Longevity News

What can be found in a human blood sample that either correlates with or predicts exceptional healthspan or lifespan? Quite the variety of research efforts touch on this question, from the development of aging clocks to the construction of omics databases for blood and tissue samples taken from centenarians. People age as a result of the same und…

Health optimization technology company Ultrahuman has partnered with health analytics platform InsideTracker to enhance cardiovascular health for US consumers. By leveraging insights from both platforms, the collaboration seeks to empower individuals with actionable data tailored to their unique physiology. The partnership introduces Bloo…

Researchers publishing in Physical Review X have discovered compounds that can double the efficiency of the sirtuin SIRT3 in processing NAD+. The researchers begin their paper by noting that most drugs administered to people are geared towards inhibition of particular enzymes in order to treat a disease. In this case, however, the goal is the o…

It is shaping up to be a big year for Alzheimer’s diagnostics, as blood-based biomarkers continue to demonstrate significant potential to change how the disease is detected. By providing a simpler alternative to the current standards for Alzheimer’s testing, it is hoped that blood tests will transform the diagnostic process by reducing the ne…

Researchers here review the evidence for age-related loss of mitochondrial function to contribute to degenerative disc disease. It is certainly a contribution, but as for every aspect of aging it is very challenging to determine how important any given contribution is versus all of the others. So yes, mitochondrial quality control falters with ag…

In mice, senolytic therapies to clear senescent cells seem such a panacea for age-related conditions that it is always interesting to see evidence for an aspect of aging that is not helped by removal of a portion of the burden of lingering senescent cells. Here, researchers show that senolytics do nothing to help aged mice resist influenza infect…

By Julia Pugachevsky – Business Insider – Brain aging accelerates at three specific points in your life, according to a recent study. The researchers looked at brain images of over 10,000 healthy adults, then tracked blood protein changes in half of them to look for “brain age gap” (BAG), a sign of cognitive aging. Their findings, published in …

Founders Longevity Forum Singapore, hosted in collaboration with the National University of Singapore (NUS) Academy for Healthy Longevity, Yong Loo Lin School of Medicine, and Longevity.Technology is set to host a pivotal two-day event on 27-28 February 2025, in Singapore. This forum aims to advance knowledge and foster growth in the rapidly evolv…

Senescent cells are created constantly throughout life, largely as somatic cells reach the Hayflick limit on replication, but also in response to cell damage and stress. In youth, the immune system rapidly removes these cells. With age, immune clearance falters and lingering senescent cells grow in number in tissues throughout the body. These cel…

A recent study linked probiotic-induced gut microbiome and metabolite changes to improved muscle functioning in older sarcopenia patients [1]. Sarcopenia is an age-related condition. People with sarcopenia suffer from a reduction in muscle mass, strength, and function, leading to a decreased quality of life and increased morbidity and mortality…

Less than a year after it emerged from stealth with $35 million in funding, Paris-based AI startup Bioptimus has announced a fresh cash injection of $41 million to accelerate its development of AI foundation models for biology. The company is on a mission to develop the first “universal AI foundation model” for biology as it seeks to enhance …

Hypertension is often called the “silent killer.” This guide covers how to monitor blood pressure, who’s at highest risk, and how best to manage it. The post All things blood pressure: from measurement to management appeared first on Peter Attia. …

Epigenetic clocks assess data derived from a bulk set of cells derived from tissues. This will be a mix of cells of different types and subpopulations, and thus some portion of age-related changes might be due to shifts in the relative numbers of these cell types. This has already been explored to some degree in the context of white blood cells i…

Cells react to the state of the extracellular matrix that they reside in. Changes to the molecules of the extracellular matrix do take place with age, and as a whole this aspect of aging is comparatively poorly studied and understood. Researchers here characterize one specific molecular alteration of extracellular matrix molecules that is found i…

By Tracy Swartz – The New York Post – Tech billionaires are pouring massive amounts of their fortune into the bitter battle to be the best Benjamin Button, propelling the market for life-extending therapeutics into a $25 billion business. OpenAI CEO Altman, 39, and Amazon founder Bezos, 60, have shelled out millions in recent years to longevity …

Evidence points to increased autophagy as an important factor in many of the interventions that slow aging to extend life in short-lived laboratory species such as flies, worms, and mice. Autophagy is a collection of cellular maintenance processes responsible for clearing out excess and damaged structures in the cell, transporting them to a lysos…

