Kiyoko Ishiguro was born in Tokyo on March 4, 1901.
She worked as a midwife from her thirties to around seventy, and after she retired she lived in Hiratsuka City.
When she fell ill in June 2015, she recovered after two months after eating her favorite food, eel. Another one of her favorite foods was salted Senbei.
According to her daughter, Aiko Harada, her older brother and her older sister also lived to be over 100 years old.
In her last years, she used a breathing tube. Kiyoko Ishiguro died on 5 December 2015 at the age of 114 years, 276 days. She was succeeded as the oldest living person in Kanagawa Prefecture by Chiyo Miyako.