Longevity Science
Updated November 2,, 2026
35 minutes
By News Medical Life Sciences – Stem cells maintain tissue homeostasis by self-renewing and differentiating into mature cells needed for tissue growth, renewal, and repair in the skin, blood, muscles, intestines, and certain regions of the brain. Neural stem cell activity is more restricted than the continual cell replacement seen in blood and int...
55 minutes
Huntington‘s disease is usually told as a story of inheritance; a child is born with too many CAG repeats in the huntingtin gene, and the rest is fate. That is only half the plot. In the brain‘s medium spiny neurons (MSNs), those repeats keep lengthening across a lifetime – a slow stutter in DNA mismatch repair – and it is this somatic expans...
2 hours
Novo has a busy week lined up in Denver. The company says it’s bringing 12 new abstracts to The Liver Meeting, the American Association for the Study of Liver Diseases congress running on 5–9 November, and one of them puts Wegovy’s active ingredient, semaglutide 2.4 mg, up against resmetirom in people with MASH [1]. Nobody outside the com...
2 hours
For most of the last century, anyone trying to understand why we age started in the same place: a cage of mice or rats. It’s a bit like trying to understand world cuisine by eating at only two restaurants. The food is reliable and well documented, but you’d miss a great deal. That is the itch Steven Austad and Arlan Richardson have spent ...
3 hours
LifeVantage released results of a two-part in vitro cell study examining how five modern environmental toxins, including pollution, microplastics, ultra-processed foods, hormone disruptors and pesticides, affect cells and how Protandim Nrf2 influences cellular oxidative stress. According to the company, researchers tested three cell types—liver (...
3 hours
Exogenus Therapeutics is coordinating ExoCordOA, a five-year, €13 million Horizon Europe-funded consortium to advance extracellular vesicle-enriched secretome therapies with an initial focus on osteoarthritis. The consortium brings together ten organisations, including Lonza, Anthony Nolan, Eliquent Life Sciences, iLoF, Utrecht University, Univer...
3 hours
Fractyl has expanded its U.S. patent portfolio for the Revita DMR system as it advances toward a planned U.S. Food and Drug Administration De Novo marketing submission for post-GLP-1 weight maintenance. According to the company, U.S. Patent No. 12,740,821, issued 22 September 2026, covers design features of Revita’s single-use catheter with a pat...
3 hours
A middling grade, two years in a row. Americans scored 60 out of 100 on preparedness for longer lives in the 2026 Longevity Preparedness Index (LPI), released 27 October by John Hancock and the Massachusetts Institute of Technology (MIT) AgeLab. The 2025 score was identical [1]. The index breaks readiness into eight areas: health, finance...
6 hours
Education, intelligence, socioeconomic status, and healthy longevity are all correlated with one another in human populations. No concrete determination of the mechanisms that make this the case has yet been established, but there is no shortage of hypothesizing on the topic. Does education produce an effect through the greater socioeconomic stat...
7 hours
Despite a number of approved devices and some widely used protocols (that are not very consistent from device to device and provider to provider), few electromagnetic therapies have demonstrated consistent benefits. Some research groups are focused on applying electromagnetic fields to the brain, specifically ultrashort wave fields that may act t...
12 hours
“Any injury you're dealing with is not a mandate to completely rest. It's not. It's a mandate to choose safer, more appropriately loaded and progressed exercises.”‒ Jeff Cavaliere The post #414 ‒ Resistance training as we age: optimizing exercise selection and training intensity for muscle growth, function, and injury risk management | Jeff Caval...
1 day
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To...
2 days
What autopsy studies can, and cannot, tell us about the risks of repetitive head impacts The post Who is actually at risk for CTE? appeared first on Peter Attia MD. ...
You toss a handful of blueberries in Greek yogurt for the flavor and texture, but did you know these little powerhouses are among the most studied foods for brain health? Human trials link them to better blood vessel function and, in some groups, small gains in memory. Here is what the studies found, how much blueberry researchers used, and how o...