Nanomedicine company Ashvattha Therapeutics has announced an extension of its Series B financing, securing up to $50 million to advance its clinical-stage hydroxyl dendrimer therapeutics (HDTs) in ophthalmology, neurology and inflammatory conditions. The funding, led by Tribe Capital alongside existing investors including Natural Capital, wil…

The Gulf Cooperation Council (GCC) region is currently experiencing significant economic growth and demographic shifts. The population across these nations has surged to nearly 60 million, and this growth is accompanied by a youthful demographic profile; in 2021, over 50% of the local population in GCC countries was under 25, while the propor…

In a preprint study, scientists from Lifespan Research Institute and the Buck Institute for Research on Aging have published their findings that Urolithin A, a molecule that has garnered a lot of attention in the longevity field, potently reduces senescence-related markers in human fibroblasts [1]. Senolytic versus senomorphic Cellular senescen…

Most epigenetic clocks are produced by applying machine learning techniques to DNA methylation data derived from immune cells in reference blood samples taken from individuals of various ages. A clock is just an algorithm based on the fraction of genomes in the sample that are methylated at a number of specific Cpg sites. It is not too surprising…

The aging of the immune system is clearly an important factor in degenerative aging as a whole. The immune system does much more than merely defend the body against pathogens and potentially harmful malfunctioning cells. It is also intimately involved in tissue maintenance, tissue functions, and regeneration from injury. All of this suffers when …

By Bruce Gil – Quartz – Google’s anti-aging company Calico released disappointing trial results of its first ever drug. Calico’s fosigotifator was tested for amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease that affects nerve cells in the brain and spinal cord and leads to paralysis. It was part of the HEALEY ALS Platform …

Cyclarity Therapeutics, a biotechnology company based at the Buck Institute in California, has launched its first human clinical trial. Its primary candidate cyclodextrin drug, UDP-003, focuses on 7-ketocholesterol, an oxidized cholesterol variant that builds up in cells as we age. Atherosclerosis involves the accumulation of plaque within arter…

In principle one could develop rejuvenation therapies without a way to measure the overall state of biological age. Each of the underlying causes of aging is measurable today: senescent cell burden, mitochondrial dysfunction, presence of amyloids, and so forth. Therapies can be assessed for efficacy in terms of the degree to which they repair the…

Epigenome editing company Tune Therapeutics has secured more than $175 million in Series B financing to advance its “genetic tuning” platform and associated therapeutic programs. Founded in 2021, the company’s approach is focused on “activating, silencing, and fine-tuning the output of specific genes to reverse cellular dysfunction and diseas…

The Founders Longevity Forum Singapore is just around the corner! This highly anticipated two-day event will bring together leading experts from science, healthcare, and investment to explore innovative breakthroughs and actionable strategies for promoting healthy aging. As global interest in longevity continues to soar, the forum will spotli…

Researchers have discovered that intermittent fasting increases myelin in aged mice, leading to better neural function and coordination. Normally, neuronal axons are coated in a protein sheath made of myelin, which is necessary for their proper function [1]. Myelination is most known to be impeded by multiple sclerosis, but it also decreases wi…

By Medical  News Today – While some studies have shown a link between insufficient sleep and the risk of cognitive impairment and dementia, other studies have failed to find a similar association between sleep duration and cognitive function. A new study published in the Journal of the American Heart AssociationTrusted Sourceshows that indi…

Frailty is a state of chronic inflammation, immunosenescence, physical weakness, and reduced resilience to stresses. It is the outcome of a high burden of the cell and tissue damage of aging, and all of the downstream consequences of that damage. Frailty is well known to correlate with an increased mortality risk, and the study here is one of man…

In the northern hemisphere, mortality increases in the winter. This is in large part because influenza is a winter phenomenon, and old people are vulnerable to infection and downstream consequences of infection. Cold weather provides a number of opportunities beyond infection for additional stresses to be placed on an aged body, however. An impor…

“Sometimes it makes it more universally easy to understand if we think of what kind of sport we do as a function of intensity and duration.” —Olav Aleksander Bu The post #331 ‒ Optimizing endurance performance: metrics, nutrition, lactate, and more insights from elite performers | Olav Aleksander Bu (Pt. 2) appeared first on Peter Attia. …

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.or…

A recent study highlights the association between blood pressure medications and risk of falls and fall-related injuries, but we can take steps to offset the danger The post A link between antihypertensive medications and fall risk reminds us to take precautions appeared first on Peter Attia. …

