment in the long term effects of changes in human nutrition that can be explored in great detail given the establishment of the UK Biobank. Researchers here show that lower sugar intake in early life correlates with improved late...

by University of Helsinki – MedicalXpress – In a 50-year follow-up study, men with low cardiovascular risk in their 40s maintained their functional capacity, happiness and quality of life better than others as they aged. The research is published in the European Journal of Preventive Cardiology. READ MORE The post Healthy lifestyle in middle age ...

If you’re on a GLP-1 medication and feel more tired than you expected, you’re not imagining it. Even if the scale is moving in the direction you want, you may feel like you’re running on empty. Fatigue is one of the most commonly reported experiences among people using these medications, for a few key reasons. It typically traces back to lower fo...

A range of gene therapies are presently available in the medical tourism community of clinics outside the US and Europe, largely originating with a small number of companies such as BioViva Sciences and Triple Helix Science. These gene therapies tend to involve intramuscular (targeting muscle) or intranasal (targeting the brain) delivery of a mod...

According to a new study using a mouse model of a rare disease, transplanted immune cells donate their mitochondria to neighboring donor cells, improving energy production and rescuing function [1]. Friedreich’s ataxia is a rare genetic disease in which deficiency in the protein frataxin impairs mitochondrial energy production, especially in ene...

Senescent cells accumulate with age, likely largely because the aging of the immune system slows down the clearance of senescent cells, but the relative importance of different contributions to the growing burden of senescence in aging tissues is an area of ongoing discussion. Senescent cells secrete inflammatory signals that are disruptive to ti...

Researchers here suggest yet another possible use for retinal imaging, in this case an assessment of the burden imposed on the central nervous system by atrial fibrillation in its early stages. The retina is a window into the health of the central nervous system; many of the pathologies of the aging brain also take place in the retina. Retinal im...

By StudyFinds Analysis – StudyFinds – Blood vessels might already be showing wear and tear by the time an individual turns 35, decades before some other organs start to change. A new study suggests that’s not random. Different tissues appear to follow distinct structural-aging patterns across adulthood, some breaking down early, some late, and som...

Like many age-related conditions, atherosclerosis is accelerated by the chronic inflammation of aging. An atherosclerotic plaque is an inflammatory environment, in which macrophage cells are overwhelmed by excess cholesterol and toxic derivatives of cholesterol. Macrophages attempt to remove cholesterol from the plaque, returning it to the bloods...

In a pilot study, patients engaging in intermittent fasting demonstrated improvements in Huntington’s disease, a neurodegenerative condition currently considered untreatable. However, the study’s size and limitations call for more research [1]. Huntington’s disease is an inherited, progressive neurodegenerative disorder caused by an expansion of...

Every tissue in the body exchanges signals with every other tissue. Every tissue is dependent on specialized functions that are conducted elsewhere in the body. Thus in the matter of neurodegenerative disease, it is possible to focus too much on the brain, where the damage is taking place. Other organs and biological systems in the body do make a...

Researchers here process data from a longitudinal study of several thousand people to show that better cardiovascular heath in the early 40s correlates with better outcomes in later old age. There are many reasons to put in the effort to maintain a better state of physical fitness, and that it meaningfully slows the pace of degenerative aging is ...

by Texas A&M University – SceinceDaily – Dogs and humans may have more in common when it comes to aging than scientists realized. Researchers with the Dog Aging Project found that patterns of small molecules in dogs’ blood were linked to longer or shorter lifespans in remarkably similar ways to those seen in people. These […] The post Dogs may ho...

“The goal of this podcast, of course, is then to walk people through the physiology carefully enough that you can see both the grains of truth on each side of those schools of thought, but perhaps more importantly, what they might be missing and therefore where we can hopefully land on a place to treat people.”‒ Peter Attia The post #408 ‒ AMA #8...

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To...

A new study found that semaglutide extended median lifespan and improved several measures of aging in female mice—but the headline requires careful interpretation. The post Can semaglutide slow aging?  appeared first on Peter Attia MD. ...

The major neurodegenerative conditions are characterized by pathology deriving from a small number of misfolded or otherwise altered proteins. Amyloid-β misfolding and aggregation is thought to be the initiating event in Alzheimer's disease, which leads to the spread of altered forms of tau protein that cause the real damage. α-synuclein, once mi...

In a new study, thymic tissue implanted in the spleen improved immune responses against viruses and tumors and reversed age-related thymic involution in mice [1]. The thymus is a small but crucial organ, where T cells mature to become the backbone of our adaptive immune system. There, they acquire their ability to recognize diverse threats along...

by Federation of European Neuroscience Societies –ScienceDaily – People who speak several languages may have brains that age more slowly, with four-language speakers showing brains that appeared about 13 years younger than those of monolinguals. Starting earlier and becoming highly fluent were also linked to a stronger effect. The new findings sug...

Interest in autophagy has grown alongside intermittent fasting, with most coverage framing it as a fasting hack tied to a specific number of hours. Autophagy is actually a continuous cellular maintenance process associated with how well your cells age, and fasting is one of several ways to support it. This article covers what autophagy is, how it...

Researchers publishing in Aging Cell have found that a cocktail of molecules released by human umbilical cord mesenchymal stem cells (hUC-MSCs) can mitigate sun-induced skin aging (photoaging) in mice by restoring their cells’ ability to get rid of their own damaged mitochondria (mitophagy). Chronic exposure to ultraviolet light is the main driv...

by Alice Park – Time – Jamie Justice admits she has no poker face. As executive director of XPrize Healthspan, a philanthropic and corporate sponsored competition, Justice oversees one of the most buzz-worthy science competitions today. The contest, launched in 2023, attracted nearly 200 applicants from groups around the world who think they can h...

By Pooja Toshniwal Paharia – Medical Life Science News – A large-scale comparison of human longevity studies reveals why some epigenetic clocks detect biological changes far more consistently than others. n a recent study published in the journal Nature Medicine, researchers explored how epigenetic aging biomarkers respond to interventions aimed a...

By RegMedNet – An interdisciplinary Penn State team has developed a bioprinting technique using microRNA-modified stem cell spheroids that simultaneously regenerate bone tissue and facilitate vascularization, offering new treatment options for severe bone trauma and infections. An interdisciplinary team of engineers and chemists at Penn State ha...

Researchers have established how a protein that is nearly absent in the literature, PTCHD4, is linked to cellular senescence. In most papers, after a customary discussion of the mechanics of cellular senescence and current methods of handling it and its repercussions, the researchers go on to discuss previous work relating to the particular appr...