3 days
Lysosomes are structures within cells packed full of enzymes capable of breaking down proteins and structures into raw materials; they serve as recycling centers. Lysosomes are the final destination of damaged or unwanted proteins and structures flagged for destruction by the cellular maintenance processes of autophagy. Lysosomes are known to bec...
3 days
If you sat down to write a wish list for a weight-loss drug, a pill that goes after fat and leaves muscle alone would probably land near the top. Rivus Pharmaceuticals says that’s what it has been building, and it has now announced where and when the early evidence will be shown [1]. The company said on October 19 that it will present pre...
3 days
Picture the follow-up appointment after a diagnosis of mild cognitive impairment (MCI). Thinking has slipped a little, daily life still works, and the question hanging over the room is whether this is the first chapter of Alzheimer’s dementia. A South Korean company thinks software can help clinicians say something more useful in that moment,...
3 days
People who reported sleeping more than eight hours had smaller hippocampi, according to one of the odder findings in a big new whole-body MRI study. The hippocampus is a brain region that plays an important role in learning and memory, so you can see why it caught the researchers’ eye. Prenuvo, which runs whole-body MRI screening, release...
3 days
In a new study, late-life treatment with a three-element senolytic vaccine led to lower senescence markers and a 12% increase in median lifespan in female B6 mice. However, short-lived controls complicate the picture [1]. Cellular Senescence As your body ages, more of your cells become senescent. Senescent cells do not divide or support the tiss...
3 days
Every dog has its day, but some have rather more of them than others. While one 12-year-old Labrador still bounds after squirrels with the enthusiasm of a puppy, another might struggle with the stairs and stare forlornly at the back door. Pedigree is part of the story. But not all of it. Much of the remainder may lie in what researchers c...
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In early October, a mountain village in central Sardinia was put forward as the world’s newest blue zone. Of Bolotana’s roughly 2,300 residents, 19 turned 100 between 2021 and 2025, and at that period’s death rates a woman who reaches 70 there has a 13.8% chance of seeing 100, more than three times the figure for American women. The cover...
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Digbi Health announced ASRA, a precision biology-powered agentic care operating system that unifies treatment for obesity, diabetes, hypertension, gastrointestinal disorders and women’s hormonal health. The platform integrates precision nutrition, lifestyle interventions and clinically appropriate pharmacotherapy, while secure AI agents perform o...
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Biogen will present new data across its Alzheimer’s disease portfolio at the 19th Clinical Trials on Alzheimer’s Disease conference, 16–19 November 2026, in Boston. Presentations will include expanded results from the Phase 2 CELIA study of diranersen (BIIB080), with a late-breaking symposium reporting 96-week long-term extension efficacy and saf...
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Eisai will present new five-year data for lecanemab and multiple real-world studies at the 19th Clinical Trials on Alzheimer’s Disease conference, 16-19 Nov. 2026, in Boston and online. Highlights include five-year treatment findings from the Clarity AD core and long-term extension phases and results from the LEADER multicenter retrospective stud...
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Sironax announced that three abstracts on its SARM1 inhibitor SIR2501 were selected for poster presentation at Neuroscience 2026 in Washington, DC, 14-18 November. The selected posters are titled: SIR2501, a Novel SARM1 Inhibitor, Demonstrates Favorable Safety and Early Evidence of Biological Activity in Patients with Amyotrophic Lateral Sclerosi...
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Researchers here propose that greater efforts should be devoted to considering the variety of G-protein coupled receptors (GPCRs) as a regulatory network in the matter of aging and age-related disease. Aging produces sweeping changes in protein levels, gene expression, protein function and interactions, and one can thus make similar arguments for...
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Researchers here provide a demonstration that a form of liver cancer can emerge from change in the epigenetic control over gene expression in the absence of mutation of nuclear DNA, rather than from mutation of nuclear DNA. It is an interesting open question as to the degree to which aging predisposes to cancer via a growing burden of mutation ve...
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By Anuj Trehan – Firstpost – The World Health Organization (WHO), in its recent data, has revealed that the global life expectancy rate has now largely recovered to the pre-pandemic levels. While this sounds like a good piece of news, the bigger question remains unanswered – are those extra years being lived in good health? […] The post We are li...
