Updated 5:40pm | May 5, 2025
3 hours
Senescent cells accumulate with age in tissues throughout the body. Senescent cells are created throughout life, largely because somatic cells reach the Hayflick limit on replication, but also as a result of various stresses. In youth, newly created senescent cells are cleared rapidly by the immune system. In later life, that capability declines,…
4 hours
In Aging Cell, researchers have explored how transcription factor EB (TFEB) promotes proteostasis in a common aging model. Why We Age: Loss of Proteostasis The loss of proteostasis is the failure of the protein-building machinery of the cell and the accumulation of misfolded proteins, which is one of the root causes of age-related diseases, inc…
11 hours
The authors of this review paper have a positive view of the future of regenerative medicine built on the ability to generate induced pluripotent stem cells from any patient cell sample. That should be tempered by a realistic expectation on timelines. At this point almost two decades have passed since the discovery of the first approach to reprog…
11 hours
One of the less frequently discussed aspects of aging, perhaps because it is seen as a less critical function, is the progressive loss of the sense of smell. When arising from the underlying cell and tissue damage of aging, this can be considered a form of neurodegeneration. Strategies in the development of regenerative medicine that are aimed at…
11 hours
by James Dean, Cornell University – Medical Express – In a demographically diverse sample of healthy people, Cornell researchers found dramatic changes over the human lifespan in the brain’s “blue spot”—a tiny region involved in cognition and believed to be the first affected by neurodegenerative conditions including Alzheimer’s disease. Using spe…
17 hours
“Low doses of radiation reduce the inflammation that is part and parcel with so many of these things… this type of therapy really works and it’s certainly something I will personally keep in mind both for myself and my patients.” —Peter Attia The post #347 – Peter’s takeaways on mastering sleep, dealing with chronic pain, developing breakthrough …
20 hours
In recent years, NMN has caught the attention of everyone from biohackers and beauty influencers to celebrities like Hailey Bieber and Jennifer Aniston. The compound’s role in cellular repair and slowing the aging process is a hot topic in beauty and longevity circles. But NMN isn’t just for A-listers. Along with its close cousin, NAD+, NMN can su…
20 hours
If you’ve spent any amount of time researching skin-care products, you’ve likely come across hyaluronic acid (HA) — whether in your favorite daily serum or your Friday-night sheet mask. This small but mighty molecule has gained popularity for its age-defying benefits, helping skin appear plumper, smoother, and more hydrated. Beyond its anti-aging…
1 day
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.or…
2 days
Mounting evidence supports the importance of incorporating psychological techniques alongside standard physiotherapy for chronic pain The post A more holistic approach to chronic back pain appeared first on Peter Attia. …
3 days
A number of proteins in the body are capable of misfolding or otherwise becoming altered in ways that allow the formation of aggregates, solid clumps that precipitate from solution to cause harm to the normal function of cells. Those harms might be direct, or result from a surrounding biochemistry of interactions with the aggregates that generate…
3 days
The Founders Longevity Forum returns to London this June, drawing a curated group of entrepreneurs, investors and longevity leaders to discuss the evolving contours of the healthy human lifespan. Among the speakers is Dr William Kapp, co-founder and CEO of Fountain Life, a trailblazer in the design and deployment of data-driven longevity clin…
3 days
After three years in stealth mode, Palo Alto-based biotech Stately Bio has emerged with $12 million in seed funding for its mission to improve regenerative medicine by integrating machine learning with cell biology. The company claims its ML-powered live-cell imaging platform is capable of delivering real-time insights into the identity, qual…
3 days
Coping with the damage and dysfunction of aging imposes a staggering cost. The funds dedicated to aging research are tiny compared to the funds spent on coping with the consequences of aging, and it is still the case that little of the activity taking place in the field of aging research is focused on establishing ways to slow or reverse aging. W…
3 days
