Longevity Science
Updated September 15,, 2026
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A few species of hydra are immortal in their normal environmental conditions, meaning that function does not decline over time and mortality risk does not increase over time. Researchers spent a good deal of time taking care of hundreds of hydra some years ago to demonstrate that this is the case. Hydra are lower animals, essentially a bundle of ...
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Dr Adil Khan didn’t set out to build a healthcare company in the US first. Tulu Health, the AI-driven platform he runs as CEO, started in India, then moved to the UAE, then Southeast Asia. Only now, after three prior markets, has it arrived in the country most people would assume comes first. There’s a reason for the detour. India, Khan s...
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Walk the floor of a nutraceutical trade show, and you’ll find plenty of companies promising the next big thing in healthy aging. What makes PhytoGaia’s pitch at Vitafoods Asia 2026 worth a second look is where its ingredients start: palm fruit, run through a formulation strategy that spans human skin, human livers and, increasingly, pet coats...
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Getting a drug approved is the easy half of the job. Getting someone else to pay for it is the half that actually determines who takes it. Canada just cleared that second, harder hurdle for LEQEMBI. On 31 August, Canada’s Drug Agency issued a final recommendation supporting public reimbursement of lecanemab for eligible patients with mild...
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Most young biotechs outsource their early research, borrowing lab time, equipment and staff from wherever they can get it cheaply. Rapalogix Health just did the opposite. The Carlsbad, California-based company, which is building a business around a still-emerging category it calls longevity-based skin health, has announced that it has opened ...
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Part of a ten-part series profiling each of the $101 million XPRIZE Healthspan competition’s Milestone 2 Awardees. Across the series, Longevity.Technology examines the science behind each team’s approach, the trial data supporting it and what stands between them and the competition’s final phase. Keisuke Goda has spent years thinking ...
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A little over a year ago, HexemBio was a single-idea company: take a patient’s own aging blood stem cells, briefly place them back in a lab-built version of the environment where the body first made them before birth, and return them rejuvenated. That idea is still the core of the business. However, the San Francisco-based company announced t...
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The U.S. Food and Drug Administration approved ISEMBYLD (apitegromab-mstn) to treat spinal muscular atrophy in adults and children aged 2 years and older who are receiving a survival motor neuron 2 targeted treatment. According to Scholar Rock Inc., approval was based on the Phase 3 SAPPHIRE study in which the recommended 10 mg/kg dose produced a...
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BioNTech and OncoC4 reported updated results from stage 1 of the PRESERVE-003 Phase 3 trial in previously treated metastatic squamous non-small cell lung cancer, showing gotistobart achieved a median overall survival of 18.5 months versus 10.0 months with docetaxel. The company claims the comparison corresponded to a hazard ratio of 0.56 with a n...
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Telomir announced a collaboration with The Ohio State University College of Veterinary Medicine, reporting preclinical in vitro findings that Telomir-Zn inhibited cell growth in human and canine osteosarcoma models. The study, conducted under Shay Bracha, evaluated Telomir-Zn across three cell lines HOS, D17 and Abrams and found dose-dependent an...
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Persistent infections such as cytomegalovirus and other herpesviruses most likely accelerate aging, primarily via harmful effects on the immune system that lead to earlier immunosenescence and chronic inflammation than would otherwise be the case. A range of mechanistic and epidemiological research broadly supports this hypothesis. It remains cha...
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Cells become senescent constantly throughout life in response to various forms of damage and stress, ceasing replication and generating a potent mix of inflammatory signals. In youth, these cells are promptly cleared by the immune system, but with advancing age they begin to linger and accumulate. The inflammatory signaling becomes disruptive to ...
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by University of California – Irvine – ScienceDaily – The 400-year-old Greenland shark may hold surprising secrets to keeping eyes healthy for a lifetime. Greenland sharks may live for 400 years without suffering the kind of retinal decline normally associated with aging. Researchers found healthy eye tissue and active proteins specially adapted f...
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One of these herbs you’d take at sunrise. The other you’d save for the hour before bed. Yet walk down any supplement aisle, and rhodiola rosea and ashwagandha sit side by side, filed under the same word: adaptogen. The label suggests they’re interchangeable, but they’re not. One revs you up for the day ahead; the other helps you power down at the...
