Updated 8:45pm | April 21, 2025
6 hours
About a decade ago, researchers developed a way to use magnetic resonance imaging (MRI) to measure the passage of fluid through channels leading from the brain into the body. One can use MRI to assess the diffusion of water molecules in many small volumes of scanned tissue. If there is a flow, then it appears as though the “diffusion” is biased i…
8 hours
In Aging Cell, researchers have linked macrophage senescence to the failure of new blood vessel formation, finding a key target that might make it easier to treat arterial clogs. Heart attack and stroke are not the only problems caused by clogged and unusable blood vessels; when this occurs in the extremities, it is known as peripheral arterial…
9 hours
Last week at Abu Dhabi Global Health Week, a new initiative was announced that seeks to transform both the region’s life sciences ecosystem and its leadership in longevity science and medicine. Officially known as the Health, Endurance, Longevity, and Medicine (HELM) cluster, the initiative revolves around the creation of an economic cluster …
9 hours
A new study published in the Journal of Cosmetic Dermatology has examined the effects of a topical formulation containing OS-01, a senotherapeutic peptide, on skin barrier function and systemic biomarkers of aging. The pilot trial, led by researchers from OneSkin and academic collaborators, explored whether treating the skin could deliver mea…
14 hours
Aged tissues are characterized by increased levels of oxidative stress, meaning the generation and presence of more oxidizing molecules than cells can comfortably handle. A major source of oxidizing molecules is the activity of mitochondria, and an increase in this production of oxidizing molecules is one of the reasons why mitochondrial dysfunct…
14 hours
Researchers here find that one of the protein components of nuclear pore structures has an independent function in regulating the response to nutrient sensing. As is now well known, low nutrient availability resulting from reduced calorie intake triggers a range of adaptive responses that collectively act to slow the progression of aging. Evidenc…
14 hours
By Junaid Mian – LinkedIn – Ever notice how we talk about GLP-1s as “weight loss drugs” when they’re actually reshaping chronic disease treatment at its core? These breakthrough therapies aren’t just treating symptoms—they’re addressing the interconnected roots of diabetes, obesity, and cardiovascular disease all at once. The most exciting part? h…
20 hours
“I frequently focus on getting people back to a good quality of life and giving them control of their life and their pain, rather than a promise to eliminate pain. In the acute setting, often, it’s eliminating pain.” —Sean Mackey The post #345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery | Sean Mackey, …
1 day
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.or…
2 days
For the first time in over 20 years, a new class of drug has been approved for pain, representing a step forward for better pain management for many. The post Expanding the toolkit for managing acute pain appeared first on Peter Attia. …
It’s not uncommon to develop fine lines and wrinkles with age, and many turn to treatments like Botox to disguise the signs of aging. But what if you could achieve smoother, plumper, more youthful-looking skin and support your overall longevity simply by changing what’s on your plate? A science-backed, anti-age diet may help target the root causes…
You can’t open a beauty magazine or social media app today without encountering content touting the benefits of collagen. From powders to drinks, collagen supplements offer the promise of smoother and more voluminous skin, reduced fine lines and wrinkles, and an overall reduction in the signs of aging. But does collagen help with wrinkles — or is …
3 days
To what degree is the burden of senescent cells in the tissues of old or obese people dynamic, capable of being reduced by circumstances? Cells become senescent constantly throughout life, and are then cleared by the immune system or destroy themselves via programmed cell death mechanisms. That clearance falters with advancing age, however. We mi…
3 days
A new longevity-focused investment firm has entered the arena, as Seveno Capital officially launched this week. Backed by a $70 million commitment from its founder, entrepreneur Allen Law, the Singapore-based firm is on a mission to invest in early and growth-stage ventures that support the extension of human healthspan. In addition to be…
3 days
At a time when mainstream interest in longevity is growing at a rapid pace, there’s a critical role to help people navigate unprecedented levels of health insight. Everyone has a sea of data they could access about their body. The rise of wearable tech and self-testing has, of course, fuelled this over recent years, and we’re now entering…
3 days
The ability of PF4 to reduce chronic inflammation and restore some degree of lost function in the aging brain has been a topic of interest for a few years now. We’ll likely be hearing much more in the years ahead as researchers move from investigation to attempts to build therapies based on the direct upregulation of PF4 expression. That said, on…
3 days
By CNN – The hunt for cancer-combatting antibodies normally relies upon human lab scientists combing through vast amounts of data. LabGenius’ automated AI robotic system has disrupted that process. Using machine learning, their model has pushed through the human cognition barrier to design, conduct and learn from its own experiments, allowing the …
