Longevity Science

GLP-1 drugs have transformed obesity treatment, but they have also created a new clinical problem: what happens when patients stop taking them. Weight regain after discontinuation is common and well documented, and it has opened a commercial opportunity for therapies designed to lock in GLP-1-driven weight loss without ongoing drug therapy. ...

Biogen Inc. stock drew renewed attention after a Canadian advisory committee issued a final positive recommendation supporting public reimbursement of Leqembi, developed with partner Eisai, for Canadians with mild cognitive impairment or mild dementia due to early Alzheimer’s disease. The recommendation could lead to provincial and territorial fu...

Oligomerix has appointed Dr. Cara Cassino as interim president and chief executive officer as the privately held biotech moves from discovery toward clinical development of its lead Alzheimer’s candidate. Cassino has served on the Oligomerix board since July 2025 and brings about 25 years of clinical drug development and commercialization experie...

NeuroSense has redesigned its PrimeC development plan in amyotrophic lateral sclerosis to pursue a potential regulatory submission faster and at materially lower cost than its previously planned path. The program is structured as three focused elements: AI-enabled modeling of Phase 2b PARADIGM clinical data to characterize PrimeC’s formulation co...

Celularity and MuseCell Innovations have agreed to establish U.S. manufacturing of Dezawa MuseCells at Celularity’s Florham Park, New Jersey, facility, with initial production to include DMCs and DMC-derived products such as Dezawa MuseExosomes and Dezawa MuseSecretome. The initial effort will focus on MCI-authenticated DMC preparations from qual...

Oligodendrocytes resident in the brain are responsible for maintaining the insulating myelin sheaths around axons that are required for the effective transmission of electrical impulses between neurons. Loss of myelin integrity is the cause of a number of debilitating conditions, but also occurs to some degree with aging. It has been an open ques...

Blood tests to assess Alzheimer's disease risk and progression exist, for example based on the presence of circulating varieties of tau protein, but there is a great deal of room for improvement. Researchers here provide evidence for an approach to the measurement of very small amounts of misfolded amyloid-β in blood to work reasonably well in pa...

By Will Stone – NPR – Tadalafil – better known by its brand name Cialis – is one of the most commonly prescribed drugs for erectile dysfunction. A closeup of a senior woman’s forearm as she lifts a red hand weight. But in some biohacking and wellness circles, it’s increasingly being repurposed for an entirely […] The post Cialis is an erectile dy...

Researchers have found that the sirtuin SIRT1 stabilizes the human genome by suppressing retrotransposition, which occurs when parts of the genome transcribe themselves onto other parts. Long interspersed elements-1 (LINE-1) have existed in organisms’ genomes, including our own, for well over a billion years [1]. They are the only autonomous ele...

Aging clocks can be readily produced by using what are by now well established machine learning techniques on any body of biological data that changes with age. Omics data is favored, as there are a great many databases of such data for large study populations, but clocks have been made using clinical chemistry results from simple blood tests, im...

Reading a brain scan for Alzheimer’s has long come down to a radiologist’s trained eye and best guess. That guesswork just got a software co-pilot with the FDA’s sign-off attached. Cortechs.ai announced on 18 August that its NeuroQuant PET platform received 510(k) clearance from the FDA, the pathway used when a device is shown to work as ...

United Therapeutics will present four oral and four poster presentations at the European Society of Cardiology Congress 2026, 28-31 August in Munich, and at the European Respiratory Society Congress 2026, 5-9 September in Barcelona. Late-breaking analyses from the phase 3 ADVANCE OUTCOMES study indicate ralinepag achieved clinical improvement in...

LifeVantage reported declines in revenue and earnings for the fourth quarter and full fiscal year 2026. For the quarter ended 30 June 2026, revenue was $42.4 million, down 23.1% year over year; net income per diluted share was $0.10 and adjusted earnings per diluted share were $0.11. Adjusted EBITDA for the quarter was $2.7 million. The company ...

Mission Therapeutics and NeuraLight have partnered to deploy NeuraLight’s eye-movement-derived brain function biomarkers across Mission’s multinational MTX325 trial in Parkinson’s disease, spanning clinical sites in the UK, Europe and Australia. NeuraLight’s platform will provide objective, repeatable measures intended to quantify neural pathway ...

By the numbers, the translational gap is expensive. Roughly nine in ten drug candidates that succeed in animal models still fail once they reach human trials, and cardiology has one of the worst records of all. Mouse hearts beat around 600 times a minute; human hearts beat around 60. That single mismatch in electrophysiology has been blamed f...