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In Aging Cell, researchers have described how increasing fibroblast growth factor 13 (FGF13) in astrocytes reduces aging throughout the bodies of mice. FGFs are signaling molecules that share structural and functional commonalities and play crucial roles in biology, including neural function [1]. Some of these molecules are secreted, and others ...
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Stem cell therapies involve a stage of expansion of cells in culture prior to injecting them into the patient. The research community has realized that both the state of the original source cells and small variations in the subsequent cell culture environment can result in large differences in the quality of the transplanted cells. For example, h...
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About 47% of the people in this study had no detectable plaque in their heart arteries, and still showed elevated inflammation around them. That’s the number that jumped out at me, and it comes from Biograph, the preventive health clinic that announced the results on 22 October [1]. It’s the clinic’s first US study using Caristo Diagnosti...
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Six monkeys per group isn’t a big study, but iBio thinks what happened in them deserves attention. The San Diego company highlighted body-composition data from an eight-week study in obese non-human primates (NHPs). The drug is IBIO-610, an antibody aimed at Activin E and described as potentially first-in-class. The data were discussed in...
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Fitnescity Health says it now has more than 1,000 places across the US where someone can get a DEXA scan or a heart calcium scan, and any health platform that wants to can offer those slots to its members through a single connection. Ten platforms have already signed on, including Superpower [1]. The connection in question is an API, whic...
4 days
Four times a day, one breath each time. That’s the dosing routine United Therapeutics plans for treprostinil SMI, a handheld soft-mist inhaler that the company is now cleared to test in people with pulmonary hypertension linked to chronic obstructive pulmonary disease (PH-COPD). The US Food and Drug Administration (FDA) granted clearance unde...
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Peripheral nerves are capable of regeneration to restore connections across gaps caused by injury, but the larger the gap the less likelihood of a successful outcome. The medical community has developed approaches that help by laying guides along the path that regrowth must take, often composed of donor nerve tissue, which may be taken from elsew...
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Many forms of cell stress provoke much the same response of increased maintenance and damage repair activities, such as increased autophagy. A mild level or intermittent stress can result in overall benefit to cell and tissue function, and when applied over time to an organism this can modestly slow aging. How the cell regulates this response to ...
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by Alex Folacci – Newsweek – The rich can afford to have almost every detail of their health managed. They hire private trainers, consult specialists, personalize nutrition, and invest in recovery and longevity treatments. Most people cannot afford that level of attention. But the essentials of staying strong, mobile, healthy, and maintaining low ...
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How to train for lasting strength—and keep doing what you love as you age. The post A longevity playbook for building strength and muscle mass appeared first on Peter Attia MD. ...
A GLP-1 medication reduces appetite, and meals tend to shrink. Smaller meals leave fewer chances to take in fiber, vitamins, minerals, and protein. Research on people taking these medications shows that gaps are common. Here’s what studies have found about nutrient intake on GLP-1 medications and low-appetite days, including where NOVOS Bar fits ...
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One of the many factors impeding the pace of research into age-related neurodegeneration is that it is relatively challenging to obtain human brain tissue from any sizable living population for study. Post-mortem tissue is more accessible, albeit burdened by the usual regulation, but this represents only a slice of the population, largely those w...
5 days
A recent study identified SRSF1, an RNA-processing and splicing factor, as a molecule with geroprotective potential. Inducing SRSF1 expression rejuvenated human cells in vitro, extended lifespan, and significantly reduced frailty in mice [1]. Differentiated cells have the capacity to rejuvenate if an appropriate molecular environment is provided...
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Researchers are engaged in finding alternative ways to induce the desirable epigenetic rejuvenation produced by exposing cells to the Yamanaka factors, without the risk of losing cell state to dedifferentiation and the creation of induced pluripotent stem cells that could give rise to tumors. Yamanaka factors are a challenging basis for many form...
