Longevity Science

Researchers have discovered that the osteoarthritis-inducing effects of excessive mechanical stress can be mitigated by increasing miR-330, a key regulator in cartilage and bone cells. It has been long-held conventional wisdom that a lifetime of heavy physical labor leads to the early development of arthritis. This has been backed up by scientif...

Axo Longevity has been announced as an exhibitor for The Longevity Show 2026, bringing its data-driven approach to preventive health and longevity optimization to Tobacco Dock this June. The company will showcase its preventive health platform on the exhibition floor, giving attendees the opportunity to explore how deep biomarker testing,...

The National University of Singapore (NUS) is continuing to build out its healthy longevity offering with a Graduate Certificate in Healthy Longevity Medicine, a semester-long postgraduate program that weaves together geroscience, precision geromedicine and the translational nuts and bolts of practice into a single curriculum. Built by th...

Scientists have long been intrigued by a biological pathway called mTOR. It sits at the center of some of the most exciting research in aging, helping regulate how cells grow, repair themselves and clear away damaged material. The problem is that while dialing down mTOR can produce promising effects in the brain, it can also create unwant...

Heart failure is often viewed through the lens of cardiology, but it is equally a longevity challenge. The condition, more often, is the result of accumulated damage – a heart attack years ago, decades of vascular wear and tear or simply the biological cost of getting older. Modern medicine has become remarkably good at helping people sur...

Once past the early stages, an atherosclerotic plaque in a blood vessel wall grows by drawing in and killing macrophage cells of the innate immune system. These cells are responsible for clearing up damage and excess lipids in blood vessel walls, but the plaque environment has become too toxic for their long term survival. Some macrophages work t...

Sepsis is a state of runaway inflammation resulting from infection, in which inflammatory signaling becomes so intense that organs fail under the stress. Crudely, one might think of initiation of sepsis as a tipping point between the normal balance of initiation and suppression of inflammation versus a runaway positive feedback loop of inflammato...

Cortechs.ai announced a strategic collaboration with Microsoft to integrate its quantitative imaging applications, including NeuroQuant and OnQ Prostate, into Microsoft’s PowerScribe One reporting environment and the broader Microsoft ecosystem. The integration will use Microsoft Azure’s cloud infrastructure and is designed to deliver automated v...

Winona has launched the Winona Research Initiative, a national program designed to expand menopause and women’s health research by supporting early-career clinicians, trainees and early faculty. The company claims selected Winona Scholars will receive a $3,000 scholarship stipend, additional conference funding, mentorship, data and publication su...

Fresenius Medical Care launched Kinexus Worldwide, a unified digital platform designed to support peritoneal dialysis and home hemodialysis programs. The platform consolidates digital modules to enable remote therapy monitoring that transmits treatment data from patients’ homes to clinics, remote prescription management to allow clinicians to ada...

Niagen Bioscience announced that the ChromaDex External Research Program has been renamed the Niagen Research Program to align the research initiative with the company’s name evolution and focus on NAD+ science. According to the company, the program has supported more than 300 research collaborations and contributed to over 45 peer-reviewed human...

BrainStorm Cell Therapeutics Inc. announced the publication of an article in the Journal of the Academy of Public Health that examines how regulatory frameworks for amyotrophic lateral sclerosis, rare diseases and regenerative medicine could be updated, according to the company. The piece, co-authored by BrainStorm board member and former FDA ass...

Cambrian Bio will present two posters on ATX-304 at the American Diabetes Association 86th Scientific Sessions, scheduled 5–8 June 2026, at the Ernest N. Morial Convention Center in New Orleans. The posters report data from a Phase 1b clinical study in prediabetic obese participants (abstract 1782-P) and mechanistic research on AMPK activation by...

Every cell contains hundreds of mitochondria, the descendants of ancient symbiotic bacteria that have by now evolved into components of the cell. Much of their original bacterial genome has migrated into the cell nucleus to become incorporated into nuclear DNA, leaving behind only a small remnant mitochondrial genome. The primary role of mitochon...

