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Updated 12:30 pm | May 4, 2026
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A new study has pit an advanced large language model against human physicians in tasks involving complex reasoning, treatment recommendations, and messy real-world patient records [1]. The dream of a ‘computer doctor’ has existed since at least 1959 [2], but until the recent rise of large language models, no computer program could come near huma…
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Human epidemiological data robustly indicates a trade-off between risk of cancer and risk of neurodegenerative conditions. Why is this the case? While all too little is understood of the precise details, at the high level it is thought that this is a reflection of the degree to which tissue maintenance activities decline with age. The less work u…
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Inflammation in the brain is thought to be important in the progression of neurodegenerative conditions, disruptive to cell and tissue function. Understanding why the other features of neurodegenerative disease activate chronic inflammation in the brain is a necessary first step on the long road to the development of therapies capable of selectiv…
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By The Roosevelt Institute – The Costs of Eldercare Are Draining Middle-Class Wealth At some point as they age, more than half of older Americans will need eldercare to assist with daily life. But eldercare is expensive, whether it’s the lost wages of an unpaid family caregiver or the exorbitant annual costs of nursing home […] The post The US ef…
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By Penn Medicine – The first-of-its-kind Phase I clinical trial uses a CAR T cell therapy modeled after natural killer cells and designed to limit T cell exhaustion. SAN DIEGO – An innovative type of CAR T cell therapy, called KIR-CAR, was shown to be safe, with increasing efficacy corresponding to higher doses of the investigational treatment …
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Scribe Therapeutics will present engineered CRISPR platform advances and lead cardiometabolic programs at the 29th ASGCT Annual Meeting in Boston, 11-15 May, and at the 94th EAS Congress in Athens, 24-27 May 2026, the company announced. At ASGCT, Scribe is scheduled to deliver two oral presentations and a workshop featuring its Epigenetic Long-Te…
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LifespanningRx launched a Partner Program that enables clinics, wellness practices, personal trainers, medspas, recovery centers and performance brands to offer clinician-guided peptide programs without managing inventory, prescriptions, fulfillment or regulatory complexity. According to the company, the program provides licensed U.S.-based clini…
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“There’s a risk to doing anything, and then there’s a risk to NOT doing something.” —Peter Attia The post #390 ‒ AMA #84: Family health history, preventing heart disease, metabolic health, strength training efficiency, dementia risk reduction, NAD supplements, and hydration appeared first on Peter Attia. …
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By John Ramos – CBS News – May 2, 2006 Berkeley, California – How long do you think you’re going to live? It’s something everyone ponders, but on Saturday, UC Berkeley hosted a conference for people who are imagining the true reach of human longevity. They say artificial intelligence may be a game-changer when it […] The post UC Berkeley confere…
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Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To …
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Why a single negative trial hasn’t diminished my interest in rapamycin as a potential geroprotector The post Disappointing results from the first rapamycin-plus-exercise trial appeared first on Peter Attia. …
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By Nicholas Wade – The New York Times – A risk-taking outsider, he brought speed, competition and controversy to one of science’s biggest races. J. Craig Venter, a scientist and entrepreneur who raced to decode the human genome, died on Wednesday in San Diego. He was 79. His death was announced by the J. Craig […] The post J. Craig Venter, Scient…
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BerkeleyCAL 2026 Convenes World-Leading Scientists, Innovators, and Advocates at Stanley Hall, UC Berkeley — May 2–3, 2026 BERKELEY, CA — May 1, 2026 — The Healthspan Action Coalition (HSAC) and the University of California, Berkeley are proud to co-host the Berkeley Conference on Aging and Longevity (BerkeleyCAL), taking place May 2–3, 2026, at S…
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The Longevity Investor Network (LIN) was created to help bridge the gap between promising longevity startups and the investors capable of helping them scale. Through curated monthly pitch sessions, educational seminars, collaborative diligence, and ecosystem-building events, LIN provides a structured platform for investors to discover, evaluate, a…
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Since the discovery that adult mice generate new neurons in the brain, and thus the brain is not wholly reliant upon structures and cells created during development, there has been considerable debate over whether or not this adult neurogenesis exists and is important in humans. This is in part a logistics problem: the human brain is inherently h…
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What happens when longevity leaves the wellness aisle? What if the future of aging well isn’t something you pick up off a shelf, but something your doctor helps you decide on? A new agreement between Chrysea Labs and nuBioAge will bring Sprevive, a high-purity spermidine complex, into US clinical settings. The deal gives nuBioAge exclusiv…