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A team of researchers has discovered that mitochondrial health and location may be critical to why cognitive plasticity decreases with age. The adage ‘you can’t teach an old dog new tricks’ is true across a wide variety of organisms; neural plasticity decreases with age in rodents, non-human primates, and people [1]. This form of cognitive decli...
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Despite considerable and growing effort put towards the development of novel means to slow and reverse aging over the past thirty years, the longest lived laboratory mice remain those lineages first established in the 1990s with mutations that disable growth hormone metabolism, such as via knockout of growth hormone or growth hormone receptor gen...
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There’s a jar sitting on a lab bench in Strasbourg that isn’t for sale. That’s kind of the point. Core Biogenesis built it, alongside its Italian distribution partner Faravelli, purely to make an argument: that the same biotech doing serious work on faces could do just as much for the rest of the body, if anyone bothered to formulate it that ...
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It started, as these things sometimes do, with someone noticing a strange gadget at a dinner party. Deepinder Goyal, the entrepreneur behind Zomato, now running a health-tech startup called Temple, says he first met Dr Robert Mohr and Dr Avi Roy at a dinner in London a few months back, after the two noticed a device strapped to his temple and...
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Four late-breaking trials. Two European conferences, back to back. And a set of drug names – ralinepag, treprostinil – that don’t mean much to anyone outside a cardiology ward. That’s the unglamorous surface of what United Therapeutics just put in front of doctors at the European Society of Cardiology Congress in Munich and the European Respi...
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For a long time, the gut microbiome sat in the “probably relevant, hard to prove” bucket of aging science. That changed, officially at least, in 2023, when the widely cited framework describing the hallmarks of aging, the biological processes researchers broadly agree drive us toward decline, expanded from nine categories to twelve. Gut dysbi...
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There’s a cleanup job happening inside your cells right now, and most of the time you’d never notice it. Mitochondria wear out. When they do, a process called mitophagy is supposed to clear them away before they cause trouble. In Parkinson’s disease, that clearing job appears to stall – damaged mitochondria pile up, dopamine-producing neurons...
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Next Generation Longevity 2026 will convene in Osaka, Japan, on 15–16 October, bringing together an international group of clinicians, researchers, founders, technologists and investors to examine how longevity medicine can move from a rapidly expanding body of knowledge into clinical and commercial practice. The inaugural two-day meeting wil...
By Mike Florio – Pro Football Talk – The NFL may not be interested in doing business with the New York Times, after all. As the league and The Athletic (owned and operated by the Times) reportedly discuss a content partnership that would create a clear conflict of interest for the Times, the Times has […] The post New study finds at least 24.5 pe...
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What if your brain could have its own biological age and, more importantly, what if that number could change? That is the question behind Brain Years, a functional brain-age model developed through a collaboration between neurotechnology company Sens.ai and the Buck Institute for Research on Aging. Rather than looking only at the brain’s ...
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NKGen Biotech announced that Chairman and CEO Paul Y. Song, M.D., will present on troculeucel, the company’s lead investigational program, at Biologics Manufacturing Korea 2026 in Incheon on 17-18 Sept. 2026, with the presentation scheduled for 18 Sept. at 11:00 a.m. KST. The presentation will cover troculeucel’s use in neurodegenerative diseases...
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Vincere Biosciences received a $2.7 million Small Business Innovation Research Phase II grant over two years from the National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health, to advance a USP30 inhibitor through IND-enabling studies for the treatment of acute kidney injury. The funding will supp...
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Resolution Therapeutics has completed enrollment in EMERALD, its Phase I/II study of RTX001 in patients with end-stage liver disease and prior hepatic decompensation. Fifteen patients have been dosed with RTX001, an engineered regenerative macrophage therapy incorporating IL-10 and MMP-9 intended to address inflammation and fibrosis. RTX001 is a...
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BioViva USA Inc. announced the issuance of U.S. Patent No. 12,653,907, titled Methods of Treating or Preventing Age-Related Disorders, covering therapeutic methods that combine human telomerase reverse transcriptase (hTERT) and Follistatin-344 (FST). The patent was issued by the United States Patent and Trademark Office on June 16, 2026, and BioV...
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Researchers here run a much larger than usual mouse study to show a ~10% slowing of aging, depending on how one slices the data, in mice genetically engineered to exhibit a growth hormone mutation that changes the interaction of circulating growth hormone with the growth hormone receptor on cell surfaces. Growth hormone is switched from a recepto...