Senescent cells accumulate with age to cause cell and tissue dysfunction, and their clearance via varied forms of senolytic treatment has been shown to produce rapid rejuvenation in animal studies. Human clinical trials have provided initially promising results. Senescent cells also serve useful purposes in regeneration from injury and suppressio…
3 days
By Ashley Fike – Vice.com – If you’ve got $250,000 burning a hole in your bloodstream—and want that bloodstream filtered and optimized—Dr. Jonathann Kuo has a plan for you. His West Village clinic, Extension Health, looks more like a luxe day spa than a doctor’s office. There’s a living wall of greenery, plush interiors, and, […] The post Inside …
4 days
Mutational damage to nuclear DNA occurs constantly throughout life, and is suspected to contribute to degenerative aging in ways other than risk of cancer. But most mutational damage occurs in somatic cells with few replications left before the Hayflick limit, and in DNA sequences that are not used in that cell type. So how can this damage cause …
4 days
For most of the history of human civilization, humanity expanded at an astonishing pace: faster than exponential, nearly hyperbolic. This trend was famously described in a 1960 paper by Heinz von Foerster and colleagues, who extrapolated global population data to predict a so-called “Doomsday”, a demographic singularity in which human numbers woul…
4 days
Back in March, senotherapeutic drug developer UNITY Biotechnology reported topline results from the Phase 2b ASPIRE trial evaluating its lead compound UBX1325 in patients with diabetic macular edema (DME). While the trial met many of its objectives, its failure to meet the primary endpoint saw the company’s stock fall some 30% on the news. …
4 days
While computer technology continues to accelerate, human beings still have to contend with age-related disease and death. Here’s some of what’s been done to support longer, healthier lives in April. Results of a Crowdfunded One-Year Human Rapamycin Trial: In Aging, Dr. Sajid Zalzala and his team have published the results of Participatory Evalu…
4 days
Neurodegeneration-focused biotech Therini Bio has announced encouraging results from a Phase 1a clinical trial evaluating its lead drug candidate, THN391, in healthy volunteers. The therapy is being investigated for its potential as a treatment for neurodegenerative diseases by addressing fibrin-driven neuroinflammation, a key pathological pr…
4 days
By Alexa Mikhail – Fortune Well – While there is no silver bullet for healthy aging, there are habits that can help you age well—especially when it comes to what you eat. In a 30-year study, researchers found that a certain diet was associated with healthy aging, defined as reaching the age of 70 without […] The post The healthiest agers followed…
4 days
Many disparate aspects of aging correlate with one another, emerging from the same underlying processes of cell and tissue damage. Similarly, any one specific form of age-related damage will tend to correlate with outcomes in aging regardless of whether it makes a sizable contribution to those outcomes. There are so many bidirectional connections…
4 days
Senolytic drugs capable of selectively destroying senescent cells in aged tissues are probably the most immediately promising of present efforts to treat aging as a medical condition. It is unfortunate that so little work presently takes place to rigorously evaluate the well established low-cost generic drug and supplement senolytics in human pat…
5 days
The consensus on the immune system and aging is that dysfunction in immune function is an important contribution age-related degeneration and disease. Firstly increased, constant inflammatory signaling drives harmful changes in cell and tissue function; all of the major age-related diseases are characterized by inflammation. Secondly, loss of imm…
5 days
Longevity Global, Mindvyne, and 3cubed.ai announced that they will be partnering to co-host the Aging Code Summit and Pitch Fest, a two-day event on June 11th and 12th that brings the latest advancements in aging research to Boston and strengthens the East Coast longevity ecosystem. The summit welcomes leading scientists, biotech entrepreneurs, …
5 days
Researchers from the University of Cologne have identified a novel mechanistic link between mitochondrial dysfunction and premature skeletal aging, demonstrating that disrupted mitochondrial metabolism in cartilage can provoke a cascade of cellular changes that culminate in tissue degeneration. Published in Science Advances, the study examine…
5 days
