Updated 6:00pm | February 04, 2025
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The Global Healthspan Summit 2025 in Riyadh continues to set the stage for critical discussions on the future of longevity science and investment. As healthspan innovation accelerates, investors and industry leaders are sharpening their focus on the opportunities and challenges shaping the market. One of the summit’s standout sessions was…
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There remains a great deal yet to be learned of the fine details of cellular biochemistry and the interactions between cells and their environments. Even just one cell remains a fantastically complex, incompletely understood collection of mechanisms. As a general rule, given further study, any aspect of cellular biology will turn out to be more c…
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Happening today and tomorrow in Riyadh, the Global Healthspan Summit 2025 brings together leading experts, investors and innovators to shape the future of healthcare science and investment. As breakthroughs in biotech, regenerative medicine and age-related disease interventions accelerate, strategic funding plays a critical role in translatin…
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Dr Fady Hannah-Shmouni, an expert in endocrinology and longevity medicine, is at the forefront of integrating advanced technologies into healthspan science. Through his work in precision medicine and AI-driven healthcare solutions, he is aiming to redefine how we monitor, predict and optimize hormonal health to extend vitality and longevity. …
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Washington State University researchers have developed a genetically engineered mouse model that mirrors human telomere dynamics, with potentially significant implications for the study of aging and disease. The breakthrough, published today in Nature Communications, addresses a long-standing limitation in aging research, where conventional m…
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Mortality among Americans aged 25-44 has risen substantially between 2011 and 2023, a new study has found, and it remains high even after having passed the COVID-related peak [1]. Despite the US being one of the world’s richest countries, Americans’ average life expectancy has been lagging behind that of comparable countries by more than four y…
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This week, over 2,500 attendees and more than 175 speakers are convening in Riyadh, Saudi Arabia, for the Hevolution Foundation’s second Global Healthspan Summit (GHS). The event, hosted by the global non-profit, is exploring the pathways and frameworks needed to drive and accelerate progress in the healthspan ecosystem.In just three years, H…
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This year Hevolution Foundation’s second Global Healthspan Summit (GHS) is notably bigger, and the healthspan narrative is undoubtedly coalescing and garnering the attention of big government and big business. “Today we have one billion people on the planet over the age of 60,” said Dr Khan kicking off the Summit this morning in his openi…
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The relative proportions of various microbial species making up the gut microbiome changes with age, in ways that provoke greater chronic inflammation and reduce the generation of beneficial metabolites such as butyrate. This likely contributes to many different age-related diseases, but producing the data to firmly support that hypothesis remain…
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Researchers here show that long term exposure to reprogramming factors in the hypothalamus of rats slows ovarian aging. It is an interesting result to add to a range of existing studies demonstrating that cell reprogramming can be conducted safely in the central nervous system. Bringing forms of reprogramming to human medicine still looks like a …
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By Fay Ghani, Abba C. Zubair – Nature – Stem cell research performed in space has provided fundamental insights into stem cell properties and behavior in microgravity including cell proliferation, differentiation, and regeneration capabilities. However, there is broader scientific value to this research including potential translation of stem cell…
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In the Journal of Nanobiotechnology, researchers have described a new method of delivering a long-lasting treatment into cartilage. Previous work has linked expression of the FGF18 protein with healthy cartilage and joints [1]. Problems with the gene responsible for FGF18 lead to osteoarthritis [2], and it has been found to be important alongsi…
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It is once again time to suggest possible areas of focus for new startups intending to develop means to treat aspects of degenerative aging, or accelerate that development. We live in the formative decades of a barnstorming era of endless possibility when it comes to biotechnology and the manipulation of cellular biochemistry. Sadly, this is join…
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On February 4-5, over 2,500 attendees and more than 175 speakers will convene in Riyadh, Saudi Arabia, for the Hevolution Foundation’s second Global Healthspan Summit (GHS). The event, hosted by the global non-profit, will explore the pathways and frameworks needed to drive and accelerate progress in the healthspan ecosystem. From insight…