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Researchers have been working towards practical approaches to inhibiting RUNX2 activity as a way to slow age-related loss of bone mineral density. Bone extracellular matrix is constantly remodeled throughout life, created by osteoblast cells and destroyed by osteoclast cells. In youth these activities are balanced, but with advancing age osteocla...
by Tampere University – Phys Org – Researchers at Tampere University have developed a versatile hydrogel platform that makes it easier to create customized biomaterials for tissue engineering, disease modeling, drug discovery and regenerative medicine. Their plug-and-play crosslinking technology enables the design of a wide range of hydrogels in...
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“I mean we have the knowledge to prevent heart disease now. It's applying it earlier in life that really makes the difference. That's my pitch to the 30-year-old, and there's a lot of pushback.”‒ Michael Davidson The post #407 ‒ Preventing cardiovascular and Alzheimer’s disease: lowering LDL early, APOE4, and promising new therapies | Michael Dav...
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Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To...
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How screens, outdoor light, and near work may influence myopia The post Nearsightedness is rising. Are screens to blame? appeared first on Peter Attia MD. ...
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The immune systems of the body and brain are distinct and separate, or at least largely separate, influencing one another via signaling. The blood-brain barrier keeps the vast majority of immune cells in the body out of the brain, and vice versa. A few channels have been discovered in recent years whereby a small number of adaptive immune cells, ...
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Six different aging clocks detected younger blood protein profiles in patients taking the experimental lung-fibrosis drug rentosertib. This suggests possible anti-aging effects, but separating those from the narrower benefits of treating fibrosis remains a challenge [1]. Many drugs developed for particular diseases act on aging-related biologica...
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With Grok Bot, SpaceXAi has created something really special and helpful. And the Evipedia Grok Bot turns this gem into something even more precious. A specialized AI assistant offering an evidence-based 2nd opinion on health and longevity interventions. It integrates Grok, the AI4L persona, the Evipedia MCP server, and Evipedia-hosted search int...
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Atherosclerosis is the largest cause of human mortality, producing stroke and heart attack when fatty plaques obstructing arteries rupture. There is accordingly a great deal of research aimed at influencing the course of the condition. Reversal of plaque growth to clear arteries and remove potentially unstable plaques remains a challenge, and few...
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Aging is a complex stochastic process of damage accumulation, shaped at the detail level by choices made, environments encountered, and the responses and interactions of countless cells. As the paper here notes, this gives rise to a sizable variance between individuals, even those with the same genetics or similar lifestyles. The research and med...
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By Tarun Sai Lomte – Medical and Life Sciences News – In a recent study published in the journal Cell Reports, researchers characterized CD4 cytotoxic T lymphocytes (CD4 CTLs) in supercentenarians. Aging is marked by a gradual functional decline, driven by cellular and molecular alterations, including cellular senescence, DNA mutations, and mitoch...
By Springer Nature – Twenty years after the discovery of induced pluripotent stem cells (iPSCs), the study of pluripotency, differentiation, and cellular reprogramming remains one of the most dynamic areas of modern biology. Questions surrounding how cell identities are established, maintained, and changed lie at the heart of developmental biolog...
In February 2023, a study in Nature Medicine found that people with higher levels of erythritol in their blood experienced more cardiovascular events over the following three years. We published our analysis at the time: Erythritol and Cardiovascular Health, March 2023. Below, you’ll find our update on what the research has shown since. ...
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Fresh from Spain’s spectacular victory in the 2026 FIFA World Cup, Madrid is preparing for another kind of world-class gathering: one focused not on winning more years of sporting glory, but on winning more healthy years of life. On September 30 and October 1, 2026, the International Longevity Summit Madrid 2026 will bring together leading scient...
Flavonoids are having a moment in longevity research. These plant compounds give fruits and vegetables their color, and a growing body of science suggests they may also help the body manage some of the wear and tear that comes with age. Two flavonoids that come up again and again are fisetin and quercetin. They’re often discussed side by side...
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Researchers have discovered and explained how calcium mishandling in muscle cells leads to long-term muscle weakness in older people. Skeletal muscle cells use calcium ions to control how and when they contract. This activity is modulated by CaMKII, a protein kinase that also regulates muscle adaptations in response to exercise [1] and serves a ...