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Aging is a multifaceted topic, and it’s becoming more and more clear that the only way to deal with it is piece by piece. Here’s what pieces our industry has put together in April. It’s Springtime and the Rejuvenation Field Is Flourishing: For those of us in the Northern Hemisphere, spring is here. This is a time of renewal and hope for better t…
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The longevity sector in 2026 is a study in paradox. On one side of the “implementation gap,” we see a golden era of bench-top science: epigenetic reprogramming, senolytic cocktails, and the decoding of the Hallmarks of Aging are no longer speculative – they are in human clinical trials. On the other side, however, sits the actual end-user: th…
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GLP-1 receptor agonists, now widely used for obesity and type 2 diabetes, are changing lives, helping people lose significant weight and, in many cases, regain control over their health. However, deeper into the headlines and before-and-after photos, clinicians have started to notice something more complicated: not all weight loss is benefici…
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An assumption baked into modern medicine is that by the time regulators see clinical trial data, it has already been cleaned, checked and carefully arranged into a story that makes sense. The US Food and Drug Administration (FDA) is now challenging that assumption. In a move that could reshape how drugs are tested and approved, the agency…
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J Craig Venter has died at the age of 79; born in Salt Lake City in 1946, Venter was a figure who rarely moved quietly through science, and who seemed, for much of his career, to operate at a different tempo altogether. He never quite fit the mold of the cautious academic – preferring speed, scale and a certain calibrated audacity – treating …
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Researchers here show that fecal microbiota transplantation from young mice to old mice suppresses age-related increase in MDM2 expression and reduces risk of liver cancer. The balance of microbial populations making up the gut microbiome changes with age in ways that promote chronic inflammation and reduce the production of beneficial metabolite…
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Some evidence suggests that deubiquitylases are relevant to aging. These enzymes remove ubiquitin from proteins; recall that the decoration of a protein with ubiquitin enables it to be broken down into raw materials for further protein synthesis by a proteasome. Alongside autophagy, the ubiquitin-proteasome system is one of the important processe…
By Bonnie Petrie – Texasa public Radio – A young mother who had beaten breast cancer once got some devastating news. The cancer had returned. Her prognosis seemed grim. Available medicines didn’t offer much hope. But what if her doctors could enlist her own immune system to fight the cancer in ways never before possible? That’s just what they’r…
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by Luke T. Rogers and George M. Hayward – U.S. Census Bureau – The nation turns 250 this year and Americans’ median age — the age at which half of the population is younger and half is older — continues to rise, climbing from 39.2 in 2024 to 39.4 in 2025. We use population estimates […] The post Women Still Outnumbered Men Among the Oldest, but G…
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BioCardia announced the allowance of a Japanese patent titled “Target Site Selection, Entry, and Update with Automatic Remote Image Annotation” to protect its Heart3D Fusion Imaging software, intended for treatment planning and real-time navigation during CardiAMP Cell Therapy procedures. The patent’s claims cover transposing preoperative three-d…
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Insilico Medicine announced that the inhalation formulation of Rentosertib (ISM001-055) has received investigational new drug clearance from China’s Center for Drug Evaluation, clearing the way for a direct-to-lung Phase 1 clinical study. The IND supports a two-part trial: a randomized, double-blind, placebo-controlled single-ascending-dose and m…
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Alector confirmed it will discontinue the Phase 2 PROGRESS-AD trial of Nivisnebart (AL101/GSK4527226) in individuals with early Alzheimer’s disease after a pre-specified futility analysis by an independent data monitoring committee concluded the study was unlikely to meet its primary endpoint of slowing disease progression at completion. Alector …
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Stealth provided a commercial and research update on FORZINITY (elamipretide) and its mitochondrial disease pipeline. FORZINITY is commercially available in the U.S. for eligible patients weighing at least 30 kg with Barth syndrome. According to the company, 33 patients have initiated therapy, 85% of patients are fully covered, the average time t…
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Renibus announced that data from the Phase 3 PROTECT trial of RBT-1 will be presented orally at the American Association for Thoracic Surgery annual meeting in Chicago on 4 May 2026. The randomized, double-blind, placebo-controlled trial enrolled 433 patients across 34 sites in the United States and Canada to assess whether a single infusion of R…
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You may recall the epidemiological study indicating that populations at moderate altitude exhibit better long term health and a lower risk of age-related disease. The authors of that study suggested that this is because a greater level physical activity is involved in day to day activities in hilly regions, but this hypothesis is far from proven….
