Pritchett was born as Charlotte Elizabeth Harper in Marengo County, Alabama, USA, on 8 February 1875, although she claimed to have been born in 1866. Her father, a South Carolina native, descended from the Cherokee tribe, while her mother, born in North Carolina, descended from the Creek tribe. Her daughter claimed that her father lived to be 104, and her mother reached 116. They were bought and sold, and eventually ended up in Marengo County where their children were born. Apart from Charlotte, they had two sons and five daughters.
It was reported she married General Pritchett sometime in the 1880s. The couple had 13 children. Her husband passed away in 1938, in his 70s.
At the time of her claimed 119th birthday (more likely 110th) in February 1985, she had 41 grandchildren, 104 great-grandchildren, and 132 great-great-grandchildren. At the time, she was almost completely blind, and was grappling with both diabetes and a heart condition. It was reported that she never smoked.
Pritchett passed away in Dixons Mill, Marengo County, Alabama, USA, on 24 December 1985. Reports indicated that she underwent gallbladder surgery before her passing.