Translate:
Updated 9:29am | Nov. 24, 2025
3 hours
This is a very readable review, for all that the authors have stapled together two quite distinct topics into the one binder. Firstly, cellular senescence in various cell types in the cardiovascular system and its role in driving the onset and progression of cardiovascular disease. Secondly, efforts to develop cell therapies to treat cardiovascul…
3 hours
Sirtuins are a family of proteins that largely undertake specific modification of other proteins, removing certain decorations that have been attached to those proteins. A great deal of the exceedingly complex regulation of cellular metabolism involves changing the function of molecules by adding or removing decorations such as acetyl groups, met…
3 hours
By Medical Life Sciences News – Southwest Research Institute (SwRI) has demonstrated a new application for its cell-expansion bioreactor to advance tissue engineering and cell-based therapies for treatment of injuries and diseases. SwRI scientists used the bioreactor to replicate induced Pluripotent Stem Cells (iPSCs) derived from adult skin, b…
3 hours
by Thorvardur de Shong – Mass Market Retailers – – Consumers shift from living longer to living better, driving demand for functional ingredients across snacks, supplements, and beverages. Natural product shoppers are no longer motivated just by living longer. Instead, they want to live better. That shift from lifespan to healthspan is reshaping n…
1 day
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To …
2 days
Revising our earlier interpretation of SELECT trial data in light of new analyses The post Cardiovascular benefits of GLP-1 drugs independent of weight loss appeared first on Peter Attia. …
2 days
A protein is a sequence of amino acids joined together to form a single molecule, and consequently amino acids are everywhere in our biochemistry. Their presence influences many processes, and the complexity of cellular biochemistry continues to ensure that relatively little of this is anywhere near completely mapped. Circulating amino acid level…
2 days
George Church, a Harvard professor and a famed geroscientist, is also known as a serial entrepreneur who has co-founded dozens of biotech companies. While Church maintains that he’s involved in them all, one company has been seeing an unusual amount of his attention: Lila Sciences, where he assumed the role of Chief Scientist. On its website, Lil…
2 days
Beacon Biosignals has expanded its strategic collaboration with Takeda to advance the development of sleep-based biomarkers and diagnostic tools for narcolepsy. Under the extended agreement, Beacon will deploy its FDA-cleared at-home EEG headband, Waveband, and AI-driven analytics to accelerate the understanding of sleep patterns and brain activit…
2 days
Aperture Therapeutics has announced the nomination of APRTX-001, a development candidate designed to target CD33 via antisense oligonucleotide (ASO) technology, for the treatment of Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS). The company said it is advancing the program through IND-enabling studies, marking a major step …
2 days
Biologists have long described aging as a matter of wear and repair: molecular damage accumulates, maintenance falters and entropy wins the long game. A new paper in Advanced Science, however, takes a more philosophical – though still mathematical – view. Researchers at the University of the Basque Country and the Paris-Saclay Institute argue…
3 days
Women’s health biotech BASE4 Biosciences has emerged with a blood-based multi-omics platform designed to offer an early view of how more than forty-five organs are aging and whether they show molecular signs of deterioration before disease becomes evident. Critically, the company’s platform is built on AI models trained exclusively on female …
3 days
Magnetic resonance imaging (MRI) uses powerful magnets and radio waves to create detailed 3D images of the body – without the ionizing radiation used in CT or PET scans. A whole-body MRI takes this a step further, scanning from head to toe to spot early signs of disease, assess organ health, and build a baseline for preventive care. Increasin…
3 days
Frailty is a state of inflammation, physical weakness, degraded immune responses, and in general a loss of resilience to stresses such as infection and injury. The state of frailty is well known to correlate with mortality risk. Clinicians assess the degree of frailty in a patient via the use of a standardized frailty index. This is a simple and …
3 days
Loss of function mutations in insulin signaling have been shown to slow aging and extend life, but at the cost of slow growth and insulin resistance. Researchers recently discovered in flies a mutation that slows aging while retaining insulin signaling function. Flies have a single receptor for their versions of insulin and insulin-like growth fa…
By Optics.org – A project at the Technical University of Munich (TUM) has successfully stimulated stem cells in a manner that reliably induced them to develop into bone cells. The technology could ultimately lead to ways to generate specific cells for biomedical applications, but is also a new step in the study of how exogenous forces can influ…
3 days
Dr. Madison Doolittle, assistant professor in the Center for Regenerative Medicine and Skeletal Development at the UConn School of Dental Medicine, recently received a grant from the American Federation for Aging and Research (AFAR) to support his research on accelerated tissue aging and test potential therapeutic treatments. AFAR’s Grants for Jun…
