Salustiano Sánchez Blázquez was born in El Tejado de Béjar, Castile and León, Spain, on 8 June 1901 (claimed 1902). He attended school until the age of 10.
At the age of 17, he moved to Cuba to work. In August 1920, he moved to the US, where he first worked in the coal mines of Lynch, Kentucky.
In 1934, he married his wife Pearl (1906–1988). The couple had two children, a son named John (born 1940) and a daughter named Irene (born 1944).
Sánchez Blázquez died in Niagara Falls, New York, USA, on 13 September 2013, at the age of 112 (claimed 111) years, 97 days.