Updated 12:49pm | March 14, 2025
47 minutes
Scientists have identified a senescence-associated surface protein that can be targeted using antibodies and published their work as a pre-print [1]. This discovery might help distinguish between beneficial and harmful senescent cells and could speed up the development of senolytic therapies. This work was done by the Lifespan Research Institute, …
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A new partnership between Cellino and Matricelf, which aims to create personalized regenerative therapies for the treatment of spinal cord injuries, has generated patient-specific neural tissues with the potential to restore lost function. Combining advanced stem cell technology with 3D tissue engineering, the collaboration is a step towards …
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The Founders Longevity Forum, a pivotal event in the global longevity sector, is set to return later this year to its inaugural host – London. The longevity sector is experiencing unprecedented growth, projected to expand from $78.4 billion in 2024 to $376.5 billion by 2032. As advancements in science, technology and investment accelerate…
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Aging is the ultimate risk factor for many diseases marked by the progression and deterioration of organs and tissues and an enhanced risk of disease initiation. Immorta Bio‘s technologies aim to leverage the power of the body’s own young stem cells and its own enhanced immune cells to deal with cancers as well as the diseases of aging just t…
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The central nervous system is inconveniently situated for those who wish to examine it in detail in living people, but one tiny portion is at least readily available for visual inspection – the retina at the back of the eye. To the degree that the retina is subject to the same mechanisms of aging as the brain, one might expect to be able to use r…
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Macrophages of the innate immune system exhibit a range of different states known as polarizations. M1 macrophages are inflammatory and focused on attacking pathogens and errant cells. M2 macrophages are anti-inflammatory and focused on tissue maintenance, playing an important role in regeneration from injury. Not a vital role, strictly speaking,…
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by by Johane du Toit – LongevityLive.com – The COVID pandemic accelerated the use of technology in the virtual and digital platforms by individuals for a whole host of unique systems, which effectively helped to improve the value and quality of life for many. The COVID pandemic accelerated the use of technology in the virtual […] The post AI, AR…
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Many major age-related neurodegenerative diseases share a common trait: proteins lose shape and clump into harmful, insoluble aggregates. For example, in Alzheimer’s disease a protein called amyloid-beta aggregates into plaques in the brain and contributes to neurodegeneration. While many treatments aim to remove these aggregates, a deeper questio…
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Nearly 15 years have passed since the first compelling demonstration of rejuvenation produced by clearance of senescent cells in the tissues of aged mice. At that time the study of senescent cells was fairly slow and sedate, not a major area of research. How things change! At present a very energetic community of academic groups and biotech compa…
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In Aging Cell, researchers have established a link between cellular senescence and cognitive decline in unmodified male mice. The authors begin their paper by noting that cognitive decline in older people varies greatly. Some people suffer serious cognitive defects; other people are scarcely impacted at all [1]. The researchers have developed a…
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Back in 2020, a seminal paper in Nature showed that treatment with a partial epigenetic reprogramming restored vision in blind mice. Since then, the world has waited with bated breath for a human trial of the technology. And waited. And waited. Now, nearly five years later, with billions invested in multiple companies seeking to harness t…
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AI-driven drug discovery powerhouse Insilico Medicine has raised $110 million in Series E funding to accelerate its clinical trials and refine its AI platforms. The latest funding reportedly valued the company at over $1 billion, marking its entry into the exclusive unicorn club. CEO Alex Zhavoronkov has stated that the funding will accel…
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This review paper looks at what is known of hypoxia-inducible factor (HIF) signaling in the aging of lung tissue, with a particular focus on the burden of cellular senescence as a measure of age-related dysfunction. In the view of these researchers, chronic expression of HIF with age promotes cellular senescence. Why HIF expression becomes dysreg…
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Age-related cataract formation in the lens of the eye causes blindness. This growing opacity of the lens appears to be driven in large part by a growing burden of cellular senescence in lens cells. Could senolytic therapies to clear senescent cells reduce the need for surgery and the development of cell therapies and tissue engineered replacement…