Senescent cells are created constantly throughout life, but are rapidly removed by the immune system. Only in later life does the efficiency of immune clearance falter to allow senescent cells to accumulate. Lingering senescent cells cause harm in proportion to their numbers, secreting inflammatory signals that disrupt tissue structure and functi…

Backed with a whopping $200 million in funding, US biotech Tenvie Therapeutics has launched to advance new treatments for neurological, cardiometabolic and ophthalmic diseases. Based in South San Francisco, the company has acquired small-molecule programs and its discovery team from Denali Therapeutics as it seeks to develop therapies that re…

Laurence Ion and Niklas Anzinger, co-founders of Vitalia, have announced they are separating their efforts into two distinct ventures in a move that aims to best fulfill their respective visions for advancing biomedical innovation through regulatory frameworks. While Ion will head Viva City, focused on establishing a city governed by its resi…

Mitochondria are the power plants of the cell, producing chemical energy store molecules used to power cell activities. Energy hungry tissues such as muscle and brain are particularly sensitive to differences in mitochondrial function. Here, researchers show in a human study population that better mitochondrial function in muscle tissue correlate…

Numerous research groups are investigating the cellular biochemistry of highly regenerative species such as salamanders and zebrafish. The goal is to find the differences that ensure regrowth of lost tissue rather than the scarring that occurs in mammals. So far, many of these differences appear to involve the continued operation of processes of …

By News Medical Life Sciences – Researchers from Trinity College Dublin have collaborated with international partners to explore if societal inequality affects our brain. Their research paper is published in Nature Aging today, [Friday, December 27th] by an international team of researchers from the Multipartner Consortium to expand dementia rese…

Cyclarity Therapeutics is pleased to announce regulatory approval to begin its first-in-human clinical trial. The trial will be conducted at CMAX, one of Australia’s leading clinical research centers, in partnership with Monash University. This effort will be led by Dr. Stephen Nicholls of the Victorian Heart Institute (VHI), a distinguished leade…

Rate of living theories of aging emerged from the observation that metabolism is generally slower in larger, longer-lived species. There are enough exceptions to disprove any specific hypothesis regarding what exactly might limit life span in species with a fast metabolism, however, and for this and other reasons rate of living theories fell to t…

In a journal called Small, researchers have described a new targeting mechanism for delivering senolytic compounds where they need to go. Why we Age: Cellular Senescence As your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit potentially harmful chem…

Swiss biotech MUVON Therapeutics today announced positive interim data from the Phase 2 clinical trial of its skeletal muscle tissue regeneration therapy. The ongoing SUISSE MPC2 study is assessing the safety and efficacy of MUVON’s muscle precursor cell (MPC)-based therapy for the treatment of stress urinary incontinence in women. The in…

By Open to Debate – Audio Podcast –  How long would you like to live, and could science and technology make it possible? Longevity science aims to extend our healthy years through advancements in CRISPR, cellular reprogramming, and drug development. While private companies and philanthropists invest heavily in these innovations, should the govern…

The nucleolus structure of the cell is where ribosomes are built, but it appears to be influential in a range of mechanisms relating to stress response, quality control, and damage repair in cells. All of these are in turn linked to pace of aging. The relationships are by no means fully understood in detail, however. This is an area of ongoing ex…

A variety of epidemiological data argues for a role for persistent viral infection in the development of Alzheimer’s disease. This is disputed, however. Some conflicting data shows no signs of a relationship, which suggests that the situation is complicated. Mechanistically, persistent viral infections such as herpesviruses might accelerate the o…

Here’s Nathan Price’s approach to science in a nutshell: “What I am is relentlessly future-oriented. I love seeing what’s the next possibility. I want to be in the fast lane, not the slow lane.”  Price comes to the Buck as a professor and Co-Director of the Center for Human Healthspan with a big-deal objective:  Change medicine from reactive “s…

By Susan Buckles – Mayo Clinic – Rochester, Minn. — People around the globe are living longer — but not necessarily healthier — lives, according to Mayo Clinic research. A study of 183 World Health Organization (WHO) member countries found those additional years of life are increasingly fraught with disease. This research by Andre Terzic, M.D., P…

Atherosclerosis is the growth of fatty plaques in blood vessel walls, eventually growing to the point of narrowing vessels to reduce blood flow. Rupture of a plaque can cause a downstream blockage, and this is the cause of heart attack and stroke. As a result, atherosclerosis is the largest cause of human mortality. This remains the case even tod…

