Longevity Science

By Ed Cara – Gizmodo – Death is inevitable. But the journey getting there is far from universal. The average life expectancy at birth worldwide is now around 73 years but varies widely between countries and even between individual states in America. I, and presumably many readers, know some people who have barely lost a […] The post How to Slow D…

Lara Lewington has long been a trusted translator of tech – taking innovations that risk becoming opaque to all but the initiated and rendering them not only comprehensible but compelling. In Hacking Humanity, which is published today, Lewington turns her attention to the rapidly converging domains of AI, gene editing, robotics and preventive…

Resting heart rate, HRV, heart rate recovery, VO₂ max, and blood pressure—how to measure and interpret them, why they matter, and what you can do to improve them The post Understanding and improving important cardiovascular metrics appeared first on Peter Attia. …

Transfusion of blood fractions from young individuals into old individuals has so far produced quite variable animal data and disappointing human clinical trial outcomes. Even so, researchers continue to search for molecules in young blood that might be a basis for therapy. That transfusions have not performed as desired doesn’t rule out the exis…

Researchers have analyzed molecular patterns from different tissues obtained from over 700 people and learned that smoking acts as an aging accelerator and involves molecular changes in tissues beyond those directly exposed to cigarette smoke [1]. Despite campaigns aimed at the reduction of tobacco smoking, it is still a very common practice an…

Primeadine GF is the only wholly food-derived spermidine supplement on the market that’s entirely gluten-free. Each serving is formulated to support cellular renewal and overall vitality through a thoughtful combination of longevity compounds, with spermidine as the star of the show: The chlorella in Primeadine GF is a unique, spermidine-r…

Longevity medicine platform Lifeforce and retinal imaging specialist Toku have joined forces in a partnership aimed at enabling earlier health insights and improving preventive care. The collaboration will see Lifeforce integrate Toku’s AI-powered retinal imaging technology, which allows routine eye exams to serve as a gateway for assessing b…

Chugai Pharmaceutical Co., Ltd. (TOKYO: 4519, hereafter “Chugai”), and Gero PTE. LTD. (hereafter “Gero”), a Singapore-based biotechnology company, announced today that they have entered into a joint research and license agreement to develop novel therapies for age-related diseases. In this collaboration, Chugai will create novel antibody drug can…

In the past decade, advances in wearable technologies have revolutionized our ability to monitor our physical health, although the same cannot be said for our brain health. British-Swiss startup Connectome is aiming to change that, leveraging cutting-edge hardware and AI-powered analytics to transform brain health monitoring into a routine, p…

It is well established that exposure to particulate air pollution increases mortality and risk of age-related conditions. The primary mechanism is thought to be increased chronic inflammation resulting from the interactions of inhaled particles with the cells of epithelial and other tissues. One of the consequences of chronic inflammation is incr…

Researchers here report an advance in understanding the biochemistry of pathological interactions between cell types in the context of vascular dementia. After mapping gene expression levels in healthy and diseased vascular tissue, the researchers find a possible basis for therapy in one specific set of altered expression levels observed in micro…

By Columbia University Mailman School of Public Health – Experts say new “Public Health 4.0” system could extend healthy life by one year, saving $38 trillion Chronic disease now drives 90 percent of U.S. health care costs, yet half of chronic conditions are preventable. Public health leaders say the nation can no longer afford to […] The post Ne…

By comparing data from industrialized and non-industrialized societies, a new study calls into question some assumptions about the relationship between inflammation and aging [1]. Inflammation accompanies us throughout our entire lives. Without it, we would not be able to fight off pathogens. Yet, inflammation also harms tissues and organs and,…

Modern hunter-gatherer populations such as the Tsimane, Hazda, and others, are increasingly of interest to researchers following publications of recent years indicating that these groups exhibit very little cardiovascular disease in comparison to populations in wealthier parts of the world. One might look at high and sustained levels of physical …

As an industry that focuses on extending both lifespan and healthspan, longevity includes a wide range of sectors including biotechnology, pharmaceuticals, Preventative Medicine, healthcare (in general) agetech and other emerging areas. Its research pipeline includes cellular and molecular mechanisms of aging, developing therapies to address …

Australian biotech Cynata Therapeutics is quietly carving out a place for itself in the regenerative medicine landscape, offering what may be one of the most scalable and clinically advanced mesenchymal stem cell (MSC) platforms in development today. At the heart of its approach lies Cymerus, a proprietary manufacturing process that produces …

In Cell Stem Cell, a trio of reviewers has proposed five hallmarks that are specific to the aging of stem cells. This review begins with a note that its classifications focus on the physical features and overall behavior rather than what is going on biochemically. This is because the hallmarks of aging are largely universal across cells; things…

