Spooner was born as Grace Louisa Sarle in Glocester, Rhode Island on 5 July 1872 as the only daughter of Joseph and Mary Melissa Elizabeth (née Hopkins) Sarle. She had two brothers, Edgar and James.
Spooner married twice. Her first marriage in the 1910s was to a man named Curtis, they later divorced and were childless. On 22 October 1924, she married John Augustus Spooner in Warren, Massachusetts. The couple remained in Massachusetts, settling in New Bedford.
As a centenarian, Spooner moved to a nursing home in Suwannee, Florida. She would pray regularly, particularly at Thanksgiving and Christmas. She died on 24 July 1982 at the age of 110 years, 19 days.