By Charles Rollet – Tech Crunch – Longevity is a hot trend in Silicon Valley these days, driven by rising interest — especially among the wealthy — in preventing disease through regular testing. A new player, Biograph, has just emerged from stealth, and it’s co-founded by one of the biggest names in longevity science: Dr. […] The post Startup co-…
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Recent research confirms the relatively minor role that genetics plays in our health, with the ‘exposome’, defined as the totality of exposures individuals experience over their lives affecting their health, responsible for 10 times more variation in mortality risk than genetic predisposition [1]. A paper published in Nature Medicine today, ‘Cit…
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The relative influence of genetics on health outcomes has been the subject of debate for decades; now, new research published in Nature Medicine today points to the overwhelming role of the exposome – the sum of environmental exposures throughout life – in determining mortality risk. According to the study, the exposome accounts for nearly te…
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The balance of microbial species making up the gut microbiome changes with age in ways that (a) promote chronic inflammation, such as via infiltration of microbes into tissue and production of harmful metabolites, and (b) reduce the supply of beneficial metabolites, such as butyrate. A growing body of work characterizes these changes and links th…
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US healthtech company Junction has raised $18 million in a Series A funding round to advance its mission to support healthcare’s shift towards decentralized models. Formerly known as Vital, the company’s platform enables healthcare organizations to deliver more personalized and efficient care by connecting patient data from labs and electroni…
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A recent country-level analysis of life expectancy among several European nations shows changes in life expectancy trends and how well-designed national policies can reduce or minimize exposure to risk factors, thus improving life expectancy [1]. Life expectancy has grown in high-income countries since at least 1900, except during the two World…
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Regeneration from injury might be thought of as an intricate and scheduled set of interactions between immune cells, various types of somatic cell present in the injured tissue, and the stem cells that support the tissue. On the immune cell side of the house, a great deal of research is focused on the innate immune cells known as macrophages. Alt…
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Neurodegenerative conditions are characterized by chronic inflammation. Does reducing that inflammation help? As researchers here note, studies attempting to find correlations between dementia risk and use of common anti-inflammatory medications have produced conflicting results. This study looks at the duration of use of anti-inflammatory medica…
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by Anjali Thakur – NDTV World News – In today’s fast-paced world, where wealth knows no bounds, billionaires are no longer satisfied with private jets, superyachts, or lavish mansions. The new status symbol: a youthful appearance and lasting longevity. Forget ageing gracefully – tech titans and business moguls are now investing millions in advance…
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Longevity biotech ReParris has launched with the goal of developing small-molecule therapies that target inflammation-driven degeneration and address the root causes of age-related diseases. The regenerative medicine company says it is on a mission to redefining aging as a treatable condition, expanding on its initial focus on canine longevit…
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Insofar as I have an opinion on politics, I’m against it. Generally it runs in its own noisy part of the world, involves a lot of unnecessary angst and drama, and at the end of the day has little to no influence on my day to day life. It is best ignored. I’ll talk about it a little today because it seems likely that some upheaval lies ahead for t…
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Applying statistical methods to a large dataset spanning almost 300 species, scientists found a positive correlation between body size and cancer prevalence [1]. Other researchers dispute that these findings invalidate the famous paradox. Cancer has forever been a mortal enemy of multicellular life. Sometimes, the cell’s “program” malfunctions,…
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Repositories of well-characterized 20+ year old stored blood samples that can be accessed for analysis are few and far between. Here, researchers make use of one such resource to characterize a proteomic aging clock for its ability to predict future health outcomes. This clock, organage, assesses a biological age for different organs based on lev…
