Claudina Higuita de Robledo was born in the village of El Naranjo, near Buriticá, Antioquia Department, Colombia, on 30 October 1910. Her parents were Aniceto Higuita and Estefania Borja. Her mother died when Claudina was only 3 years old. During her childhood, she helped her father to make hats and sell them.

At age 15, she met Luis Alberto Robledo, who was from Santa Fe de Antioquia, and she married him when she was 17. The couple had 10 children. After the marriage, she moved to Santa Fe de Antioquia, more specifically to the village of La Aldea, where she lived in the same house until the end of her life. The house she lived in was estimated to be more than 120 years old, the walls were made of mud and it worked with the wood stove. She was widowed at the age of 58.

At the age of 90, she was seriously ill and hospitalized, but managed to recover. Her eldest son Gerardo died in 2019 at the age of 90. As of May 2020, she had five living children: Laurentina (aged 87), Luisito (aged 80), Manuel (aged 73), Alicia (aged 72), and Diocelina (aged 67). As of October 2020, she had 60 grandchildren, 80 great-grandchildren, 145 great-great-grandchildren, four great-great-great-grandchildren, and one great-great-great-great-grandchild.

Higuita de Robledo died in the village of La Aldea, near Santa Fe de Antioquia, Antioquia Department, Colombia on 20 December 2022 at the age of 112 years, 51 days.