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Every field of specialist knowledge consists of a series of concentric circles, the greatest knowledge at the center, the scientists advancing the state of the art, and the least knowledge at the outskirts, the public at large. In between we find lesser scientists, patient advocates, laypeople with a strong interest in the field, and so forth - v...
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Aging clocks built using machine learning techniques applied to biological data are colloquially said to measure biological age, or at least aspire to measure biological age. Biological age is nebulous and debated at the detail level, but a rigorous definition is the increase over time in risk of mortality from intrinsic causes. A greater mortali...
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The accumulation of senescent cells is an important contribution to degenerative aging; the inflammatory secretions of senescent cells actively degrade tissue structure and function. Animal studies have shown that selective destruction of senescent cells produces a meaningful degree of rejuvenation in old animals, alongside reversal of the pathol...
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ByEric Ralls – earth.com – A protein that guards the tips of chromosomes turns out to be what keeps muscle able to repair itself for a lifetime. When you pull a muscle, specialized repair cells along the fibers spring into action to rebuild the tissue. But keeping those cells alive and dividing doesn’t guarantee healing. […] The post Muscle repai...
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Without careful study design, studies in which the use of GLP-1 receptor agonists such as semaglutide lowered calorie intake significantly via suppression of appetite might be expected to teach us little that we did not already know. Reducing calorie intake without compromising minimum necessary levels of essential nutrients slows aging and exten...
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In a recent study, researchers have evaluated how responsive several DNA methylation (DNAm) biomarkers are to a range of longevity interventions [1]. Testing lifespan-extending interventions in humans has a major problem: it can take many years, or even decades, to see results. Nobody wants to wait that long. Therefore, it is essential to find p...
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Past research has noted that socioeconomic status is a part of a web of correlations that include wealth, intelligence, education, lifestyle choices, and longevity. Untangling all of that to make definitive pronouncements on what exactly drives the observed variation in human life span has proven challenging. It is a reasonable assumption, based ...
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Screening compound libraries for effects on aging in short-lived species has grown to become a significant area of interest in the aging research community. As a general rule, discoveries are modest in effect size, and largely take the form of novel ways to influence the beneficial maintenance and repair activities (such as autophagy) triggered b...
By Nina Bai, Stanford Medicine – SciTechDaily – Stanford Medicine researchers and colleagues found a way to make natural killer cells better at attacking cancer. In mice, the enhanced cells entered solid tumors and slowed their growth. One of the biggest successes of modern cancer treatment has been learning how to turn the immune system into a ...
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by Daniel Lawler – Phys Org – Peppercorn-sized clumps of human brain cells grown in a lab for a record seven years aged similarly to those inside our heads, suggesting they “recorded the passage of time,” scientists said Wednesday. These tiny clumps, called organoids, are grown from stem cells by scientists around the world in […] The post Oldest...
If you’ve ever felt like your metabolism is “slowing down,” you’re not imagining it. Lower energy, creeping weight gain, harder-to-keep muscle, and blood sugar swings are all common with age. Many people understandably go on the hunt for supplements for metabolism, only to find a dizzying array of products promising to fire up caloric burn. A...
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At the high level, without delving into specific mechanisms, the consensus view on aging is that it exists in the shadow of natural selection. The selection pressure that drives the spread of changes in genes, systems, biology in general in any given species operates most strongly on early life reproductive success. This inevitably gives rise to ...
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In a new study, semaglutide given late in life increased median lifespan in female mice by more than 12% and improved various health markers. Semaglutide’s effect possibly went beyond caloric restriction [1]. GLP-1 receptor agonists, which act on a hormone that regulates insulin secretion and appetite, have revolutionized obesity treatment, show...
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One of the goals of the Dog Aging Project is to better establish that the characteristics of aging in dogs are close enough to the characteristics of aging in humans to make the results of interventions on dog life span relevant to the development of human medicine. Thus the paper here, in which researchers establish that comorbidity, the presenc...
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In recent years, researchers have been gathering as much data as possible on the behavior of aging clocks of various sorts. The study here is an example of the type, in which multiple proteomic clocks were assessed in large epidemiological study populations. As one might expect, where there is age acceleration, meaning a higher clock age than chr...
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By Angela Yeager – Oregon Health & Science University – The NIH award supports development of stem cells designed to avoid immune rejection, preserve vision. Millions of older adults face vision loss from age-related macular degeneration, or AMD, a leading cause of irreversible blindness. A researcher at Oregon Health & Science University has rece...
