Supercentenarians are an extraordinarily resilient group of people. Reaching the age of 110 requires overcoming a century’s worth of adversity. Beyond their mental toughness, supercentenarians are biologically resilient as well.

Our friends at Rejuve.AI have outlined the factors behind the “startling immune resilience” observed in centenarians and supercentenarians. Their immune systems are dynamic and capable of responding to new threats, as demonstrated by studies on centenarians who contracted COVID-19. Rejuve.AI notes:

“Researchers collected blood samples from centenarians who were residents in a long-term care facility and had been infected with or exposed to SARS-CoV-2, which causes COVID-19. They then tested these samples for the presence of antibodies specific to the SARS-CoV-2 spike protein that the virus uses to enter cells.

Amazingly, the study revealed that centenarians produce potent spike-specific antibodies that prevent the virus from infecting cells and spreading. Plus, these antibodies were still detectable in their blood 60 days after they were first diagnosed with COVID-19 [11].”

The ability of supercentenarians to survive COVID-19 is exemplified by María Branyas Morera, the world’s oldest person. Sra. Branyas contracted COVID-19 in April 2020 at the age of 113. She survived despite the lack (at the time) of effective therapeutics to combat the disease. Sra. Branyas’s predecessor as the world’s oldest person, Ms. Lucile Randon, also recovered from the disease at the age of 116.

Rejuve.AI, pioneering as the world’s first decentralized AI longevity research network, seamlessly merges blockchain, artificial intelligence, and advanced longevity research. Their vision is to democratize healthy aging, making it accessible to everyone—possibly even extending the lives of supercentenarians.


María Branyas Morera, the oldest validated living person in the world, became the oldest person ever in the entire history of Spain.

Sra. Branyas Morera became the oldest person in the history of Spain after surpassing the age of the previous record holder of Mrs. Ana María Vela Rubio on 21 April 2023, at the age of 116 years and 48 days.

Maria lives her daily life at her residence in Santa Maria del Tura in the city of Olot, Catalonia, Spain.

Branyas expresses that while she doesn’t feel anything special about the record of being the oldest living person in the world or the oldest person ever in the history of Spain because she only feels “older”, she appreciates the fact of continuing to live, and enjoy life in a healthy way.