Longevity Science

Osteoarthritis shapes how millions of people wake up, walk, work and age. California-based biotech Biosplice Therapeutics aims to change that through a New Drug Application (NDA) with the US Food and Drug Administration for lorecivivint (LOR), a drug designed to treat knee osteoarthritis in a fundamentally different way [1]. For decades, …

A recent review of literature investigated the risks and benefits of hormone replacement therapy. The authors point out that this approach could be used as a geroprotector to extend the healthspan of women. However, the risk-benefit ratio should be individually evaluated. [1] Female and male aging trajectories differ, and one contributor is sex-…

The gray muzzle that shows up seemingly overnight. Longer naps. Slower climb up the stairs. Most dog owners know the moment. Aging in dogs feels familiar, almost expected… and yet quietly unfair, given how brief their lives already are. This week, San Francisco-based biotech company Loyal moved one step closer to changing that reality. Th…

By Chinese Academy of Sciences – SciTechDaily – A new method for engineering natural killer cells could make cancer immunotherapy more efficient, scalable, and affordable, potentially reshaping how these treatments are produced. Chinese scientists have reported a new technique that makes it easier to genetically modify natural killer (NK) cells …

EyePoint Pharmaceuticals provided a corporate update outlining its anticipated pivotal milestones for 2026 centered on the advancement of DURAVYU (vorolanib intravitreal insert), an investigational sustained-release therapy being developed for wet age-related macular degeneration (wet AMD) and diabetic macular edema (DME). The company said its Pha…

AI-native biotech Proxima has raised $80 million in an oversubscribed seed round to advance new medicines designed to control how proteins interact with one another. Previously known as VantAI, the company has rebranded as Proxima to reflect its focus on “proximity modulation” – a therapeutic strategy designed to influence which proteins come…

Regenxbio Inc. outlined key catalysts expected in 2026 and reported positive long‑term functional outcomes in its lead Duchenne muscular dystrophy gene therapy program, according to the company. The firm said new Phase I/II data for RGX‑202 show durable treatment effects at 18 months post‑treatment, with patients surpassing expected disease progre…

On paper, it sounds like an unlikely pairing: a company best known for powering video games and large language models joining forces with a pharmaceutical giant founded nearly 150 years ago. But Nvidia and Eli Lilly’s newly announced $1 billion investment in an AI-driven drug discovery lab reflects a deeper shift in medicine and in how we thi…

The peptide therapeutics market is projected to grow from an estimated USD 84.2 billion in 2025 to USD 162.4 billion by 2035, registering a compound annual growth rate of 6.8 percent during the period, according to Research and Markets’ latest industry report. The report outlines trends in market distribution by peptide type, route of administrati…

MBX Biosciences, Inc., a clinical‑stage biopharmaceutical firm focused on precision peptide therapies for endocrine and metabolic disorders, said it will provide a 2026 outlook and business update during its presentation at the 44th Annual J.P. Morgan Healthcare Conference in San Francisco on January 13, 2026, the company said that. The webcast is…

Dyno Therapeutics, a genetic technologies company, announced the launch of Dyno-yp2, a novel adeno-associated virus (AAV) gene delivery vector engineered for central nervous system delivery. According to the company, Dyno-yp2 is designed to bind the human transferrin receptor (hTfR1) to cross the blood-brain barrier and demonstrated high-performan…

LifeVantage Corporation held its 2026 Global Kickoff, a virtual event uniting its worldwide Consultant network and outlining strategic initiatives for the year, according to the company. The event introduced “Breakthrough” as the theme for 2026 to emphasize growth, innovation and expanded global alignment following the integration of LoveBiome. A…

Saudi Arabia’s push to shape the future of healthy aging took another step forward last week as the Hevolution Foundation, a global non-profit organization dedicated to extending healthy human lifespan, announced a new cohort of scientists funded under its second Open Call for Grants in the Kingdom [1]. Thirteen researchers from leading S…

Juvena Therapeutics, a clinical‑stage biotechnology company developing AI‑enabled regenerative biologics intended to restore tissue function, has closed a $33.5 million Series B financing round led by Bison Ventures, the company said. The round also included participation from Eli Lilly and Company, Jefferson Life Sciences, Mubadala Capital and Ma…