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Dr Arthur Caplan, a leading bioethicist and founding head of the Division of Medical Ethics at NYU School of Medicine in New York City, is one of the most influential voices in medical ethics today. With a career spanning decades, his work has shaped global discussions on transparency, fairness and responsibility in biomedical research. At th…
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Last month, longevity biotech Fauna Bio quietly revealed that its first development candidate will be a therapeutic targeting heart failure with preserved ejection fraction (HFpEF). The drug, Faun1083, was discovered through the company’s AI-powered drug discovery platform, which leverages comparative genomics and AI to identify novel therape…
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As rejuvenation research advances from theory to practice, more therapies start making their way into the clinic. 2025 continues with both mouse experiments and human clinical trials. Cyclarity Launches Human Trial to Cure Atherosclerosis: Recently, Cyclarity Therapeutics announced the launch of a Phase 1 human clinical trial for a drug that ai…
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Here find an interview with the founder of Rubedo, a senolytic drug discovery company, also one of the co-founders of Turn Bio, one of the first cellular reprogramming companies. Of note, Rubedo recently released more information on their lead program. The senolytic space is expanding considerably in terms of potential target mechanisms. It begin…
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The concept of “healthy aging” is well-intentioned but pernicious. By definition, aging is a loss of health, the rise of mortality risk due to failure of vital biological systems in the body. Aging less rapidly is better than aging more rapidly, and advocacy for greater physical activity to slow the progression aging is a good thing, but painting…

From The Editor – Before we launch into news on the healthspan front, let’s acknowledge the elephant in the room. US health agencies, including the National Institutes of Health and the FDA, are currently in a state of limbo as the dust settles on a new and aggressively change-oriented administration. The entire healthcare field…
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“Cholesterol is almost certainly the most important molecule in the brain.” —Tom Dayspring The post #334 – Cardiovascular disease, the number one killer: development, biomarkers, apoB, cholesterol, brain health, and more | Tom Dayspring, M.D. appeared first on Peter Attia. …
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Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.or…
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Recent mouse studies indicate that FDA-approved CGRP blockers might offer a new treatment option for a condition affecting millions The post Unlocking the potential of migraine medications for endometriosis treatment appeared first on Peter Attia. …
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Among the many dysfunctions of aging, significant loss of salivary gland activity is one of those that likely never crosses the mind of anyone other than those suffering from or treating its consequences. Nonetheless, the salivary gland is a complex structure, and like all tissues, is negatively impacted by the mechanisms of aging. Inadequate pro…
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The first Global Conference on Gerophysics will take place on the 5th and 6th of March at the National University of Singapore; chaired by Brian Kennedy, Jan Gruber and Max Unfried, the event aims to formalize gerophysics as a new sub-discipline within longevity research. With an expected attendance of 150–200 participants from around the wor…
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German scientists have created lab-grown “patches” of heart muscle tissue derived from pluripotent stem cells. Following a success with rhesus monkeys, they have obtained approval for a human trial [1]. As one of the most hard-working tissues in the body, the heart muscle is subject to incessant wear and tear due to aging and various health con…
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On February 4-5, over 2,500 attendees and more than 175 speakers will convene in Riyadh, Saudi Arabia, for the Hevolution Foundation’s second Global Healthspan Summit (GHS). The event, hosted by the global non-profit, will explore the pathways and frameworks needed to drive and accelerate progress in the healthspan ecosystem.In just three yea…
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A recent study [1] has added exciting new insights to the ongoing discourse on the potential of spermidine in rectifying dysfunctional autophagy. They looked specifically at two rare cell trafficking disorders that involve problems with how cells transport materials inside the body. They found that both disorders were underpinned by dysfunc…
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One way to look at the impact of aging versus the impact of an intervention to slow aging is to examine transcriptional changes in cells. Pick a tissue and cell type, assess the whole transcriptome of RNA molecules produced by that cell type, then compare old versus young animals and treated versus untreated old animals. Here, researchers compare…
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There is a growing appreciation for the contribution of supporting cells in the brain to the progression of neurodegenerative conditions. Astrocytes perform a diverse range of functions in the brain, but can undergo maladaptive changes in behavior in response to the damage of aging and disease, making things worse. These reactive astrocytes are i…