3 days
Circulating oxytocin levels are known to decline with age, and a number of research groups have focused on upregulation of oxytocin as an approach to treating aging. A couple of papers published a few months ago are indicative of the animal studies presently taking place, the first focused on increased longevity in mice achieved via the combined …
3 days
Researchers publishing in Aging Cell have documented a key reason why older people are much more likely to get melanoma. While melanoma is much more treatable now than in the past, it still remains a serious danger. Melanoma can develop resistance to otherwise effective techniques [1], meaning that they only delay instead of permanently stop the…
3 days
Consumer health platform Function has reached a $2.5 billion valuation after securing a whopping $298 million Series B financing from a host of VCs, strategic backers, sports stars and celebrities. The company, which has grown rapidly since launching its biomarker testing membership in 2023, is expanding its model beyond diagnostics as it con…
3 days
In 2012, scientists Jennifer Doudna and Emmanuelle Charpentier made the Nobel Prize-winning discovery that the CRISPR system could be turned into a programmable tool for gene editing, sparking an explosion of research and laying the foundation for many of today’s most advanced therapeutics. The technology’s promise is profound: the ability to…
by GOAI –Gene Online – Japanese researchers are exploring a novel, minimally invasive method to repair spinal fractures using body fat-derived cells. The experimental approach involves converting fat cells into bone tissue, offering a potential alternative to traditional surgical procedures for treating such injuries. This technique aims to prov…
4 days
AGC Biologics has announced a collaboration with Repair Biotechnologies to develop and manufacture a novel mRNA therapeutic designed to stabilise and shrink atherosclerotic plaques in major blood vessels. The initiative addresses atherosclerosis—whose plaque rupture leading to heart attack or stroke is cited as the cause of 27% of global mortality…
4 days
Epirium Bio, Inc., a clinical‑stage biopharmaceutical company focused on neuromuscular and fibrotic diseases, announced positive Phase 1 results for its lead candidate MF‑300, which were presented as a late‑breaker at the Gerontological Society of America Annual Scientific Meeting. The oral small‑molecule therapy inhibits the enzyme 15‑hydroxypros…
4 days
Biotechnology firm Vasa Therapeutics announced that the U.S. Food & Drug Administration (FDA) has granted Fast Track designation to its lead investigational compound, VS‑041, which is being developed to treat Heart Failure with Preserved Ejection Fraction (HFpEF). The Fast Track designation gives Vasa enhanced regulatory interaction, potential…
4 days
Alzheon, Inc. announced it will present a suite of nine posters at the 18ᵗʰ Clinical Trials on Alzheimer’s Disease (CTAD) conference (San Diego, December 1–4 2025) covering its investigational oral therapy valiltramiprosate/ALZ‑801. The data—drawn from Phase 2 and Phase 3 trials—include long‑term extension analyses, quantitative systems pharmacolo…
4 days
Epigenetic clocks have existed for long enough for numerous large study databases to include data on their use. Thus meta-analysis papers are emerging to assess this body of data as a whole. This is a necessary part of the process of gaining confidence in the ability of epigenetic clocks, and indeed aging clocks in general, to rapidly assess the …
4 days
EyePoint Pharmaceuticals announced that its independent Data Safety Monitoring Committee (DSMC) has completed its second scheduled review of the pivotal Phase 3 trials—named LUGANO and LUCIA—evaluating DURAVYU for the treatment of wet age-related macular degeneration (wet AMD). The committee recommended that both trials continue as planned with no…
4 days
Biotechnology firm Oligomerix, Inc. announced that it has been awarded a US$0.5 million Phase I Fast-Track grant from the National Institute on Aging (NIA) of the National Institutes of Health (NIH) to advance its lead compound, OLX-07010. The company said the grant will fund non-clinical safety studies required to support future long-term dosing …
4 days
TDP-43 is one of a small number of proteins in the brain that can misfold or otherwise become altered in ways that allow toxic aggregates to form, or even encourage other molecules of the same protein to become dysfunctional in the same way. TDP-43 aggregation in later life is a relatively recent discovery, and has a neurodegenerative condition n…
4 days
By BioTechniques – Two separate studies have identified age-related molecular changes in the brain and adjusted them to improve memory. New research from Virginia Tech (VA, USA) shows that memory loss is tied to specific molecular changes in the brain and that adjusting those processes can improve memory. In two complementary studies, Timothy Ja…
The longevity supplement space is booming, and celebrity names are taking notice. David Beckham’s IM8 Longevity Powder has entered the market, claiming to target all 12 hallmarks of aging — but that claim doesn’t hold up. IM8 addresses only a handful of these mechanisms, and there’s no published evidence that it influences all 12. By contras…
4 days