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Researchers publishing in Aging Cell have described how stopping growth hormone receptor production in midlife significantly lengthens the lives of mice. Growth hormone affects the metabolism of fats (lipids), increasing the levels of circulating fatty acids while increasing insulin-like growth factor 1 (IGF-1) and impairing the function of insu...
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There are a good many affordable interventions that may well produce enough of an effect on aging to justify widespread use. At the more compelling end of the spectrum, based on a relatively large effect size in animal data and very limited supporting human data, we might consider the senolytic combination of dasatinib and quercetin, stem cell an...
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Written byLaura Tran, PhD – The Scientist – People who live past 100 years old appear to have an abundance of specialized T cells that may help protect them against infection and cancer. Aging is an inevitable part of life, but some remarkable individuals remain healthy well into extreme old age, living to 110 years […] The post Supercentenarians...
by Children’s Hospital Boston – Medical Xpress – Patients with sickle cell disease are often hesitant to undergo transformative gene therapy—the current lengthy process requires multiple hospital visits to collect enough stem cells. Researchers from Boston Children’s Hospital have helped smooth the road to gene therapy with a new approach that co...
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In this “Ask Me Anything” (AMA) episode, Peter delves into the critical subject of blood pressure, which is one of the three primary causes of atherosclerosis, along with high apoB and smoking. He begins by unraveling the nature of high blood pressure, its prevalence, and why it often goes undiagnosed. Peter describes in detail the… The post Bloo...
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Local estrogen therapy treats symptoms, prevents UTIs, is safe, and likely saves lives The post Vaginal estrogen: a potentially life-saving therapy appeared first on Peter Attia MD. ...
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by Alice Park – Time – Dr. Shinya Yamanaka can no longer enjoy a beer in peace. After a long day at a recent conference in Montreal, the scientist found a seat at the quiet hotel bar, hoping for a few moments to himself. “But unfortunately, or fortunately, a group of Japanese businessmen came into […] The post Shinya Yamanaka Made Cells Young Aga...
By Tohoku University – Stem cells possess the unique ability to self-renew and transform into different types of cells. For example, rare hematopoietic stem cells found in bone marrow can become any type of blood cell. Throughout life, they can produce new blood cells to replace those lost because of infection, bleeding, or chemotherapy. However...
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Filmmaker Tim Maupin has spent a number of years developing The Last Generation to Die, a near-future film about what happens when the first true rejuvenation technologies arrive and who gets left behind. The project has now reached the top 65 of the Future Vision XPrize, a global contest seeking optimistic visions of humanity’s future. We talked ...
Your body runs on a roughly 24-hour internal clock that coordinates when you sleep, when hormones peak, when your cells repair themselves, and when your immune system is most active. This is your circadian rhythm, and it changes as you age. Research shows that the circadian system undergoes shifts over time, affecting sleep-wake cycles, tempe...
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By Deborah Vankin – The Los Angeles Times – Balance is critical in helping older adults prevent falls — and it’s now considered a marker for longevity. It also helps younger people optimize athletic performance and prevent injuries. This is the first in a five-piece-series addressing how to test and train your balance at home. […] The post This p...
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Driven by ongoing support from their community, The Longevity Science Foundation is extending the deadline for the Invested in Her campaign to October 1, 2026, as they work toward a $250,000 fundraising target to support early-stage research into ovarian aging and menopause. Hundreds of millions of women live longer than men yet spend more years ...
by Ty Tkacik, Pennsylvania State University – Phys Org – An interdisciplinary team of engineers and chemists at Penn State has laid the groundwork for 3D printing spheroids—tiny clusters of living cells—capable of regenerating bone tissue in response to severe trauma or infections. By introducing different strands of genetic information into und...
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By Darren Orf – Popular Mechanics – Mitochondria have long been understood as the powerhouse of the cell. Are they also the powerhouse of rejuvenation? On average, the human body is made of 37 trillion cells, and many of those cells contain mitochondria, a membrane-bound organelle whose primary job is to transform food and oxygen […] The post Sci...
You’re probably familiar with creatine as something people take for workouts, but it does a lot more than help you lift heavier or recover faster. Researchers have started to examine how it might support healthy aging, from maintaining muscle to supporting brain function and overall resilience. A big part of aging comes down to how well your ...