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By Melissa Rudy, Fox News – The New York Post – The brain plays a big part in the aging process, and scientists think they’ve pinpointed the specific cells that control it. In a study of mice, researchers at the Allen Institute identified certain cells that showed “major changes” with age, particularly in one specific “hotspot,” according to a p…
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Autophagy is the name given to a collection of processes for recycling damaged structures in the cell. It is complex, involving means of determining that a structure is in some way damaged or excess to requirements, wrapping that structure in a membrane called an autophagosome, transporting the autophagosome into contact with a lysosome, and then…
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Researchers have devised a method of reducing brain inflammation by creating a long-lasting inhibitor of the inflammatory factor NF-κB. This study, published in the Nature journal Experimental & Molecular Medicine, begins with a discussion of age-related chronic inflammation (inflammaging) and its contributions to aging. Specifically, the r…
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Consumer health startup Nucleus has closed a $14 million Series A funding round supporting its “real-time quantified health platform” based on clinical-grade whole-genome DNA analysis. By providing accurate risk assessments for more than 800 conditions, including cancers, heart disease and Alzheimer’s, the company aims to give people the info…
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NF-κB is important in inflammatory signaling, and one of many possible targets for suppression of inflammation. The usual caveats apply, in that unwanted, harmful, chronic inflammation uses the same signaling pathways as normal, necessary, short-term inflammatory responses to pathogens and injury. Researchers have yet to find a suppression approa…
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An exerkine is a signaling molecule secreted in response to exercise. Classifying signaling in this way is a fairly recent development, and so mapping the space of exerkines is an ongoing exercise. Myokines, signal molecules released by muscle, are another recently established category, and there is some overlap between exerkines and myokines. Ex…
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By Jaci Conry – Boston Magazine – Your retirement dreams might sparkle with well-padded 401(k)s and European escapades—but is that rosy vision ready for reality’s age-tinted glasses? Where will you live when you need an extra hand with daily care? How will you navigate doctor’s visits and grocery runs? With people living longer than ever—so-calle…
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Environmental assaults on the body, such as pesticides, heavy metal ingestion, and even byproducts of metabolism, and how they affect aging had long been on Julie Andersen, PhD’s mind, and the topic of her research for years. The Buck professor was invited to give a talk at a 2020 National Academy of Sciences workshop about how toxins contribute…
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Cancer is, evidently, an age-related disease. The immune system becomes less able to prevent precancerous cells from progressing to form a cancer. The burden of mutational damage is higher, increasing the odds of a cancerous combination of mutations arising. Lingering senescent cells pump out pro-growth, pro-inflammatory factors that make tissues…
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On February 4-5, 2025, Hevolution Foundation will hold its second Global Healthspan Summit (GHS) in Riyadh, Saudi Arabia. The two-day event at the Four Seasons Hotel brings together international attendees, including world leaders, policymakers, researchers & scientists, and experts from the biotechnology, pharmaceutical, healthcare, and priva…
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The Founders Longevity Forum Singapore is poised to convene global leaders, clinicians, academics and investors to advance knowledge and drive growth in the longevity sector. With a significant focus on longevity investment, the conference aims to explore innovative strategies to promote healthy aging – Singapore, recognized for its dynamic s…
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BioAge Labs, a clinical-stage biopharmaceutical company specializing in therapies for metabolic diseases through targeting the biology of human aging, has announced significant updates to its research and development programs. The company is advancing its pipeline with next-generation APJ agonists and NLRP3 inhibitors, while also establishing…
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The increasingly competitive obesity drug market welcomes a new player as Helicore Biopharma emerged from stealth mode with $65 million in Series A financing to develop a pipeline of glucose-dependent insulinotropic peptide (GIP) antagonists. The company’s therapeutic platform is centered around monoclonal antibodies designed to neutralize GI…
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A new study suggests that low-intensity pulsed ultrasound (LIPUS) can be beneficial in eliminating senescent cells through the recruitment and activation of immune cells [1]. One of the characteristics of an aging organism is the accumulation of senescent cells. Various approaches are being developed to remove or neutralize those cells. Senesc…