Here, researchers report on their investigation of gene therapy to introduce a bacterial enzyme, lipoic acid protein ligase A (LplA), into mammals in order to improve mitochondrial metabolism. LplA undertakes lipoylation of proteins, attaching lipoic acid to the protein, and does so somewhat more efficiently than the analogous enzymes in mammals....

One might think that an alteration to the machinery of gene expression that systemically changes the amino acid components of proteins, in effect giving all proteins the possibility of multiple single nucleotide polymorphisms, would be quite harmful. But some forms of mistranslation of RNA into protein actually extend life span, as demonstrated i...

By Science Alert – Bones do more than hold your body upright. Inside many of them is a living factory that constantly produces the cells that make up your blood and immune system: bone marrow. Immune cells produced there enter the bloodstream and travel to the muscles, lungs, brain, and other organs. This means that […] The post One Overlooked Pa...

“People should have hope, in the sense that it's very important to be as empowered as possible by keeping a log of information, by providing their clinicians or the treating physicians or providers with the details of their headache, and recognizing the importance of those lifestyle factors, which can't be overstated.”‒ Brian Grosberg The post #4...

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To...

The balancing act of volume and fatigue The post A better way to think about Zone 2 appeared first on Peter Attia MD. ...

Osteoporosis results from the slow loss of bone mineral density that occurs with advancing age, eventually leaving bones dangerously weak and prone to fracture. Bone extracellular matrix is constantly remodeled throughout life: osteoblast cells build up the matrix while osteoclast cells break it down. With age, a variety of mechanisms tip the bal...

Michael Snyder, Director of the Center for Genomics and Personalized Medicine at Stanford University, is obsessed with health-tracking wearables. During our interview, he wore four wrist-worn devices – watches and bands – and two rings. He is convinced that these small but powerful gadgets will help drive the transition from today’s “sickcare” to ...

Sleep has become one of the most talked-about levers in longevity science, credited with everything from metabolic health to cognitive resilience. AstronauTx, a UK biotech founded by SV Health’s Dementia Discovery Fund, is now translating that interest into a drug pipeline. The company has exercised its option under a 2023 research collab...

Most of medicine still works the same way it did a century ago: something goes wrong, a person notices and only then does the system spring into action. Function Health thinks that order of operations is backward, and on 12 August, it announced a research partnership with New York University (NYU) Grossman School of Medicine built around flip...

BTT Medical Institute, in collaboration with BTT Corp., has initiated a first-in-human clinical and biological safety trial (ClinicalTrials.gov Identifier: NCT07564440) to evaluate induced hyperthermia delivered by the Abreu BTT 700 Temperature Management System, a noninvasive computerized, brain-guided platform that raises body temperature into a...

Celularity and MuseCell Innovations announced a U.S. manufacturing collaboration to establish production of Dezawa MuseCells at Celularity’s Florham Park, New Jersey facility. The initial program is intended to authenticate and manufacture Dezawa MuseCells from qualified perinatal, bone marrow or adipose sources using the licensed Dezawa Method a...

AlzeCure will present at the Pareto Securities 17th Annual Healthcare Conference in Stockholm on 2 September, with CEO Martin Jönsson scheduled to deliver a presentation and answer questions. The presentation and one-on-one meetings are planned at Hotel At Six, Brunkebergstorg 6, with the company scheduling the session for 17:05-17:25 CEST and sa...

Researchers here show that a few different senolytic approaches improve the state of the population of microglia in the white matter of the brain in aged mice. This is much as one might expect, given past work into the effects of clearing senescent cells on cognitive function and neurodegeneration in various mouse models. Microglia are innate imm...

Amyotrophic lateral sclerosis (ALS) is characterized by the loss of motor neurons. Aggregation of TDP-43 is thought to be involved in producing cell death in the brain. Here researchers present evidence in a mouse model of ALS for microglia to destroy motor neurons, and identify key cell surface features that enable this activity. Whether the mod...

by Valerio Nannin – PharmaPhorum – For forty years, fitness was sold as a promise of appearance. That promise has lost its grip. The market is now organising around a different proposition: live longer, live better, stay functional. The central challenge facing modern health systems is no longer lifespan alone. It is the widening gap […] The post...

If you have spent any time in longevity circles, you’ve probably heard the claim that sauna use can help you live longer. The idea is appealing because it seems refreshingly simple: Sit in a hot enclosure, sweat, relax, meditate, and maybe do something good for your future self at the same time.  The sauna longevity research is intriguing, bu...

Glaucoma is a condition of progressive blindness driven by the death of retinal cells and degeneration of the optic nerve. It is driven by increased pressure in the aqueous humor, which fills a fluid compartment behind the cornea and also flows into the rest of the interior of the eye. Aqueous humor is produced at some pace in the ciliary process...

