Marita Camacho Quiros was born in San Ramon, Alajuela, Costa Rica on 10 March 1911, as the seventh daughter of Salustio Camacho Muñoz and Zeneida Quirós Quirós. She was baptized on 21 June 1911. Her second cousin, Daniel Oduber Quirós (1921–1991), served as President of Costa Rica from 1974 to 1978.
On 16 April 1932, she married Francisco Orlich Bolmarcich in Naranjo, Alajuela, Costa Rica. The couple adopted two children, Francisco José and Mauricio Orlich Camacho. Her husband was the 34th President of Costa Rica from 1962 to 1966. She made history as the first woman to actively participate alongside her husband in the presidential handover ceremony on 8 May 1962—before then, First Ladies did not have a direct role in the event. As First Lady, she dedicated herself to advocating for children and championed a Costa Rican Social Security initiative that provided housing for underprivileged families.
She accompanied her husband on numerous international trips and played a key role in welcoming U.S. President John F. Kennedy and other Central American and Panamanian leaders to Costa Rica in 1963. That same year, she also visited the Vatican, where she met with Pope John XXIII. In 1962, she toured several European countries, including Spain, where she met Francisco Franco, the nation’s leader from 1939 to 1975.