De los Bueis Rodríguez was born in Becerril de Campos, located in the province of Palencia in Castile and León, on 6 July 1900. She was married and had seven daughters.
After being widowed in around 1962, De los Bueis Rodríguez moved to Barcelona. In her later years, she lived in a nursing home in the city. On her 106th birthday, she claimed that working and eating a lot was the secret to her longevity.
De los Bueis Rodríguez died on 8 July 2010 at the age of 110 years, 2 days.
De los Bueis Rodríguez’s age was verified by Emilio Ibáñez, David Guarnizo, and Miguel Quesada, and was validated by the GRG on 18 August 2014.