A recent study has examined whether senescence might allow cancer cells to survive oncogene withdrawal and become even more dangerous [1]. Many cancers depend heavily on a particular oncogenic signal to maintain their growth. Drugs that block these drivers can, therefore, produce dramatic tumor shrinkage. A major clinical problem, however, is th...

By National Institutes of Health – The brain contains specialized immune cells called microglia. The origins of microglia in humans have been a mystery. Most immune cells form from stem cells in the bone marrow and then enter the bloodstream. But a biological wall called the blood-brain barrier stops most cells and substances in the […] The post ...

Cognitive decline is often the one vital sign primary care does not routinely check. Claremedica, a value-based senior primary care organisation serving more than 34,000 Medicare Advantage patients across 35-plus sites in Florida, is trying to change that. Seven months after replacing its paper-based Mini-Mental State Exam (MMSE) with a digit...

The Alzheimer’s Association International Conference has spent the last several years dominated by amyloid. This year, tau got its moment. Ionis Pharmaceuticals and partner Biogen presented full Phase 2 CELIA data for diranersen, an antisense oligonucleotide designed to reduce tau protein at its genetic source, and the results gave the field ...

Oura Health is preparing for a potential U.S. initial public offering that could raise up to $3 billion and value the smart ring maker at more than $16 billion. The company filed confidentially for the IPO in May and has retained Goldman Sachs, Morgan Stanley, JPMorgan Chase, Allen & Co. and Jefferies as underwriters. The proposed offering i...

Retro Biosciences is expanding its phase 1 safety trial of RTR 242 by adding two higher-dose cohorts and increasing enrollment from 76 to 108 participants, a more than 42% rise. The trial is being conducted in Australia in healthy volunteers aged 18 to 65. The company claims RTR 242 is designed to restore lysosomal acidity and stimulate autophagy...

Properties of the extracellular matrix that supports cells change with age. Increased stiffness is common in many tissues as a result of chemical cross-linking and other changes. Researchers here report on a proof of concept in vitro study in which increased stiffness of the local matrix is shown to promote gene expression changes in cells charac...

The composition of the gut microbiome, the population size of each bacterial species, changes with age. Microbes that provoke inflammation increase in number, while microbes producing a range of metabolites necessary for tissue function diminish in number. Animal studies have demonstrated that restoring a youthful composition of the gut microbiom...

What the evidence says about their growing list of established and emerging uses The post GLP-1 medications beyond weight loss: how far could their benefits extend? appeared first on Peter Attia MD. ...

The immune system is very complex, and immune cells exist in a continuum of states rather than being separated into clearly demarcated pigeonholes of behavior. Many of the categorizations applied to immune cells, largely based on cell surface marker differences, are conceptually useful, but also greatly oversimplify a complex reality. Sometimes o...

A new study compared high-intensity sprint-interval exercise with moderate-intensity exercise. The former produced larger changes in circulating protein and metabolite levels than the latter and stimulated proteins associated with cardiometabolic health benefits [1]. Exercise is a well-known lifestyle factor that can positively impact health. Ex...

This popular science article discusses recent research that categorizes age-related changes a few thousand different cell populations in the body, distinguished by transcriptional behavior. This big picture view of aging shows a wide variety of responses to aging between cell types that occur in a staged progression throughout life, which the res...

Circadian rhythm becomes disrupted with age, and a growing body of evidence points to this form of dysfunction as a contribution to many aspects of aging. The fine details of how and why circadian regulation of cell and tissue activity runs awry are complex and incompletely understood. Different circadian clocks operate in different parts of the ...

by Alan Booth – Labmate – Researchers have described a preclinical strategy that uses targeted antibodies and epitope-edited stem cells to make blood stem cell transplantation safer and more precise for sickle cell disease, beta-thalassaemia, immune deficiencies and some blood cancers A research group at the of the Dana-Farber/Boston Children’s ...

by Sadie Harley – Medical Xpress – Why do women, on average, live longer than men yet often face a greater burden of chronic disease later in life? Why do some of the most fertile animals in nature, including queen bees and naked mole-rat queens, also live exceptionally long lives? A perspective published in Cell […] The post Why women need to be...

You might recall the paper published late last year, in which researchers reported that dietary supplementation with the L-form enantiomer of β-aminoisobutyric acid (L-BAIBA) enhanced the response of muscle and bone tissue to exercise in aged mice. L-BAIBA is one of many molecules both secreted by muscle cells during exercise, and which interact ...