The Forever Healthy Foundation today publicly launched evipedia.ai, an open online encyclopedia of in-depth evidence reviews covering more than 500 health and longevity interventions, including first-generation rejuvenation therapies, supplements, botanicals, lifestyle protocols, and more. Evipedia was built to solve a problem familiar to anyone ...

Every biotech startup promises to push boundaries. Few name themselves after the idea. This week, longevity biotech NewLimit appears to be making a serious attempt to live up to its own branding. The company has raised $435 million in a Series C financing round led by Founders Fund, with participation from Thrive Capital, Greenoaks, Quiet...

“The industry has reached a now-or-never moment where generic claims are no longer good enough. Now that wellness is healthcare’s new front door, companies need to meet a higher standard of proof, and we’ve stepped in to enable that.” It’s a bold statement from Rony Sellam, the CEO of InsideTracker, a company best known for helping consum...

Scientists have been making remarkable discoveries about the brain, such as identifying genes linked to Alzheimer’s disease, uncovering new pathways involved in Parkinson’s and developing increasingly sophisticated therapies designed to target neurological disorders. Yet many of those breakthroughs run into the same frustrating problem: getti...

Dubai has built its reputation around what’s next for so many years – the tallest buildings, the newest technologies, the most ambitious developments. Now more than ever, the city is turning its attention to something more personal: longevity. Across the Gulf, conversations around health are evolving. People are no longer waiting until so...

Neurodegeneration has long been medicine’s slow-burn catastrophe – familiar, heavily funded and still maddeningly resistant to elegant solutions. Alzheimer’s, Parkinson’s, ALS and Huntington’s continue to exact their toll while treatments remain frustratingly modest; the field has had no shortage of hypotheses, only a shortage of answers that...

C2N Diagnostics has formed a collaboration with SouthGenetics to expand access to its Precivity portfolio of blood tests for Alzheimer’s disease assessment across Latin America and the Caribbean. The alliance will initially target Argentina, Chile, Colombia, Dominican Republic, Ecuador, Jamaica, Mexico, Uruguay and Venezuela and aims to support i...

Voyager Therapeutics announced FDA clearance of its Investigational New Drug application for VY1706 on 1 June 2026, enabling a multi-site, open-label, dose-escalation clinical trial of a one-time IV gene therapy in adults with early alzheimer’s disease; dosing is expected to begin in the second half of 2026, according to the company. The trial wi...

Eccogene and AstraZeneca will present multiple clinical datasets for Elecoglipron (AZD5004/ECC5004) at the American Diabetes Association Scientific Sessions in New Orleans, 5-8 June 2026. Eccogene plans a late-breaking Phase 1b poster from a China study evaluating safety, tolerability, pharmacokinetics and pharmacodynamics in adults living with o...

Augustine Therapeutics will present a late-breaking poster at the American Diabetes Association 86th Scientific Sessions in New Orleans on 7 June 2026, during the late-breaking poster session (Poster 3067-LB, 12:30 PM to 1:30 PM CT) in Poster Hall D-E. The presentation will feature in vivo efficacy results from a preclinical mouse model of heart ...

Corsair Pharma completed a first-in-human phase 1 trial of the TRX-248 transdermal system, a once-daily patch that delivers an inactive treprostinil prodrug, which is converted to active treprostinil after absorption. The single-dose study enrolled nine female volunteers who each received a single 24-hour patch per treatment period and evaluated ...

No part of the body is truly isolated; all organs, systems, and cell populations interact with all of the others in various ways. Cells secrete and take up countless varieties of molecules and vesicles, carried throughout the body by the circulatory system to cause reactions elsewhere. Given the strong impact of reproductive success on the evolut...

It is not surprising to find aspects of aging correlated with one another; some people have a greater burden of cell and tissue damage than others, and thus tend to be more greatly impacted in all organs and systems as a result. Equally, the failing capacity of any one organ or system can accelerate the decline of all the others. The immune syste...

By Anne Wainscott-Sargen – Aerospace America – Cedars Sinai, Cleveland Clinic, and University of Pittsburgh discuss how ISS has helped drive disease research and treatments WASHINGTON, D.C. – The biological research onboard the International Space Station (ISS) over the last 26 years hasn’t only benefited astronauts; it’s driven new understanding ...

