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Updated 3:13pm | Jan, 07, 2026
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The overt manifestations of the aging of hair follicles, going gray and losing hair, often appear to bother people to a greater degree than the impending failure of their internal organs. In principle a sufficient understanding of the mechanisms of aging should lead to ways to avoid both outcomes. Rejuvenation therapies that repair the cell and t…
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Preventive health biotech Corsera Health today announced it has secured an $80 million Series A financing to advance its mission to boost human healthspan by “predicting and preventing” cardiovascular disease. The Boston-based company also revealed has begun dosing participants in its first in-human clinical trial of its lead program – an RNA…
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It’s a biotech year that finally feels alive again. For the first time in a while, biotech is starting a new year with something it has sorely lacked: confidence. In the first half of 2026, a new round of readouts is poised to test whether the momentum can last. Few companies sit more squarely at the center of that story than the major Am…
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Neuroplasticity, the brain’s ability to adapt, rewire and recover, has been central to how scientists think about learning, aging and neurodegenerative disease. But while researchers have long known what neuroplasticity is, measuring it reliably in humans outside tightly controlled labs has remained a challenge. This week, Belfast-based C…
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A recent study investigated biomarkers that can help monitor trajectories of Alzheimer’s disease-related molecular processes, such as neuronal cell death, and how patients respond to treatments. The authors reported that using biomarkers enabled them to gain insights into the molecular processes that contribute to improved cognition following huma…
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Dietary restriction remains one of the most reproducible lifespan-extending interventions in the lab – but its effects depend on more than nutrient intake alone. In C elegans, researchers have shown that food-associated sensory cues can modulate the same longevity circuitry that dietary restriction engages, pointing to a brain-to-gut pathway …
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By William A. Haseltine, – Forbes – Treating brain diseases is extraordinarily challenging, because drugs often work poorly and implants require risky surgery that can jeopardize critical brain functions. A group at MIT has sought a different approach, using the natural ability of living cells to detect diseased brain areas and ferry microscopic …
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by Kiran Kumar & Jen Scheinman – Timeline – 2025 was a landmark year for longevity science, with breakthroughs spanning immunology, metabolism, and cell biology. This roundup highlights key studies from the year and what they mean in the longevity sphere. Each study carries clinically relevant implications, pointing toward strategies that might he…
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Function announced the launch of its Eat Different campaign, a public-facing effort aimed at challenging what the company describes as a food system prioritising convenience over health and nutrition. The initiative focuses on raising awareness of the links between diet, chronic disease and long-term health outcomes, and advocating for systemic ch…
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Fountain Life said its data‑driven healthcare model demonstrates measurable improvements in key health outcomes by tracking longitudinal clinical information rather than relying on isolated checks or generic recommendations. The preventive health and longevity brand reported that it has assembled one of the largest long‑term datasets, with more th…
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Ikarovec Ltd and VectorBuilder have entered an exclusive worldwide option agreement that gives Ikarovec the rights to use VectorBuilder’s proprietary AAV capsid technology in combination with its gene therapy candidate IKAR‑003 for intermediate age‑related macular degeneration (AMD), a condition currently without approved drug treatments and at hi…
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Fractyl Health announced the appointment of Lara Smith‑Weber as Chief Financial Officer, bringing experienced financial leadership to support the company’s transition toward commercial‑stage operations and strategic growth. Smith‑Weber will lead oversight of financial planning, budgeting, capital strategy, investor relations and corporate reportin…
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Biosplice Therapeutics announced that it has submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) seeking approval of lorecivivint (LOR) for the treatment of knee osteoarthritis (OA). The filing is based on data from 11 clinical trials, including the Phase 3 OA‑07 study, and represents what the company describes as…
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Anavex Life Sciences said the U.S. Food and Drug Administration (FDA) provided constructive feedback on its Alzheimer’s disease clinical development program during a Type C meeting, reflecting the agency’s interest in the progress and regulatory planning for its lead candidate blarcamesine (ANAVEX®2‑73). The FDA invited the company to present its …