Precision medicine company Maze Therapeutics has filed for an initial public offering (IPO) with the Securities and Exchange Commission. The San Francisco-based company focuses on developing novel, small molecule precision medicines for renal, cardiovascular and related metabolic diseases, including obesity. Founded in 2017, Maze company …

In a new study, researchers have found that lithocholic acid, a metabolite found in the serum of calorically restricted mice, can mimic the effects of caloric restriction [1]. Caloric restriction without malnutrition improves healthspan and extended lifespan in multiple model organisms and has been found to have health benefits in human studies…

Vitalia co-founders Niklas Anzinger and Laurence Ion today announced that they will be leading two new, separate organizations, Viva City and Infinita City. “Together, we built Vitalia from the ground up, establishing a foundation that has led us to this exciting new chapter,” said Anzinger and Ion in a joint statement. “This decision stems from…

Telomir Pharmaceuticals, a pharmaceutical company specializing in age-reversal science, has announced findings from a preclinical study that demonstrate the potential of Telomir-1 to restore lifespan and normalize accelerated aging in models of progeria, a rare genetic condition. Conducted in collaboration with Nagi Bioscience, the research u…

A new advisory by the US Surgeon General highlights a topic that – as the document itself notes – has been flying mostly under the public’s radar: the relationship between alcohol consumption and cancer. While most people are aware of smoking and obesity being risk factors for cancer, apparently, less than half of Americans know that a growing bod…

Danish biotech Vesper Bio has commenced a Phase 1b/2a proof-of-concept study to evaluate its investigational small molecule drug in patients with genetic mutations that lead to frontotemporal dementia (FTD). The SORT-IN-2 trial focuses on asymptomatic individuals with progranulin gene (GRN) mutations, a causal factor in FTD(GRN), a fatal vers…

By Eleanor Garth – Longevity.Technology – Dr Eric Verdin of The Buck Institute for Research on Aging on finding the longevity sweet spot between realism and optimism. The longevity field was stirred in October 2024 by a provocative paper published in Nature Aging titled The Implausibility of Radical Life Extension in Humans in the 21st Century….

The countdown to the Founders Longevity Forum Singapore has begun! Set to gather top minds from the worlds of science, healthcare and investment, this two-day event next month will delve into groundbreaking research and practical solutions for healthy aging. As interest in longevity accelerates worldwide, the forum aims to drive meaningful di…

Growing up with an alcoholic parent, I developed a complicated relationship with alcohol. It seemed like it could only go one of two ways – either join in or become repulsed by it. When I lived in Switzerland, I did enjoy drinking fine wines but found cheap wines left me feeling like I’d actually been poisoned! It didn’t take me long to rea…

Raghav Sehgal, PhD, Scientific Principal at LongevityTech.fund and Director of Bioinformatics at Healthy Longevity Clinic, has been named to the prestigious Forbes 30 Under 30 list for 2025. This recognition highlights Sehgal’s significant contributions to aging research and the application of computational biomedicine in addressing the globa…

San Francisco-based biotech General Proximity has emerged from stealth with $16 million in funding to advance the development of induced proximity medicines targeting ‘undruggable’ proteins associated with conditions such as cancer, cardiometabolic disease, neurodegeneration and longevity. Founded in 2019, the company aims to leverage the con…

In JCI Insight, researchers have explored the possibility of using gene therapy to restore a crucial protein and repair hearing loss. Hearing and its failure In mammals, afferent neurons, which originate from the inner ear, transform received stimuli (sound waves) into electrical signals [1]. This process is known as mechanoelectrical transduct…

“I really believe in bridging education, mental health, and medical. If you want to make an impact on child well-being and health.”‒ Trenna Sutcliffe The post #330 – Autism, ADHD, and Anxiety: Understanding the rise in autism and a multidisciplinary approach to diagnosis and treatment of each condition in children | Trenna Sutcliffe, M.D. appeare…

by Rockefeller University – Phys.org – If you looked at two snapshots of the same maple tree taken in July and December, you’d see a dramatic change from summer’s full green crown to winter’s bare branches. What those two photos don’t show you, however, is how the change occurred—gradually or all at once? In truth, deciduous trees tend to hold ou…

A spotlight on a few inspirational people doing amazing things in their 80s, 90s, and beyond  The post The endless possibilities of living well in your marginal decade appeared first on Peter Attia. …

The Roundtable of Longevity Clinics took place at the Buck Institute in California recently. Organized by the International Institute for Longevity, the event brought together leaders and innovators from all over the world intent on identifying effective diagnostics and recommendations for longevity-focused interventions, supplements, and t…