You might recall that gene therapy to overexpress caveolin-1 in the brain was recently shown to reduce pathology in a mouse model of Alzheimer's disease. In today's open access paper, researchers apply the same gene therapy to a mouse model of TDP-43 pathology in the aging brain. In this model, the mice express higher than normal levels of TDP-43...

The longevity field remains small and starved for resources, especially the subfield devoted to the fundamental biology of aging, despite near-universal agreement that solving aging requires understanding it first. With VCs looking for clinical successes and state funding drying up for many projects, some enthusiasts are turning to a nonprofit mod...

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If you have spent any time in the longevity space, you will know that the supplement landscape has never been more exciting, or more crowded. NAD+ boosters, senolytics, urolithin A, resveratrol, berberine - the options available to the informed, proactive person who wants to age on their own terms have multiplied dramatically in recent year...

Macular degeneration involves the death of vital cells in the retina, leading to progressive blindness. The less common neovascular (or "wet") form of the condition involves the inappropriate growth of leaky blood vessels in the retina and underlying choroid. Existing treatments focus on trying to prevent this blood vessel growth or remove the ve...

Researchers continue to produce new aging clocks at a fair pace. Any sufficiently complex set of biological data obtained from people of various ages can yield a clock given the use of various forms of machine learning. It is straightforward to make a new clock. Most of these will vanish into obscurity, as they will demonstrate no advantages over...

By NYU Langone Health – Longevity was once defined as simply living longer. Today it’s about living better for longer—adding more healthy, active years to life. As conversations around health span and longevity surge across social media and the news, so does misinformation. Between supplements, hormone therapies, and viral wellness trends, it can ...

By King’s College London – SciTechDaily– Wool-derived keratin membranes helped regenerate organized, stable bone tissue and may offer a promising alternative to collagen in regenerative medicine. A new study found that keratin, a structural protein taken from wool, can support bone regeneration in living animals. The material produced bone tissu...

In a sense, exercise is damaging. It places stress on cells, but we have evolved to react to that stress and damage with greater maintenance, repair, and a shift of cell metabolism into a more beneficial state. That a mild or short term stress results in a long term benefit is called hormesis, and it is the case for near all forms of stress. Ther...

Approaches that modify the processes of aging at their roots have gone well beyond basic research and into therapies intended for the clinic within the next few years. Here’s how the field has advanced in May. The Longevity Investor Network Looks Back at 2025: Through curated monthly pitch sessions, educational seminars, collaborative diligence,...

One of the outcomes of the past few decades of focus on the development of tissue engineering and cell therapies is an increased understanding of what can be achieved with nanomaterials, meaning any manufactured substance or structure with nanoscale features that can engage with cells in a defined way. The use of nanoscale scaffolding to emulate ...

Allostatic load is a fairly fuzzy concept, meaning the degree of wear and tear on the body that acts degrades its ability to resist stress and function correctly. Debates over exactly how to measure allostatic load are a microcosm of the debates over exactly how to measure biological age: various scientists all using the same conceptual term to d...

by Buck Institute – Research from the Buck Institute reveals that the protective APOE2 variant, already associated with exceptional longevity and reduced Alzheimer’s risk, keeps human brain cells genomically stable and resistant to cellular senescence People who carry the APOE2 version of the apolipoprotein E gene are more likely to live to advanc...

By Cindy Krischer Goodman – Sun Sentinel & Tampa Bay Times –  Florida is one of five states that has green-lighted stem-cell use for conditions not yet approved by the U.S. Food and Drug Administration. Inside a pristine laboratory at GBI Biomanufacturing in Plantation, stem-cell production ramps up, producing regenerative medicine with the...

“Different drugs vary in how quickly they work, how long they last, and which sleep problems they target. We need to match the medication's pharmacology to the patient's specific sleep challenges.” —Peter Attia The post #394 ‒ Sleep pharmacology: the role of medications in healthy sleep, the promise of emerging therapies, and the evidence for com...

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To...