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Any broad consideration of exosomes is entirely too broad to fit in one paper. Exosomes are one category of extracellular vesicles, membrane-wrapped packages of molecules released by cells as a part of cell to cell communication. At this point the diversity of extracellular vesicles and circumstances leading to their generation and selection of s…
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Researchers here present indirect evidence for the toxic aggregation of amyloid-β and tau protein in the aging brain to drive the accumulation of white matter hyperintensities seen in brain imaging. These hyperintensities are areas of damage, resulting from a range of causes that include rupture of blood vessels, localized inflammatory response, …
Telomir reports Telomir-1 significantly reduced tumor growth and spread in preclinical cancer models
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Telomir Pharmaceuticals said its investigational small-molecule therapy Telomir-1 (Zn-Telomir) produced statistically significant reductions in both primary tumor growth and metastatic dissemination in preclinical tumor xenograft models of aggressive triple-negative breast cancer (TNBC). In these animal studies, Telomir-1 lowered primary tumor bur…
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Models are not reflections of real systems, but are better thought of as tools to help us understand how real systems might work under the hood. The production, assessment, and consideration of models over time helps researchers to constrain and guide research into real systems. Any individual model may not be all that helpful on its own. Certain…
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A shingles vaccine may do more than prevent a painful rash; it may also reduce the risk of developing dementia and could even slow progression in those already diagnosed, according to a large analysis of health records from Wales. In a new study published in Cell, researchers examined the NHS rollout of the live shingles vaccine Zostavax,…
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AI drug discovery company Variant Bio today announced the launch of Inference, a genomics-powered discovery platform it has been building over the past seven years. The Seattle-based company also announced a $120 million partnership with Boehringer Ingelheim to use the platform for target discovery in kidney disease. Described by Variant …
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How did the year 2025 turn out for longevity biotech? Was it surprising or more of the same? Exciting or disappointing? Was the progress fast-moving or excruciatingly slow? What should we expect in 2026? We asked five leading experts to weigh in. Longevity biotech exceeded my expectations in 2025 in how quickly it went mainstream within big pha…
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Last month, California-based biotech companies Halozyme Therapeutics (HALO) and Skye Bioscience announced a collaboration that looked modest. There was no drug reveal or sweeping acquisition. Instead, the agreement focused on an increasingly critical aspect of modern medicine: how drugs are delivered to patients. Under the partnership, Sk…
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Mirror, mirror on the wall… can really just gazing at it for 30 seconds tell you all? Imagine looking in the mirror every morning and seeing not just your reflection, but also a glimpse of your future health. That’s what Canadian tech company NuraLogix is promising with its new Longevity Mirror, unveiled at CES 2026 [1]. The startup, …
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“Blue zones” have occupied a strange place in the longevity conversation. Celebrated by wellness circles. Questioned by critics and skeptics. And of course, inevitably, caught in the crossroads between science and self-help. These regions – including Okinawa in Japan, Sardinia in Italy, Ikaria in Greece and Costa Rica’s Nicoya Peninsula –…
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Insilico Medicine announced a multi-year research and development collaboration valued at up to US$888 million with Servier, an independent international pharmaceutical company, to discover and develop innovative oncology drug candidates by combining Insilico’s artificial intelligence (AI)-driven discovery platform with Servier’s cancer drug devel…
By Anne Trafton, Massachusetts Institute of Technology – ScitTechDaily – As the immune system weakens with age, researchers have found a way to temporarily boost its function by reprogramming liver cells to support T-cell development. As people get older, the immune system often becomes less effective. T cell numbers shrink and these cells tend …
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Here find a tour of an aspect of mitochondrial structure that might be unfamiliar, the boundary between the inner and outer mitochondrial membranes and their features called the mitochondrial contact site and cristae organizing system (MICOS). It is of interest to the researchers here because their data shows that MICOS becomes particularly disar…
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It is well established that greater physical fitness correlates with improved late life health and greater life expectancy. Here researchers report a modest decrease in the predicted age produced by a proteomic aging clock following a 12 week program of exercise. This is much as one would expect given what we know about the effects of regular exe…