Canadian-Israeli healthtech startup Sensifai Health has emerged from stealth with an AI-powered preventive medicine platform that detects systemic inflammation before symptoms appear. The Montreal-based company claims it has developed the first “clinically validated” technology capable of identifying early immune signals using only data from …

Transcranial magnetic stimulation has been shown to produce benefits in some studies, but reproduction in this field is challenging. There are many options for equipment, frequency, power, duration of treatment, and so forth, and many of these parameters are (a) likely important in determining whether or not the treatment has any beneficial effec…

As researchers note here, the LAG-3 receptor on T cells acts as a checkpoint to suppress T cell activity. Like other such receptors that reduce T cell activity, it has been explored in the context of checkpoint inhibitor therapies to treat cancer by preventing tumor-induced reductions in immune activity. Interfering in the activity of LAG-3 was n…

By i, T.Y., Gao, A.W., Yang, R. et al. – Nature Cell Biololgy – Lysosomes are cytoplasmic organelles central for the degradation of macromolecules to maintain cellular homoeostasis and health. However, how lysosomal activity can be boosted to counteract ageing and ageing-related diseases remains elusive. Here we reveal that silencing specific vacu…

Atherosclerosis is the name given to the growth of fatty plaques in artery walls. It is universal in later life, and the primary cause of human mortality via heart attack, stroke, heart failure, and so forth. Once a plaque grows past a given size, the mechanisms that caused its creation fade in importance in comparison to very simple feedback loo…

The longevity field hasn’t been very good at naming things, but one notable exception is “inflammaging”: the low-grade chronic inflammation that correlates with aging. Recognition has been growing that inflammation, the ubiquitous reaction of the immune system to various stressors, is a major driver of many age-related diseases and possibly one of…

Gero, the AI-driven Singapore-based biotech, has entered into a major research and license agreement with Chugai Pharmaceutical, a member of the Roche Group. The collaboration centers on the development of novel antibody therapeutics for age-related diseases, using Gero’s human dataset–trained AI platform to identify high-value targets, and C…

French ophthalmology biotech PulseSight Therapeutics has initiated the first-in-human clinical trial of its lead gene therapy candidate for the treatment of dry age-related macular degeneration and its advanced form, geographic atrophy. The Paris-based company, which emerged from stealth last year, announced the first patient has been dosed i…

More and more men are investing in longevity — and for good reason. With a record 74% of U.S. adult males now taking dietary supplements, there’s growing awareness of the factors that slow down or speed up aging. Whether it’s for energy, longevity, performance, or looks, men are seeking smart ways to increase their health span and lifespan. W…

You may have heard of sirtuins, perhaps in the context of fasting, resveratrol, or various anti-aging headlines. But beyond the buzz, what do sirtuins actually do? And why are they getting so much attention in the longevity world? Turns out, sirtuins work behind the scenes to switch on helpful genes, manage energy, and support cellular functi…

We are thrilled to announce the second edition of the International Longevity Summit (www.TransVisionMadrid.com) in beautiful Madrid after the major success in 2024. Organized by the Illustrious College of Medical Doctors of Madrid (ICOMEM) and the International Longevity Alliance (ILA), this year we expect over 500 participants with more intern…

Aging is an accumulation of forms of cell and tissue damage, and a complex network of downstream consequences of that damage that interact with one another to accelerate further dysfunction. It should not be too surprising to find that other approaches to producing damage in a living individual resemble aging, at least superficially. This is the …

A burden of lingering senescent cells contributes to the chronic inflammation of aging and is disruptive to tissue structure and function. Excess visceral fat tissue is know to generate an increased burden of senescent cells. It does also dysregulate metabolism and provoke chronic inflammation in a range of other ways, however. So while senescent…

By Drug Target Review – Shift Bioscience has announced new aging research, highlighting the discovery of SB000. This novel single-gene target reverses cellular aging without activating dangerous pluripotency pathways. Shift Bioscience, a biotechnology company, uses dataset-driven discovery to understand and manipulate cell rejuvenation. They recen…

“The bones are mechanical sensory entities that are going to remodel in proportion to how much mechanical stress they’re under…so lifting heavy stuff matters.” —Peter Attia The post Navigating bone health: early life influences and advanced strategies for improvement and injury prevention (#214 rebroadcast) appeared first on Peter Attia. …

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.or…

Exercise for improving cancer survival, ketogenic diets with GLP-1 drugs, the additive effects of longevity drugs, and a novel fibromyalgia treatment The post Research Worth Sharing: July 2025 Edition appeared first on Peter Attia. …

In today’s open access paper, researchers argue that the regeneration of outer, visible ear tissue is a useful area of focus for understanding why mammals are limited in their regenerative capacity. Species such as salamanders and zebrafish can regenerate limbs and internal organs, and researchers would like to understand how to enable this capab…