3 days
Given sufficient sensitivity and the right target, many age-related conditions could be detected in their earliest, pre-symptomatic stages. Early detection offers a greater opportunity to change course to slow progression, even with the techniques of today. Here, researchers note a specific transfer RNA fragment that appears in the context of Par…
4 days
Senescent cells accumulate with age in all tissues, including skin. These errant cells secrete inflammatory signals that degrade tissue structure and function when sustained for the long term. OneSkin is one of the earlier longevity industry companies, built on the development of a senotherapeutic compound called OS-01. The founders chose to take…
4 days
Last month, financial services giant Manulife announced a new longevity focused initiative with the World Economic Forum, with a focus on addressing the profound demographic shifts occurring across Asia. The “Innovating for Asia’s Demographic Future” challenge seeks to catalyze solutions that enable long-term financial resilience and well-bei…
4 days
A sizable body of evidence demonstrates that exposure to particulate air pollution correlates with an increased risk of neurodegenerative conditions and cognitive decline with age. The most plausible biological explanations revolve around the harmful downstream effects of increased inflammation resulting from the interaction of particles with cel…
4 days
The evidence for long term exposure to forms of air pollution to increase the risk of age-related disease and mortality is quite compelling, including large studies in very similar populations with different levels of exposure. The important underlying mechanism is likely increased chronic inflammation deriving from the interactions of respirator…
4 days
By Smriti Mallapaty – Nature – Induced pluripotent stem cells are being tested to treat blindness, paralysis, Parkinson’s disease and more. Approvals might be around the corner. Japan is brimming with signs of an approaching medical revolution. Shiny white robots are tending dishes of cells, rows of incubators hum in new facilities, and a deluxe, …
5 days
This is where the world’s top innovators, thought leaders, entrepreneurs, and investors come together to build a better world with synthetic biology. Join us in San Jose as we explore how synbio is transforming industries from healthcare, agriculture, biomanufacturing, and more. This year, we are excited to spotlight the rapidly developing interse…
5 days
Researchers publishing in Aging Cell have used large databases to discover a causal relationship between multiple genes and overall mortality risk, finding a new potential target in the process. These researchers introduce their study by discussing genetic databases, which have previously been used to determine associations of specific genes wi…
5 days
There may be a tendency for the unfit to look at the fit and feel somewhat hopeless, that a mountain lies between where they stand in unfitness and any benefits that might result from exercise. In fact, the data on exercise and measures of health suggests quite the opposite. The further removed from the pinnacle of fitness one stands, the more on…
5 days
By Adrienne B. Mendoza, MHA – LinkedIn – The infrastructure behind Advanced Therapies is deeply rooted in global supply chains, and that foundation is shifting. With new U.S. tariffs taking effect and global trade tensions escalating, cell and gene therapy programs are facing renewed pressure to protect continuity — the seamless, dependable flow o…
5 days
In a move that signals both the ambitions of Abu Dhabi’s life sciences sector and the evolving global approach to aging, M42 has announced a strategic investment and partnership with clinical-stage biotech company Juvenescence. The collaboration – unveiled during Abu Dhabi Global Health Week – combines M42’s AI and genomic platforms with Juve…
5 days
RAADfest is the world’s largest and most immersive gathering dedicated to super longevity and radical life extension. Celebrating its 10th anniversary this year, RAADfest 2025 will take place from 10th to 13th July at the Red Rock Casino Resort and Spa in Las Vegas. More than just a conference, RAADfest is a dynamic fusion of cutting-edge sci…
5 days
After 83% of longevity clinics in our recent survey revealed that they offer their clients guidance on supplementation, personalized supplements company Bioniq has announced a partnership with Remedy Place, which describes itself as the world’s first “social wellness club.” The collaboration merges Bioniq’s AI-powered, blood biomarker-bas…
5 days
The inflammatory signaling produced by senescent cells is harmful when sustained over the long term, and the number of these cells grows with age. Much of the signaling produced by cells is carried in extracellular vesicles, and here researches identify CAP1 as a important cargo in senescent cell extracellular vesicles that accelerates dysfunctio…
5 days
The immune system of the central nervous system is distinct from that of the rest of the body, although there is a great deal of direct and indirect cross-talk between the two. The innate immune cells known as microglia are the central nervous system version of macrophages, and are involved in defense against pathogens, clearance of metabolic was…
6 days