Women’s health biotech Granata Bio has announced the acquisition of female reproductive longevity company Oviva Therapeutics. The move aims to strengthen Granata’s position in reproductive medicine, adding a novel therapeutic platform aimed at enhancing female healthspan through the modulation of ovarian biology. The financial terms of the de…
5 days
A study published in JAMA Internal Medicine suggests that a higher intake of butter is associated with increased mortality while a higher intake of plant-based oils is associated with reduced mortality [1]. Previous research has found that not all dietary fats are created equal. Results of different studies encourage the consumption of unsatura…
5 days
By News Medical Life Sciences – A new research paper was published in Aging (Aging-US) on March 18, 2025, in Volume 17, Issue 3, titled “Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness.” Researchers from the University of Ark…
5 days
A great many ways to slow the progression of atherosclerosis have been demonstrated in mice, and some these have been shown to work in large mammals such as pigs and non-human primates. Slowing atherosclerosis isn’t the hard problem; regressing existing atherosclerotic plaque so as to clear arteries and restore cardiovascular function is the outc…
5 days
Why does the ability to generate new blood vessels decline with age? One manifestation is a loss of capillaries, which become less dense in tissues with age. Another issue is that efforts to produce therapies that provoke the growth of new vessels, as a way to treat conditions such as peripheral artery disease results from reduced blood flow thro…
6 days
Microglia are innate immune cells resident in the brain, somewhat analogous to macrophages elsewhere in the body. Like macrophages, microglia exhibit a diverse set of states, and can shift from one state to another in response to circumstances. At the high level, much of the literature focuses on the inflammatory M1 state, capable of hunting and …
6 days
The accumulation of senescent cells is increasingly seen as a major contributor to aging and age-related diseases. These senescent cells – often referred to as “zombie cells” because they cease dividing but refuse to die – build up in tissues over time, secreting inflammatory and tissue-damaging factors. Their presence has been linked to chro…
6 days
A new study defines the concept of immune resilience and positions it as a central determinant of aging trajectories, linking it to survival, inflammation control, and the body’s ability to withstand stress [1]. Geroscientists have long suspected that the immune system plays an outsized role in aging, one that has deep evolutionary roots and st…
6 days
A new paper published this week in npj Parkinson’s Disease highlights the therapeutic potential of ZyVersa Therapeutics’ lead investigational drug in addressing the underlying mechanisms that contribute to the progression of Parkinson’s disease. The preclinical study demonstrates that IC 100, the company’s humanized IgG4 monoclonal antibody, …
6 days
By Drug Target Review – Discover how Immorta Bio’s cellular therapies are addressing cancer and liver failure, with the potential to transform healthcare. Recent years have witnessed remarkable advancements in cellular therapies, particularly in the development of treatments that harness the power of stem cells and the immune system. At the forefr…
6 days
One of the potential complications following surgery or injury (or indeed many other forms of acute stress) in older individuals is inflammation in the brain, triggered by inflammation in the body. This can lead to issues such as postoperative delerium, or more lasting cognitive decline. Researchers here provide evidence to suggest that the infla…
6 days
A growing body of work implicates the accumulation of senescent cells in degeneration of function and structure in the discs that separate vertebrae in the spine. This is a prevalent issue, causing pain and loss of function. The ability to restore lost function is limited at best, but clearance of senescent cells via senolytic drugs has shown pro…
1 week
Broadly, there are viewpoints on the approach the treatment of aging as a medical condition. The first approach is most clearly represented by the Strategies for Engineered Negligible Senescence (SENS). The goal is to repair or otherwise address the underlying cell and tissue damage that causes aging. This damage is already catalogued and new add…
1 week
Extending human healthspan, allowing for a greater number of years lived in good health and free from debilitating age-related diseases, is a significant and achievable goal. This is distinct, however, from the extension of maximal lifespan – the absolute length of human life one can live. Both are important. Who would want to die when they j…