The scale is moving in the direction you want, and your clothes are starting to fit again. Yet you’re tired by mid-afternoon, your face looks a little hollow in photos, and you can’t remember the last time you finished a full meal. GLP-1 medications like semaglutide mimic a gut hormone that slows digestion and reduces appetite. For many peopl...

One way of looking at human longevity is that it results from a greater resilience to the damage and dysfunction of aging, whether that resilience emerges from lifestyle choice or genetic differences. The research community spends a great deal of effort in attempting to understand how centenarians survive to old age, which of the many differences...

Aging is so very complex that almost every research project, limited in time and resources, is by necessity restricted to just examining one tiny part of the whole process. That leads to papers like this one, in which the effects of changing expression of a single gene in a single organ are considered. It is relatively straightforward to expand t...

by Sadie Harley – Medical Xpress – The brain’s immune system has long been thought to exist independently from the rest of the body, complete with its own specialized immune cells and a blood-brain barrier that limits what can travel into the brain. Now, Stanford researchers have found that aging brings with it a large […] The post Discovery reve...

Researchers have found that an upstream promoter of two extracellular matrix proteins increases healing and strength capabilities in the tendons of rats. Previous research has found that, like with many other injuries, tendon injuries have an age-related component. The tendons of the biceps and rotator cuffs are more commonly injured in older pe...

Senescent cells accumulate with age throughout the body, either in response to forms of damage and stress or on reaching the Hayflick limit on replication. A senescent cell ceases to replicate, grows in size, and secretes a potent mix of pro-growth, pro-inflammatory signals. In youth, the immune system efficiently clears senescent cells, but with...

The various mitochondrial protein complexes are the building blocks of the electron transport chain, the complicated mechanism inside mitochondria that generates adenosine triphosphate (ATP), the chemical energy store molecule used to power cell activities. Nothing in a cell is simple, and the mitochondrial complexes do not operate neatly in isol...

by Sadie Harley – Medical Xpress – Why do women, on average, live longer than men yet often face a greater burden of chronic disease later in life? Why do some of the most fertile animals in nature, including queen bees and naked mole-rat queens, also live exceptionally long lives? A perspective published in Cell introduces the Reproductive Resi...

By Neuroscience News – A new study challenges the classical “inside-out” model of cortical development. Using Mosaic Analysis with Double Markers (MADM) single-cell lineage tracing, the team demonstrated that radial glial progenitor cells split early in brain development into distinct, parallel developmental branches. Rather than a single progen...

By Elanor Garth – Longevity.Technology – Ahead of Longevity Investors Conference, Steve Horvath discusses how to separate genuine aging science from persuasive biological storytelling. The Longevity Investors Conference (LIC) returns to Gstaad, Switzerland, next month, once again bringing together investors, founders, clinicians and researchers to...

“The disease can be reversible and that's why we make so much hay about intervening early. We address the metabolic drivers, and we see that steatosis and fibrosis in the earlier stages can regress, especially the earlier the fibrosis is caught.”‒ Peter Attia The post #405 ‒ AMA #88: Metabolic liver health: how to assess risk, catch dysfunction e...

Gum recession is common, often silent, and sometimes worsened by the very habits meant to protect your teeth. The post Gum recession: a common oral health issue that often goes unnoticed appeared first on Peter Attia MD. ...

A new study suggests that in amyotrophic lateral sclerosis – and possibly other neurodegenerative diseases – the brain’s immune cells devour stressed but still living neurons due to altered signaling [1]. Amyotrophic lateral sclerosis (ALS), an age-related neurodegenerative disease, is characterized by the progressive loss of motor neurons. Hist...

By Signal Transduction and Targeted Therapy = Abstract Chimeric antigen receptor (CAR) T-cell therapy has revolutionized oncology, and its foundational logic—precise antigen recognition coupled with durable effector activity—extends naturally to chronic non-malignant diseases sustained by long-lived pathological cells. These include viral reserv...

By Currie Engel – Health – Longevity is a major focus in wellness culture, with some people turning to strategies like peptide stacking and intensive health tracking to help them live longer. But HEALTH’s new survey suggests that Americans aren’t just chasing longer lifespans—they also want to live well. For many respondents, that means staying […...

Using cohort studies and a mouse model, researchers have found that the circulating factor ANGPTL8, which is produced by senescent fat cells, is related to age-related diseases and mortality in mice and people. Chronic Inflammation Chronic inflammation refers to a persistent, low-grade buzz of immune activity that settles into the body without t...

Cold plunges and ice baths are nothing new, with the earliest uses dating back centuries. From the Ancient Greeks to Hippocrates, various civilizations incorporated cold water immersion for therapeutic purposes.  More recently, cold water therapy has surged in popularity among longevity enthusiasts. But what does the science actually say abou...