Supercentenarians are an extraordinarily resilient group of people. Reaching the age of 110 requires overcoming a century’s worth of adversity. Beyond their mental toughness, supercentenarians are biologically resilient as well.

Our friends at Rejuve.AI have outlined the factors behind the “startling immune resilience” observed in centenarians and supercentenarians. Their immune systems are dynamic and capable of responding to new threats, as demonstrated by studies on centenarians who contracted COVID-19. Rejuve.AI notes:

“Researchers collected blood samples from centenarians who were residents in a long-term care facility and had been infected with or exposed to SARS-CoV-2, which causes COVID-19. They then tested these samples for the presence of antibodies specific to the SARS-CoV-2 spike protein that the virus uses to enter cells.

Amazingly, the study revealed that centenarians produce potent spike-specific antibodies that prevent the virus from infecting cells and spreading. Plus, these antibodies were still detectable in their blood 60 days after they were first diagnosed with COVID-19 [11].”

The ability of supercentenarians to survive COVID-19 is exemplified by María Branyas Morera, the world’s oldest person. Sra. Branyas contracted COVID-19 in April 2020 at the age of 113. She survived despite the lack (at the time) of effective therapeutics to combat the disease. Sra. Branyas’s predecessor as the world’s oldest person, Ms. Lucile Randon, also recovered from the disease at the age of 116.

Rejuve.AI, pioneering as the world’s first decentralized AI longevity research network, seamlessly merges blockchain, artificial intelligence, and advanced longevity research. Their vision is to democratize healthy aging, making it accessible to everyone—possibly even extending the lives of supercentenarians.


LongeviQuest is delighted to announce the age validation of Ana María Urrea Solano of Colombia at age 108. She was born in Pradera, Valle del Cauca, Colombia on 26 June 1915. She is a wife and a mother.

On her 103rd birthday in 2018. (Source: Entérate Pradera - Martv Prod)
On her 103rd birthday in 2018.
(Source: Entérate Pradera – Martv Prod)

She still currently lives in Pradera, Valle del Cauca, Colombia.

For more information, please view Ana María Urrea Solano’s Directory Profile here.

LongeviQuest is pleased to announce that Montreal, Canada has a new supercentenarian. Maria Lacasse has recently celebrated her 110th birthday, surrounded by her family and friends. It was shared that Lacasse is confident that she will blow out the candles not only for her 111th birthday but also for her 112th. Despite her impressive age, she has not lost any of her lucidity.

Maria Lacasse 110th Birthday Celebration

Maria Lacasse was born in Chertsey, Lanaudière, Canada on 4 December 1913. Lacasse’s caretakers describe her as a joy to work with, always smiling and eager to help, despite the demanding nature of their job. They spend almost more time with her than with their own families. Lacasse surprisingly claims that her bad temper is actually the key to her long life. To live a long time, she says, you need to be “uncomfortable.”

LongeviQuest is pleased to report that the European Supercentenarian Organisation (ESO) has validated the age of Custódia Maria Inácia at 110. She was born in Odemira, Beja District, Alentejo, Portugal on 26 April 1913. Inácia’s first job was picking olives at the age of four. From a very young age, she worked in agriculture, and later as a housekeeper.

Inácia on her 108th birthday (Source: Gerontology Wiki)

In 2018, at the age of 105, Inácia moved into a nursing home in Faro, Faro District. She recovered from COVID-19 aged 107. She became the first supercentenarian born in the region of Alentejo in 2023. Inácia was first noted for her longevity, apart from a brief mention aged 103, on her 108th birthday. Her 110th birthday was also widely reported in Portuguese media.

She died in

LongeviQuest congratulates Custódia Maria Inácia’s family on her posthumous recognition.

For more information, please view Inácia’s Directory Profile here.

LongeviQuest is pleased to announce the age validation of Maria Paschoalina De Castro of Brazil at age 112. She was born in Conceição do Rio Verde, Minas Gerais, Brazil on 2 May 1911. She is of Native American descent. Maria Paschoalina De Castro was a sister to 3 siblings, a wife, and a mother to 13 children.

In May 2022, aged 111. (Source: Facebook/Dalton Silva)
In May 2022, aged 111.
(Source: Facebook/Dalton Silva)

Even at 97 years old, Maria Paschoalina de Castro was still able to do household chores like washing clothes, cooking, and washing dishes. She is a devout Catholic with a strong devotion to Nossa Senhora Aparecida. At 107 years old, she had five living children, 22 grandchildren, and an unspecified number of great-grandchildren and great-great-grandchildren. Her relatives and friends call her “la.”

For more information, please view Mrs. De Castro’s Directory Profile here.

LongeviQuest is pleased to announce the age validation of María Anastasia Colón Aponte of Puerto Rico. She was born in Salinas, Puerto Rico on 27 April 1891 and passed away in Salinas on 28 October 2003 at the age of 112 years. María Anastasia was known by her relatives as “Provi” (short for Providencia) and Güelin. She was married to Eusebio Massó Ledée and they had seven children.

LongeviQuest congratulates María Anastasia Colón Aponte’s family on her posthumous recognition.

For more information, please view María Anastasia’s Directory Profile here.

María Branyas Morera, the oldest validated living person in the world, became the oldest person ever in the entire history of Spain.

Sra. Branyas Morera became the oldest person in the history of Spain after surpassing the age of the previous record holder of Mrs. Ana María Vela Rubio on 21 April 2023, at the age of 116 years and 48 days.

Maria lives her daily life at her residence in Santa Maria del Tura in the city of Olot, Catalonia, Spain.

Branyas expresses that while she doesn’t feel anything special about the record of being the oldest living person in the world or the oldest person ever in the history of Spain because she only feels “older”, she appreciates the fact of continuing to live, and enjoy life in a healthy way.