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A perspective published in Aging Cell details the replacement-based approaches being investigated by several research organizations. This perspective begins by noting the inherent difficulty of rejuvenating the human body because of the vast variety of interventions that need to be performed at multiple levels, from the molecular to the whole-bo…
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When biotech companies announce patent deals, it’s easy to file them under “routine corporate updates.” But every so often, a line in a press release hints at a deeper strategic shift in how we’re trying to understand and potentially intervene in diseases like Alzheimer’s. Rafael Holdings’ latest move falls into that category. Through its…
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Obesity drugs have worked like volume controls on appetite, where you turn it down and hope the body follows. What if the real issue isn’t how much we eat, but how efficiently our bodies hold on to what we eat? What if the problem isn’t hunger, but storage? These are the questions driving Antag Therapeutics’ latest data, presented at the…
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Millions of people living with Type 1 diabetes have their lives built around maintenance – checking blood sugar, calculating meals, injecting insulin and constantly adjusting. It’s a routine that never really lets up. Now, Seattle-based Sana Biotechnology is making a move that challenges that entire model. In a newly announced collaborati…
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Metashape Pharma announced that new preclinical data from a study of MS 001 combined with semaglutide will be presented at the American Diabetes Association 2026 Scientific Sessions, 5–8 June 2026 in New Orleans. The company’s abstract was selected for both the ADA Late Breaking Poster Session (poster 3059-LB, category 23-A Obesity – Animal) on S…
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VectorY Therapeutics has received authorization from the U.K. Medicines and Healthcare products Regulatory Agency and approval from the European Medicines Agency to initiate its Phase 1/2 PIONEER-ALS clinical trial of VTx-002 in people living with amyotrophic lateral sclerosis. The approvals expand a study already underway in the United States an…
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Infinite Epigenetics completed an asset purchase of Tally Health, a consumer-focused biotechnology business that offers epigenetic testing and personalized longevity interventions. The transaction, described by the company as the largest in epigenetic age testing, brings together advanced diagnostics, proprietary datasets and consumer-facing supp…
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The preview breakfast for the Longevity Show’s B2B conference brought together senior decision-makers to explore how the shift to 100-year lifespans is reshaping commercial strategy, healthcare delivery and consumer expectations. Hosted at Edelman’s UK HQ, this event brought together select guests to explore one of the themes being addressed …
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The company Seragon funded researchers to run a study of their combination therapy. The results indicate an improvement on the effects of rapamycin treatment in aged mice. Neither Seragon nor the researchers reveal the identity of all of the combination components, but it includes a number of well-known supplements. In general, one should be skep…
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In the matter of treating aging as a medical condition, emulating centenarians is not good enough; these survivors to advanced old age are still greatly impacted by aging, are frail and vulnerable, with high mortality rates. Nonetheless, the study of centenarian biochemistry might tell us something about which aspects of aging are more or less im…
By Benjamin Boettner – Wyss Institute – New study combines tissue engineering with synthetic biology tools to grow healthy liver tissue inside the body, and lays foundation for “smart” solid organ therapies (BOSTON) — In patients developing end-stage liver disease, the damage has become too severe for the liver’s normally extraordinary regenerat…
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By Ava Durgin – MindBodyGreen – When it comes to brain health, most of us think of puzzles, meditation, or learning a new language. But, according to physician and double board-certified psychiatrist Daniel Amen, M.D., one of the most impactful tools for brain health is surprisingly simple—and surprisingly fun. On the mindbodygreen podcast, Amen s…
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Every cell contains hundreds of mitochondria, the descendants of ancient symbiotic bacteria that evolved to become components of the cell. Along the way most of the original mitochondrial genome migrated into the cell nucleus, leaving only a small remnant genome inside mitochondria. The primary task undertaken by mitochondria is the production of…
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In an era where the supplement aisle is increasingly cluttered with the latest “must-have” molecules, Nuchido arrives with a refreshing commitment to the rigors of molecular biology. The UK-based firm, which has carved out a distinct niche within the crowded NAD+ landscape, will join the upcoming Longevity Show at Tobacco Dock as a Catalyst P…
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A member of Julie Andersen’s lab, Chaska Walton is the recipient of a $2.4 million NIH Transformative Research Award for his work on the development of smart delivery systems to treat multiple pathologies of Alzheimer’s disease. The NIH awarded only 9 such awards in the country. Walton received his PhD in molecular bioscience from CSIC/Autonomo…
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A recent study found an association between longer and more frequent daytime napping and higher mortality risk. The authors suggest using napping frequency and duration as behavioral markers of increased mortality risk [1]. Daytime napping is a relatively common activity among older adults. It is estimated that between 20% and 60% of older adult…
