Jeanne Bot was born on 14 January 1905 in the military barracks in Mont-Louis, Occitanie region, France, where her father was a soldier, she was one of five children. She spent 50 years working as a bookkeeper in a car garage in Perpignan, Pyrenees-Orientales, France. She never married or had children.
Two months before her 100th birthday in 2005, Bot underwent hip surgery which permitted her to walk until she was 112.
Bot lived in her apartment in Perpignan, Occitanie, France. Her hearing was poor, but she was still able to watch television. She received care from her nephew, a nurse, and a physiotherapist. At the time of her 112th birthday in 2017, Bot reportedly had no major health problems and was able to move with her walker between her bedroom and living room. However, by her 114th birthday in 2019, her health had reportedly deteriorated.
On her 116th birthday in 2021, she was reportedly deaf and too tired to read, making communication near impossible. She also had reportedly become frailer, needing a nurse to make meals and clean her apartment.
Before her death, Bot began to become weaker by the day and she reportedly stopped wanting to eat. Bot died on the night of 22 May 2021.
Bot became the last surviving French person born in 1905 following the death of Mathilde Lartigue on 24 March 2018. She later became the last surviving person in the whole of Europe born in that year following the death of Dutch Geertje Kuijntjes on 24 December 2019.