The global geriatric care devices market is expected to grow from about USD 14.80 billion in 2025 to USD 26.83 billion by 2033, at a compound annual growth rate of approximately 7.74 percent, according to a market analysis report. The projected growth is attributed to the increasing global elderly population, rising life expectancy and widespread …

Why does exercise slow the age-related loss of bone mineral density leading to osteoporosis? Researchers here find a critical role for mechanotransduction, the sensing of physical forces placed upon a cell, such as pressure or mechanical stress. Specifically the mechanosensor Piezo1 is triggered in mesenchymal stem cells in the bone marrow, and t…

RNA splicing is the assembly of exons (and discarding of introns) to form a protein. Many genes contain the instructions for multiple proteins, and which protein is produced is governed by the operation of the splicing machinery. That operation is known to change with age, but the question remains open as to just how important RNA splicing is to …

by Kyle Umipig – Longevity,Technology – – Singapore-based healthcare firm expands into stem cell therapies and longevity as demand for proactive aging solutions grows across Asia. Singapore-based health technology company EUDA Health Holdings Limited has taken a major step in its longevity strategy with the launch of a comprehensive stem cell ther…

The composition of the gut microbiome changes with age in ways that harm long-term health, via growth in inflammatory species versus loss of species producing beneficial metabolites. This is well demonstrated in a range of species, including extensive human data. Presently widely available probiotic and prebiotic approaches only produce short-ter…

We keep talking about longevity like it’s a moonshot science problem. It isn’t. The science is moving fast; what’s lagging is the economic machinery needed to turn that science into approved interventions at scale. Until we fix that, the most exciting biology in the world will stay trapped in papers, not prescriptions. The fundamental cha…

2025 was a good year for geroscience, marked by rapid strides and critical milestones. Yet, the path wasn’t always smooth: progress in some areas lagged, research hit dead ends, and familiar bottlenecks persisted. Against this backdrop, we asked five prominent geroscientists to share their perspectives on the highs and lows of 2025, along with th…

Longevity biotech Juvena Therapeutics has secured $33.5 million in a Series B financing as it moves deeper into clinical development and expands a pipeline built around regenerative biologics. Drawing on insights from human biology, the Redwood City–based company is developing engineered proteins designed to restore tissue function, with a fo…

Sensors such as cGAS in the cell evolved to detect invading pathogens and then interact with inflammatory regulators such as STING to produce an appropriate response. With age, however, many of the dysfunctions that arise in a cell can produce a maladaptive response on the part of cGAS and STING. The example noted here is the activation of dorman…

Researchers here discuss what is known of the bidirectional relationship between the aging of skeletal muscle and the aging of the gut microbiome. Muscle tissue is metabolically active, generating myokine signals influential on other tissues. This signaling is far from fully mapped, but is known to be important to health, such as via mediating so…

By Anna Silman – The New York Times – A few weeks ago, a group of girlfriends and I were messaging about their upcoming trip to visit me in New York City. The topic turned to what they should wear to look cool at a series of scene-y downtown bars they had heard about online […] The post This Is the Year Millennials Officially Got Old first appear…

By Frank Vinluan – MedCity News – A rare but severe stem cell transplant complication that often becomes fatal now has its first FDA-approved treatment, a therapy developed by biotechnology company Omeros. Omeros’s complement system drug Yartemlea is now FDA approved for treating a severe and potentially fatal complication of hematopoietic stem …

Swiss preventive health startup Ahead Health today announced it has raised $6 million to accelerate its mission to make preventive healthcare more accessible in Europe. The Zurich-based company is building an AI-powered platform that ingests data from full-body MRI scans, advanced blood testing and other diagnostic modalities into a single, “…

Mesoblast Limited reported that sales of its allogeneic cell therapy Ryoncil® (remestemcel‑L‑rknd) increased approximately 60 percent to US $35.1 million in the December quarter compared to the prior period. The company said this reflects broader uptake of Ryoncil in the treatment of pediatric patients with steroid‑refractory acute graft‑versus‑ho…