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Extracellular vesicles secreted by cells are divided into types by size, in the absence of greater knowledge that would allow functional classification. Exosomes are one of these size classes, and a popular choice as a basis for therapies intended to replace the transplantation of stem cells. Stem cell therapies produce benefits via the signaling...
By Memorial Sloan Kettering Cancer Center – Science Daily – Cancer immunotherapy can lose its punch when tumor-fighting T cells become exhausted, but researchers may have found a way to keep them going longer. Scientists at Memorial Sloan Kettering Cancer Center identified a signaling molecule called MEK that can push T cells to burn through thei...
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by DZNE – German Center for Neurodegenerative Diseases – ScienceDaily – A study by DZNE finds that healthy eating is associated with slower biological aging—and that there is more than one way to eat healthily. The researchers examined ten dietary patterns considered healthy, including the Mediterranean, Nordic, and a plant-based diet, as well as ...
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One of the oldest and biggest longevity conferences moved this year across the Atlantic, from Copenhagen to Boston. The new location brought ARDD close to several important longevity hubs and might have contributed to this edition’s practical, entrepreneurial, and forward-oriented spirit. We have already reported on the unprecedented panel where F...
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The gut microbiome is made up of thousands of distinct microbial species, interacting with one another to process food and generate a broad range of metabolite molecules that are varying degrees of necessary, helpful, and harmful to the tissues of the body. The balance of these microbial populations changes with age in detrimental ways; microbes ...
6 days
Life Biosciences (“Life Bio”), a biotechnology company pioneering cellular rejuvenation medicines to reverse diseases of aging, announced interim data from its Phase 1 clinical trial of ER-100 in three participants with open angle glaucoma (OAG). The data demonstrated that a single intravitreal administration along with daily oral doxycycline was ...
6 days
Senescent cells accumulate with age to drive the onset and progression of age-related disease and loss of function. Over the past decade, a broad range of research and development efforts have emerged to attempt to address this cause of aging. Senostatic therapies reduce the pace at which senescent cells are created. Senolytic therapies selective...
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Researchers here relate an interesting story: they designed and synthesized a small peptide that is intended to interfere with an interaction between amyloid-β and zinc ions, with the aim of suppressing a necessary part of the process of amyloid-β aggregation. This amyloid-β aggregation, proceeding slowly over years, is thought to be the causativ...
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BY Carrie MacMillan – Yale Medicine – CAR-T cell therapy, approved to treat some blood cancers, is now being studied for lupus, multiple sclerosis, and scleroderma. Yale Medicine experts explain how it works, its risks, and who can benefit. It may sound like science fiction: removing a person’s immune cells, modifying them in a lab, […] The post ...
6 days
Microglia are innate immune cells of the brain, similar in behavior to tissue resident macrophages elsewhere in the body, but with an additional portfolio of duties relating to maintenance of neural networks. Like macrophages, microglia can adopt packages of behavior, and switch between them depending on environment cues; pro-inflammatory M1 focu...
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Researchers are developing biomedical repair therapies to address multiple age-related diseases at once, yet they are forced to put them through regulatory pathways built for single-disease drugs. The result is delay, duplication, and unnecessary cost precisely when speed matters the most. Current regulation still treats age-related diseases as ...
1 week
By University of Bonn – ScienceDaily – Scientists have turned blood cells from an 80-year-old into neural stem cells with a molecular age of less than 20, effectively reversing more than 60 years of cellular aging in the laboratory. The discovery offers a new way to investigate how cells become younger and could help researchers […] The post Reju...
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Despite the only small benefits shown to Alzheimer's patients following clearance of amyloid-β aggregates in the aging brain, the consensus remains that a slow accumulation of amyloid-β aggregates over years is the inciting form of dysfunction that gives rise to the later tau aggregation, neuroinflammation, and cell death in Alzheimer's disease. ...
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Recovery and transplantation of organs following vitrification using cryoprotectant is an important step along the road to the future technological capability of whole body vitrification and recovery - and recovery of those individuals already preserved at low temperature by the cryonics industry. It is particularly important because it is a high...