1 week
A new multinational study published today in the American Journal of Preventive Medicine provides new evidence linking higher consumption of ultra-processed foods, or UPFs, to an increased risk of premature death. The study adds to a growing body of evidence suggesting that UPFs are not merely linked to chronic illnesses like obesity, diabete…
1 week
Researchers have discovered a cocktail of micro-RNA strands that make some extracellular vesicles (EVs) effective in reducing cellular senescence and published their findings in Aging Cell. Why We Age: Cellular Senescence As your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they a…
1 week
By Ashley Milne-Tyte – NPR – “ROMEO” stands for “retired older men eating out” — and it’s one way to keep older guys from being too isolated. Just don’t call it a support group! Self-reliance is a core American trait, and men in particular embrace it. So how do you offer help to someone who […] The post Aging men and social connection. Is there a…
1 week
Researchers here report on a novel approach to encourage nerve regeneration, and demonstrate positive results in mice with spinal cord injury. Delivering platelet-derived growth factor BB (PDGF-BB) as a protein therapy to the injured nerve tissue changes the behavior of pericyte cells that normally interfere in any possible regrowth of the axons …
1 week
This very interesting paper finds evidence of early adult impairment of cognitive function to correlate with Alzheimer’s-associated biomarkers such as tau and neurofilament light chain. It is well known that Alzheimer’s disease has a decades-long onset. Measurable biomarkers are associated with future pathology well in advance. Nonetheless, to ex…
1 week
“I love getting to know the patients who I care for. It makes me happy to think I’m helping.” —Susan Desmond-Hellmann The post #346 ‒ Scaling biotech and improving global health: lessons from an extraordinary career in medicine | Susan Desmond-Hellmann, M.D., M.P.H. appeared first on Peter Attia. …
1 week
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.or…
1 week
Quercetin, a bioactive flavonoid present in red wine, can impair alcohol metabolism The post Ever experienced a headache from drinking red wine? Researchers may have identified a reason appeared first on Peter Attia. …
It’s easy to overlook amino acids when building a longevity regimen. Antioxidants, collagen supplements, and superfoods tend to get the spotlight, but there’s an underrated nutrient worth considering: lysine. This essential amino acid promotes collagen production and skin health, making it a promising anti-aging nutrient. Plus, it’s easy to includ…
Getting older is a part of life, but the way we age is increasingly within our control. Among the many regimens available to increase longevity, L-carnosine has gained attention for its potentially powerful anti-aging effects on both skin and cellular health. From protecting the skin from glycation to supporting mitochondrial function, this natura…
1 week
A recent study featured in the Journal of Cosmetic Dermatology has analyzed the impact of a topical product containing OS-01. This is a senotherapeutic peptide that targets senescence, affecting the skin’s barrier function and multiple aging biomarkers [1]. Conducted by a team from OneSkin alongside academic partners, this initial trial aimed to…
1 week
Metabolic healthtech company Biolinq has closed a $100 million Series C financing round to take its “autonomous intradermal glucose sensor” from development to commercial readiness. The company says the funding will support the final stages of regulatory review in the United States following the completion of a pivotal clinical trial. San…
1 week
by Roger Kreuz Ph.D. – Psychology Today – Recent work suggests a connection between verbal factors and a longer lifespan. In a study published earlier this year in Psychological Science, a team of researchers reported a link between verbal fluency and mortality risk. The multinational group, led by Paolo Ghisletta of the University of Geneva, […] …
1 week
Ossium Health, a clinical-stage bioengineering company based in the US, is pioneering a new category in biobanking with its development of the world’s first bone marrow bank sourced from deceased organ donors. Founded with the mission to enhance human vitality and extend healthspan, Ossium secured $52 million in Series C funding in 2023 to ad…
1 week