The human gut microbiome is made up of a few thousand distinct microbial species. The relative sizes of these populations shift in response to day to day circumstances, such as variations in diet, but one would expect consistency from one year to the next. Over longer spans of time, the gut microbiome ages. Populations producing beneficial metabo…
4 days
Mitochondrial therapeutics biotech Vincere Biosciences has been awarded a $5 million grant from The Michael J Fox Foundation for Parkinson’s Research to move its lead Parkinson’s program into the clinic. The funding will advance the company’s USP30 inhibitor and biomarker development strategy through IND-enabling studies in preparation for a …
By Sabrina Richards – Fred Hutch Cancer Center – Bioengineer Dr. Matthias Stephan developed a quick-foaming solution that he hopes could one day turn gene therapy into an outpatient procedure The special properties of methylcellulose foam could make it a vehicle for bedside genetic engineering, according to a proof-of-principle study from bioen…
4 days
Earlier this year, the US administration’s FY 2026 budget proposal landed with an unhelpfully heavy thud in the biomedical research community; the suggested reduction in NIH funding approached 40 percent, with the National Institute on Aging facing a similar contraction. Although Congress has since indicated little appetite for cuts of that m…
4 days
A recent review in the Journal of Ovarian Research summarizes current knowledge of the impact of various polyphenols on different aspects of ovarian aging. The researchers discuss that polyphenol supplementation could be used as an intervention to delay ovarian aging [1]. Ovarian aging and cessation of proper ovarian functioning precede aging in…
5 days
Zymo Research has entered a strategic partnership with biomodal, integrating biomodal’s “duet” multiomics technology into Zymo’s NGS Services platform. The agreement makes Zymo an authorized provider of biomodal’s evoC and +modC assays, enabling simultaneous analysis of 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC), and standard DNA bases…
5 days
Annovis Bio announced that the U.S. Food and Drug Administration has scheduled a Type C meeting in January 2026 to discuss the development pathway for its oral drug candidate buntanetap in the treatment of Parkinson’s disease dementia (PDD). The upcoming meeting will focus on trial design parameters, patient population definition and a potential r…
5 days
Annovis Bio has reported new biomarker findings from its Phase 3 trial in early Parkinson’s disease, showing that roughly 25 percent of participants exhibited amyloid (Alzheimer’s-type) co-pathology—and these individuals experienced markedly faster cognitive decline compared to those without. According to the company, treatment with its drug bunta…
5 days
Muscle mass and strength decline with age, a long-term consequence of accumulating molecular damage and its effects on muscle stem cell populations and neuromuscular junctions, among other mechanisms. Once past an arbitrary line in the sand, this loss is defined as an age-related disease and called sarcopenia, a part of age-related frailty. Here,…
5 days
HCW Biologics Inc. has commenced its first‑in‑human clinical trial of HCW9302, a novel interleukin‑2 (IL‑2) fusion protein designed to expand regulatory T‑cells (T₍reg₎) for the treatment of autoimmune diseases. The company said that dosing of the first cohort has been completed and the trial is actively enrolling multiple dose levels. This milest…
5 days
Ochre Bio has announced the successful completion of its research collaboration with GSK, delivering two rich human-liver datasets that could accelerate drug discovery for liver disease. Over the course of the project, Ochre generated (1) a large-scale functional genomics dataset by systematically knocking down every known hepatocyte gene in prima…
5 days
The composition of the gut microbiome changes with age. Microbial populations that produce beneficial metabolites needed for optimal tissue function decline in number, while microbial populations that provoke the immune system into chronic inflammatory signaling increase in number. In recent years, researchers have demonstrated a range of specifi…
5 days
By Eve Herold – Physiology Today – Healthspan Compass editor in chief Eve Herold speaks with journalist and psychotherapist Paula Fontenelle about the psychological dangers and pitfalls of over-reliance on robot and chatbot relationships. “Relating to AI” focuses on the seismic societal changes occurring with interactive technology, also the subje…
5 days
Cambridge, MA, USA – November 18, 2025: Vincere Biosciences today announced the receipt of a $5 million grant from The Michael J. Fox Foundation for Parkinson’s Research (MJFF) through its Therapeutics Pipeline Program, which supports the advancement of promising therapies through preclinical and clinical stages. The initiative focuses on candidat…
5 days
The distinctive biochemistry of senescent cells has enabled researchers to produce proof of concept demonstrations for a range of ways to destroy senescent cells while having relatively little effect on non-senescent cells. The most established approach to date is to target well explored mechanisms that function to hold back senescent cells from …
5 days
Scientists have genetically modified human mesenchymal progenitor cells to express a more potent version of the “longevity gene” FOXO3, producing rejuvenative effects in monkeys, mice, and human cells [1]. Stem cell exhaustion is one of the mechanisms of aging. Replenishing the aging stem cell pool with new exogenous cells sounds like a good ide…