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The glymphatic system of the brain is a recently discovered pathway allowing cerebrospinal fluid to drain from the brain into the body, carrying metabolic waste with it. Another path through pores in the cribriform plate behind the nose also appears important. Both of these drainage pathways decline in efficacy with age. It is thought that this l…
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By Gretchen Reynolds – The Washington Post – For those hoping to cure death, and they are legion, a 2016 experiment at the Salk Institute for Biological Studies in San Diego has become liminal — the moment that changed everything. The experiment involved mice born to live fast and die young, bred with a rodent […] The post Inside the scientific q…
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By Dan Pontefrac – Forbes – Business leaders continue to obsess over AI and climate change. It’s hard to argue over their obsession. But there’s another categorical change underway that few people are discussing, one that will reshape economies and workforces just as profoundly: demographics. According to the World Health Organization, by 2030, ap…
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Cellular reprogramming involves expressing the Yamanaka factors discovered twenty years ago. Given robust expression over days, a somatic cell dedifferentiates into an induced pluripotent stem cell, replicating what happens to germline cells in early embryonic development. But with just a little expression of the Yamanaka factors, partial reprogr…
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A newly developed positron emission tomography (PET) imaging probe, derived from the drug edaravone, has demonstrated potential for detecting oxidative stress in the central nervous system – an underlying factor in neurodegenerative diseases such as Alzheimer’s and amyotrophic lateral sclerosis (ALS). Researchers at St Jude Children’s Re…
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Longevity biotech Immorta Bio has announced proof-of-concept findings supporting the potential of its personalized exosome technology to counteract chemotherapy-induced accelerated aging. The company says it has filed a patent application for its approach, which leverages patient-derived exosomes to rejuvenate damaged tissue and mitigate the …
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In the Nature publication Signal Transduction and Targeted Therapy, researchers have described how glibenclamide, a drug used to treat type 2 diabetes, partially reverses epigenetic alterations and fights cellular senescence in mice. This paper begins with a discussion of the relationship between epigenetic alterations and cellular senescence. …
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A diabetic metabolism is widely considered to accelerate aging, on the basis of very good evidence, and to the point at which researchers have often used diabetic mice as a faster, cheaper stand-in for aged mice in their studies. Reasonably, one should expect any decent measure of biological age to report accelerated biological aging in diabetic …
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Researchers here produce a mouse model incorporating a DNA sequence that produces a luminescent protein only in the case of a readthrough error, where the translation machinery ignores a stop codon in the DNA sequence. This is a way to gauge the degree to which readthrough errors increase with age, producing aberrant RNA molecules and consequent …
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By Danny Sullivan – Longevity.Technology – Another tech giant has revealed new progress in the mission to harness the power of AI to advance biomedical research. Following the recent revelation that OpenAI’s new GPT-4b micro model had been developed with longevity biotech Retro Bio, Google just unveiled “co-scientist” – an AI tool designed to acce…
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“My coping skills live in a part of the brain that gets hijacked when the emotional brain takes over, and this doesn’t always have to be about trauma.” —Jeff English The post #339 – Unpacking trauma: How early wounds shape behavior and the path toward healing | Jeff English appeared first on Peter Attia. …
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Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.or…
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A Mendelian randomization study provides compelling evidence that obesity may directly trigger autoimmune conditions The post A causal link between obesity and autoimmune disease appeared first on Peter Attia. …
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Whenever reading about the effects of an intervention and environmental influence on aging clocks, one has to spend a little time thinking about what it is that these clocks measure and what is known of how the clocks behave. An aging clock is produced from a reference data base of biological measures taken at various ages. If an individual has a…
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If you are a student or early career professional interested in breaking into longevity biotech, this is a fellowship program just for you. Applications are open for our fellowship program at LongX (Longevity Xplorer) until March 31, 2025! Our summer program lasts from June to August 2025 and is meant to be a first step […] The post The Xplore Pr…