Earlier this year, we brought you the story of Epicore Biosystems, which secured $26 million in Series B funding to advance its wearable biosensors that non-invasively analyze sweat to provide real-time, personalized health insights. The company’s platform uses microfluidic channels and biosensors to detect and quantify biomarkers in perspire…
1 week
Longevity drug developer MetroBiotech this week initiated dosing of the first patients in a Phase 1a clinical trial of a new NAD+ booster drug candidate thought to have potential in the treatment or prevention of age-related diseases. Founded by aging researchers Dr David Sinclair and Dr Rajendra Apte, the company aims to address the underlyi…
1 week
In Aging, researchers have described how the well-known supplement fisetin may fight calcification of the blood vessels, seeing significant successes in both cellular and mouse models. Calcification is not the same as ‘hardening’ of blood vessel walls (atherosclerosis), which occurs due to plaque deposits. Calcification occurs when phosphates i…
1 week
By David Nield – Science Alert – Would you add a few more vegetables and whole grains to your diet in return for a healthy old age? A new study has broken down in detail the food groups that increase the likelihood of healthy aging – and identified the best diet overall. For the purposes […] The post A 30-Year Study May Have Found The Single Best…
1 week
A new UK research network has been launched to examine the interplay between the gut, brain and immune system – an increasingly formative triumvirate in the science of aging and chronic disease. The UK Gut-Immunology-Brain Axis Network+, led by Professor Jonathan Swann at the University of Southampton, will unite researchers across discipline…
1 week
Preventive healthcare platform Superpower has secured $30 million in Series A funding to further its mission to bring personalized, proactive healthcare to a broad population. The San Francisco-based healthtech startup is developing an AI-powered, app-based approach to health monitoring that analyzes more than 100 biomarkers, including two co…
1 week
A team of researchers at the University of California, Irvine, has demonstrated a method for delivering therapeutic proteins to the brain using engineered human microglia derived from induced pluripotent stem cells (iPSCs) [1]. These modified cells act as living drug delivery systems, capable of detecting amyloid plaque build-up – a hallmark …
1 week
New research suggests that digital technologies provide beneficial effects on cognition in middle-aged and older adults who did not grow up with such technologies [1]. For younger people, it is difficult to imagine living in a world without the internet and digital technologies. However, older people grew up in a world without computers, smartp…
1 week
By Eric Topol – New York Times – The dream of reversing aging has captivated humans for centuries, and today science is closer than it ever has been to achieving that goal. Which is to say: It’s still pretty far away. That’s not for lack of trying. Some researchers are attempting to reprogram cells to […] The post The New Science of Aging Can Pre…
1 week
A new paper published in the Journal of NeuroImmune Pharmacology and Therapeutics highlights the potential of Coya Therapeutics’ latest combination therapeutic to modulate the immune response in inflammatory and neurological conditions. Coya develops combination biologics that address chronic inflammatory and neurodegenerative diseases with r…
1 week
Disrupting mitochondrial function may not sound like a promising route to healthier aging – after all, mitochondria are essential for cellular energy production, and their decline is considered a hallmark of aging. But new research from The Jackson Laboratory, published in Nature Communications, turns this logic on its head – at least for a s…
1 week
Clonal hematopoiesis, a condition linked to numerous age-related disorders, can be caused by overachieving mitochondria, and it may be susceptible to drugs such as MitoQ and metformin [1]. The human body constantly produces vast numbers of blood cells from hematopoietic stem and progenitor cells (HSPCs). Over time, some HSPCs may acquire mutati…
1 week
Caffeine is considered to be the most widely consumed drug in the world. What are its pros and cons when it comes to health? The post Short- and long-term effects of caffeine on health and performance appeared first on Peter Attia. …
1 week
By Alexa Mikhail – Fortune – In a new study published today, researchers at Brown University analyzed the survival rates and wealth of older adults in the U.S. and Europe over 12 years. They found that Americans’ survival rate was lower than their European counterparts across all wealth tiers. The wealthiest in Northern and Western […] The post E…