Elastin is an important component of the extracellular matrix in flexible tissues. It is, as the name might suggest, necessary for tissue elasticity. Elastin fibers in the extracellular matrix become damaged with age, and this process is thought to be important in a number of ways, not just because it alters the structural properties of the tissu…
6 days
Researchers have tested a synthetic and natural senolytic combination of RG-7112 and o-vanillin in mice with early-onset low back pain and disc degeneration. They observed reduced signs of back pain; decreased senescence and disc degeneration; and improvements in vertebral bone quality [1]. Globally, low back pain is responsible for the most ti…
6 days
Earlier this year, we brought you the story of General Proximity, which emerged from stealth with $16 million to advance the development of next-generation “induced proximity” medicines. The company’s technology leverages the concept of biological proximity – the interaction or nearness of macromolecules – to precisely control molecular inter…
6 days
We might think of medicine as largely a matter of exerting control over cells, beginning with changing their behavior in defined ways, and moving on to creating cells and complex structures made of cells as needed. For all that this is an age of biotechnology, the research community has yet not advanced all that far along this road. Present capab…
6 days
Researchers here look at differences in life expectancy by income over the period of time in which obesity emerged to became a major issue. Recall that income, wealth, status, education, intelligence, and life expectancy all tend to correlate with one another, and identifying the arrow of causation is a challenge. Researchers found that the diffe…
1 week
It’s a scientist’s dream: a database that contains enormous amounts of genetic information on hundreds of thousands of people, plus biological and clinical data, and thousands of characteristics measured from those same people, all freely available to approved researchers worldwide. Such a remarkable tool exists in the UK Biobank, and Buck r…
1 week
Neurogenesis is the process by which new neurons are created from neural stem cell populations, then mature, migrate, and integrate into neural circuits. This is necessary for memory, learning, normal tissue maintenance in the brain, and the small degree of regeneration from injury the brain is capable of. Neurogenesis declines with age, for a ra…
1 week
The search for pharmacological interventions that may extend healthspan has increasingly turned toward repurposing existing therapeutics; among these, rapamycin – an mTOR inhibitor initially developed as an immunosuppressant – has emerged as a compound of interest within geroscience. The PEARL trial (Participatory Evaluation of Aging wit…
1 week
In Aging, Dr. Sajid Zalzala and his team have published the results of Participatory Evaluation of Aging with Rapamycin for Longevity (PEARL), a randomized, controlled human clinical trial that was crowdfunded by Lifespan.io. Rapamycin: Benefits, Side Effects, and Research Rapamycin is a macrolide, a class of antibiotic and it exhibits potent …
1 week
The PEARL trial of rapamycin was crowdfunded by Lifespan.io, something that we should see happen more often, at a much larger scale, for all of the presently available low-cost treatments that might influence aging. While results were initially published late last year, the researchers have had some months since then to refine the paper and furth…
1 week
Some lower animal species are capable of exceptional feats of regeneration. Planarians are capable of regrowing an entire new body after being cut in half, for example. One way of thinking about this is that some of these species blur the line between developmental growth and regeneration. Adults make continued use of processes that occur during …
1 week
By Serafina Kenny – Business Insider – Professor James White researches whether restricting our calories could help us live longer. He practices caloric restriction in his own life — in a safe and sustainable way. White shared how he does this, plus his other habits for a long, healthy life. A scientist who studies whether […] The post A scientis…
1 week
“Higher addiction potential occurs with the higher the concentration, the faster absorption, and the greater the total consumption.” —Peter Attia The post #344 – AMA #70: Nicotine: impact on cognitive function, performance, and mood, health risks, delivery modalities, and smoking cessation strategies appeared first on Peter Attia. …
1 week
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.or…
1 week
By David Nield – Science Alert – As we get older, the essential cleaning processes that our brains need to keep functioning start to break down and fail. In new research, scientists have figured out how to boost waste removal cycles in the brains of mice – with dramatic effects on their memory. Led by […] The post Clearing Brain Waste Dramaticall…
1 week
Links between erectile dysfunction and cardiovascular health provide more reason not to ignore sexual health concerns The post Erectile dysfunction as an indicator of cardiovascular health appeared first on Peter Attia. …
1 week
Subsense is developing a groundbreaking, non-surgical brain-computer interface (BCI) that leverages nanoparticle technology to read from and write to the brain. With a dual-system approach using plasmonic and magnetoelectric nanoparticles, Subsense aims to deliver a new standard in neurotechnology – bypassing traditional surgical implants to …
1 week