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Researchers here demonstrate that the increased level of arginase II observed with advancing age is causing some degree of issues, using mice from a lineage in which arginase II was removed by genetic engineering. Mice lacking arginase II exhibit slowed loss of muscle mass with age, and a lower burden of cellular senescence. Given what is known o…
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The aged intestinal wall exhibits an impaired mucosal barrier, leading to leakage of microbes from the intestines into tissues and circulatory system. This is known to provoke chronic inflammation, which in turn is disruptive to tissue function and contributes to the onset and progression of age-related conditions. Here, researchers identify one …
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By Cactus Communications – SciTechDaily – Innovative therapies revive a once-undruggable mitochondrial aging regulator through a revolutionary enzyme activation mechanism. Researchers at CCM Biosciences, Inc. have leveraged a novel biophysical mechanism of enzyme activation to discover and characterize groundbreaking enzyme activators for a prev…
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How does stochastic nuclear DNA damage contribute to degenerative aging? Most mutation occurs in regions of the genome that are not used, in somatic cells with few divisions remaining before the Hayflick limit and self-destruction. Thus the impact is minimal. One point of view on this topic is that only mutations in stem cells are important. Thes…
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Scientists have presented GroceryDB, an open-access online database that measures the degree of processing of tens of thousands of products sold in three major US grocery chains [1]. While there is no universally accepted definition, the NOVA food classification system is widely used, and it defines ultra-processed food as “industrially manufac…
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The second Global Healthspan Summit (GHS 2025) is set to take place in Riyadh, Saudi Arabia, on February 4–5, 2025. Hosted by the Hevolution Foundation, this event aims to foster international collaboration on healthspan science, bringing together scientists, policymakers, investors and innovators to address the challenges of global aging. Wi…
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HealthTech startup Percipio Health has raised $20 million in a Series A funding round and officially launched its AI-powered population health monitoring platform. The company claims its platform leverages only a smartphone to collect and analyze multiple health signals and provide a comprehensive, real-time view of an individual’s health. …
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In today’s fast-paced world, making time for health and self-care can feel overwhelming. However, tapping into a state of radiant wellness isn’t as complicated as you might think. Building sustainable habits starts with small, intentional changes that grow into powerful routines over time. To guide us on this journey, we turned to the Holis…
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Senescent cells accumulate with age in part because the immune system becomes less able to clear senescent cells in a timely manner. Researchers have much yet to discover regarding the details of this decline, but some of the existing discoveries seem analogous to the ways in which cancer cells can shield themselves from the immune system via alt…
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In recent years, the level of GATA4 expression has been connected to a variety of age-related issues, such as scarring in heart tissue. More generally GATA4 is associated with cellular senescence, a major issue in aging. Senescent cells accumulate with age to disrupt tissue structure and function via pro-inflammatory signaling. Additionally, sene…
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By Alexa Mikhail – Fortune – British soccer star David Beckham may not be dominating midfield anymore since retiring from the sport over a decade ago, but the drive that led him to three FIFA world cups remains the same. “I wasn’t the most talented player on the pitch, but I knew that I worked harder than anyone else,” he tells Fortune. “That’s…
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With advancing age, muscle mass and muscle strength are both steadily reduced, leading to sarcopenia and dynapenia. Interestingly, a sizable fraction of the observed outcomes of aging on muscle function in wealthier populations are avoidable, a consequence of our modern age of comfort and machineries of transport. We exercise a good deal less tha…
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In Cell Metabolism, researchers have described how a microRNA (miRNA) derived from exosomes generated by human embryonic stem cells (hESCs) restores function and fights senescence in cell cultures and mice. Why we Age: Cellular Senescence As your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissue…
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Hot on the heels of the news that it co-developed a new AI model for longevity science with OpenAI, Retro Biosciences is reportedly raising $1 billion to fuel the next stages of its development. According to the Financial Times, the longevity biotech, led by CEO Joe Betts-LaCroix, is also preparing to launch its first clinical trial this year…