Optimized programs with heavy weights are the gold standard for trained athletes. How much do they matter when starting fresh? The post Resistance training: lowering the barrier to entry appeared first on Peter Attia. ...

Astrocytes make up a sizable fraction of the supporting cells of the brain, and undertake a wide range of tasks in order to maintain function. They supply metabolites needed for neural function, maintain other aspects of brain chemistry, provide structural support, and are a component of the blood-brain barrier, among many other activities. It ha...

The report, titled “Pathways to Longevity”, introduces several important longevity concepts to the general reader and is another sign that the field is coming of age and entering the mainstream. From time to time, Harvard Health Publishing issues Special Health Reports – consumer-facing, doctor-reviewed guides translating medical research for ge...

Teeth do age, becoming more brittle and prone to fracture as the cell populations of the dental pulp become less capable of conducting the necessary maintenance processes. This has only relatively recently become a topic of interest in the dental community, and so relatively little is understood in detail of the mechanisms of tooth aging. Researc...

Researchers here note a mechanism that encourages the innate immune cells known as microglia to better clear amyloid-β in the aging brain. The protein PM20D1 acts in the formation of N-acylamides, and generation of the product N-oleoyl-leucine encourages microglia to more efficiently remove amyloid-β aggregates. In animal models of Alzheimer's di...

By Maureen Salamon – Harvard Health – A surprising set of forces can prompt your body to grow older before its time. If we’re naming things that speed up looking and feeling older, factors such as sun exposure, stress, or smoking may come to mind. But here’s something you might not have considered: worrying about […] The post What factors speed u...

By Neurology Advisor – Dopaminergic cell replacement therapy is re-emerging as an investigational strategy for Parkinson disease (PD), supported by a growing number of early-phase clinical trials reporting favorable preliminary safety findings and early motor improvements. Evolution of Dopamine Cell Replacement in PD Early efforts to replace do...

In a preprint published in arXiv, researchers from Altos Labs have described a machine learning algorithm that performs end-to-end prediction of how cells’ gene expression will respond to interventions. Simulating biological processes on a computer is an incredibly difficult task. While advanced algorithms such as Google’s AlphaFold have revolut...

The Apolipoprotein E (APOE) gene exhibits a small number of common sequence variants across the human population, of which the desirable APOE2 variant is associated with modestly greater longevity, and the undesirable APOE4 variant is associated with a sizable increase in the risk of Alzheimer's disease. APOE is one of only a few genes to exhibit...

Scientists have demonstrated how cancer cells influence neighboring cells to create a favorable niche for the tumor to grow. Understanding this can inform future early-stage cancer therapies [1] Cancer is a disease of aging. With the exception of childhood cancers, most of which stem from inherited genetic errors, adult cancers tend to occur late...

A sizable proportion of past gains in human life expectancy arose from public health strategies to better control the burden of infectious disease. Exposure to pathogens doesn't just increase the risk of an earlier death due to fatal infection, but also places a burden of damage on the survivors that increases late life mortality. Researchers her...

Machine learning techniques can be used to generate aging clocks from any sufficiently complex set of biological data obtained from individuals of varying chronological ages. The research community is generating new clocks at a fair pace, most of which are doomed to vanish into obscurity, while trying to better understand best use cases and limit...

By News Medical Life Sciences – Organoids are three-dimensional tissue cultures made from embryonic stem cells, adult stem cells, or induced pluripotent stem cells. They are produced in a supporting matrix and can also be created by combining epithelial progenitors with mesenchymal and endothelial cells. Organoids’ 3D microenvironment allows f...

By ScienceDaily – Scientists have discovered that a topical anti-aging drug called ABT-263 can dramatically improve wound healing in older skin. The treatment works by removing damaged “senescent” cells that accumulate with age and slow the body’s repair process. In aged mice, wounds healed much faster after treatment, while the drug also activate...

The aging of the adaptive immune system, made up of B cells and T cells, is a complex process. Broadly, the pace at which new adaptive immune cells are created declines to a tiny fraction of youthful levels in most people by age 50, and this lack of replacements allows the adaptive immune system to become ever more populated by exhausted, senesce...

