Irene Mafalda Cinquegrani was born in Scranton, Pennsylvania, USA on 4 February 1911. Her parents were Italian immigrants Pasquale Cinquegrani and Rosalia “Lena” Martellaro. She had four siblings: Grace Tellie, Josephine Andriole, Vincent and Robert. She grew up on Robinson Street, in the Hyde Park section of Scranton. She first attended St. Francis Cabrini Elementary School, then Scranton High School, and subsequently graduated from Lackawanna Business School.
After graduating, she started working at Community Chest. Two years later, she started working as a bookkeeper at Northeastern National Bank. She retired after 38 years of service. She never married nor had children.
Irene Cinquegrani passed away in Scranton, Pennsylvania, USA on 16 February 2021, at the age of 110 years, 12 days.
Her age was validated by LongeviQuest on 19 May 2023.