By tweaking genes used by placental and cancerous cells to evade immune detection, scientists have created non-immunogenic neuronal grafts that may help Parkinson’s patients [1]. In recent years, scientists have learned to produce cells via cellular reprogramming, a process in which differentiated cells are driven back to a pluripotent, stem-li…
This Hearty Vegetable Soup is part of a series of recipes exclusively developed for NOVOS, following the principles of the NOVOS Longevity Diet. While many recipes online cater to specific dietary protocols—like keto, carnivore, or vegetarian—these recipes are designed to focus solely on promoting longevity and building your health for the long te…
This Veggie Breakfast Skillet is part of a series of recipes exclusively developed for NOVOS, following the principles of the NOVOS Longevity Diet. This recipe provides a powerhouse of fiber, protein, and essential nutrients in one easy meal. The ingredients were selected to support long-term health, with a focus on promoting gut health, steady en…
1 week
by David Shaywitz – Timmerman Report – Dying, with few exceptions, has never been especially popular, and our shared interest in not dying hardly constitutes breaking news. Nevertheless, the aspiration of living longer — and remaining healthier while doing it — appears to be all the rage. Consider these recent headlines: “Why is longevity sudden […
1 week
Experimenting on rodents, researchers have found a pathway through which exercise could fight Parkinson’s disease and a molecule that might recapitulate this effect. Parkinson’s disease is characterized by Lewy bodies and the loss of dopaminergic neurons [1]. Recent work has found that this degeneration is related to neuroinflammation: the incr…
1 week
by Corrie Pelc – Medical News Today – With people living longerTrusted Source than ever, we all want to know the secrets to healthy aging. Previous research has shown that certain lifestyle factors like not smoking, limiting alcohol useTrusted Source, exercising regularly, getting enough sleep, and eating healthy all play a role in healthy aging. …
1 week
Brain health tech company MYndspan has announced a strategic investment from wearable neurotech firm EMOTIV as the companies seek to combine their technologies for proactive brain health assessment. The investment comes as MYndspan kicks off a crowdfunding campaign on Crowdcube. MYndspan is a developer of consumer-accessible clinical-grad…
1 week
US biotech Serina Therapeutics has announced the completion of a $5 million financing round supported by strategic shareholders to advance its lead clinical candidate into clinical development for the treatment of advanced Parkinson’s disease. The company plans to initiate a Phase 1 clinical trial in the fourth quarter of 2025. Serina’s l…
1 week
A team of scientists has identified a mitochondrial membrane protein – TMEM65 – as a key player in maintaining cellular calcium balance, with potentially wide-ranging implications for the treatment of cardiovascular and neurodegenerative diseases. The findings, published in Nature Metabolism, describe how TMEM65 regulates NCLX, the mitochondr…
1 week
A recent study investigated the impact of eight different mid-life dietary patterns on the odds of healthy aging, including cognitive, mental, and physical health [1]. Diet is an easily modifiable intervention in aging, as what we eat has a tremendous impact on our health. There is a wealth of evidence that good diets can be beneficial in preve…
1 week
By Joseph Coughlin – Forbes – The recent passing of Gene Hackman and his wife Betsy Arakawa reveals a profound truth about our current approach to later life. Their deaths—occurring days apart and discovered only by chance—serve as a stark reminder that our current conception of retirement planning is dangerously incomplete. By nearly any standard…
1 week
A new study has found that the immune remodeling associated with fasting can be recapitulated by activating a subset of neurons in the hypothalamus. The findings could be important in the context of fasting mimicking, metabolic disorders, and cancer [1]. Decades after the modern field of geroscience was born, caloric restriction still holds the…
1 week
South Korean biotech ABL Bio has entered a licensing agreement with pharma giant GSK to develop new treatments for neurodegenerative diseases based on its bispecific antibody technology. The collaboration centers around ABL Bio’s proprietary Grabody-B platform, which is designed to address a key challenge in neurological drug development: the…
1 week
A serendipitous discovery made while caring for dolphins has led to a renewed interest in an unexpected nutrient – pentadecanoic acid, or C15:0 – which is now the subject of a new book claiming it may be critical to healthy aging. In The Longevity Nutrient: The Unexpected Fat That Holds the Key to Healthy Aging, Dr Stephanie Venn-Watson,…
1 week
Ora Biomedical, in partnership with Rapamycin Longevity Lab, announces the successful funding of the first subproject under its ambitious initiative to conduct a rapid lifespan analysis of 601 mTOR inhibitors in roundworms. With $50,000 secured, Ora Biomedical will now commence the next phase of the first subproject. This will be a high-throughp…
1 week
By Mayo Clinic Press Editors – The obsession with anti-aging skincare has many of us searching for the secret to looking younger. But our skin isn’t just about appearance—it’s a vital barrier against infection and plays a key role in regulating body temperature. In this episode of Aging Forward, Dr. Saranya Wyles breaks down the […] The post Skin…