Alnylam Pharmaceuticals has launched its Alnylam 2030 Strategy, a long-term plan designed to expand its role in RNAi (RNA interference) therapeutics and broaden patient impact. The strategy outlines objectives across four pillars: substantially growing revenue beyond current core products, advancing a diversified pipeline of investigational RNAi m…

Omada Health, a digital health provider focused on chronic-disease prevention and care, reported preliminary, unaudited revenue results for the fourth quarter and full fiscal year ending December 31, 2025. The company said preliminary revenue for Q4 2025 is approximately US $67 million, up from US $62 million in Q4 2024, reflecting continued deman…

Function Health announced the launch of a new integration with Claude, an advanced artificial intelligence model developed by Anthropic, to enhance its medical intelligence capabilities. The company said this feature enables members to interact with their health data through natural language, allowing questions about biomarkers, imaging results, l…

Calcification of tissues involves the inappropriate deposition of calcium structures. It is a feature of aging in the cardiovascular system particularly, where calcification contributes to stiffening and dysfunction of tissues. Calcification proceeds alongside the development of atherosclerotic plaque, and thus has long been used as a marker to a…

Researchers publishing in Aging Cell have found that Hevin, a protein found in the extracellular matrix that increases with age, leads to heart problems in older male mice. Chronic Inflammation Chronic inflammation refers to a persistent, low-grade buzz of immune activity that settles into the body without the drama of an infection or obvious in…

Longevity has always been a matter of interest, but absent an earnest scientific endeavor focused on intervention in aging it remained in the realm of fantasy, fraud, and futile wishes. That scientific endeavor was late in arriving, this delay largely the result of a cultural battle spanning the late 20th century that took place between the found…

Aging clocks are a way to obtain a measure of the state of biological age, the burden of damage and dysfunction that causes age-related disease and mortality. A wide variety of clocks have been developed, but this technology has yet to realize its full promise, which is to be used as a standardized measure of the efficacy of potential age-slowing…

By Smithsonian Magazine – Creating mini mitochondria factories helped recharge damaged cells in a dish, providing proof-of-concept work that could pave the way to new regenerative medicine therapies Most of your cells rely on microscopic structures within them called mitochondria. These so-called “powerhouses of the cell” generate energy needed fo…

By Matt Hoffman – CGTlive – As 2025 comes to a close, CGTLive has looked back on some of the most-read and most impactful FDA regulatory decisions and news in the cell and gene therapy space. These approvals and regulatory actions marked major progress for patients with previously limited or no treatment options, and also reflected increasing FDA…

“Our objective is to be able to maintain optionality around being physical for as long as possible, and that is tantamount to having as high a VO2 max as possible, in addition to being as strong as possible.” —Peter Attia The post #379 – AMA #79: A guide to cardiorespiratory training at any fitness level to improve healthspan, lifespan, and long-…

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To…

Social media personalities have been challenging conventional wisdom on atherosclerosis, but their evidence doesn’t hold up to scrutiny The post Pitting facts against sensationalism regarding the role of LDL cholesterol in ASCVD appeared first on Peter Attia. …

Disruption of the regulation of circadian rhythms is a known feature of aging. As for everything to do with our biochemistry, this disruption of the circadian clock is complicated. As a starting point, there isn’t just one clock. The brain runs clocks, the periphery runs more clocks, and they coordinate with one another via signaling. That coordi…

By inhibiting the aging-related enzyme 15-PGDH, scientists have shifted cartilage cells towards a healthier phenotype, leading to a significant improvement in a mouse model of osteoarthritis [1]. Articular cartilage (the smooth, load-bearing cartilage on the ends of bones) doesn’t repair well with age or after injury [2], which is why osteoarthr…

Exercise and physical fitness has been shown to reduce the predicted biological age generated by various epigenetic clocks. Researchers here provide evidence for some of this effect to be mediated by a reduction in inflammatory signaling, also well known as an outcome of exercise and physical fitness. Chronic inflammation is harmful to tissue str…

Retro Biosciences was one of the more comprehensively funded companies in the longevity industry at launch, and has pursued a number of different programs. The first program to reach an initial clinical trial is a small molecule drug to upregulate autophagy, a goal pursued by a wide range of programs, most notably those focused on mTOR inhibitors…

By David Ewing Duncan – The post How healthy am I? My immunome knows the score. first appeared on Healthspan Action….