Research shows that adjusting food intake can influence how we age.Eating less—whether through caloric restriction or fasting—has been linked to: In fact, among studied longevity interventions, including prescription drugs, hormone therapies, senolytics, supplements, and parabiosis (blood transfers), caloric restriction has the greatest impact on …
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As Chair of the British Society for Research on Ageing I often get asked where is the best place in the UK for the biology of aging and it’s difficult to answer. Many institutions across the whole country carry out research in this area. That’s why our annual meetings are so fascinating – scientists studying the biology of aging interact with…
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LyGenesis, a clinical-stage biotech pecializing in organ regeneration, has received approval from its Data and Safety Monitoring Board (DSMB) to proceed and escalate dosing in its Phase 2a clinical trial. This trial investigates the company’s novel approach to organ regeneration, particularly for patients with end-stage liver disease (ESLD). …
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A new peer-reviewed study in the journal GeroScience highlights the associations between the next-generation epigenetic aging clock, CheekAge, and a variety of diseases and conditions. CheekAge serves as the foundation TallyAge Test, a non-invasive at-home buccal swab test offered by consumer longevity company Tally Health. Comparing Chee…
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Researchers here make inroads into mapping a relationship between EDA2R expression and age-related inflammation. They show that EDA2R expression robustly increases with age and correlates with inflammation in multiple tissues types in mice as well as in muscle biopsies from a human study. When overexpressing EDA2R in cells in culture, those cells…
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Tau protein becomes phosphorylated and aggregates into neurofibrillary tangles in the aging brain. This harms neurons, and along with inflammation is the dominant pathology in later stages of Alzheimer’s disease and other tauopathies. Researchers here engineer neurons to harbor each of the six possible tau isoforms, one by one, and demonstrate th…
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By Tarun Sai Lomte – News Medical Life Sciences – In a recent study published in The American Journal of Clinical Nutrition, researchers assessed associations between the intake of flavonoids and flavonoid-rich foods and aging outcomes in older adults. Aging results from the accumulation of cellular and molecular damage, leading to a gradual reduc…
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A chimeric antigen receptor (CAR) T cell has been genetically engineered to express a receptor that both binds to a desired target, such as a distinctive surface feature on a cancer cell, and activates the T cell once bound, provoking it into destroying the target. Making this technology into a therapy involves sampling a patient’s T cells, incor…
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In Molecular Therapy, a team of researchers has described how increasing the expression of a form of Klotho, a protein that has been frequently found to have rejuvenative effects, leads to longer lifespans in male mice. In their introduction, the researchers distinguish between the various forms of Klotho. The full mRNA sequence that generates …
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Last October, a new clinic quietly opened its doors in the heart of Berlin, with a mission to offer patients a unique approach to managing their health and longevity. Focusing on prevention and personalized care, YEARS is a full-service medical center designed to provide individuals with a holistic understanding of their health. Backed by the…
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The blood-brain barrier surrounds blood vessels passing through the brain and tightly controls which molecules are allowed to pass. It separates the metabolism of the brain from that of the rest of the body. With age, the blood-brain barrier becomes dysfunctional, allowing unwanted cells and molecules to leak into the brain, where they contribute…
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Dr. Priyom Bose, PhD – News Medical Life Sciences – New research pinpoints faulty branched-chain amino acid (BCAA) metabolism as a driving force behind sarcopenia, highlighting a potential pathway to slow muscle deterioration and improve aging health. A recent Nature Aging study uses multi-omics to identify the molecular and metabolic signatures o…
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Longevity.Technology recently announced the launch of its consumer products division, expanding its commitment to evidence-based longevity solutions. The division’s first product, FLT LONGEVITY, is formulated with a precise combination of clinically studied ingredients designed to support cellular function and enhance healthspan. A key co…
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Heart disease focused biotech Tenaya Therapeutics has announced the pricing of its public offering of 75 million new shares, expected to generate approximately $52.5 million in gross proceeds. Shares in the company fell sharply on the news, as it plans to allocate the net proceeds toward the advancement of clinical stage gene therapy candidat…