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Researchers here report a novel approach to improving mitochondrial function in aged muscle tissue, involving a reduction in the activity of the ghrelin receptor, either via gene knockout or by using an inverse agonist small molecule. It is interesting to note that while this improves muscle function, it fails to improve either muscle mass or lon…
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The study of the comparative biology of aging, and comparative biology more generally, is alive and well. A sizable community of researchers consider that the study of differences between long-lived and short-lived species is a good path to a better understanding of aging that may ultimately inform the development of life-extending therapies. Whe…
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By Aimee DeCamillo and Diane Ty – Fortune – Americans are living longer than ever before, which is a remarkable achievement. But making those additional years healthy, secure, and fulfilling will require better planning across households, retirement systems, employers, and communities. In 2026, the oldest baby boomers will turn 80. This demographi…
By ScienceDAily – Researchers have found a way to make cancer-killing immune cells more powerful and precise. By adding specific signaling components, they boosted the cells’ readiness to attack tumors. Surprisingly, briefly suppressing the cells with a drug before use made them even more effective later. The approach could help create safer, s…
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The 2026 UCI HD-CARE & HDSA Educational Symposium was held on Saturday, April 25, 2026, from 8:30 AM to 2:00 PM at the UC Irvine Sue & Bill Gross Stem Cell Research Center. This in-person event, organized by HD-CARE and the Orange County HDSA Chapter, focused on providing the Huntington’s disease (HD) community with updates […] The post UCI HD-CA…
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A new study calls for caution in using the well-known senolytic treatment of dasatinib and quercetin (D+Q), showing that it causes damage in certain regions of the brain, similar to what is observed in multiple sclerosis [1]. Multiple sclerosis (MS) is a brain disorder in which the patient’s own immune system attacks oligodendrocytes: cells in t…
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Naked mole-rats are an unusually long-lived mammalian species, of a similar size to mice but with a life span of decades rather than just a few years. This species also exhibits a near complete absence of cancer and very little age-related decline in function until very late in life. Investigations of their biochemistry have uncovered a range of …
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A new study has suggested that T cells might retain a pro-inflammatory phenotype long after normal weight is regained following a period of obesity. In mice, the effect lasts for weeks, while its existence and duration in humans are to be determined [1]. Obesity is a chronic, relapsing condition linked to many adverse health outcomes and increas…
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Risk-stratified targets and a six-step playbook for choosing, combining, and escalating lipid-lowering therapy The post Reducing cardiovascular risk: a playbook for lipid-lowering pharmacotherapy appeared first on Peter Attia. …
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Presently largely irreversible lung disease like idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease were one of the first conditions targeted for the development of senolytic therapies to clear senescent cells. A range of evidence supports a prominent role for an increased burden of senescent cells in airway and lung tissues …
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Senescent cells accumulate with age, but not all senescent populations are equal. Evidence suggests that some types of senescent cell cause more harm than others, and the research here is an example of this. Researchers find that a population of senescent macrophages in liver tissue acts as an important driver of chronic inflammation and dysfunct…
By Cordis – Eu research – Neurological diseases are one of Europe’s most urgent and rapidly expanding health challenges. Advances in stem cell medicine by the EU-funded NSC-Reconstruct project could lead to targeted and effective treatments. As Europe ages, the incidence of debilitating and incurable neurodegenerative diseases has increased. Th…
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ByLaia Farran Graves – Forbes – Longevity beauty is fast emerging as one of the beauty industry’s strongest new categories, with brands investing in science-led innovation designed to support skin function over time rather than deliver short-term cosmetic results. As consumer demand increasingly shifts toward preventative skincare, longevity beaut…
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It is well established that long term exposure to forms of air pollution increases the risk of mortality and numerous age-related conditions. The mechanisms of interest revolve around increased systemic chronic inflammation that is provoked by the interaction of pollutants, such as fine particles, with airway and lung cells. Is this exposure and …
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A team of scientists has examined how younger and older mice heal from wounds and found that more robust senescent cell activation in younger animals helps them heal faster. Cellular Senescence As your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit p…
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Researchers here identify a common mechanism in the cellular responses to various forms of stress that appears to drive aspects of hematopoietic stem cell aging via impairment of mitochondrial function. Hematopoietic cells are responsible for generating immune cells and red blood cells. Aging produces alterations in the character and lineages of…