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By Courtney Shapiro – Woman’s World – New research reveals how daily tea consumption can help slow biological aging and boost health Tea is perfect for curling up with a book, boosting energy in the morning or enjoying a soothing sip throughout the day. It’s also a beverage that’s good for you! Tea has many health benefits, plus there’s no harm …
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“The notion that aging is not malleable, though wrong and provably wrong, is still the overwhelming opinion even of reasonably educated scientists and certainly of the lay public.” ‒ Rich Miller The post #333 ‒ Longevity roundtable — the science of aging, geroprotective molecules, lifestyle interventions, challenges in research, and more | Steven…
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Even light-intensity exercise can help to improve sleep among those with insomnia The post Sleepless nights? Try boosting your physical activity level appeared first on Peter Attia. …
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Researchers have discovered a small molecule that effectively kills cancer cells in the most prevalent type of breast cancer. The new drug could help against cancer recurrence and decrease the need for surgery [1]. Medicine has made great strides in treating breast cancer, but the fight is far from over. About 70% of all cases are estrogen rece…
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Researchers at the University of Galway have announced a significant advance in the field of 3D bioprinting – successfully fabricating functional human heart tissue. Their research, which has been published in Advanced Functional Materials, describes the development of bioprinted hydrogels that mimic the mechanical, electrical and biochemical…
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Healthspan-focused biotech LinkGevity revealed has been selected for the prestigious KQ Labs Programme, delivered by the Francis Crick Institute. The program provides equity investment and access to a global network of scientific expertise, selecting 10 startups annually through a rigorous evaluation process. Founded by sisters Dr Carina …
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Dr. Marco Quarta runs one of the most interesting start-ups in the longevity field: Rubedo, which focuses on utilizing the senolytic approach to cellular senescence. This company has developed ingenious ways to cope with the notorious heterogeneity of senescent cells and is one of the first to bring its senolytic drug candidate into clinical trial…
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By Aging – A new research perspective was published in Aging (listed by MEDLINE/PubMed as “Aging (Albany NY)” and “Aging-US” by Web of Science) Volume 16, Issue 22 on December 9, 2024, entitled “Nuclear lipid droplets: a novel regulator of nuclear homeostasis and ageing.” In this article, Dr. Konstantinos Palikaras from the National and Kapodist…
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Lisbon, Portugal – The Global 3rd Longevity Med Summit, the premier global event in longevity medicine, wellness, and healthcare innovation, is set to take place in Lisbon from May 6 to 8, 2025. This year’s summit promises an expanded agenda featuring groundbreaking topics, world-renowned speakers, and an exclusive Pre-Summit Day focused on the Fu…
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In Aging Cell, researchers have described how different combinations of gut bacteria impact muscle strength in mice. The link between gut bacteria and health is well-documented, and multiple biomarkers have confirmed that a healthy gut leads to health elsewhere [1]. This is not just due to inflammation caused by pathogenic bacteria: previous wo…
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Recently, Cyclarity Therapeutics announced the launch of a Phase 1 human clinical trial for a drug that aims to remove the arterial plaques that lead to heart attacks and strokes. Cyclarity Therapeutics is working on a cost-effective small molecule drug aimed at eliminating arterial plaque, thus potentially addressing the globally leading cause …
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By Leah Buletti – University of Forida Health – GAINESVILLE, Fla. — As humans age, we develop chronic inflammation in our blood and tissues that gradually decreases the function of blood stem cells in our bone marrow. These defects harm blood cell production and the immune system, often leading to a slew of complications and weakening responses t…
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Chaired by Prof Brian Kennedy, Assoc Prof Jan Gruber and Dr Maximilian Unfried, this pioneering conference will bring together leading theoretical physicists and eminent researchers in ageing and rejuvenation biology to explore a transformative new field: ‘Gerophysics’. Organised by the Healthy Longevity Translational Research Programme at the Yon…
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A recent study has found that the overexpression of telomerase reverse transcriptase (TERT), which is a subunit of telomerase, an enzyme essential for telomere maintenance, leads to lifespan extension in mice without significant side effects [1]. Telomere shortening is a well-known hallmark of aging. Telomeres are protective DNA sequences at th…
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By Ken Moritsugu – AP News – BEIJING (AP) — A growing number of countries are confronting the dual challenges of population decline and aging, as younger generations opt to have fewer children and advances in healthcare extend life expectancy. China said Friday that its population fell for the third straight year in 2024, falling by almost 1.4…