A recent study compared premenopausal, perimenopausal, and postmenopausal women’s cardiovascular health. Perimenopausal women had about twice the odds of having a poor overall score when compared with premenopausal women, after adjusting for age [1]. The menopausal transition, and the associated changes in hormonal levels, especially declining e...

Cambridge, MA — May 26, 2026 — Insilico Medicine (“Insilico”, 3696.HK), a clinical-stage generative artificial intelligence (AI)-driven biotechnology company, and Human Life Foundation Models, Inc. (HLFM), a newly launched company established by Human Longevity, Inc. today announced a multi-million-dollar AI co-development collaboration to build i...

There is something quietly radical about eating with the seasons. Not because it is trendy. Not because a nutritionist told you to. But because for most of human history, it was simply how we ate and our bodies evolved in step with it. The food that appears in spring and early summer is not coincidental. It is precisely what a body when de...

By Insurance Business – Japan’s health ministry advisory panel cleared Sumitomo Pharma’s Parkinson’s disease treatment Amchepry for inclusion in the national insurance program on May 13, opening public coverage for what regulators describe as the first iPS cell-derived product to reach commercial status anywhere in the world. Coverage takes effe...

By King’s College London – SciTechDaily– Wool-derived keratin membranes helped regenerate organized, stable bone tissue and may offer a promising alternative to collagen in regenerative medicine. A new study found that keratin, a structural protein taken from wool, can support bone regeneration in living animals. The material produced bone tissue ...

There is a particular kind of cultural guilt that surrounds sleep. The glorification of early mornings, packed schedules, and relentless productivity has long positioned rest as something to be minimized. Science is pushing back on that narrative with increasing force. Diet, exercise, stress management – the pillars of healthy longevity – ...

At Oxford Healthspan, one of our commitments to you is to share the science as it unfolds, not just once it's been neatly packaged for public consumption. So when a compelling new preprint exploring spermidine's potential role in liver health landed on our radar, we felt it was worth bringing to you directly [1]. For transparency: this ma...

Scientists have uncovered an unexpected function of the tau protein, which is mostly known for its role in Alzheimer’s and related disorders: helping encode long-term memory. This can inform novel approaches that target tau [1]. Tau is a protein found mainly in neurons, where its textbook job is to bind and stabilize microtubules, which provide ...

By RegMedNet – A new clinical trial is evaluating whether a single mesenchymal stem cell infusion can stabilize cognitive decline in patients with mild cognitive impairment or early Alzheimer’s disease. A new investigator-initiated clinical trial at the University of Miami Miller School of Medicine is exploring whether a single infusion of mesen...

By Ava Durgin – mindbodygreen – If you’re in your 30s or 40s and starting to notice subtle changes—sleep that’s not quite as restorative, mood shifts, or cycles that suddenly feel unpredictable—you might be entering perimenopause, the hormonal transition leading up to menopause. And according to a massive new study presented at the 2025 Annual […]...

Despite the mechanism, growth hormone has not delivered on its promise for adult tissue repair The post Growth hormone for musculoskeletal system repair appeared first on Peter Attia. ...

Researchers have discovered the role of cellular senescence in the interaction between omega-3 polyunsaturated fatty acids (PUFAs) and chronic kidney disease (CKD). Several clinical trials have found that taking omega-3 PUFAs has benefits for older people. One study found that it reduces the rate of aging according to epigenetic clocks [1], whil...

“Poor problem definition almost guarantees some sort of false positive.” —Peter Attia The post #393 ‒ AMA #85: A guide to medications and supplements: determining what to take, what to skip, and how to know if they’re working for you appeared first on Peter Attia. ...

Pap smears transformed cervical cancer prevention. Now, self-collected HPV testing may help more women stay up to date on screening. The post What at-home HPV testing means for cervical cancer screening appeared first on Peter Attia. ...

Scientists have found that the levels of phosphatidylcholine, the most abundant lipid in mitochondrial membranes, decline with age, driving mitochondrial aging in worms and possibly humans. Supplementing the lipid helped in an in vitro experiment [1]. Mitochondria are the cell’s energy-generating organelles, and their decline is a hallmark of ag...