By Venya Patel – Nutrition Insight – New research has found that a chemical in dark chocolate has anti-aging properties. The team analyzed blood levels of the plant compound theobromine in relation to biological age markers. Examining participant data from the TwinsUK and KORA studies, King’s College London, UK, researchers correlated higher theob…
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NADclinic, a UK-based global group specialising in longevity, advanced diagnostics and performance optimisation, has entered a strategic partnership with HarleyDoc, a doctor-led healthcare platform focused on clinical leadership, medical governance and international concierge medicine. The agreement aims to create a medically governed model design…
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Scientists have found that a single microbial species can blunt the negative effects of a high-fat diet due to the unique mix of lipids it produces [1]. They intend to identify its specific lipids in future work. The billions of gut microbes that we share our bodies with can profoundly influence our health. For instance, microbiome diversity is …
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At the high level, the lymphatic system has a lot in common with the vascular system. The cargo is lymph and immune cells rather than blood and immune cells, but the structure and function of vessels is quite similar. Both types of vessel are lined with endothelial cells, while a layer of smooth muscle manages contraction, dilation, and pulsation…
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The debut episode of Longevity.Technology UNLOCKED drops today. This episode features two distinguished guests: Dr Eric Verdin, CEO of the Buck Institute for Research on Aging, and Dr Jens Juul Holst, Professor of Medical Physiology at the University of Copenhagen, renowned for his discovery of the hormone GLP-1, now central to today’s mo…
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French healthtech Withings today announced the launch of its latest connected scale product at the CES 2026 tradeshow in Las Vegas, describing the product as a “home longevity station” geared towards early detection and monitoring of chronic disease risk. Scheduled for release in the second quarter of 2026, pending FDA clearance for certain m…
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We’re closer to 2050 than to 2000, and technology is advancing apace; this includes technologies that help us stop aging in all its forms. Here’s the highlights of what’s been accomplished last month. A Year of Rejuvenation Research and Journalism: Winter is in full swing for those of us in the Northern Hemisphere. It is a time for cozy nights b…
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Senescent cells accumulate with age as the immune system slows down and clears them less effectively. The immune system itself also accumulates senescent cells of various types. Once senescent, a cell ceases to replicate, grows in size, and generates pro-growth, pro-inflammatory signaling that becomes harmful when sustained over time. The more se…
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Autophagy is the name given to an important collection of processes that identify broken and unwanted cellular structures and convey them to a lysosome, where they are broken down and recycled. The identification and conveyance differ greatly from target to target, but all of the specific forms of autophagy converge on delivery to a lysosome. Up …
By Drug Target Review – Kobe University researchers have developed a new way of freeze induced pluripotent stem cells (iPS cells) directly in their culture dishes without losing viability or pluripotency. Researchers at Kobe University have developed a novel method that allows induced pluripotent stem cells (iPS cells) to be frozen directly in t…
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By Longevity Biotechnology Association – Longevity Biotechnology Association (LBA) held its inaugural Investors Conference on October 23, 2025, in New York City — an event that brought together leading investors, early-stage biotech founders, and scientists advancing therapies that target the biology of aging. The event convened 9 companies and 15…
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“We really need to take advantage of lifestyle behavior changes [during that perimenopause window] to have this lifelong impact to improve health span.” —Abbie Smith-Ryan The post #378 ‒ Women’s health and performance: how training, nutrition, and hormones interact across life stages | Abbie Smith-Ryan, Ph.D. appeared first on Peter Attia. …
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Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To…
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Highlighting past articles on two common target areas for new year’s resolutions: nutrition and exercise The post Oldies-But-Goodies: January 2026 Edition appeared first on Peter Attia. …
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That genetic variation appears to determine little of the variation in life expectancy for the vast majority of people is perhaps the most useful information yet to emerge from the creation of very large databases of genetic and health information, such as the UK Biobank. That this is the case doesn’t rule out the existence of rare beneficial mut…
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2025 was a stellar year for the Healthspan Action Coalition, and we’re deeply grateful to our members, associates and colleagues for helping us make important strides in our mission to end common age-related conditions and extend the global healthspan. That’s a tall order, but the journey of a thousand miles begins with a single step, and thankful…