1 week
“What is an emotion? It's a set of predictions that tells a story about what a set of sensory signals mean to you in that situation.”‒ Lisa Feldman Barrett The post #413 ‒ The neuroscience of emotion: challenging conventional theories of emotion, how the brain predicts and constructs our experiences, and gaining greater control over how we feel |...
1 week
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To...
1 week
A phase III trial for personalized melanoma vaccination foreshadows a new era of cancer treatment The post Personalized medicine comes to cancer immunotherapy appeared first on Peter Attia MD. ...
by The Francis Crick Institute – MedicalXpress – Three years ago, George Kassiotis and his team made an unexpected discovery: A specific way of producing a protein called calbindin was found to help cancer cells survive by preventing them from aging. This left Kassiotis, who runs the Crick’s Retroviral Immunology Laboratory, confused. Why would ...
1 week
The vascular system is prone to calcification with advancing age. Cells in the vasculature inappropriately take on the features and behavior of the osteoblast cells responsible for building bone extracellular matrix. These errant vascular cells deposit calcium phosphate structures into vascular tissue, stiffening it. Calcification proceeds in par...
1 week
Laura Minquini is not a scientist, but that hasn’t stopped her from joining the front lines of the war on aging: specifically, female reproductive aging. Several years ago, after a successful stint in consumer technology, Laura discovered the longevity field when decentralized science was all the rage. Inspired by VitaDAO’s success, she founded At...
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by The Mount Sinai Hospital / Mount Sinai School of Medicine – ScienceDaily – Scientists have discovered that a protein linked to youth helps protect the brain’s immune cells from age-related decline. Restoring the protein in older mice improved the cells’ ability to clear debris and reduced signs of inflammation, raising hopes for future treatmen...
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A team of researchers has written a paper with a surprising finding: that many of the benefits of caloric restriction and increased NAD+ may be due to their effects on the cilia of hypothalamic neurons. Nicotinamide Adenine Dinucleotide (NAD): Benefits and Research Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells. ...
by Annica Hulth, Uppsala University – Phys.org – In early 2024, laboratory-grown neurospheres (i.e. clusters of neural stem cells) were sent to the International Space Station (ISS) to be exposed to microgravity. The return trip was delayed several times due to bad weather in the landing zone. As a result, the cells were outside controlled cultu...
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By Investment Reports Bernard Siegel, founder of the Healthspan Action Coalition (HSAC), discusses his transition from law to patient advocacy and outlines HSAC’s mission to make healthy longevity globally accessible rather than an exclusive privilege for the wealthy. Investment Reports is a publication that is featured by #Newsweek and World-Clas...
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By Duke-NUS Medical School – ScienceDaily– Scientists have uncovered a hidden biological mechanism that helps explain how exercise can reverse some of the damage caused by muscle aging. The key is a gene called DEAF1, which becomes overactive with age and interferes with the muscles’ ability to clear damaged proteins and repair themselves. Exercis...
Nausea, constipation, reflux — if you’re already managing these side effects on a GLP-1 medication, the last thing you want is a new product that makes it worse. That’s a fair concern. Getting some relief starts with finding out what’s actually causing gastrointestinal (GI) discomfort on these medications and what can realistically help. NOVOS Vi...
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A new study suggests that CT scans can provide information about a wide range of conditions, including some not typically diagnosed through imaging. Direct comparison with human radiologists is the next step [1]. A CT scan’s goal is usually to answer a concrete clinical question, such as what is causing abdominal pain or whether a suspected tumo...
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by Science Translational Medicine – Aging is characterized by progressive functional decline, yet metabolomic signatures across the human life span remain incompletely defined. Here, we profiled plasma metabolomes from 18,476 participants aged 1 to 96 years across six centers in China using nano-assisted laser desorption/ionization mass spectromet...
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Researchers publishing in Aging Cell have found that the regulatory protein MTR4 fights DNA damage in the blood vessel lining but decreases with aging. This paper begins by noting the properties, and aging, of vascular endothelial cells (VECs), which line the blood vessels and govern their permeability [1]. As these cells are directly exposed to...