By Genetic Engineering adn Biotechnology News – Cancer immunotherapy transforms a patient’s immune cells into a “search‑and‑destroy” force against tumors. But many cancers learn to camouflage themselves from dendritic cells—the immune system’s scouts—making them harder to detect and target. Dendritic cells normally collect tumor antigens and pre…

Last year, we reported on Life Unvaped as a newly launched, student-led effort responding to the growing normalization of vaping among teens in Santa Clarita. At the time, it was a passion project—driven by concern, urgency, and firsthand experience. One year later, Life Unvaped has evolved into a structured, community-focused public health campai…

As you may know, there are significant differences in incidence and outcomes of Alzheimer’s disease between the sexes. In research, differences of this nature can help in developing a better understanding of which mechanisms are more versus less important in the disease process, and so guide efforts to produce therapies. The biochemistry of the b…

In a paper published in Aging Cell, researchers have described how older cells send long interspersed nuclear element-1 (LINE-1) RNA to other cells in extracellular vesicles (EVs), spurring inflammation. In the literature, EVs are often discussed in a therapeutic context, as they can be used to send beneficial signals. However, EVs are the natur…

Cystathionine γ-lyase (CSE) levels are reduced with age, and researchers here show that removing CSE entirely in mice reproduces aspects of brain aging. That isn’t enough to prove that the smaller reductions that take place with age do in fact make a meaningful contribution to neurodegeneration, but it is sufficient to justify greater attention a…

Treatment immediately following stroke is not the most obvious path to take for the clinical development of therapies intended to improve drainage of cerebrospinal fluid via the glymphatic system, but nonetheless that is the approach taken by the research program noted here. A range of compelling evidence points to age-related impairment of the d…

by Tel-Aviv University – MedXpress – A new international study led by Prof. Carmit Levy of the Department of Human Genetics and Biochemistry at the Gray Faculty of Medical & Health Sciences at Tel Aviv University finds that melanoma cancer cells paralyze immune cells by secreting extracellular vesicles (EVs), which are tiny, bubble-shaped con…

By Danny Sullivan – Longevity.Technology – Initial focus on epilepsy could drive progress in aging and healthspan therapeutics targeting the mTOR pathway. US biotech Aeovian Pharmaceuticals today secured a $55 million Series B funding round to advance its lead program in a rare form of epilepsy – a move that could ultimately shape how longevity-li…

Scientists in Japan have discovered that multiple strains of bacteria taken from frogs, newts, and lizards can be effective against human colon cancer in a mouse model. One particular microbe achieved a perfect response rate and survival [1]. Recent research has illuminated the enormous impact of the microbiome on overall health. Microbes that l…

In Aging Cell, researchers have identified bone marrow stromal antigen 2 (BST2) as a key protein in age-related hearing loss in a mouse model. Demyelination, the loss of neurons’ protective sheaths, is known to be fundamental in multiple serious neurological disorders, including both amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS…

A new study proposes a novel approach to fighting immune system decline caused by thymic involution: making the liver produce proteins that support T cell development and function [1]. Immunosenescence, the gradual deterioration of the immune system, is a central aspect of aging. Research has tied it to increased cancer incidence, vulnerability …

Dr. Maximina Yun, principal investigator at Chinese Institutes for Medical Research in Beijing (CIMR), studies some of the most amazing animals in the world: salamanders, a group of amphibians that includes newts and species such as the universally loved axolotl. On top of being cute, salamanders possess unparalleled regeneration abilities for ver…

ARLINGTON, Va. (Jan. 7, 2026) – Research!America, a nonprofit alliance that advocates for science, discovery, and innovation to achieve better health for all, announced today the appointment of three individuals as Special Advisors to the organization. Special Advisors will provide counsel to Research!America, its Board of Directors, and the CEO. …