6 days
Researchers here assess the effects of supplementation with the L-BAIBA metabolite combined with exercise in older mice. It modestly improves both muscle and bone, adding it to the long list of approaches that can help in some small way to resist the age-related declines in muscle mass, muscle strength, and bone mineral density. As often noted he…
6 days
The well understood pathways by which cerebrospinal fluid drains from the brain are the glymphatic system and cribriform plate. These paths become less functional with age, for different reasons, and the consequently reduced drainage of cerebrospinal fluid allows metabolic waste to build up in the brain. This includes the misfolded and normally f…
6 days
by Bioengineer.org – In recent years, the concept of longevity clinics has gained remarkable traction across the globe, emerging as a novel frontier in personalized and preventive healthcare. These clinics, located in diverse regions from the United States and Switzerland to the United Arab Emirates, aim to extend human healthspan—the period durin…
By Jennie Erin Smith – Science – Texas voters this week made a bet that their state could build on a legacy of success in cancer research and become a powerhouse in neurological research as well. The Dementia Prevention and Research Institute of Texas (DPRIT), approved by two-thirds of voters in a 4 November ballot measure, authorizes $3 billion…
6 days
Gene expression is the complex process of producing proteins from a specific gene sequence encoded in DNA. The DNA in the nucleus of a cell is constantly surrounded by the machinery of gene expression. That machinery will attempt to start the process of transcription, the first step of gene expression, for any sequence it bumps into. Recall that …
6 days
In Aging Cell, researchers have discovered a potential way to use a microRNA to diagnose sarcopenia, the age-related loss of muscle. Previous research has been able to distinguish sarcopenia by its sources. Primary sarcopenia directly comes from the processes of aging, while secondary sarcopenia is a side effect of such things as poor nutrition,…
1 week
Finding molecules or nanoparticles that selectively target mitochondria and induce improved function is the most developed of the various strategies that might be employed to at least partially reverse the age-related loss of mitochondrial capacity thought to be important in age-related disease and dysfunction. Most of the small molecules develop…
1 week
Researchers here present a list of open problems in aging research, mined from the literature and outreach to the scientific community. This is certainly a topic on which opinions differ as to which of these areas of research are more or less important than others. An assessment of literature and community will tend to capture these differences o…
1 week
By Emily Shiffer – Upworthy – “Eventually you will end up in that CVS aisle you always skipped because it didn’t pertain to you.” Hands down, no one can speak on the truths about aging quite like Boomers (those born 1946 to 1964) or Gen X (those born 1965 to 1980). With years of life […] The post Gen Xers and Boomers share the sobering warning si…
by Kermit Pattison – Harvard Gazette – Findings on adrenaline’s role in process raise new possibilities for regenerative medicine Biologists long have been fascinated by the ability of salamanders to regrow entire limbs. Now Harvard researchers have solved part of the mystery of how they accomplish this feat — by activating stem cells throughou…
Researching the best longevity supplement brands can feel overwhelming, especially with so many different options available. In our comparison series featuring various longevity supplements, we’ve looked at how other supplements compare to NOVOS Core — and the results may surprise you. The truth is, there’s only one product that meets all the cri…
1 week
“Hypothyroidism is not that naive disease that we thought it was. It’s a deadly disease. It can affect significantly the quality of life of patients.” —Antonio Bianco The post #373 – Thyroid function and hypothyroidism: why current diagnosis and treatment fall short for many, and how new approaches are transforming care | Antonio Bianco, M.D., Ph…
1 week
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To …
1 week
Nov. 8, 2025 – Availiable now Realting To AI Podcast on Youtube Healthspan Compass editor in chief Eve Herold speaks with journalist and psychotherapist Paula Fontenelle about the psychological dangers and pitfalls of over-reliance on robot and chatbot relationships. “Relating to AI” focuses on the seismic societal changes occurring with interac…
1 week
The FDA has announced it will remove health warnings on HRT products, following the recommendations of an expert panel The post Warning label requirements on hormone replacement products are soon to be lifted appeared first on Peter Attia. …
1 week
A number of approaches to inducing muscle growth or improving muscle strength have been demonstrated in laboratory animals, in early human clinical trials, and in recent years employed in medical tourism clinics. These approaches are compensatory in the context of aging, they do not address any of the underlying issues that lead to loss of muscle…