AI models for drug discovery are becoming more capable, more flexible and, in some cases, more biologically agnostic. One of the more recent entries into this growing field comes from Singapore-based biotech Gero, which has announced ProtoBind-Diff: a generative model for small molecule discovery that works entirely without protein structural…

Swedish biotech Epigenica this week secured $2.2 million in funding to accelerate the commercialization of its high-throughput epigenetic technologies and expand its market presence, particularly in the United States. The company’s core technology enables simultaneous analysis of multiple epigenetic markers across a wide array of sample types…

The Oxford & Cambridge Club in London played host to a landmark event last month as the Oxford Biohacking Society (OBS) marked its first anniversary with a gala celebration. The evening brought together over 120 scientists, researchers, entrepreneurs and thought leaders, united by a shared passion for biohacking and biotechnology. …

Scientists have shown that aberrant metabolism of glycogen in neurons is linked to the accumulation of harmful tau protein. Caloric restriction, genetic interventions, and small molecules might help [1]. Aberrant aggregation of microtubule-associated protein tau (MAPT), or simply tau protein, is a hallmark of several neurodegenerative diseases …

Microglia are innate immune cells of the brain, similar to macrophages elsewhere in the body. A growing body of evidence points to maladaptive inflammatory behavior of microglia in the aging brain as an important contribution to the onset and progression of neurodegenerative conditions such as Alzheimer’s disease. Some microglia become inflammato…

A mountain of human epidemiological data demonstrates that physical activity and fitness correlate with a reduced incidence of age-related disease, a slower age-related decline of function. Adding to that, researchers here show that cumulative physical activity over the long term correlates with slowed loss of cognitive function. While human data…

by Mike Silver – Tufts Now – When cells assemble into tiny biological robots called Anthrobots, they become biologically younger than their original adult cells. Modern humans have existed for over 200,000 years, and each new generation has begun with a single cell—dividing, changing shape and function, organizing into tissues, organs, and limbs. …

Variants of the APOE gene (the most common labeled as APOE-ε2, APOE-ε3, and APOE-ε4) have been show to alter the risk of developing Alzheimer’s disease. Work in recent years has pointed to effects on the behavior of microglia in the aging brain as the important mechanism is driving risk. Bad variants of APOE, predominantly APOE-ε4 in the populati…

As machine learning begins to reshape how scientists model biology, a new study from Shift Bioscience has called time on a persistent flaw in the benchmarking of single-cell perturbation models – the overperformance of the dataset mean. This statistical average, often outperforming state-of-the-art predictors in common metrics, has become som…

In Aging Cell, a team of researchers has described how the health of skin fibroblasts relates to physical and functional ability. This paper begins with an explanation of how frailty and capacity are defined. The World Health Organization defines it as an overall state of reduced strength, endurance, and physiogical functions that increase the …

Last week, Edmonton-based health tech company NiaHealth secured $5.75 million in seed funding to accelerate its mission to bring proactive, preventive healthcare to Canadians. The company has developed a tech-enabled platform that integrates wearables, clinical-grade testing and personalized guidance from human clinicians, to help users impro…

The signal molecules secreted by senescent cells can encourage other nearby cells to also become senescent. Thus the high burden of lingering senescent cells in aged tissues is both directly harmful to tissue structure and function, but also indirectly harmful by encouraging further growth of that burden of cellular senescence. The research commu…

Base editing, such as via the various CRISPR-based approaches, is a powerful technology for making small changes to DNA sequences. It only works in the nuclear genome, however. Researchers have recently demonstrated base editing that works for the hundreds of mitochondrial genomes present in a cell. This is good for patients with single detriment…

By Science News – Electric fields help differentiate healthy and ‘senescent’ cells. Scientists in Tokyo have developed a groundbreaking, label-free method to identify aging human cells using electric fields. This new technique avoids the downsides of chemical tagging, which can distort results and slow research. By analyzing how cells move under a…

The researchers of a recent study published in Aging Cell described their novel CD38 peptide vaccine, which improved many measurements of physical health and prevented cognitive decline in aged mice [1]. Many anti-aging strategies, such as supplementation, require regular, daily intake. A vaccine, on the other hand, is a therapeutic approach th…

Mitochondrial uncoupling is the process by which mitochondria in cells switch from producing the chemical energy store molecule adenosine triphosphate (ATP) to releasing that energy as heat. This is of interest in the context of aging because upregulation of mitochondrial uncoupling via a range of strategies appears to somewhat slow aging in anim…

Despite living longer than men, women often face years – even decades – of delayed diagnoses, vague syndromes and under-researched symptoms. This isn’t just a healthcare problem – it’s a longevity problem, and as the science of healthspan advances, a glaring omission remains: women’s data. Some companies are beginning to take that omissio…