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Longevity Investors announces the upcoming Longevity Investors Lunch 2026, an exclusive, application-only gathering designed specifically for investors seeking exposure to the most compelling opportunities emerging at the intersection of longevity science, technology, and capital. Held during the World Economic Forum in Davos, the event convenes a…
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Histones are structures in the cell nucleus that act as spools. Regions of nuclear DNA are compacted into a protected, inactive form when spooled around histones. The modification of histones by the addition and removal of chemical decorations are an important part of determining the winding and unwinding of DNA, and thus which gene sequences are…
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Researchers here discuss the application of lipid nanoparticle delivery of messenger RNA as a basis for the development of cancer vaccines. As is the case for vaccines against infectious disease, there are many different ways to provoke an immune response to cancer-specific antigens. Use of messenger RNA to express the desired antigen is the most…
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By Tokyo Metropolitan Institute for Geriatrics and Gerontology (TMIG) – SciTechDaily – Researchers in Japan have shown that the mitochondrial protein COX7RP extends healthy lifespan in mice by enhancing mitochondrial energy efficiency. As people around the world are living longer than ever before, attention is increasingly shifting from simply ext…
by Science Daily – Researchers have revealed that so-called “junk DNA” contains powerful switches that help control brain cells linked to Alzheimer’s disease. By experimentally testing nearly 1,000 DNA switches in human astrocytes, scientists identified around 150 that truly influence gene activity—many tied to known Alzheimer’s risk genes. The f…
by ScienceBlog – Researchers at the University of Illinois Urbana-Champaign have engineered a solution using tiny microgels packed with antioxidant crystals. Published in Advanced Functional Materials, their work demonstrates how a single dose of these protective capsules, called CROSS (Cellular RedOx Spreading Shield), can keep stem cell culture…
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The proof of concept demonstration outlined in today’s research materials is chiefly interesting as a demonstration that energy metabolism may be more important than suspected in the onset and progression of Alzheimer’s disease. The brain has high energy requirements, and it was certainly thought that age-related neurodegeneration is caused in pa…
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Companies working on novel therapeutics targeting senescent cells, to selectively destroy these errant cells or alter their metabolism to reduce harmful inflammatory signaling, are largely steering clear of neurodegenerative conditions, at least for now. Any successful systemic treatment that destroys senescent cells or suppresses the inflammator…
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The lack of consistency between clinical trials conducted for any given medical condition is a continual point of complaint in the research community. It is a hard problem to solve, as illustrated by the long history of such complaints and little consequent difference in the state of trial design. Still, one can make efforts. The best way forward…
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By Advanced Research Projects Agency for Health – ARPA-H is a U.S. federal agency that will deliver breakthroughs for mental health measurement, diagnosis, and treatment. “Demystifying the field of mental health.” This is a vast unmet need. The Healthspan Action Coalition is a proud partner of the ARPA-H Customer ExperienceHub. Bernard Siegel – Ex…
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As 2025 winds to a close, it is time once again to look back at some of the aging and longevity research published in the past year. Matters do move forward, even in tough times. The research community continues to turn out interesting new papers, the XPRIZE Healthspan competition reached 100 participating teams, and the medical community continu…
By Danny Sullivan – Information.Technology – As we reflect on some of the interviews we’ve conducted over the past 12 months, it’s apparent that the longevity field is finally starting to get to grips with some of the key issues that have limited its progress. From expanding “right to try” laws and how to pitch healthspan to governments, to the …
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By Danny Sullivan – Longevity.Technology – Healthspan as a universal right, the need for new regulation, the age of mitochondrial therapies and 7 shifts to accelerate longevity. As we reflect on some of the interviews we’ve conducted over the past 12 months, it’s apparent that the longevity field is finally starting to get to grips […] The post I…
We all have off days — whether it’s a low mood that lingers, irritability that sneaks up on us, or a mental fog that just won’t lift. For many people, especially as they age, these mood shifts become more frequent and harder to shake. While therapy, movement, and quality sleep are essential, there’s another layer that often gets overlooked: y…
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Mitochondrial uncoupling involves directing a greater fraction of the energetic activity of the electron transport chain in mitochondria to produce heat rather than the adenosine triphosphate (ATP) chemical energy store molecule needed to power cell operations. This uncoupling is how mammals maintain body temperature. Small molecules can be used …