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The authors of a recent study describe Ginkgolide B, a compound with senotherapeutic potential that improved muscle health, metabolism, frailty, inflammation, and senescence metrics and increased lifespan in female mice [1]. Ginkgolide B is a compound that can be extracted from Ginkgo biloba, an East Asian tree known as the maidenhair tree. Pre…
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By Men’s Health – How “moderation in excess” might be the ticket to living longer and better—and how it helps to start now, no matter your age. Will there come a day when we can walk into a doctor’s office and walk out with pills that help us delay—if not reverse—the effects of aging? We […] The post ‘Healthspan’ Is Critical. Here’s How to Build …
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Nuritas, a Dublin-based biotech specializing in AI-driven peptide discovery, is set to introduce PeptiSleep, a plant-derived ingredient designed to support sleep across multiple phases. The ingredient will be showcased at this week’s Natural Products Expo West in Anaheim, California, where industry professionals will have the opportunity to e…
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A massive study from the University of Oxford has evaluated the relative impact of genetic and non-genetic factors on aging, mortality, and disease prevalence. The question of how strongly genes affect our longevity has been asked before, and the emerging answer is not very much [1]. Most of the variation in human lifespan seems to come from ex…
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The Founders Longevity Forum London (FLF:LDN) will return on 10th June 2025, at OXO2, one of London’s most striking riverside venues. Held during London Tech Week, the event, which is organized by Longevity.Technology and Founders Forum, will bring together a select group of founders, investors and industry leaders to explore the rapidly evol…
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De-extinction biotech Colossal Biosciences has announced a significant milestone in its mission to revive the woolly mammoth and other extinct species using CRISPR-based gene editing. The company today unveiled the Colossal Woolly Mouse, a genetically engineered mouse model that expresses multiple mammoth-like traits adapted for cold environm…
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by Helen Kirwan-Taylor – The Telegraph Health – The longevity business is booming and for high society, the quest for eternal life has become an expensive hobby Automatic doors open on to a cavernous lobby that could double as a spaceship. Reclining on white leather chairs are several young-looking men, glow-in-the dark intravenous drips attached …
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The Longevity Science Foundation (LSF) is thrilled to announce that it is organizing the Longevity Science Summit in Miami – the future hub of longevity sciences in the United States. The event will spotlight the latest advancements in healthy human longevity research and unite the local community for an evening of networking, collaboration, and c…
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Renowned healthy aging expert Dr Peter Attia has created a stir with the launch of preventive health and diagnostics clinic Biograph. Co-founded by Attia and tech entrepreneur John Hering, the clinic adopts a proactive healthcare model that prioritizes early detection and personalized care. Currently operating in the San Francisco Bay Are…
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February might be the shortest month of the year, but it still has room for plenty of research and advancements. Here’s what’s happened over the last four weeks. Junevity Is Silencing RNA to Treat Obesity and Diabetes: Some longevity biotech companies fit neatly into one of the big buckets we have in this field, like senolytics or cellular repr…
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By Business Wire – Junevity, a biotechnology company on a mission to extend lifespan and healthspan by resetting cell damage from age-related diseases, today announced $10 million in seed funding led by Goldcrest Capital and Godfrey Capital. Founded by a team of experts in aging biology, machine learning and drug development and based on pioneerin…
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“You need to tackle the foe [type 2 diabetes] by addressing more than one leg of the stool at a time.” —Peter Attia The post #338 ‒ Peter’s takeaways on aerobic exercise and VO2 max, insulin resistance, rising healthcare costs, treating children with autism and ADHD, and strength training | Quarterly Podcast Summary #4 appeared first on Peter Att…
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New results add to mounting evidence that high-risk HPV types negatively impact male fertility, underscoring the importance of vaccination in both sexes The post Concerning links between human papillomavirus (HPV) infection and male infertility appeared first on Peter Attia. …
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Researchers publishing in Cellular Signaling have explained how the protein AP2A1 affects stress fibers that change with cellular senescence. Why We Age: Cellular Senescence As your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit potentially harmful …