Scientists have analyzed the differences between mammalian species that can regrow ear tissue after injury and those that cannot. Their findings can pave the way for novel regenerative therapies [1]. Many animal species have amazing regenerative abilities. On the one side of the spectrum sit planarian worms: slice them up, and every slice will …

Animal health biotech Gallant has secured $18 million in Series B financing to support the advancement and commercialization of its “off-the-shelf” stem cell therapies for pets. The San Diego-based company says the investment will enable it to accelerate the path to conditional FDA approval of its lead therapy and expand its pipeline of regen…

By Katie Collins – CNET – The quest to live longer and maximize our health spans is going mainstream. I listened to the experts, and I have some thoughts. I’m standing in a drafty room with several hundred people in London’s Truman Brewery, all of us shaking our hands above our heads, woo-wooing our way […] The post I Took a Quick Tour Through Lo…

This month, in between reporting on new methods of affecting aging at its most basic levels, we caught up with AI developers and a longevity fund. Here’s what’s happened in June. Springtime for the Longevity Industry: If you are in the Northern Hemisphere, then spring is well underway and the weather is warming up. This is the season of renewa…

The question of how to intervene pharmacologically in age-related metabolic decline without damaging the very tissues that preserve vitality has become a key challenge for longevity science. GLP-1 receptor agonists may be enjoying their moment in the sun, with headlines touting their capacity to drive weight loss and improve glycemic control …

Hot on the heels of a human trial that demonstrated its technology lowered biological age, therapeutic plasma exchange (TPE) provider Circulate Health has landed $12 million in seed funding, led by Khosla Ventures. The company’s patented TPE procedure removes, separates and replaces your plasma, with the goal of reducing inflammation and impr…

A groundbreaking study published in Nature Cell Biology in August 2024 reveals that spermidine, a naturally occurring polyamine, is essential for the autophagy (cell renewal) benefits associated with caloric restriction and intermittent fasting. Researchers from institutions including the University of Graz and the Medical University of G…

By – Longevity.Technology – Longevity Summit Dublin CEO Martin O’Dea on why Dublin is becoming a new frontier in healthspan innovation and investment. The longevity sector continues to evolve from promising research to practical applications, and this year’s Longevity Summit Dublin reflects that maturation. Taking place from July 2 to 4 at Trinity…

In This Issue – News about an announcement from Germany’s National Academy of Sciences calling for a reorientation of their healthcare system, a new development in CAR-T therapies, a new discovery about limb regeneration (axolotls strike again!), and new evidence of how aging becomes systemic. Follow that up with a report on body mass index as an …

Glycogen, the stored form of glucose, has traditionally been viewed as a passive energy reserve in neurons, with its primary roles attributed to liver and muscle tissues. However, recent research from the Buck Institute for Research on Aging challenges this notion, demonstrating that neuronal glycogen plays an active role in mitigating neurod…

Researchers have ascertained that excessive amounts of complement C3, an essential immune protein that increases with aging, are responsible for causing dementia in a mouse model. The complement system is a key immune system component that is involved in removing misfolded proteins, infectious diseases, and various cellular fragments from the b…

by Lizelda Lopez  –  UC San Diego Today – First-of-its kind study reveals signs of premature biological aging in teenagers with MS pointing to new treatment possibilities beyond immunosuppression Researchers from University of California San Diego School of Medicine have discovered that children living with multiple sclerosis (MS) show signs of ac…

“Beauty and aesthetics is an integral part of being human… and choosing to make changes that are appropriate for your situation, has the potential of increasing quality of life.” —Tanuj Nakra The post #355 – Skincare strategies, the science of facial aging, and cosmetic-intervention guidance | Tanuj Nakra, M.D. & Suzan Obagi, M.D. appeared fi…

New results suggesting that the use of AI causes cognitive deficits have triggered widespread fear, but is this interpretation justified? The post Thinking critically about a new study on AI and cognition appeared first on Peter Attia. …

Scientists have found that visceral fat and subcutaneous fat produce different responses to obesity in male mice and human patients and identified an important regulator of these processes [1]. It has been known that visceral fat, which accumulates around organs in the abdomen, and subcutaneous fat, which accumulates under the skin, are differe…

By University College London – SciTechDaily – Necrosis drives aging and disease by triggering damaging inflammation. Interrupting it may offer new treatments for chronic conditions and improve health in space travel. Necrosis, a form of uncontrolled cell death, may hold one of the most promising keys to altering the course of human aging, disease,…

As China’s population ages rapidly, the development of the longevity industry has been prioritized to the level of national strategy since 2024. To drive its growth, government policies support a broad spectrum of longevity innovations, ranging from preventive wellness to nutritional supplements. Free Trade Zones such as those in Shanghai have b…