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Reduced cerebral blood flow is an important component of loss of function in the aging brain. A number of different mechanisms contribute to this issue, including heart failure and thus a reduced ability to pump blood uphill to the brain, loss of capillary density with age, and various impairments in the small-scale regulation of blood flow via c…
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Control of hypertension is arguably one of the best success stories for small molecule drug development relevant to aging, emerging from an era prior to any meaningful attempt to address the root causes of age-related conditions. The results are about the best one could expect from this compensatory manipulation of cell behavior, in that the prob…
Millions of adults struggle with sleep, whether that means falling asleep, staying asleep, or waking too early. According to the National Heart, Lung, and Blood Institute, one in three adults does not consistently get enough restorative sleep to support long-term health and performance. As we age, sleep problems often become more common. It’s…
By Cleveland Clinic – Patient with quadruple refractory multiple myeloma achieves complete response with cell therapy A Cleveland Clinic patient participated in a clinical trial of allogenic CAR T-cell therapy to treat highly resistant multiple myeloma and achieved a complete response. Five years later, her remission has endured. “The duration o…
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By Karen E. Todd – sPychology Today – Creativity may slow brain aging. Here is what this new study reveals. Key points: Creative activities were linked to brains that appeared years younger than expected. Greater expertise in dance, music, art, or gaming showed stronger brain-aging benefits. Even short-term creative learning improved brain efficie…
Everyday fatigue is so common, it’s easy to normalize. You wake up feeling groggy despite a full night’s sleep, need an afternoon caffeine hit to push through, and crash by early evening. The usual solutions — coffee, energy drinks, B12 shots — might offer short bursts of alertness, but they don’t explain why your body feels persistently drained….
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By Drug Target Review – Scientists have developed an organ-on-a-chip platform that replicates age-related immune decline, offering a long-missing tool for testing cancer vaccines in older adults. Researchers at the Terasaki Institute have announced a pioneering organ-on-a-chip platform capable of replicating age-dependent immune responses, offerin…
by James Lim, PhD – The Scientist – Let’s face it: Nobody pursues a career in science for the joy of culturing cells. But this thankless and time-intensive task is the backbone of biological research. When it’s done extremely well, the results generated from experiments can open entirely new avenues of scientific pursuit, leading to the developm…
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A special end-of-year newsletter on how you can apply James Clear’s laws of behavior change to a few of the actionable steps we learned about on The Drive in 2025 The post Using “atomic habits” to reach your health goals appeared first on Peter Attia. …
Longevity gummies are popping up everywhere, but not all of them are actually built for longevity. With so many new products hitting the market, it’s easy to confuse general wellness supplements with those designed to target aging at the cellular level. NOVOS has shaped this category with science-first formulations, including the Vital longe…
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By Science News – A simple two-drug combo restored youthfulness and greatly extended life—but only in old male mice. Summary: Scientists found that combining oxytocin with an Alk5 inhibitor revitalized extremely old male mice, boosting their lifespan and strength. Female mice showed only short-term improvements, highlighting a major sex difference…
By UCI Health News – CIRM award will support first-of-its-kind clinical trial in humans This award will support a first-in-human safety and tolerability study of an embryonic stem cell-derived neural stem cell product for Huntington’s disease, a milestone for patients who currently have no available therapies that alter the course of this deva…
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By Science Direct – Cell Stem Cell – Summary Aging impairs hematopoietic stem cells (HSCs), driving clonal hematopoiesis, myeloid malignancies, and immune decline. The role of lysosomes in HSC aging—beyond their passive mediation of autophagy—is unclear. We show that lysosomes in aged HSCs are hyperacidic, depleted, damaged, and aberrantly activat…
By Mayo Clinic – A Mayo Clinic study published in the September 2025 issue of Science Advances explores a novel approach to retinal gene therapy using fibrin hydrogels encapsulating adeno-associated virus 2-green fluorescent protein (AAV2-GFP). The findings suggest a promising, less invasive alternative for the treatment of blinding retinal dise…
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A recent review evaluated studies that included over 5.5 million participants to assess the impact of multivitamin and mineral supplements on different aspects of health [1]. A big market Multivitamin and mineral (MVM) supplements are widely used worldwide, and in the United States, around 40% of adults report taking MVMs regularly [2]. While th…