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In the context of Alzheimer’s disease, the data for anti-amyloid immunotherapies, the most recent of which do effectively clear the aggregation of amyloid-β in the brain, is not compelling. Clinical trials and following studies show minimal to no benefit to patients even at earlier stages of the condition. There is some hope in the research and d…
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By Zaid Elayyan – Texas A&M University – New therapy is turning back the clock in aging brains, healing inflammation, restoring memory and reshaping the future of brain age-related therapies. Picture this: your brain is a high-performance engine. Over decades, it doesn’t just wear down, it also starts to run hot. Tiny “fires” of inflammation […] …
by Heather McKenzie – BioSpace – Approved Thursday via the FDA’s Commissioner’s National Priority Voucher program, Otarmeni is the first gene therapy for hearing loss—and the first treatment to target an underlying cause of the condition. Regeneron Pharmaceuticals won approval Thursday for its gene therapy for hearing loss, completing what has …
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“The goal of thinking scientifically is not simply to be right. It’s to be less wrong over time. Science is a process built around that principle.” —Peter Attia The post #389 – Thinking scientifically: why it’s hard, why it matters, and a practical toolkit appeared first on Peter Attia. …
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Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To…
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The pitfalls of the lipid energy model and why “lean mass hyper-responders” should still take high LDL cholesterol seriously. The post There is no safe gamble with high LDL cholesterol appeared first on Peter Attia. …
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A few species such as salamanders and zebrafish can regenerate lost limbs and even large sections of internal organs, provided they survive the injury. In comparison, mammals exhibit far less of a capacity for such proficient regeneration as adults, but the actual limits of regeneration vary widely across mammalian species. Spiny mice can regener…
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A new study has found that partial reprogramming mitigates the damage of myocardial infarction in mice by helping heart muscle cells to complete division [1]. When a heart attack (myocardial infarction, MI) kills a patch of heart muscle, the adult mammalian heart cannot replace it, since the lost contractile muscle cells (cardiomyocytes, CMs) do…
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For those of us in the Northern Hemisphere, spring is here. This is a time of renewal and hope for better times ahead, echoing what our field is trying to achieve: the rejuvenation of aging cells and tissues to keep older people free from age-related diseases. On that note, let’s take a look at what has been going on at Lifespan News and the wide…
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Longevity Day at NFC Summit Lisbon has announced its confirmed speaker lineup ahead of its debut on 4 June 2026 at the Unicorn Factory in Lisbon. The event will bring together scientists, clinicians, founders, and investors from across the longevity ecosystem for a full-day program spanning ancestral wisdom, cutting-edge science, and frontier biot…
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An investigation into the aging immune system identified age-related changes, including sex-dependent differences, in immune cell subpopulations and gene expression. In general, females showed greater age-related changes than males, including greater changes in autoimmune gene expression [1]. Aging results in changes to the function and composit…
By Tia Ghose – Live Science – It’s a running joke that a cure for type 1 diabetes is only five years away and has been for 50 years, but new stem cell trials and immune drugs hint that we’re closer than ever to a functional cure for the disease. My first clue that something was wrong was the smell of cotton candy. It was March 15, 2016, and I …
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By Avivah Wittenberg-Cox – Forbes – There is a moment, somewhere in the middle of reading Longevity Nation, when you realise that Michael Clinton is not writing a book. He is taking attendance. Each chapter is a room full of people — scientists, entrepreneurs, HR directors, city planners, educators, Re-Imagineers of every stripe — who […] The pos…
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According to a new study, rapamycin probably interferes with exercise, blunting its effects in older human subjects. This result, however, might be specific to the particular protocol. Physical activity is one of the most potent pro-longevity interventions currently available [2]. Rapamycin is the undisputed champion of small molecules for exten…
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BioAge Labs, Inc. (Nasdaq: BIOA) (“BioAge” or the “Company”), a clinical-stage biopharmaceutical company developing therapeutic product candidates for metabolic diseases by targeting the biology of human aging, today reported results from the Phase 1 clinical trial of BGE-102, a potent, structurally novel, orally available, brain-penetrant small m…
By Sarah Pelta – Stanford Medicine – Could the gut microbiome hold the key to better cancer treatment outcomes? “We send your T cells to boot camp.” That is how hematologist-oncologist and Stanford Cancer Institute member Melody Smith, MD, describes CAR-T cell therapy to her patients, a simple metaphor for a treatment that is changing the way …
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By Pranjal Malewar – Tech Explorist – Environment strongly influences brain aging, study finds. Aging is not just in our genes; our environments play a major role. A new large-scale study from the Global Brain Health Institute (GBHI) at Trinity College Dublin has found that the physical and social exposome, the total of our environmental […] The …