Interest in longevity supplements has skyrocketed in recent years — and with it, so has confusion. As part of our NOVOS comparison series, we’ve already looked at how NOVOS Core stacks up against the Blueprint protocol. This time, we’re comparing NOVOS Core and Tally Health. Both promise to support long-term health and cellular resilience. Bu…
1 week
A new study reveals a surprising mechanism that might be behind the beneficial effects of NAD+ in preclinical models of Alzheimer’s [1]. Not every part of a DNA sequence gets translated into a protein. Each sequence consists of exons, which are included in the final RNA transcript, and introns, which are thrown away. However, nothing is that si…
By Stanford Medicine – ScienceDaiiy – A Stanford-led team has replaced toxic pre-transplant chemotherapy with a targeted antibody, allowing children with Fanconi anemia to receive stem cell transplants safely. The antibody, briquilimab, removes diseased stem cells without radiation, enabling nearly complete donor cell replacement. The approach a…
1 week
by University of Tsukuba – ScienceDaily – Scientists discovered that a blood molecule called CtBP2 may play a major role in how we age. It helps regulate metabolism and appears to link aging across the entire body. Lower levels are tied to poor health and faster aging, while higher levels are found in longer-living people. […] The post A hidden b…
1 week
In GeroScience, a large team of researchers, including João Pedro de Magalhães, has described a hundred currently unsolved problems in the field. Understanding the fundamental nature of aging has been a problem since people first endeavored to live longer, to the point that finding the right questions can matter more than finding the right answe…
By Stem Cells Translational Medicine – Purpose In biliary atresia (BA), it has been demonstrated that biliary epithelial-mesenchymal transition (EMT) of reactive ductular cells is associated with liver fibrosis. This study aimed to develop an ex vivo biliary EMT model of liver ductal organoids for exploring the involvement of biliary EMT in …
1 week
by Kermit Pattison – Harvard Gazette – Findings on adrenaline’s role in process raise new possibilities for regenerative medicine Biologists long have been fascinated by the ability of salamanders to regrow entire limbs. Now Harvard researchers have solved part of the mystery of how they accomplish this feat — by activating stem cells throughout …
1 week
The idea of living longer, healthier lives thanks to rejuvenation biotechnology has steadily become more common. Gradually increasing numbers of articles are discussing this idea, especially as science is starting to catch up and may eventually even deliver on it. With that in mind, I was pleasantly surprised this week to be greeted by an interes…
1 week
A recent study of over 80,000 Europeans concluded that speaking more than one language is associated with delayed aging. Further analysis suggested that the protective effect of speaking one foreign language diminished with age, while the protective effect of speaking two or more foreign languages was more robust with aging [1]. Learning a forei…
1 week
ByJennie Erin Smith – Science – New effort is modeled after the state’s long-running cancer research institute Texas voters this week made a bet that their state could build on a legacy of success in cancer research and become a powerhouse in neurological research as well. The Dementia Prevention and Research Institute of Texas (DPRIT), […] The p…
by Institute of Science Tokyo – MedicalXpress – As chronic liver disease becomes more widespread, researchers at Science Tokyo have developed a lab-grown organoid that replicates a regenerating liver, offering new hope for future treatments. The model recreates interactions between hepatocytes and hepatic stellate cells, two cell types involved i…
1 week
A new Phase 1 trial produced encouraging safety and efficacy results for a CRISPR-based gene therapy that silences a gene important for lipid regulation. This therapy might increase adherence and reduce side effects [1]. High levels of LDL cholesterol (LDL-C) and triglycerides are a major risk factor for cardiovascular disease and mortality. The…
We tend to think of aging in terms of wrinkles, memory lapses, or slower metabolism. But what if one of the clearest predictors of longevity is hidden in your bones? Bone loss doesn’t just lead to fractures. It accelerates decline in ways most people don’t realize. A broken hip, for example, can double your risk of death within a year. And ye…
By William A. Haseltine – Forbes – New research from DeepMind and Yale University has created AI that now generates biological hypotheses that can lead to new medical discoveries. The collaboration between recently produced C2S-Scale 27B, a powerful AI model trained to interpret cellular data at an unprecedented scale. Built upon Google’s Gemma t…
1 week
By Bonnie Tsui – MIT Technology Review – The more we move, the more our muscle cells begin to make a memory of that exercise. “Like riding a bike” is shorthand for the remarkable way that our bodies remember how to move. Most of the time when we talk about muscle memory, we’re not talking […] The post How do our bodies remember? first appeared on…
1 week
Researchers have discovered that butyrate, a short-chain fatty acid with well-documented gut benefits, fights senescence in T cells. Why We Age: Cellular Senescence As your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit potentially harmful chemical s…