Alejandro was born as Juliana Espinoza García in San José de Raíces (near Galeana), Nuevo León, Mexico, on 19 June 1898. Her parents were Jorge Espinoza and Maria de Jesus García. Her father was recruited by Pancho Villa’s Rebel Army to fight in the Mexican Revolution. He never returned from the war, leading the family to believe he had died valiantly in battle. She grew up on her parents’ farm, tending to her animals and her garden.

At the age of 15, she married Esteban Alejandro. The couple had nine children.

In 1954, she moved to the Rio Grande Valley in the USA. Her husband passed away in 1977.

Her mother lived to be 102, and her older sister Nemecia died in 2002 at 105. Her eldest son Jose (26 November 1916 – 12 January 2019) lived to be 102. At least three of her daughters died in their 90s.

Juliana Alejandro passed away in Weslaco, Hidalgo County, Texas, USA on 27 February 2010 at the age of 111. She was survived by six children (Jose, Santos, Teresa Reyes, Gregoria Mendoza, Teresa Miranda, and Maria Guadalupe Villarreal), 52 grandchildren, 147 great-grandchildren, 176 great-great-grandchildren and 10 great-great-great-grandchildren.